Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WU15_LEIDO

TriTrypDb:

LdBPK_161110.1 , LdCL_160016100 , LDHU3_16.1340

Length:

516

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WU15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.589
CLV_C14_Caspase3-7	442	446	PF00656	0.531
CLV_NRD_NRD_1	105	107	PF00675	0.493
CLV_NRD_NRD_1	201	203	PF00675	0.693
CLV_NRD_NRD_1	260	262	PF00675	0.547
CLV_NRD_NRD_1	362	364	PF00675	0.429
CLV_NRD_NRD_1	403	405	PF00675	0.608
CLV_NRD_NRD_1	477	479	PF00675	0.593
CLV_PCSK_KEX2_1	105	107	PF00082	0.498
CLV_PCSK_KEX2_1	201	203	PF00082	0.690
CLV_PCSK_KEX2_1	362	364	PF00082	0.509
CLV_PCSK_KEX2_1	403	405	PF00082	0.498
CLV_PCSK_KEX2_1	477	479	PF00082	0.665
CLV_PCSK_SKI1_1	215	219	PF00082	0.465
CLV_PCSK_SKI1_1	431	435	PF00082	0.463
CLV_PCSK_SKI1_1	496	500	PF00082	0.485
CLV_PCSK_SKI1_1	503	507	PF00082	0.491
DEG_APCC_DBOX_1	221	229	PF00400	0.496
DEG_SCF_TRCP1_1	168	174	PF00400	0.592
DEG_SPOP_SBC_1	196	200	PF00917	0.695
DOC_MAPK_gen_1	144	152	PF00069	0.497
DOC_MAPK_gen_1	407	417	PF00069	0.593
DOC_MAPK_MEF2A_6	119	126	PF00069	0.512
DOC_MAPK_MEF2A_6	410	419	PF00069	0.496
DOC_PP4_FxxP_1	87	90	PF00568	0.431
DOC_USP7_MATH_1	180	184	PF00917	0.608
DOC_USP7_MATH_1	196	200	PF00917	0.695
DOC_USP7_MATH_1	2	6	PF00917	0.657
DOC_USP7_MATH_1	318	322	PF00917	0.584
DOC_USP7_MATH_1	90	94	PF00917	0.418
DOC_WW_Pin1_4	192	197	PF00397	0.755
DOC_WW_Pin1_4	203	208	PF00397	0.560
DOC_WW_Pin1_4	382	387	PF00397	0.506
DOC_WW_Pin1_4	390	395	PF00397	0.427
DOC_WW_Pin1_4	510	515	PF00397	0.460
DOC_WW_Pin1_4	54	59	PF00397	0.655
LIG_14-3-3_CanoR_1	14	22	PF00244	0.560
LIG_14-3-3_CanoR_1	209	217	PF00244	0.677
LIG_14-3-3_CanoR_1	222	226	PF00244	0.594
LIG_14-3-3_CanoR_1	407	413	PF00244	0.616
LIG_14-3-3_CanoR_1	45	52	PF00244	0.564
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BRCT_BRCA1_1	83	87	PF00533	0.542
LIG_CSL_BTD_1	87	90	PF09270	0.449
LIG_FHA_1	253	259	PF00498	0.462
LIG_FHA_1	301	307	PF00498	0.641
LIG_FHA_1	414	420	PF00498	0.538
LIG_FHA_2	15	21	PF00498	0.566
LIG_FHA_2	156	162	PF00498	0.598
LIG_FHA_2	355	361	PF00498	0.534
LIG_FHA_2	77	83	PF00498	0.614
LIG_Integrin_RGD_1	468	470	PF01839	0.575
LIG_Integrin_RGD_1	63	65	PF01839	0.524
LIG_LIR_Apic_2	381	387	PF02991	0.464
LIG_LIR_Apic_2	84	90	PF02991	0.449
LIG_LIR_Gen_1	329	340	PF02991	0.500
LIG_LIR_Gen_1	504	514	PF02991	0.532
LIG_LIR_Nem_3	230	236	PF02991	0.418
LIG_LIR_Nem_3	247	252	PF02991	0.530
LIG_LIR_Nem_3	321	326	PF02991	0.564
LIG_LIR_Nem_3	329	335	PF02991	0.442
LIG_LIR_Nem_3	338	343	PF02991	0.344
LIG_LIR_Nem_3	484	490	PF02991	0.682
LIG_Pex14_2	73	77	PF04695	0.527
LIG_SH2_CRK	249	253	PF00017	0.476
LIG_SH2_CRK	332	336	PF00017	0.463
LIG_SH2_CRK	384	388	PF00017	0.552
LIG_SH2_CRK	409	413	PF00017	0.419
LIG_SH2_CRK	430	434	PF00017	0.539
LIG_SH2_NCK_1	384	388	PF00017	0.497
LIG_SH2_SRC	166	169	PF00017	0.625
LIG_SH2_SRC	436	439	PF00017	0.483
LIG_SH2_SRC	81	84	PF00017	0.607
LIG_SH2_STAP1	241	245	PF00017	0.371
LIG_SH2_STAT3	263	266	PF00017	0.363
LIG_SH2_STAT5	102	105	PF00017	0.558
LIG_SH2_STAT5	234	237	PF00017	0.399
LIG_SH2_STAT5	263	266	PF00017	0.377
LIG_SH2_STAT5	384	387	PF00017	0.441
LIG_SH2_STAT5	436	439	PF00017	0.559
LIG_SH2_STAT5	473	476	PF00017	0.502
LIG_SH3_3	18	24	PF00018	0.621
LIG_SH3_3	303	309	PF00018	0.659
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.462
LIG_SUMO_SIM_par_1	278	284	PF11976	0.462
LIG_TRAF2_1	227	230	PF00917	0.501
LIG_TRAF2_1	357	360	PF00917	0.664
LIG_TRFH_1	508	512	PF08558	0.529
LIG_TYR_ITIM	330	335	PF00017	0.456
LIG_TYR_ITIM	428	433	PF00017	0.518
LIG_UBA3_1	142	147	PF00899	0.524
LIG_UBA3_1	494	503	PF00899	0.612
MOD_CDK_SPxK_1	203	209	PF00069	0.559
MOD_CDK_SPxK_1	510	516	PF00069	0.464
MOD_CK1_1	129	135	PF00069	0.485
MOD_CK1_1	191	197	PF00069	0.644
MOD_CK1_1	211	217	PF00069	0.622
MOD_CK1_1	224	230	PF00069	0.641
MOD_CK1_1	441	447	PF00069	0.537
MOD_CK1_1	5	11	PF00069	0.607
MOD_CK2_1	14	20	PF00069	0.561
MOD_CK2_1	224	230	PF00069	0.477
MOD_CK2_1	354	360	PF00069	0.514
MOD_CK2_1	90	96	PF00069	0.533
MOD_CMANNOS	389	392	PF00535	0.582
MOD_Cter_Amidation	259	262	PF01082	0.472
MOD_GlcNHglycan	167	171	PF01048	0.699
MOD_GlcNHglycan	177	180	PF01048	0.615
MOD_GlcNHglycan	240	244	PF01048	0.414
MOD_GlcNHglycan	332	335	PF01048	0.505
MOD_GlcNHglycan	394	397	PF01048	0.514
MOD_GlcNHglycan	478	481	PF01048	0.611
MOD_GlcNHglycan	68	71	PF01048	0.711
MOD_GlcNHglycan	74	77	PF01048	0.687
MOD_GSK3_1	1	8	PF00069	0.559
MOD_GSK3_1	171	178	PF00069	0.715
MOD_GSK3_1	187	194	PF00069	0.689
MOD_GSK3_1	217	224	PF00069	0.569
MOD_GSK3_1	244	251	PF00069	0.511
MOD_GSK3_1	72	79	PF00069	0.604
MOD_N-GLC_1	109	114	PF02516	0.489
MOD_N-GLC_1	126	131	PF02516	0.533
MOD_N-GLC_1	187	192	PF02516	0.700
MOD_N-GLC_1	28	33	PF02516	0.678
MOD_N-GLC_1	318	323	PF02516	0.637
MOD_N-GLC_1	330	335	PF02516	0.409
MOD_NEK2_1	1	6	PF00069	0.670
MOD_NEK2_1	115	120	PF00069	0.534
MOD_NEK2_1	126	131	PF00069	0.457
MOD_NEK2_1	143	148	PF00069	0.392
MOD_NEK2_1	155	160	PF00069	0.492
MOD_NEK2_1	171	176	PF00069	0.753
MOD_NEK2_1	189	194	PF00069	0.641
MOD_NEK2_1	217	222	PF00069	0.632
MOD_NEK2_1	494	499	PF00069	0.503
MOD_PIKK_1	2	8	PF00454	0.610
MOD_PIKK_1	81	87	PF00454	0.615
MOD_PK_1	254	260	PF00069	0.447
MOD_PKA_2	13	19	PF00069	0.661
MOD_PKA_2	143	149	PF00069	0.479
MOD_PKA_2	208	214	PF00069	0.699
MOD_PKA_2	221	227	PF00069	0.578
MOD_PKA_2	476	482	PF00069	0.719
MOD_PKA_2	65	71	PF00069	0.643
MOD_Plk_1	109	115	PF00069	0.476
MOD_Plk_1	155	161	PF00069	0.605
MOD_Plk_1	171	177	PF00069	0.752
MOD_Plk_1	239	245	PF00069	0.367
MOD_Plk_1	318	324	PF00069	0.628
MOD_Plk_1	330	336	PF00069	0.410
MOD_Plk_4	254	260	PF00069	0.561
MOD_Plk_4	83	89	PF00069	0.475
MOD_ProDKin_1	192	198	PF00069	0.757
MOD_ProDKin_1	203	209	PF00069	0.559
MOD_ProDKin_1	382	388	PF00069	0.499
MOD_ProDKin_1	390	396	PF00069	0.416
MOD_ProDKin_1	510	516	PF00069	0.464
MOD_ProDKin_1	54	60	PF00069	0.662
MOD_SUMO_for_1	367	370	PF00179	0.463
TRG_DiLeu_BaEn_1	231	236	PF01217	0.430
TRG_DiLeu_BaEn_1	275	280	PF01217	0.438
TRG_ENDOCYTIC_2	233	236	PF00928	0.397
TRG_ENDOCYTIC_2	249	252	PF00928	0.406
TRG_ENDOCYTIC_2	332	335	PF00928	0.451
TRG_ENDOCYTIC_2	409	412	PF00928	0.422
TRG_ENDOCYTIC_2	430	433	PF00928	0.510
TRG_ER_diArg_1	104	106	PF00400	0.567
TRG_ER_diArg_1	201	203	PF00400	0.669
TRG_ER_diArg_1	397	400	PF00400	0.517
TRG_ER_diArg_1	403	405	PF00400	0.566
TRG_ER_diArg_1	44	47	PF00400	0.512
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	296	301	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM4	Leptomonas seymouri	68%	100%
A0A0S4KPP2	Bodo saltans	32%	100%
A0A1X0NYW7	Trypanosomatidae	42%	100%
A0A422NAT9	Trypanosoma rangeli	44%	100%
A4H8N3	Leishmania braziliensis	83%	99%
A4HX03	Leishmania infantum	100%	100%
C9ZW04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AQR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
Q4QER0	Leishmania major	95%	100%