DNA-directed RNA polymerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-directed rna polymerase I largest subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WU48_LEIDO

TriTrypDb:

LdBPK_161420.1 , LdCL_160019200 , LDHU3_16.1700

Length:

1810

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	12
GO:0005634	nucleus	5	11
GO:0005736	RNA polymerase I complex	4	1
GO:0030880	RNA polymerase complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	1

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Expansion

Sequence features

A0A3S7WU48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006351	DNA-templated transcription	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0018130	heterocycle biosynthetic process	4	12

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	12
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0034062	5'-3' RNA polymerase activity	5	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1063	1067	PF00656	0.388
CLV_C14_Caspase3-7	1491	1495	PF00656	0.469
CLV_C14_Caspase3-7	1518	1522	PF00656	0.351
CLV_C14_Caspase3-7	712	716	PF00656	0.393
CLV_NRD_NRD_1	1103	1105	PF00675	0.270
CLV_NRD_NRD_1	117	119	PF00675	0.540
CLV_NRD_NRD_1	1220	1222	PF00675	0.248
CLV_NRD_NRD_1	1501	1503	PF00675	0.290
CLV_NRD_NRD_1	1511	1513	PF00675	0.163
CLV_NRD_NRD_1	1638	1640	PF00675	0.234

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4V8	Leptomonas seymouri	82%	99%
A0A0S4JSQ7	Bodo saltans	56%	94%
A0A1X0NZF6	Trypanosomatidae	62%	96%
A0A422NDG9	Trypanosoma rangeli	58%	99%
A4H8R3	Leishmania braziliensis	90%	100%
A4HX31	Leishmania infantum	100%	100%
C9ZVW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AQU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O54889	Rattus norvegicus	30%	100%
P10964	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%

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