Emopamil binding family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTZ6_LEIDO

TriTrypDb:

LdBPK_160350.1 , LdCL_160008400 , LDHU3_16.0420

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	6
GO:0016020	membrane	2	6
GO:0031090	organelle membrane	3	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WTZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTZ6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	6
GO:0008152	metabolic process	1	6
GO:0008202	steroid metabolic process	4	6
GO:0016125	sterol metabolic process	4	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901615	organic hydroxy compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016853	isomerase activity	2	6
GO:0016860	intramolecular oxidoreductase activity	3	6
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4	6
GO:0047750	cholestenol delta-isomerase activity	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	270	272	PF00675	0.436
CLV_NRD_NRD_1	275	277	PF00675	0.454
CLV_NRD_NRD_1	70	72	PF00675	0.383
CLV_PCSK_KEX2_1	270	272	PF00082	0.451
CLV_PCSK_KEX2_1	275	277	PF00082	0.477
CLV_PCSK_PC7_1	271	277	PF00082	0.463
CLV_PCSK_SKI1_1	184	188	PF00082	0.240
CLV_PCSK_SKI1_1	26	30	PF00082	0.569
DEG_Nend_Nbox_1	1	3	PF02207	0.549
DOC_CDC14_PxL_1	208	216	PF14671	0.283
DOC_CKS1_1	18	23	PF01111	0.348
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.382
DOC_MAPK_MEF2A_6	166	173	PF00069	0.289
DOC_PP2B_LxvP_1	242	245	PF13499	0.289
DOC_PP4_FxxP_1	38	41	PF00568	0.345
DOC_PP4_FxxP_1	6	9	PF00568	0.348
DOC_USP7_MATH_1	77	81	PF00917	0.592
DOC_WW_Pin1_4	17	22	PF00397	0.348
DOC_WW_Pin1_4	220	225	PF00397	0.258
LIG_14-3-3_CanoR_1	142	150	PF00244	0.363
LIG_14-3-3_CanoR_1	257	263	PF00244	0.540
LIG_14-3-3_CanoR_1	63	69	PF00244	0.564
LIG_AP2alpha_1	6	10	PF02296	0.348
LIG_AP2alpha_2	8	10	PF02296	0.314
LIG_APCC_ABBA_1	115	120	PF00400	0.382
LIG_APCC_ABBA_1	3	8	PF00400	0.517
LIG_FHA_1	126	132	PF00498	0.326
LIG_FHA_1	13	19	PF00498	0.411
LIG_FHA_1	29	35	PF00498	0.305
LIG_FHA_2	96	102	PF00498	0.534
LIG_LIR_Apic_2	4	9	PF02991	0.348
LIG_LIR_Gen_1	134	144	PF02991	0.297
LIG_LIR_Gen_1	188	197	PF02991	0.298
LIG_LIR_Gen_1	8	18	PF02991	0.348
LIG_LIR_Nem_3	134	139	PF02991	0.300
LIG_LIR_Nem_3	188	193	PF02991	0.282
LIG_LIR_Nem_3	194	200	PF02991	0.258
LIG_LIR_Nem_3	252	256	PF02991	0.512
LIG_LIR_Nem_3	8	13	PF02991	0.314
LIG_PCNA_yPIPBox_3	104	118	PF02747	0.535
LIG_Pex14_2	2	6	PF04695	0.483
LIG_Pex14_2	228	232	PF04695	0.303
LIG_SH2_CRK	197	201	PF00017	0.289
LIG_SH2_NCK_1	136	140	PF00017	0.352
LIG_SH2_PTP2	253	256	PF00017	0.551
LIG_SH2_SRC	74	77	PF00017	0.586
LIG_SH2_STAP1	143	147	PF00017	0.360
LIG_SH2_STAP1	90	94	PF00017	0.572
LIG_SH2_STAT3	202	205	PF00017	0.289
LIG_SH2_STAT5	108	111	PF00017	0.289
LIG_SH2_STAT5	202	205	PF00017	0.278
LIG_SH2_STAT5	229	232	PF00017	0.303
LIG_SH2_STAT5	241	244	PF00017	0.329
LIG_SH2_STAT5	253	256	PF00017	0.475
LIG_SH2_STAT5	37	40	PF00017	0.313
LIG_SH3_3	162	168	PF00018	0.314
LIG_SH3_3	176	182	PF00018	0.458
LIG_SUMO_SIM_par_1	156	162	PF11976	0.289
LIG_TRAF2_1	73	76	PF00917	0.583
LIG_TRAF2_1	98	101	PF00917	0.559
LIG_TRFH_1	241	245	PF08558	0.382
LIG_TYR_ITIM	239	244	PF00017	0.289
LIG_UBA3_1	160	166	PF00899	0.289
MOD_CK1_1	269	275	PF00069	0.639
MOD_CK2_1	156	162	PF00069	0.289
MOD_CK2_1	95	101	PF00069	0.507
MOD_Cter_Amidation	273	276	PF01082	0.465
MOD_GlcNHglycan	152	155	PF01048	0.459
MOD_GlcNHglycan	208	211	PF01048	0.459
MOD_GlcNHglycan	276	279	PF01048	0.522
MOD_GSK3_1	142	149	PF00069	0.373
MOD_N-GLC_1	150	155	PF02516	0.529
MOD_N-GLC_2	258	260	PF02516	0.368
MOD_NEK2_1	12	17	PF00069	0.318
MOD_NEK2_1	150	155	PF00069	0.286
MOD_PIKK_1	191	197	PF00454	0.289
MOD_PKA_2	269	275	PF00069	0.670
MOD_Plk_1	218	224	PF00069	0.283
MOD_Plk_4	156	162	PF00069	0.348
MOD_Plk_4	196	202	PF00069	0.289
MOD_Plk_4	258	264	PF00069	0.622
MOD_Plk_4	89	95	PF00069	0.565
MOD_ProDKin_1	17	23	PF00069	0.348
MOD_ProDKin_1	220	226	PF00069	0.258
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.342
TRG_ENDOCYTIC_2	136	139	PF00928	0.280
TRG_ENDOCYTIC_2	174	177	PF00928	0.517
TRG_ENDOCYTIC_2	197	200	PF00928	0.271
TRG_ENDOCYTIC_2	229	232	PF00928	0.289
TRG_ENDOCYTIC_2	241	244	PF00928	0.289
TRG_ENDOCYTIC_2	253	256	PF00928	0.475
TRG_ENDOCYTIC_2	90	93	PF00928	0.587
TRG_ER_diArg_1	104	107	PF00400	0.477
TRG_ER_diArg_1	254	257	PF00400	0.554
TRG_ER_diArg_1	68	71	PF00400	0.572
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.360
TRG_PTS1	282	285	PF00515	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8Q4	Leptomonas seymouri	70%	100%
A0A0S4JDK8	Bodo saltans	51%	100%
A0A1X0NZ45	Trypanosomatidae	53%	100%
A0A3R7MCA0	Trypanosoma rangeli	53%	100%