Polyketide_cyclase_/_dehydrase_and_lipid_transpor t_putative/Pfam:PF03364

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Polyketide cyclase / dehydrase and lipid transport, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WU24_LEIDO

TriTrypDb:

LdBPK_161150.1 , LdCL_160016600 , LDHU3_16.1410

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WU24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU24

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	8
GO:0006743	ubiquinone metabolic process	5	8
GO:0006744	ubiquinone biosynthetic process	6	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009987	cellular process	1	8
GO:0015980	energy derivation by oxidation of organic compounds	4	8
GO:0042180	cellular ketone metabolic process	3	8
GO:0042181	ketone biosynthetic process	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044281	small molecule metabolic process	2	8
GO:0044283	small molecule biosynthetic process	3	8
GO:0045333	cellular respiration	5	8
GO:0071704	organic substance metabolic process	2	8
GO:1901576	organic substance biosynthetic process	3	8
GO:1901661	quinone metabolic process	4	8
GO:1901663	quinone biosynthetic process	5	8

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0048038	quinone binding	2	8
GO:0048039	ubiquinone binding	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.558
CLV_C14_Caspase3-7	198	202	PF00656	0.403
CLV_C14_Caspase3-7	90	94	PF00656	0.595
CLV_NRD_NRD_1	166	168	PF00675	0.347
CLV_NRD_NRD_1	175	177	PF00675	0.347
CLV_NRD_NRD_1	229	231	PF00675	0.450
CLV_NRD_NRD_1	282	284	PF00675	0.297
CLV_NRD_NRD_1	32	34	PF00675	0.714
CLV_NRD_NRD_1	350	352	PF00675	0.428
CLV_PCSK_KEX2_1	166	168	PF00082	0.288
CLV_PCSK_KEX2_1	175	177	PF00082	0.288
CLV_PCSK_KEX2_1	294	296	PF00082	0.411
CLV_PCSK_KEX2_1	32	34	PF00082	0.714
CLV_PCSK_KEX2_1	350	352	PF00082	0.428
CLV_PCSK_KEX2_1	70	72	PF00082	0.522
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.411
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.522
CLV_PCSK_PC7_1	346	352	PF00082	0.421
CLV_PCSK_SKI1_1	104	108	PF00082	0.768
CLV_PCSK_SKI1_1	295	299	PF00082	0.306
DEG_APCC_DBOX_1	294	302	PF00400	0.297
DEG_Nend_UBRbox_2	1	3	PF02207	0.565
DEG_SPOP_SBC_1	113	117	PF00917	0.610
DEG_SPOP_SBC_1	20	24	PF00917	0.690
DOC_AGCK_PIF_2	322	327	PF00069	0.297
DOC_CYCLIN_yCln2_LP_2	37	40	PF00134	0.545
DOC_MAPK_MEF2A_6	313	321	PF00069	0.347
DOC_PP1_SILK_1	295	300	PF00149	0.347
DOC_PP2B_LxvP_1	37	40	PF13499	0.573
DOC_PP2B_LxvP_1	41	44	PF13499	0.541
DOC_PP4_FxxP_1	327	330	PF00568	0.256
DOC_USP7_MATH_1	105	109	PF00917	0.695
DOC_USP7_MATH_1	113	117	PF00917	0.599
DOC_USP7_MATH_1	194	198	PF00917	0.452
DOC_USP7_MATH_1	21	25	PF00917	0.647
DOC_USP7_MATH_1	293	297	PF00917	0.347
DOC_USP7_MATH_1	51	55	PF00917	0.549
DOC_USP7_MATH_2	137	143	PF00917	0.297
DOC_WW_Pin1_4	133	138	PF00397	0.313
DOC_WW_Pin1_4	177	182	PF00397	0.342
DOC_WW_Pin1_4	183	188	PF00397	0.349
DOC_WW_Pin1_4	95	100	PF00397	0.790
LIG_14-3-3_CanoR_1	223	227	PF00244	0.367
LIG_14-3-3_CanoR_1	253	261	PF00244	0.311
LIG_14-3-3_CanoR_1	283	291	PF00244	0.297
LIG_14-3-3_CanoR_1	71	79	PF00244	0.680
LIG_14-3-3_CanoR_1	9	17	PF00244	0.620
LIG_APCC_ABBA_1	124	129	PF00400	0.479
LIG_BRCT_BRCA1_1	323	327	PF00533	0.259
LIG_deltaCOP1_diTrp_1	304	307	PF00928	0.347
LIG_EVH1_1	38	42	PF00568	0.564
LIG_FHA_1	163	169	PF00498	0.437
LIG_FHA_1	204	210	PF00498	0.267
LIG_FHA_1	219	225	PF00498	0.288
LIG_FHA_1	286	292	PF00498	0.328
LIG_FHA_1	314	320	PF00498	0.297
LIG_FHA_2	188	194	PF00498	0.403
LIG_FHA_2	29	35	PF00498	0.617
LIG_FHA_2	85	91	PF00498	0.558
LIG_LIR_Apic_2	324	330	PF02991	0.256
LIG_LIR_Apic_2	353	359	PF02991	0.361
LIG_LIR_Gen_1	138	147	PF02991	0.355
LIG_LIR_Gen_1	148	158	PF02991	0.363
LIG_LIR_Gen_1	210	220	PF02991	0.256
LIG_LIR_Nem_3	138	144	PF02991	0.331
LIG_LIR_Nem_3	148	153	PF02991	0.396
LIG_LIR_Nem_3	210	216	PF02991	0.256
LIG_LIR_Nem_3	304	310	PF02991	0.262
LIG_MYND_1	39	43	PF01753	0.531
LIG_NRBOX	2	8	PF00104	0.562
LIG_Pex14_2	277	281	PF04695	0.241
LIG_Pex14_2	321	325	PF04695	0.256
LIG_PTB_Apo_2	326	333	PF02174	0.347
LIG_PTB_Phospho_1	326	332	PF10480	0.347
LIG_Rb_pABgroove_1	231	239	PF01858	0.347
LIG_REV1ctd_RIR_1	279	288	PF16727	0.269
LIG_SH2_CRK	141	145	PF00017	0.256
LIG_SH2_CRK	356	360	PF00017	0.358
LIG_SH2_NCK_1	141	145	PF00017	0.347
LIG_SH2_STAP1	141	145	PF00017	0.351
LIG_SH2_STAP1	150	154	PF00017	0.305
LIG_SH2_STAP1	220	224	PF00017	0.256
LIG_SH2_STAT5	220	223	PF00017	0.322
LIG_SH3_1	175	181	PF00018	0.269
LIG_SH3_3	14	20	PF00018	0.602
LIG_SH3_3	165	171	PF00018	0.332
LIG_SH3_3	175	181	PF00018	0.347
LIG_SH3_3	36	42	PF00018	0.571
LIG_SH3_3	361	367	PF00018	0.458
LIG_SUMO_SIM_anti_2	316	321	PF11976	0.297
LIG_WRC_WIRS_1	278	283	PF05994	0.297
LIG_WRC_WIRS_1	322	327	PF05994	0.288
LIG_WW_2	39	42	PF00397	0.532
MOD_CK1_1	114	120	PF00069	0.635
MOD_CK1_1	12	18	PF00069	0.674
MOD_CK1_1	222	228	PF00069	0.347
MOD_CK1_1	252	258	PF00069	0.353
MOD_CK1_1	262	268	PF00069	0.255
MOD_CK1_1	82	88	PF00069	0.704
MOD_CK2_1	133	139	PF00069	0.347
MOD_CK2_1	187	193	PF00069	0.403
MOD_CK2_1	21	27	PF00069	0.685
MOD_CK2_1	28	34	PF00069	0.563
MOD_CK2_1	84	90	PF00069	0.558
MOD_Cter_Amidation	228	231	PF01082	0.328
MOD_GlcNHglycan	150	153	PF01048	0.297
MOD_GlcNHglycan	17	20	PF01048	0.639
MOD_GlcNHglycan	255	258	PF01048	0.339
MOD_GlcNHglycan	266	269	PF01048	0.365
MOD_GlcNHglycan	272	275	PF01048	0.402
MOD_GlcNHglycan	359	362	PF01048	0.454
MOD_GlcNHglycan	75	78	PF01048	0.586
MOD_GlcNHglycan	82	85	PF01048	0.531
MOD_GSK3_1	111	118	PF00069	0.577
MOD_GSK3_1	129	136	PF00069	0.391
MOD_GSK3_1	157	164	PF00069	0.296
MOD_GSK3_1	183	190	PF00069	0.318
MOD_GSK3_1	203	210	PF00069	0.292
MOD_GSK3_1	218	225	PF00069	0.292
MOD_GSK3_1	248	255	PF00069	0.377
MOD_GSK3_1	264	271	PF00069	0.386
MOD_GSK3_1	73	80	PF00069	0.642
MOD_GSK3_1	9	16	PF00069	0.555
MOD_N-GLC_1	249	254	PF02516	0.332
MOD_N-GLC_1	52	57	PF02516	0.548
MOD_N-GLC_1	73	78	PF02516	0.576
MOD_NEK2_1	1	6	PF00069	0.603
MOD_NEK2_1	205	210	PF00069	0.288
MOD_NEK2_1	277	282	PF00069	0.401
MOD_NEK2_1	79	84	PF00069	0.739
MOD_PIKK_1	105	111	PF00454	0.627
MOD_PKA_2	111	117	PF00069	0.537
MOD_PKA_2	222	228	PF00069	0.367
MOD_PKA_2	252	258	PF00069	0.297
MOD_PKA_2	262	268	PF00069	0.227
MOD_Plk_1	1	7	PF00069	0.561
MOD_Plk_1	52	58	PF00069	0.532
MOD_Plk_4	139	145	PF00069	0.343
MOD_Plk_4	222	228	PF00069	0.347
MOD_Plk_4	277	283	PF00069	0.398
MOD_Plk_4	351	357	PF00069	0.423
MOD_ProDKin_1	133	139	PF00069	0.256
MOD_ProDKin_1	177	183	PF00069	0.342
MOD_ProDKin_1	95	101	PF00069	0.789
MOD_SUMO_rev_2	306	314	PF00179	0.297
MOD_SUMO_rev_2	324	330	PF00179	0.164
TRG_DiLeu_BaEn_1	2	7	PF01217	0.560
TRG_DiLeu_LyEn_5	2	7	PF01217	0.560
TRG_ENDOCYTIC_2	141	144	PF00928	0.299
TRG_ENDOCYTIC_2	150	153	PF00928	0.357
TRG_ENDOCYTIC_2	332	335	PF00928	0.540
TRG_ER_diArg_1	166	169	PF00400	0.347
TRG_ER_diArg_1	175	177	PF00400	0.347
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIQ5	Leptomonas seymouri	57%	68%
A0A1X0NYV9	Trypanosomatidae	36%	88%
A4HX08	Leishmania infantum	100%	100%
C9ZVZ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AQS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
Q4QEQ6	Leishmania major	91%	99%