Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WU51_LEIDO

TriTrypDb:

LdBPK_161500.1 , LdCL_160020000 , LDHU3_16.1780

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WU51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.522
CLV_NRD_NRD_1	12	14	PF00675	0.697
CLV_NRD_NRD_1	312	314	PF00675	0.581
CLV_NRD_NRD_1	51	53	PF00675	0.507
CLV_NRD_NRD_1	95	97	PF00675	0.553
CLV_PCSK_KEX2_1	102	104	PF00082	0.547
CLV_PCSK_KEX2_1	12	14	PF00082	0.697
CLV_PCSK_KEX2_1	120	122	PF00082	0.603
CLV_PCSK_KEX2_1	50	52	PF00082	0.507
CLV_PCSK_KEX2_1	95	97	PF00082	0.526
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.526
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.603
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.505
CLV_PCSK_SKI1_1	191	195	PF00082	0.601
CLV_PCSK_SKI1_1	26	30	PF00082	0.741
CLV_PCSK_SKI1_1	299	303	PF00082	0.524
CLV_PCSK_SKI1_1	313	317	PF00082	0.457
CLV_PCSK_SKI1_1	43	47	PF00082	0.454
DOC_MAPK_gen_1	146	155	PF00069	0.696
DOC_MAPK_gen_1	50	58	PF00069	0.539
DOC_MAPK_MEF2A_6	236	244	PF00069	0.596
DOC_PP1_RVXF_1	297	304	PF00149	0.556
DOC_USP7_MATH_1	36	40	PF00917	0.736
DOC_USP7_UBL2_3	120	124	PF12436	0.603
DOC_USP7_UBL2_3	146	150	PF12436	0.693
DOC_USP7_UBL2_3	187	191	PF12436	0.550
DOC_WW_Pin1_4	317	322	PF00397	0.549
LIG_14-3-3_CanoR_1	26	34	PF00244	0.743
LIG_14-3-3_CanoR_1	3	7	PF00244	0.742
LIG_BRCT_BRCA1_1	19	23	PF00533	0.717
LIG_EH1_1	223	231	PF00400	0.448
LIG_FHA_1	320	326	PF00498	0.500
LIG_FHA_1	61	67	PF00498	0.559
LIG_FHA_2	139	145	PF00498	0.620
LIG_FHA_2	246	252	PF00498	0.601
LIG_LIR_Nem_3	33	37	PF02991	0.637
LIG_LIR_Nem_3	88	92	PF02991	0.646
LIG_SH2_CRK	298	302	PF00017	0.566
LIG_SH2_STAP1	78	82	PF00017	0.580
LIG_SH2_STAT5	283	286	PF00017	0.721
LIG_SH2_STAT5	34	37	PF00017	0.622
LIG_SH2_STAT5	44	47	PF00017	0.491
LIG_SH3_3	285	291	PF00018	0.582
LIG_SH3_3	298	304	PF00018	0.499
LIG_SUMO_SIM_anti_2	328	334	PF11976	0.499
LIG_SUMO_SIM_par_1	238	243	PF11976	0.700
LIG_SUMO_SIM_par_1	253	259	PF11976	0.522
LIG_SUMO_SIM_par_1	328	334	PF11976	0.493
LIG_TRFH_1	58	62	PF08558	0.717
LIG_UBA3_1	178	187	PF00899	0.524
LIG_WRC_WIRS_1	338	343	PF05994	0.496
MOD_CK1_1	17	23	PF00069	0.757
MOD_CK1_1	243	249	PF00069	0.629
MOD_CK1_1	39	45	PF00069	0.550
MOD_CK2_1	138	144	PF00069	0.719
MOD_GlcNHglycan	16	19	PF01048	0.636
MOD_GlcNHglycan	162	165	PF01048	0.520
MOD_GlcNHglycan	226	229	PF01048	0.497
MOD_GlcNHglycan	248	251	PF01048	0.536
MOD_GlcNHglycan	271	274	PF01048	0.593
MOD_GlcNHglycan	335	338	PF01048	0.584
MOD_GlcNHglycan	7	10	PF01048	0.683
MOD_GSK3_1	220	227	PF00069	0.558
MOD_GSK3_1	32	39	PF00069	0.678
MOD_GSK3_1	333	340	PF00069	0.521
MOD_GSK3_1	7	14	PF00069	0.698
MOD_N-GLC_1	199	204	PF02516	0.682
MOD_N-GLC_1	224	229	PF02516	0.485
MOD_NEK2_1	189	194	PF00069	0.615
MOD_NEK2_1	224	229	PF00069	0.639
MOD_NEK2_1	333	338	PF00069	0.630
MOD_NEK2_1	341	346	PF00069	0.595
MOD_NEK2_1	7	12	PF00069	0.676
MOD_PKA_2	11	17	PF00069	0.650
MOD_PKA_2	2	8	PF00069	0.699
MOD_PKA_2	235	241	PF00069	0.463
MOD_Plk_1	224	230	PF00069	0.646
MOD_Plk_1	240	246	PF00069	0.463
MOD_Plk_1	32	38	PF00069	0.625
MOD_Plk_4	148	154	PF00069	0.752
MOD_Plk_4	2	8	PF00069	0.723
MOD_Plk_4	235	241	PF00069	0.596
MOD_ProDKin_1	317	323	PF00069	0.545
MOD_SUMO_for_1	286	289	PF00179	0.569
MOD_SUMO_rev_2	249	255	PF00179	0.447
TRG_DiLeu_BaEn_2	84	90	PF01217	0.515
TRG_ENDOCYTIC_2	298	301	PF00928	0.556
TRG_ENDOCYTIC_2	335	338	PF00928	0.575
TRG_ENDOCYTIC_2	78	81	PF00928	0.583
TRG_ER_diArg_1	11	13	PF00400	0.681
TRG_ER_diArg_1	49	52	PF00400	0.511
TRG_NES_CRM1_1	144	156	PF08389	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL8	Leptomonas seymouri	63%	69%
A0A1X0NYW3	Trypanosomatidae	42%	100%
A0A3R7JY16	Trypanosoma rangeli	36%	94%
A4H8S0	Leishmania braziliensis	81%	100%
A4HX38	Leishmania infantum	100%	100%
E9AQV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QEM4	Leishmania major	95%	100%
V5BMN4	Trypanosoma cruzi	40%	96%