Amidase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Amidase, putative

Gene product:

amidase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WU46_LEIDO

TriTrypDb:

LdBPK_161430.1 , LdCL_160019300 , LDHU3_16.1710

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7WU46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU46

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.480
CLV_NRD_NRD_1	166	168	PF00675	0.219
CLV_NRD_NRD_1	536	538	PF00675	0.300
CLV_PCSK_KEX2_1	134	136	PF00082	0.268
CLV_PCSK_KEX2_1	165	167	PF00082	0.216
CLV_PCSK_KEX2_1	536	538	PF00082	0.300
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.268
CLV_PCSK_SKI1_1	322	326	PF00082	0.268
CLV_PCSK_SKI1_1	433	437	PF00082	0.260
CLV_PCSK_SKI1_1	460	464	PF00082	0.264
CLV_PCSK_SKI1_1	5	9	PF00082	0.266
CLV_PCSK_SKI1_1	580	584	PF00082	0.369
DEG_SCF_FBW7_1	375	381	PF00400	0.468
DOC_CKS1_1	375	380	PF01111	0.468
DOC_CYCLIN_RxL_1	457	468	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	503	509	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	518	524	PF00134	0.438
DOC_MAPK_DCC_7	438	448	PF00069	0.424
DOC_MAPK_gen_1	178	188	PF00069	0.438
DOC_MAPK_gen_1	536	542	PF00069	0.490
DOC_MAPK_MEF2A_6	181	190	PF00069	0.424
DOC_MAPK_MEF2A_6	395	403	PF00069	0.433
DOC_MAPK_MEF2A_6	5	12	PF00069	0.486
DOC_MAPK_NFAT4_5	5	13	PF00069	0.516
DOC_PP1_RVXF_1	458	465	PF00149	0.373
DOC_PP2B_LxvP_1	141	144	PF13499	0.436
DOC_PP2B_LxvP_1	456	459	PF13499	0.468
DOC_PP2B_LxvP_1	518	521	PF13499	0.424
DOC_PP2B_PxIxI_1	342	348	PF00149	0.503
DOC_PP4_FxxP_1	554	557	PF00568	0.516
DOC_USP7_MATH_1	157	161	PF00917	0.434
DOC_USP7_MATH_1	276	280	PF00917	0.474
DOC_USP7_MATH_1	378	382	PF00917	0.491
DOC_USP7_MATH_1	51	55	PF00917	0.567
DOC_USP7_MATH_2	387	393	PF00917	0.433
DOC_WW_Pin1_4	171	176	PF00397	0.434
DOC_WW_Pin1_4	260	265	PF00397	0.447
DOC_WW_Pin1_4	316	321	PF00397	0.510
DOC_WW_Pin1_4	374	379	PF00397	0.468
LIG_14-3-3_CanoR_1	166	176	PF00244	0.449
LIG_14-3-3_CanoR_1	438	444	PF00244	0.414
LIG_APCC_ABBA_1	540	545	PF00400	0.503
LIG_BIR_II_1	1	5	PF00653	0.617
LIG_BIR_III_4	581	585	PF00653	0.549
LIG_Clathr_ClatBox_1	480	484	PF01394	0.468
LIG_deltaCOP1_diTrp_1	121	127	PF00928	0.424
LIG_EH_1	504	508	PF12763	0.503
LIG_eIF4E_1	20	26	PF01652	0.391
LIG_eIF4E_1	214	220	PF01652	0.424
LIG_FHA_1	191	197	PF00498	0.448
LIG_FHA_1	214	220	PF00498	0.442
LIG_FHA_1	235	241	PF00498	0.424
LIG_FHA_1	28	34	PF00498	0.270
LIG_FHA_1	284	290	PF00498	0.434
LIG_FHA_1	451	457	PF00498	0.482
LIG_FHA_2	144	150	PF00498	0.424
LIG_FHA_2	355	361	PF00498	0.515
LIG_FHA_2	564	570	PF00498	0.518
LIG_FHA_2	88	94	PF00498	0.448
LIG_GBD_Chelix_1	575	583	PF00786	0.262
LIG_IBAR_NPY_1	212	214	PF08397	0.413
LIG_IBAR_NPY_1	99	101	PF08397	0.424
LIG_LIR_Apic_2	338	343	PF02991	0.472
LIG_LIR_Apic_2	553	557	PF02991	0.450
LIG_LIR_Gen_1	371	378	PF02991	0.528
LIG_LIR_Gen_1	389	398	PF02991	0.487
LIG_LIR_Gen_1	410	417	PF02991	0.414
LIG_LIR_Gen_1	512	522	PF02991	0.424
LIG_LIR_Gen_1	590	599	PF02991	0.587
LIG_LIR_Nem_3	371	375	PF02991	0.495
LIG_LIR_Nem_3	389	393	PF02991	0.462
LIG_LIR_Nem_3	410	416	PF02991	0.414
LIG_LIR_Nem_3	512	518	PF02991	0.415
LIG_LIR_Nem_3	590	594	PF02991	0.542
LIG_MAD2	323	331	PF02301	0.516
LIG_NRBOX	476	482	PF00104	0.424
LIG_Pex14_1	42	46	PF04695	0.582
LIG_PTB_Apo_2	252	259	PF02174	0.413
LIG_PTB_Phospho_1	252	258	PF10480	0.456
LIG_Rb_LxCxE_1	79	93	PF01857	0.480
LIG_SH2_CRK	22	26	PF00017	0.269
LIG_SH2_CRK	340	344	PF00017	0.474
LIG_SH2_CRK	586	590	PF00017	0.444
LIG_SH2_GRB2like	101	104	PF00017	0.424
LIG_SH2_GRB2like	372	375	PF00017	0.424
LIG_SH2_NCK_1	511	515	PF00017	0.413
LIG_SH2_PTP2	372	375	PF00017	0.438
LIG_SH2_SRC	101	104	PF00017	0.439
LIG_SH2_SRC	372	375	PF00017	0.516
LIG_SH2_STAP1	22	26	PF00017	0.292
LIG_SH2_STAP1	511	515	PF00017	0.413
LIG_SH2_STAT5	101	104	PF00017	0.451
LIG_SH2_STAT5	24	27	PF00017	0.281
LIG_SH2_STAT5	266	269	PF00017	0.424
LIG_SH2_STAT5	372	375	PF00017	0.420
LIG_SH2_STAT5	511	514	PF00017	0.413
LIG_SH3_2	317	322	PF14604	0.483
LIG_SH3_3	169	175	PF00018	0.474
LIG_SH3_3	310	316	PF00018	0.516
LIG_SH3_3	372	378	PF00018	0.526
LIG_SH3_3	487	493	PF00018	0.442
LIG_SH3_3	523	529	PF00018	0.490
LIG_SH3_CIN85_PxpxPR_1	493	498	PF14604	0.456
LIG_SUMO_SIM_anti_2	83	90	PF11976	0.516
LIG_SUMO_SIM_par_1	478	484	PF11976	0.433
LIG_TRFH_1	308	312	PF08558	0.516
LIG_TYR_ITIM	370	375	PF00017	0.438
LIG_WRC_WIRS_1	235	240	PF05994	0.424
LIG_WRC_WIRS_1	390	395	PF05994	0.433
LIG_WRC_WIRS_1	88	93	PF05994	0.468
MOD_CDC14_SPxK_1	319	322	PF00782	0.450
MOD_CDK_SPxK_1	316	322	PF00069	0.450
MOD_CDK_SPxK_1	374	380	PF00069	0.468
MOD_CDK_SPxxK_3	171	178	PF00069	0.438
MOD_CDK_SPxxK_3	316	323	PF00069	0.510
MOD_CK1_1	236	242	PF00069	0.426
MOD_CK1_1	275	281	PF00069	0.433
MOD_CK1_1	379	385	PF00069	0.449
MOD_CK1_1	402	408	PF00069	0.450
MOD_CK1_1	439	445	PF00069	0.426
MOD_CK2_1	143	149	PF00069	0.424
MOD_CK2_1	221	227	PF00069	0.415
MOD_CK2_1	347	353	PF00069	0.456
MOD_CK2_1	354	360	PF00069	0.473
MOD_CK2_1	462	468	PF00069	0.516
MOD_CK2_1	538	544	PF00069	0.456
MOD_CK2_1	66	72	PF00069	0.500
MOD_CK2_1	80	86	PF00069	0.420
MOD_CK2_1	87	93	PF00069	0.451
MOD_CMANNOS	124	127	PF00535	0.224
MOD_GlcNHglycan	1	4	PF01048	0.446
MOD_GlcNHglycan	159	162	PF01048	0.227
MOD_GlcNHglycan	223	226	PF01048	0.234
MOD_GlcNHglycan	274	277	PF01048	0.295
MOD_GlcNHglycan	278	281	PF01048	0.295
MOD_GlcNHglycan	43	46	PF01048	0.383
MOD_GlcNHglycan	493	496	PF01048	0.285
MOD_GlcNHglycan	563	566	PF01048	0.324
MOD_GlcNHglycan	68	71	PF01048	0.291
MOD_GSK3_1	167	174	PF00069	0.509
MOD_GSK3_1	272	279	PF00069	0.465
MOD_GSK3_1	374	381	PF00069	0.518
MOD_GSK3_1	402	409	PF00069	0.507
MOD_GSK3_1	411	418	PF00069	0.537
MOD_N-GLC_1	157	162	PF02516	0.208
MOD_N-GLC_1	191	196	PF02516	0.243
MOD_N-GLC_2	426	428	PF02516	0.190
MOD_NEK2_1	188	193	PF00069	0.442
MOD_NEK2_1	399	404	PF00069	0.466
MOD_NEK2_1	415	420	PF00069	0.516
MOD_NEK2_1	436	441	PF00069	0.467
MOD_NEK2_1	509	514	PF00069	0.416
MOD_NEK2_1	571	576	PF00069	0.476
MOD_NEK2_1	71	76	PF00069	0.509
MOD_NEK2_2	411	416	PF00069	0.416
MOD_PIKK_1	297	303	PF00454	0.424
MOD_PIKK_1	347	353	PF00454	0.425
MOD_PIKK_1	415	421	PF00454	0.468
MOD_PK_1	536	542	PF00069	0.520
MOD_PKA_1	536	542	PF00069	0.516
MOD_PKA_2	379	385	PF00069	0.453
MOD_PKA_2	51	57	PF00069	0.597
MOD_PKA_2	536	542	PF00069	0.480
MOD_PKB_1	165	173	PF00069	0.416
MOD_Plk_1	544	550	PF00069	0.459
MOD_Plk_4	135	141	PF00069	0.429
MOD_Plk_4	368	374	PF00069	0.434
MOD_Plk_4	399	405	PF00069	0.507
MOD_Plk_4	476	482	PF00069	0.516
MOD_Plk_4	528	534	PF00069	0.532
MOD_Plk_4	87	93	PF00069	0.468
MOD_ProDKin_1	171	177	PF00069	0.434
MOD_ProDKin_1	260	266	PF00069	0.447
MOD_ProDKin_1	316	322	PF00069	0.510
MOD_ProDKin_1	374	380	PF00069	0.468
MOD_SUMO_rev_2	129	136	PF00179	0.443
MOD_SUMO_rev_2	407	414	PF00179	0.459
TRG_DiLeu_BaEn_1	452	457	PF01217	0.433
TRG_ENDOCYTIC_2	22	25	PF00928	0.404
TRG_ENDOCYTIC_2	372	375	PF00928	0.424
TRG_ER_diArg_1	165	167	PF00400	0.416
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.216
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3K3	Leptomonas seymouri	79%	100%
A0A0S4JR69	Bodo saltans	45%	100%
A0A1X0NYV8	Trypanosomatidae	62%	99%
A0A3R7KJH6	Trypanosoma rangeli	61%	99%
A4H8R4	Leishmania braziliensis	87%	100%
A4HX32	Leishmania infantum	100%	100%
B8GL95	Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)	26%	100%
C9ZVW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AQU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O00519	Homo sapiens	27%	100%
Q05AM4	Danio rerio	38%	100%
Q0ACB5	Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)	24%	100%
Q4QEN1	Leishmania major	97%	100%
Q60CK8	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	25%	100%
Q6DH69	Danio rerio	38%	100%
Q6GMR7	Homo sapiens	36%	100%
Q8FPZ0	Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)	24%	100%
Q8R679	Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)	26%	100%
Q9LCX3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	25%	100%
V5BS79	Trypanosoma cruzi	61%	100%