Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WU10_LEIDO

TriTrypDb:

LdBPK_161160.1 , LdCL_160016700 , LDHU3_16.1430

Length:

157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WU10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WU10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.680
CLV_NRD_NRD_1	2	4	PF00675	0.525
CLV_NRD_NRD_1	65	67	PF00675	0.592
CLV_NRD_NRD_1	69	71	PF00675	0.585
CLV_PCSK_FUR_1	66	70	PF00082	0.589
CLV_PCSK_KEX2_1	119	121	PF00082	0.603
CLV_PCSK_KEX2_1	2	4	PF00082	0.525
CLV_PCSK_KEX2_1	65	67	PF00082	0.588
CLV_PCSK_KEX2_1	68	70	PF00082	0.593
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.603
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.605
CLV_PCSK_PC7_1	65	71	PF00082	0.555
CLV_PCSK_SKI1_1	106	110	PF00082	0.587
CLV_PCSK_SKI1_1	65	69	PF00082	0.552
DEG_Nend_UBRbox_1	1	4	PF02207	0.613
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.468
DOC_PP2B_LxvP_1	108	111	PF13499	0.566
DOC_PP2B_LxvP_1	132	135	PF13499	0.474
DOC_USP7_MATH_1	73	77	PF00917	0.536
DOC_USP7_MATH_1	8	12	PF00917	0.512
DOC_USP7_MATH_1	87	91	PF00917	0.654
DOC_USP7_MATH_1	95	99	PF00917	0.582
DOC_USP7_MATH_2	135	141	PF00917	0.470
DOC_WW_Pin1_4	4	9	PF00397	0.646
LIG_BIR_III_4	94	98	PF00653	0.561
LIG_BRCT_BRCA1_1	34	38	PF00533	0.529
LIG_eIF4E_1	58	64	PF01652	0.555
LIG_FHA_1	121	127	PF00498	0.515
LIG_FHA_2	78	84	PF00498	0.660
LIG_LIR_Gen_1	35	46	PF02991	0.586
LIG_LIR_Nem_3	127	132	PF02991	0.491
LIG_LIR_Nem_3	35	41	PF02991	0.498
LIG_Pex14_1	129	133	PF04695	0.487
LIG_Pex14_2	38	42	PF04695	0.523
LIG_SH2_SRC	133	136	PF00017	0.471
LIG_SH2_STAT5	133	136	PF00017	0.471
LIG_SH2_STAT5	43	46	PF00017	0.574
LIG_SH3_3	48	54	PF00018	0.506
LIG_TYR_ITIM	41	46	PF00017	0.571
MOD_CK1_1	124	130	PF00069	0.554
MOD_CK2_1	9	15	PF00069	0.674
MOD_GlcNHglycan	11	14	PF01048	0.675
MOD_GlcNHglycan	139	142	PF01048	0.463
MOD_GlcNHglycan	20	23	PF01048	0.585
MOD_GlcNHglycan	4	7	PF01048	0.636
MOD_GlcNHglycan	73	76	PF01048	0.653
MOD_GlcNHglycan	85	88	PF01048	0.640
MOD_GSK3_1	120	127	PF00069	0.578
MOD_GSK3_1	4	11	PF00069	0.658
MOD_GSK3_1	71	78	PF00069	0.703
MOD_GSK3_1	83	90	PF00069	0.512
MOD_NEK2_1	9	14	PF00069	0.562
MOD_OFUCOSY	44	49	PF10250	0.477
MOD_PKA_1	2	8	PF00069	0.515
MOD_PKA_2	2	8	PF00069	0.585
MOD_Plk_1	121	127	PF00069	0.539
MOD_Plk_1	32	38	PF00069	0.535
MOD_Plk_4	37	43	PF00069	0.472
MOD_Plk_4	59	65	PF00069	0.601
MOD_ProDKin_1	4	10	PF00069	0.647
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.487
TRG_ENDOCYTIC_2	43	46	PF00928	0.574
TRG_ENDOCYTIC_2	58	61	PF00928	0.480
TRG_ER_diArg_1	1	3	PF00400	0.531
TRG_ER_diArg_1	64	66	PF00400	0.609
TRG_ER_diArg_1	69	71	PF00400	0.580
TRG_NLS_MonoExtN_4	65	72	PF00514	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJB6	Leptomonas seymouri	60%	92%
A0A1X0NYY4	Trypanosomatidae	38%	100%
A0A422MWL5	Trypanosoma rangeli	40%	100%
A4H8N8	Leishmania braziliensis	79%	100%
A4HX09	Leishmania infantum	99%	100%
C9ZVZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%