EF-hand domain pair/EF-hand domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar calcium-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTZ3_LEIDO

TriTrypDb:

LdBPK_160930.1 , LdCL_160014500 , LDHU3_16.1100

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	17
GO:0031514	motile cilium	5	17
GO:0042995	cell projection	2	17
GO:0043226	organelle	2	17
GO:0043227	membrane-bounded organelle	3	17
GO:0110165	cellular anatomical entity	1	17
GO:0120025	plasma membrane bounded cell projection	3	17
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7WTZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTZ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	19
GO:0005509	calcium ion binding	5	19
GO:0043167	ion binding	2	19
GO:0043169	cation binding	3	19
GO:0046872	metal ion binding	4	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.385
CLV_NRD_NRD_1	9	11	PF00675	0.624
CLV_PCSK_KEX2_1	49	51	PF00082	0.350
CLV_PCSK_KEX2_1	86	88	PF00082	0.415
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.472
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.415
CLV_PCSK_PC7_1	82	88	PF00082	0.367
CLV_PCSK_SKI1_1	115	119	PF00082	0.364
CLV_PCSK_SKI1_1	145	149	PF00082	0.473
CLV_PCSK_SKI1_1	86	90	PF00082	0.424
DEG_APCC_DBOX_1	114	122	PF00400	0.361
DOC_CKS1_1	35	40	PF01111	0.454
DOC_PP1_RVXF_1	19	26	PF00149	0.391
DOC_USP7_MATH_1	186	190	PF00917	0.424
DOC_USP7_UBL2_3	7	11	PF12436	0.714
DOC_WW_Pin1_4	34	39	PF00397	0.487
LIG_14-3-3_CanoR_1	50	59	PF00244	0.358
LIG_Actin_WH2_2	67	84	PF00022	0.435
LIG_FHA_1	54	60	PF00498	0.413
LIG_FHA_1	76	82	PF00498	0.412
LIG_FHA_1	96	102	PF00498	0.356
LIG_FHA_2	15	21	PF00498	0.531
LIG_FHA_2	35	41	PF00498	0.262
LIG_FHA_2	58	64	PF00498	0.397
LIG_GBD_Chelix_1	108	116	PF00786	0.328
LIG_LIR_Gen_1	110	118	PF02991	0.375
LIG_LIR_Gen_1	123	131	PF02991	0.374
LIG_LIR_Nem_3	110	114	PF02991	0.372
LIG_LIR_Nem_3	123	127	PF02991	0.401
LIG_LIR_Nem_3	128	134	PF02991	0.454
LIG_LIR_Nem_3	156	160	PF02991	0.499
LIG_LIR_Nem_3	165	171	PF02991	0.409
LIG_LIR_Nem_3	46	51	PF02991	0.327
LIG_Rb_pABgroove_1	125	133	PF01858	0.385
LIG_SH2_STAT5	120	123	PF00017	0.338
LIG_SH2_STAT5	124	127	PF00017	0.339
LIG_SUMO_SIM_anti_2	126	133	PF11976	0.381
LIG_TRAF2_1	60	63	PF00917	0.503
MOD_CDK_SPxxK_3	34	41	PF00069	0.480
MOD_CK1_1	189	195	PF00069	0.453
MOD_CK2_1	51	57	PF00069	0.432
MOD_GlcNHglycan	135	139	PF01048	0.502
MOD_GlcNHglycan	175	178	PF01048	0.440
MOD_GlcNHglycan	191	194	PF01048	0.471
MOD_GlcNHglycan	98	101	PF01048	0.414
MOD_GSK3_1	10	17	PF00069	0.652
MOD_GSK3_1	53	60	PF00069	0.446
MOD_GSK3_1	76	83	PF00069	0.433
MOD_GSK3_1	87	94	PF00069	0.479
MOD_N-GLC_1	173	178	PF02516	0.494
MOD_N-GLC_1	3	8	PF02516	0.723
MOD_N-GLC_1	96	101	PF02516	0.546
MOD_NEK2_1	125	130	PF00069	0.392
MOD_NEK2_1	95	100	PF00069	0.548
MOD_NMyristoyl	1	7	PF02799	0.593
MOD_PK_1	80	86	PF00069	0.362
MOD_PKA_1	10	16	PF00069	0.471
MOD_PKA_2	189	195	PF00069	0.394
MOD_Plk_1	125	131	PF00069	0.374
MOD_Plk_2-3	57	63	PF00069	0.344
MOD_Plk_4	125	131	PF00069	0.395
MOD_Plk_4	163	169	PF00069	0.502
MOD_Plk_4	67	73	PF00069	0.338
MOD_ProDKin_1	34	40	PF00069	0.480
MOD_SUMO_rev_2	13	18	PF00179	0.503
MOD_SUMO_rev_2	143	150	PF00179	0.444
TRG_DiLeu_BaEn_2	106	112	PF01217	0.515
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.287
TRG_ENDOCYTIC_2	122	125	PF00928	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S0	Leptomonas seymouri	63%	95%
A0A0S4J8L5	Bodo saltans	36%	100%
A0A0S4KMR0	Bodo saltans	40%	100%
A0A1X0NZ95	Trypanosomatidae	61%	95%
A0A1X0P0A5	Trypanosomatidae	57%	100%
A0A1X0P0I3	Trypanosomatidae	64%	89%
A0A3R7KL32	Trypanosoma rangeli	63%	100%
A0A422NDP3	Trypanosoma rangeli	60%	95%
A4H8L5	Leishmania braziliensis	78%	100%
A4H8L6	Leishmania braziliensis	74%	100%
A4HWY6	Leishmania infantum	97%	100%
A4HWY7	Leishmania infantum	97%	100%
C9ZW14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	89%
C9ZW16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	84%
E9AQQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9AQQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
P07749	Trypanosoma cruzi	56%	92%
P17882	Trypanosoma brucei brucei	55%	84%
Q26677	Trypanosoma brucei brucei	58%	85%
Q26680	Trypanosoma brucei brucei	56%	89%
Q27052	Trypanosoma rangeli	59%	96%
V5D941	Trypanosoma cruzi	56%	78%