LeishMANIAdb
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Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184), putative
Species:
Leishmania donovani
UniProt:
A0A3S7WU13_LEIDO
TriTrypDb:
LdBPK_161060.1 * , LdCL_160015600 , LDHU3_16.1210
Length:
940

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 120
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 36
NetGPI no yes: 0, no: 36
Cellular components
Term Name Level Count
GO:0016020 membrane 2 20
GO:0110165 cellular anatomical entity 1 27
GO:0005794 Golgi apparatus 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9

Expansion

Sequence features

A0A3S7WU13
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU13

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 35
GO:0016740 transferase activity 2 35
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 332 336 PF00656 0.476
CLV_C14_Caspase3-7 499 503 PF00656 0.308
CLV_C14_Caspase3-7 611 615 PF00656 0.338
CLV_MEL_PAP_1 202 208 PF00089 0.594
CLV_NRD_NRD_1 158 160 PF00675 0.651
CLV_NRD_NRD_1 194 196 PF00675 0.669
CLV_NRD_NRD_1 225 227 PF00675 0.575
CLV_NRD_NRD_1 39 41 PF00675 0.524
CLV_NRD_NRD_1 519 521 PF00675 0.667
CLV_NRD_NRD_1 522 524 PF00675 0.629
CLV_NRD_NRD_1 557 559 PF00675 0.576
CLV_NRD_NRD_1 595 597 PF00675 0.674
CLV_NRD_NRD_1 673 675 PF00675 0.595
CLV_NRD_NRD_1 819 821 PF00675 0.675
CLV_PCSK_FUR_1 520 524 PF00082 0.616
CLV_PCSK_FUR_1 593 597 PF00082 0.631
CLV_PCSK_KEX2_1 158 160 PF00082 0.657
CLV_PCSK_KEX2_1 194 196 PF00082 0.643
CLV_PCSK_KEX2_1 38 40 PF00082 0.537
CLV_PCSK_KEX2_1 45 47 PF00082 0.508
CLV_PCSK_KEX2_1 519 521 PF00082 0.667
CLV_PCSK_KEX2_1 522 524 PF00082 0.589
CLV_PCSK_KEX2_1 556 558 PF00082 0.534
CLV_PCSK_KEX2_1 595 597 PF00082 0.651
CLV_PCSK_KEX2_1 673 675 PF00082 0.595
CLV_PCSK_KEX2_1 819 821 PF00082 0.675
CLV_PCSK_PC1ET2_1 45 47 PF00082 0.487
CLV_PCSK_PC7_1 34 40 PF00082 0.463
CLV_PCSK_SKI1_1 195 199 PF00082 0.616
CLV_PCSK_SKI1_1 338 342 PF00082 0.667
CLV_PCSK_SKI1_1 34 38 PF00082 0.565
CLV_PCSK_SKI1_1 392 396 PF00082 0.610
CLV_PCSK_SKI1_1 429 433 PF00082 0.615
CLV_PCSK_SKI1_1 434 438 PF00082 0.571
CLV_PCSK_SKI1_1 523 527 PF00082 0.643
CLV_PCSK_SKI1_1 673 677 PF00082 0.645
CLV_PCSK_SKI1_1 781 785 PF00082 0.676
CLV_PCSK_SKI1_1 865 869 PF00082 0.657
DEG_APCC_DBOX_1 304 312 PF00400 0.459
DEG_SPOP_SBC_1 107 111 PF00917 0.439
DOC_CKS1_1 604 609 PF01111 0.280
DOC_CKS1_1 680 685 PF01111 0.439
DOC_CYCLIN_yCln2_LP_2 563 569 PF00134 0.311
DOC_MAPK_DCC_7 648 657 PF00069 0.386
DOC_MAPK_gen_1 316 325 PF00069 0.398
DOC_MAPK_gen_1 390 399 PF00069 0.397
DOC_MAPK_gen_1 556 567 PF00069 0.419
DOC_MAPK_gen_1 648 657 PF00069 0.425
DOC_MAPK_HePTP_8 676 688 PF00069 0.437
DOC_MAPK_MEF2A_6 392 401 PF00069 0.394
DOC_MAPK_MEF2A_6 558 567 PF00069 0.417
DOC_MAPK_MEF2A_6 679 688 PF00069 0.436
DOC_MAPK_MEF2A_6 762 769 PF00069 0.477
DOC_PP1_RVXF_1 902 909 PF00149 0.371
DOC_PP2B_LxvP_1 437 440 PF13499 0.300
DOC_PP2B_LxvP_1 563 566 PF13499 0.388
DOC_PP2B_LxvP_1 868 871 PF13499 0.410
DOC_PP4_FxxP_1 115 118 PF00568 0.427
DOC_PP4_FxxP_1 680 683 PF00568 0.407
DOC_USP7_MATH_1 124 128 PF00917 0.483
DOC_USP7_MATH_1 254 258 PF00917 0.378
DOC_USP7_MATH_1 352 356 PF00917 0.482
DOC_USP7_MATH_1 549 553 PF00917 0.251
DOC_USP7_MATH_1 857 861 PF00917 0.463
DOC_USP7_MATH_1 912 916 PF00917 0.468
DOC_WW_Pin1_4 114 119 PF00397 0.497
DOC_WW_Pin1_4 127 132 PF00397 0.486
DOC_WW_Pin1_4 195 200 PF00397 0.455
DOC_WW_Pin1_4 260 265 PF00397 0.379
DOC_WW_Pin1_4 323 328 PF00397 0.378
DOC_WW_Pin1_4 392 397 PF00397 0.310
DOC_WW_Pin1_4 578 583 PF00397 0.432
DOC_WW_Pin1_4 603 608 PF00397 0.307
DOC_WW_Pin1_4 679 684 PF00397 0.439
LIG_14-3-3_CanoR_1 14 22 PF00244 0.672
LIG_14-3-3_CanoR_1 158 166 PF00244 0.432
LIG_14-3-3_CanoR_1 194 198 PF00244 0.493
LIG_14-3-3_CanoR_1 226 232 PF00244 0.402
LIG_14-3-3_CanoR_1 305 309 PF00244 0.429
LIG_14-3-3_CanoR_1 361 366 PF00244 0.393
LIG_14-3-3_CanoR_1 376 380 PF00244 0.327
LIG_14-3-3_CanoR_1 450 458 PF00244 0.306
LIG_14-3-3_CanoR_1 474 481 PF00244 0.398
LIG_14-3-3_CanoR_1 522 532 PF00244 0.313
LIG_14-3-3_CanoR_1 556 565 PF00244 0.345
LIG_14-3-3_CanoR_1 766 770 PF00244 0.469
LIG_14-3-3_CanoR_1 787 795 PF00244 0.414
LIG_14-3-3_CanoR_1 936 940 PF00244 0.447
LIG_Actin_WH2_2 346 363 PF00022 0.507
LIG_Actin_WH2_2 606 624 PF00022 0.278
LIG_BIR_III_2 601 605 PF00653 0.401
LIG_BRCT_BRCA1_1 580 584 PF00533 0.355
LIG_BRCT_BRCA1_1 724 728 PF00533 0.481
LIG_FHA_1 132 138 PF00498 0.589
LIG_FHA_1 207 213 PF00498 0.455
LIG_FHA_1 299 305 PF00498 0.519
LIG_FHA_1 604 610 PF00498 0.452
LIG_FHA_1 872 878 PF00498 0.398
LIG_FHA_1 918 924 PF00498 0.394
LIG_FHA_2 107 113 PF00498 0.456
LIG_FHA_2 117 123 PF00498 0.452
LIG_FHA_2 196 202 PF00498 0.372
LIG_FHA_2 242 248 PF00498 0.340
LIG_FHA_2 330 336 PF00498 0.475
LIG_FHA_2 442 448 PF00498 0.383
LIG_FHA_2 638 644 PF00498 0.380
LIG_FHA_2 70 76 PF00498 0.422
LIG_Integrin_RGD_1 80 82 PF01839 0.655
LIG_LIR_Apic_2 112 118 PF02991 0.428
LIG_LIR_Apic_2 230 235 PF02991 0.486
LIG_LIR_Apic_2 920 924 PF02991 0.377
LIG_LIR_Apic_2 934 940 PF02991 0.407
LIG_LIR_Gen_1 210 221 PF02991 0.375
LIG_LIR_Gen_1 281 292 PF02991 0.295
LIG_LIR_Gen_1 452 463 PF02991 0.307
LIG_LIR_Gen_1 502 513 PF02991 0.335
LIG_LIR_Gen_1 629 636 PF02991 0.364
LIG_LIR_Gen_1 682 693 PF02991 0.391
LIG_LIR_Gen_1 926 935 PF02991 0.458
LIG_LIR_LC3C_4 891 896 PF02991 0.443
LIG_LIR_Nem_3 210 216 PF02991 0.348
LIG_LIR_Nem_3 414 420 PF02991 0.373
LIG_LIR_Nem_3 502 508 PF02991 0.329
LIG_LIR_Nem_3 547 553 PF02991 0.318
LIG_LIR_Nem_3 562 567 PF02991 0.311
LIG_LIR_Nem_3 581 587 PF02991 0.425
LIG_LIR_Nem_3 629 635 PF02991 0.358
LIG_LIR_Nem_3 682 688 PF02991 0.430
LIG_LIR_Nem_3 725 731 PF02991 0.395
LIG_LIR_Nem_3 878 883 PF02991 0.431
LIG_MAD2 787 795 PF02301 0.431
LIG_MYND_1 114 118 PF01753 0.428
LIG_MYND_1 184 188 PF01753 0.432
LIG_Pex14_2 59 63 PF04695 0.244
LIG_PTB_Apo_2 239 246 PF02174 0.428
LIG_PTB_Apo_2 399 406 PF02174 0.359
LIG_PTB_Apo_2 650 657 PF02174 0.375
LIG_PTB_Phospho_1 239 245 PF10480 0.322
LIG_PTB_Phospho_1 399 405 PF10480 0.361
LIG_PTB_Phospho_1 650 656 PF10480 0.397
LIG_RPA_C_Fungi 893 905 PF08784 0.474
LIG_SH2_CRK 213 217 PF00017 0.459
LIG_SH2_CRK 225 229 PF00017 0.445
LIG_SH2_CRK 550 554 PF00017 0.362
LIG_SH2_CRK 92 96 PF00017 0.534
LIG_SH2_GRB2like 400 403 PF00017 0.562
LIG_SH2_GRB2like 656 659 PF00017 0.483
LIG_SH2_NCK_1 505 509 PF00017 0.403
LIG_SH2_NCK_1 92 96 PF00017 0.526
LIG_SH2_SRC 174 177 PF00017 0.499
LIG_SH2_SRC 275 278 PF00017 0.329
LIG_SH2_SRC 505 508 PF00017 0.402
LIG_SH2_SRC 685 688 PF00017 0.527
LIG_SH2_SRC 742 745 PF00017 0.600
LIG_SH2_STAP1 524 528 PF00017 0.467
LIG_SH2_STAP1 544 548 PF00017 0.345
LIG_SH2_STAT3 799 802 PF00017 0.577
LIG_SH2_STAT5 179 182 PF00017 0.421
LIG_SH2_STAT5 21 24 PF00017 0.523
LIG_SH2_STAT5 270 273 PF00017 0.393
LIG_SH2_STAT5 405 408 PF00017 0.410
LIG_SH2_STAT5 467 470 PF00017 0.533
LIG_SH2_STAT5 532 535 PF00017 0.372
LIG_SH2_STAT5 564 567 PF00017 0.377
LIG_SH2_STAT5 587 590 PF00017 0.442
LIG_SH2_STAT5 62 65 PF00017 0.266
LIG_SH2_STAT5 656 659 PF00017 0.478
LIG_SH2_STAT5 685 688 PF00017 0.543
LIG_SH2_STAT5 92 95 PF00017 0.536
LIG_SH3_3 137 143 PF00018 0.592
LIG_SH3_3 178 184 PF00018 0.577
LIG_SH3_3 433 439 PF00018 0.348
LIG_SH3_3 601 607 PF00018 0.544
LIG_SH3_3 826 832 PF00018 0.510
LIG_SH3_3 916 922 PF00018 0.460
LIG_SH3_3 92 98 PF00018 0.564
LIG_SH3_CIN85_PxpxPR_1 514 519 PF14604 0.490
LIG_SUMO_SIM_anti_2 459 466 PF11976 0.412
LIG_SUMO_SIM_anti_2 891 897 PF11976 0.524
LIG_SUMO_SIM_par_1 321 326 PF11976 0.482
LIG_SUMO_SIM_par_1 493 499 PF11976 0.382
LIG_SUMO_SIM_par_1 606 611 PF11976 0.287
LIG_SUMO_SIM_par_1 873 879 PF11976 0.510
LIG_SUMO_SIM_par_1 891 897 PF11976 0.336
LIG_TRAF2_1 718 721 PF00917 0.524
LIG_TRAF2_1 741 744 PF00917 0.583
LIG_TYR_ITIM 211 216 PF00017 0.535
LIG_WRC_WIRS_1 212 217 PF05994 0.450
MOD_CDK_SPK_2 578 583 PF00069 0.453
MOD_CK1_1 127 133 PF00069 0.603
MOD_CK1_1 24 30 PF00069 0.503
MOD_CK1_1 307 313 PF00069 0.507
MOD_CK1_1 355 361 PF00069 0.594
MOD_CK1_1 441 447 PF00069 0.447
MOD_CK1_1 99 105 PF00069 0.583
MOD_CK2_1 106 112 PF00069 0.568
MOD_CK2_1 116 122 PF00069 0.573
MOD_CK2_1 195 201 PF00069 0.477
MOD_CK2_1 241 247 PF00069 0.406
MOD_CK2_1 441 447 PF00069 0.469
MOD_CK2_1 637 643 PF00069 0.472
MOD_CK2_1 661 667 PF00069 0.530
MOD_CK2_1 69 75 PF00069 0.520
MOD_CK2_1 738 744 PF00069 0.450
MOD_CK2_1 810 816 PF00069 0.582
MOD_CK2_1 91 97 PF00069 0.528
MOD_Cter_Amidation 43 46 PF01082 0.626
MOD_GlcNHglycan 137 140 PF01048 0.577
MOD_GlcNHglycan 23 26 PF01048 0.517
MOD_GlcNHglycan 355 358 PF01048 0.587
MOD_GlcNHglycan 440 443 PF01048 0.605
MOD_GlcNHglycan 476 479 PF01048 0.546
MOD_GlcNHglycan 485 488 PF01048 0.626
MOD_GlcNHglycan 558 561 PF01048 0.375
MOD_GlcNHglycan 664 667 PF01048 0.523
MOD_GlcNHglycan 789 792 PF01048 0.518
MOD_GlcNHglycan 859 862 PF01048 0.576
MOD_GlcNHglycan 99 102 PF01048 0.592
MOD_GSK3_1 10 17 PF00069 0.569
MOD_GSK3_1 114 121 PF00069 0.606
MOD_GSK3_1 127 134 PF00069 0.574
MOD_GSK3_1 20 27 PF00069 0.516
MOD_GSK3_1 254 261 PF00069 0.477
MOD_GSK3_1 420 427 PF00069 0.439
MOD_GSK3_1 508 515 PF00069 0.419
MOD_GSK3_1 93 100 PF00069 0.583
MOD_LATS_1 359 365 PF00433 0.454
MOD_LATS_1 521 527 PF00433 0.362
MOD_LATS_1 554 560 PF00433 0.267
MOD_N-GLC_1 216 221 PF02516 0.488
MOD_N-GLC_1 241 246 PF02516 0.523
MOD_N-GLC_1 392 397 PF02516 0.456
MOD_N-GLC_1 637 642 PF02516 0.432
MOD_N-GLC_1 90 95 PF02516 0.592
MOD_N-GLC_2 222 224 PF02516 0.281
MOD_NEK2_1 133 138 PF00069 0.557
MOD_NEK2_1 258 263 PF00069 0.463
MOD_NEK2_1 304 309 PF00069 0.443
MOD_NEK2_1 353 358 PF00069 0.591
MOD_NEK2_1 360 365 PF00069 0.496
MOD_NEK2_1 539 544 PF00069 0.396
MOD_NEK2_1 591 596 PF00069 0.539
MOD_NEK2_1 636 641 PF00069 0.504
MOD_NEK2_1 749 754 PF00069 0.418
MOD_NEK2_1 917 922 PF00069 0.471
MOD_NEK2_2 549 554 PF00069 0.354
MOD_PIKK_1 124 130 PF00454 0.553
MOD_PIKK_1 152 158 PF00454 0.563
MOD_PK_1 810 816 PF00069 0.654
MOD_PKA_1 556 562 PF00069 0.252
MOD_PKA_2 10 16 PF00069 0.742
MOD_PKA_2 157 163 PF00069 0.537
MOD_PKA_2 193 199 PF00069 0.616
MOD_PKA_2 298 304 PF00069 0.530
MOD_PKA_2 353 359 PF00069 0.542
MOD_PKA_2 360 366 PF00069 0.419
MOD_PKA_2 375 381 PF00069 0.411
MOD_PKA_2 449 455 PF00069 0.361
MOD_PKA_2 556 562 PF00069 0.252
MOD_PKA_2 765 771 PF00069 0.564
MOD_PKB_1 67 75 PF00069 0.461
MOD_Plk_1 241 247 PF00069 0.449
MOD_Plk_1 90 96 PF00069 0.582
MOD_Plk_2-3 241 247 PF00069 0.399
MOD_Plk_2-3 298 304 PF00069 0.640
MOD_Plk_2-3 801 807 PF00069 0.600
MOD_Plk_4 211 217 PF00069 0.446
MOD_Plk_4 227 233 PF00069 0.456
MOD_Plk_4 241 247 PF00069 0.428
MOD_Plk_4 254 260 PF00069 0.488
MOD_Plk_4 329 335 PF00069 0.550
MOD_Plk_4 420 426 PF00069 0.438
MOD_Plk_4 69 75 PF00069 0.460
MOD_ProDKin_1 114 120 PF00069 0.621
MOD_ProDKin_1 127 133 PF00069 0.604
MOD_ProDKin_1 195 201 PF00069 0.557
MOD_ProDKin_1 260 266 PF00069 0.445
MOD_ProDKin_1 323 329 PF00069 0.455
MOD_ProDKin_1 392 398 PF00069 0.352
MOD_ProDKin_1 578 584 PF00069 0.526
MOD_ProDKin_1 603 609 PF00069 0.351
MOD_ProDKin_1 679 685 PF00069 0.537
MOD_SUMO_rev_2 897 906 PF00179 0.639
MOD_TYR_CSK 170 178 PF07714 0.488
TRG_DiLeu_BaEn_1 182 187 PF01217 0.538
TRG_DiLeu_BaEn_1 914 919 PF01217 0.484
TRG_DiLeu_BaEn_4 182 188 PF01217 0.518
TRG_ENDOCYTIC_2 213 216 PF00928 0.481
TRG_ENDOCYTIC_2 225 228 PF00928 0.570
TRG_ENDOCYTIC_2 275 278 PF00928 0.426
TRG_ENDOCYTIC_2 505 508 PF00928 0.549
TRG_ENDOCYTIC_2 550 553 PF00928 0.385
TRG_ENDOCYTIC_2 564 567 PF00928 0.393
TRG_ENDOCYTIC_2 569 572 PF00928 0.389
TRG_ENDOCYTIC_2 656 659 PF00928 0.483
TRG_ENDOCYTIC_2 685 688 PF00928 0.543
TRG_ENDOCYTIC_2 92 95 PF00928 0.536
TRG_ENDOCYTIC_2 928 931 PF00928 0.430
TRG_ER_diArg_1 319 322 PF00400 0.507
TRG_ER_diArg_1 37 40 PF00400 0.625
TRG_ER_diArg_1 389 392 PF00400 0.484
TRG_ER_diArg_1 518 520 PF00400 0.534
TRG_ER_diArg_1 522 524 PF00400 0.442
TRG_ER_diArg_1 556 558 PF00400 0.384
TRG_ER_diArg_1 593 596 PF00400 0.536
TRG_ER_diArg_1 66 69 PF00400 0.440
TRG_ER_diArg_1 672 674 PF00400 0.475
TRG_ER_diArg_1 8 11 PF00400 0.725
TRG_Pf-PMV_PEXEL_1 429 433 PF00026 0.473

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NYY7 Trypanosomatidae 43% 100%
A0A3Q8IAD3 Leishmania donovani 53% 100%
A0A3Q8IAF8 Leishmania donovani 77% 100%
A0A3Q8IAK8 Leishmania donovani 83% 100%
A0A3Q8IJ32 Leishmania donovani 100% 100%
A0A3S5H6Y1 Leishmania donovani 81% 100%
A0A3S7WTZ8 Leishmania donovani 67% 100%
A0A422NAR5 Trypanosoma rangeli 44% 100%
A4H8M5 Leishmania braziliensis 64% 100%
A4H8M7 Leishmania braziliensis 74% 99%
A4H8N0 Leishmania braziliensis 51% 100%
A4H8N1 Leishmania braziliensis 52% 100%
A4HWZ5 Leishmania infantum 99% 100%
A4HWZ6 Leishmania infantum 79% 100%
A4HWZ8 Leishmania infantum 81% 100%
A4HX00 Leishmania infantum 66% 100%
A4HX01 Leishmania infantum 53% 96%
A4HX05 Leishmania infantum 76% 100%
E8NHI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
E9AQQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AQR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
E9AQR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 99%
E9AQR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
E9AQR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 100%
E9AQR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 100%
Q4QER2 Leishmania major 53% 100%
Q4QER3 Leishmania major 63% 100%
Q4QER4 Leishmania major 79% 100%
Q4QER5 Leishmania major 89% 98%
Q4QER6 Leishmania major 89% 98%
Q4QER7 Leishmania major 82% 98%
Q4QER8 Leishmania major 76% 100%
Q4QER9 Leishmania major 76% 100%
Q4QES0 Leishmania major 90% 100%
V5ANJ8 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS