Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTX8_LEIDO

TriTrypDb:

LdBPK_160840.1 , LdCL_160013700 , LDHU3_16.1010

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTX8

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.422
CLV_C14_Caspase3-7	544	548	PF00656	0.577
CLV_C14_Caspase3-7	590	594	PF00656	0.616
CLV_C14_Caspase3-7	783	787	PF00656	0.588
CLV_C14_Caspase3-7	88	92	PF00656	0.634
CLV_MEL_PAP_1	274	280	PF00089	0.636
CLV_NRD_NRD_1	130	132	PF00675	0.536
CLV_NRD_NRD_1	174	176	PF00675	0.773
CLV_NRD_NRD_1	295	297	PF00675	0.567
CLV_NRD_NRD_1	310	312	PF00675	0.526
CLV_NRD_NRD_1	366	368	PF00675	0.585
CLV_NRD_NRD_1	454	456	PF00675	0.745
CLV_NRD_NRD_1	459	461	PF00675	0.753
CLV_NRD_NRD_1	532	534	PF00675	0.688
CLV_NRD_NRD_1	577	579	PF00675	0.651
CLV_NRD_NRD_1	584	586	PF00675	0.688
CLV_NRD_NRD_1	62	64	PF00675	0.490
CLV_NRD_NRD_1	670	672	PF00675	0.571
CLV_PCSK_FUR_1	128	132	PF00082	0.544
CLV_PCSK_FUR_1	172	176	PF00082	0.648
CLV_PCSK_KEX2_1	130	132	PF00082	0.536
CLV_PCSK_KEX2_1	174	176	PF00082	0.773
CLV_PCSK_KEX2_1	295	297	PF00082	0.616
CLV_PCSK_KEX2_1	310	312	PF00082	0.526
CLV_PCSK_KEX2_1	366	368	PF00082	0.585
CLV_PCSK_KEX2_1	459	461	PF00082	0.745
CLV_PCSK_KEX2_1	577	579	PF00082	0.638
CLV_PCSK_KEX2_1	584	586	PF00082	0.688
CLV_PCSK_KEX2_1	670	672	PF00082	0.571
CLV_PCSK_PC7_1	126	132	PF00082	0.537
CLV_PCSK_PC7_1	455	461	PF00082	0.607
CLV_PCSK_SKI1_1	311	315	PF00082	0.516
CLV_PCSK_SKI1_1	460	464	PF00082	0.653
CLV_PCSK_SKI1_1	560	564	PF00082	0.475
DEG_APCC_DBOX_1	559	567	PF00400	0.532
DEG_APCC_DBOX_1	611	619	PF00400	0.606
DEG_SCF_FBW7_1	626	633	PF00400	0.693
DOC_CDC14_PxL_1	520	528	PF14671	0.664
DOC_CKS1_1	711	716	PF01111	0.658
DOC_CYCLIN_RxL_1	775	786	PF00134	0.563
DOC_MAPK_FxFP_2	390	393	PF00069	0.545
DOC_MAPK_gen_1	467	475	PF00069	0.714
DOC_MAPK_gen_1	533	540	PF00069	0.731
DOC_PP1_RVXF_1	729	736	PF00149	0.382
DOC_PP2B_LxvP_1	521	524	PF13499	0.723
DOC_PP4_FxxP_1	390	393	PF00568	0.543
DOC_PP4_FxxP_1	711	714	PF00568	0.618
DOC_USP7_MATH_1	112	116	PF00917	0.567
DOC_USP7_MATH_1	146	150	PF00917	0.470
DOC_USP7_MATH_1	187	191	PF00917	0.624
DOC_USP7_MATH_1	276	280	PF00917	0.766
DOC_USP7_MATH_1	282	286	PF00917	0.528
DOC_USP7_MATH_1	29	33	PF00917	0.494
DOC_USP7_MATH_1	357	361	PF00917	0.747
DOC_USP7_MATH_1	409	413	PF00917	0.465
DOC_USP7_MATH_1	548	552	PF00917	0.676
DOC_USP7_MATH_1	55	59	PF00917	0.396
DOC_USP7_MATH_1	589	593	PF00917	0.617
DOC_USP7_MATH_1	706	710	PF00917	0.514
DOC_USP7_MATH_1	84	88	PF00917	0.668
DOC_WW_Pin1_4	237	242	PF00397	0.723
DOC_WW_Pin1_4	267	272	PF00397	0.744
DOC_WW_Pin1_4	353	358	PF00397	0.727
DOC_WW_Pin1_4	613	618	PF00397	0.505
DOC_WW_Pin1_4	626	631	PF00397	0.570
DOC_WW_Pin1_4	642	647	PF00397	0.442
DOC_WW_Pin1_4	697	702	PF00397	0.499
DOC_WW_Pin1_4	710	715	PF00397	0.521
LIG_14-3-3_CanoR_1	116	123	PF00244	0.622
LIG_14-3-3_CanoR_1	289	295	PF00244	0.614
LIG_14-3-3_CanoR_1	296	302	PF00244	0.581
LIG_14-3-3_CanoR_1	57	67	PF00244	0.409
LIG_14-3-3_CanoR_1	718	728	PF00244	0.588
LIG_14-3-3_CanoR_1	767	772	PF00244	0.584
LIG_Actin_WH2_2	160	176	PF00022	0.556
LIG_Actin_WH2_2	502	519	PF00022	0.565
LIG_Actin_WH2_2	690	706	PF00022	0.558
LIG_AP2alpha_1	402	406	PF02296	0.502
LIG_APCC_ABBA_1	399	404	PF00400	0.496
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_BIR_III_4	547	551	PF00653	0.689
LIG_BRCT_BRCA1_1	386	390	PF00533	0.435
LIG_CaM_NSCaTE_8	634	641	PF13499	0.542
LIG_CSL_BTD_1	711	714	PF09270	0.618
LIG_CtBP_PxDLS_1	542	546	PF00389	0.500
LIG_deltaCOP1_diTrp_1	212	219	PF00928	0.463
LIG_deltaCOP1_diTrp_1	394	402	PF00928	0.403
LIG_deltaCOP1_diTrp_1	666	672	PF00928	0.523
LIG_deltaCOP1_diTrp_1	675	680	PF00928	0.559
LIG_deltaCOP1_diTrp_1	772	779	PF00928	0.537
LIG_eIF4E_1	503	509	PF01652	0.435
LIG_FHA_1	103	109	PF00498	0.581
LIG_FHA_1	148	154	PF00498	0.439
LIG_FHA_1	330	336	PF00498	0.592
LIG_FHA_1	345	351	PF00498	0.577
LIG_FHA_1	370	376	PF00498	0.388
LIG_FHA_1	394	400	PF00498	0.447
LIG_FHA_1	40	46	PF00498	0.454
LIG_FHA_1	428	434	PF00498	0.700
LIG_FHA_1	535	541	PF00498	0.760
LIG_FHA_1	568	574	PF00498	0.547
LIG_FHA_1	627	633	PF00498	0.683
LIG_FHA_1	643	649	PF00498	0.549
LIG_FHA_1	751	757	PF00498	0.684
LIG_FHA_1	766	772	PF00498	0.591
LIG_FHA_2	631	637	PF00498	0.622
LIG_FHA_2	86	92	PF00498	0.552
LIG_LIR_Apic_2	387	393	PF02991	0.525
LIG_LIR_Apic_2	709	714	PF02991	0.624
LIG_LIR_Gen_1	290	299	PF02991	0.613
LIG_LIR_Gen_1	394	405	PF02991	0.402
LIG_LIR_Gen_1	427	435	PF02991	0.490
LIG_LIR_Gen_1	480	491	PF02991	0.545
LIG_LIR_Gen_1	737	746	PF02991	0.510
LIG_LIR_Gen_1	772	782	PF02991	0.530
LIG_LIR_LC3C_4	725	730	PF02991	0.561
LIG_LIR_Nem_3	115	121	PF02991	0.588
LIG_LIR_Nem_3	290	294	PF02991	0.611
LIG_LIR_Nem_3	404	408	PF02991	0.415
LIG_LIR_Nem_3	427	432	PF02991	0.493
LIG_LIR_Nem_3	480	486	PF02991	0.529
LIG_LIR_Nem_3	622	628	PF02991	0.542
LIG_LIR_Nem_3	674	680	PF02991	0.579
LIG_LIR_Nem_3	683	688	PF02991	0.583
LIG_LIR_Nem_3	772	777	PF02991	0.501
LIG_LIR_Nem_3	790	795	PF02991	0.554
LIG_LYPXL_yS_3	625	628	PF13949	0.624
LIG_MYND_1	518	522	PF01753	0.547
LIG_MYND_1	539	543	PF01753	0.665
LIG_NRBOX	634	640	PF00104	0.516
LIG_NRBOX	9	15	PF00104	0.435
LIG_PCNA_PIPBox_1	773	782	PF02747	0.528
LIG_PCNA_yPIPBox_3	767	780	PF02747	0.563
LIG_Pex14_1	287	291	PF04695	0.619
LIG_Pex14_1	735	739	PF04695	0.437
LIG_Pex14_2	378	382	PF04695	0.461
LIG_Pex14_2	402	406	PF04695	0.469
LIG_RPA_C_Fungi	291	303	PF08784	0.464
LIG_SH2_CRK	164	168	PF00017	0.484
LIG_SH2_CRK	227	231	PF00017	0.456
LIG_SH2_CRK	611	615	PF00017	0.603
LIG_SH2_GRB2like	227	230	PF00017	0.478
LIG_SH2_GRB2like	405	408	PF00017	0.390
LIG_SH2_GRB2like	739	742	PF00017	0.541
LIG_SH2_NCK_1	503	507	PF00017	0.558
LIG_SH2_PTP2	156	159	PF00017	0.427
LIG_SH2_PTP2	291	294	PF00017	0.610
LIG_SH2_SRC	281	284	PF00017	0.630
LIG_SH2_STAP1	227	231	PF00017	0.476
LIG_SH2_STAP1	481	485	PF00017	0.550
LIG_SH2_STAT3	481	484	PF00017	0.520
LIG_SH2_STAT5	156	159	PF00017	0.397
LIG_SH2_STAT5	209	212	PF00017	0.583
LIG_SH2_STAT5	291	294	PF00017	0.507
LIG_SH2_STAT5	391	394	PF00017	0.506
LIG_SH2_STAT5	405	408	PF00017	0.289
LIG_SH2_STAT5	739	742	PF00017	0.536
LIG_SH2_STAT5	792	795	PF00017	0.498
LIG_SH3_1	611	617	PF00018	0.609
LIG_SH3_3	231	237	PF00018	0.696
LIG_SH3_3	420	426	PF00018	0.705
LIG_SH3_3	485	491	PF00018	0.580
LIG_SH3_3	536	542	PF00018	0.723
LIG_SH3_3	611	617	PF00018	0.594
LIG_SH3_3	645	651	PF00018	0.525
LIG_SH3_5	401	405	PF00018	0.392
LIG_SUMO_SIM_anti_2	504	510	PF11976	0.572
LIG_SUMO_SIM_anti_2	724	731	PF11976	0.532
LIG_TRAF2_1	183	186	PF00917	0.739
LIG_TRAF2_1	722	725	PF00917	0.590
LIG_TRAF2_1	788	791	PF00917	0.500
LIG_TRFH_1	514	518	PF08558	0.497
LIG_TYR_ITIM	154	159	PF00017	0.395
LIG_Vh1_VBS_1	552	570	PF01044	0.546
MOD_CDK_SPxK_1	712	718	PF00069	0.566
MOD_CDK_SPxxK_3	697	704	PF00069	0.562
MOD_CK1_1	149	155	PF00069	0.466
MOD_CK1_1	2	8	PF00069	0.598
MOD_CK1_1	290	296	PF00069	0.589
MOD_CK1_1	352	358	PF00069	0.769
MOD_CK1_1	412	418	PF00069	0.474
MOD_CK1_1	568	574	PF00069	0.625
MOD_CK1_1	58	64	PF00069	0.383
MOD_CK1_1	710	716	PF00069	0.585
MOD_CK2_1	116	122	PF00069	0.600
MOD_CK2_1	187	193	PF00069	0.796
MOD_CK2_1	501	507	PF00069	0.438
MOD_CK2_1	654	660	PF00069	0.602
MOD_CK2_1	719	725	PF00069	0.581
MOD_CK2_1	794	800	PF00069	0.607
MOD_Cter_Amidation	364	367	PF01082	0.555
MOD_Cter_Amidation	531	534	PF01082	0.691
MOD_GlcNHglycan	1	4	PF01048	0.701
MOD_GlcNHglycan	175	178	PF01048	0.676
MOD_GlcNHglycan	189	192	PF01048	0.773
MOD_GlcNHglycan	22	25	PF01048	0.464
MOD_GlcNHglycan	278	281	PF01048	0.736
MOD_GlcNHglycan	283	287	PF01048	0.488
MOD_GlcNHglycan	567	570	PF01048	0.629
MOD_GlcNHglycan	639	642	PF01048	0.483
MOD_GlcNHglycan	682	685	PF01048	0.640
MOD_GlcNHglycan	721	724	PF01048	0.578
MOD_GSK3_1	112	119	PF00069	0.563
MOD_GSK3_1	122	129	PF00069	0.549
MOD_GSK3_1	185	192	PF00069	0.738
MOD_GSK3_1	203	210	PF00069	0.559
MOD_GSK3_1	263	270	PF00069	0.741
MOD_GSK3_1	349	356	PF00069	0.747
MOD_GSK3_1	458	465	PF00069	0.714
MOD_GSK3_1	486	493	PF00069	0.603
MOD_GSK3_1	512	519	PF00069	0.548
MOD_GSK3_1	561	568	PF00069	0.551
MOD_GSK3_1	626	633	PF00069	0.603
MOD_GSK3_1	706	713	PF00069	0.541
MOD_GSK3_1	752	759	PF00069	0.655
MOD_GSK3_1	85	92	PF00069	0.631
MOD_N-GLC_1	263	268	PF02516	0.716
MOD_N-GLC_1	412	417	PF02516	0.453
MOD_N-GLC_1	686	691	PF02516	0.603
MOD_N-GLC_1	740	745	PF02516	0.594
MOD_N-GLC_1	89	94	PF02516	0.688
MOD_N-GLC_1	95	100	PF02516	0.665
MOD_N-GLC_2	437	439	PF02516	0.487
MOD_NEK2_1	173	178	PF00069	0.753
MOD_NEK2_1	20	25	PF00069	0.372
MOD_NEK2_1	297	302	PF00069	0.568
MOD_NEK2_1	561	566	PF00069	0.616
MOD_NEK2_1	680	685	PF00069	0.578
MOD_NEK2_1	751	756	PF00069	0.749
MOD_NEK2_1	765	770	PF00069	0.565
MOD_NEK2_2	512	517	PF00069	0.562
MOD_PIKK_1	357	363	PF00454	0.779
MOD_PIKK_1	561	567	PF00454	0.553
MOD_PK_1	256	262	PF00069	0.704
MOD_PK_1	767	773	PF00069	0.577
MOD_PKA_1	534	540	PF00069	0.647
MOD_PKA_2	165	171	PF00069	0.518
MOD_PKA_2	173	179	PF00069	0.579
MOD_PKA_2	276	282	PF00069	0.756
MOD_PKA_2	458	464	PF00069	0.689
MOD_PKA_2	486	492	PF00069	0.525
MOD_PKA_2	516	522	PF00069	0.612
MOD_PKA_2	717	723	PF00069	0.622
MOD_Plk_1	185	191	PF00069	0.780
MOD_Plk_1	393	399	PF00069	0.510
MOD_Plk_2-3	654	660	PF00069	0.563
MOD_Plk_2-3	794	800	PF00069	0.605
MOD_Plk_4	149	155	PF00069	0.364
MOD_Plk_4	256	262	PF00069	0.766
MOD_Plk_4	381	387	PF00069	0.362
MOD_Plk_4	412	418	PF00069	0.564
MOD_Plk_4	516	522	PF00069	0.572
MOD_Plk_4	548	554	PF00069	0.681
MOD_Plk_4	599	605	PF00069	0.574
MOD_Plk_4	630	636	PF00069	0.508
MOD_Plk_4	707	713	PF00069	0.519
MOD_ProDKin_1	237	243	PF00069	0.727
MOD_ProDKin_1	267	273	PF00069	0.744
MOD_ProDKin_1	353	359	PF00069	0.725
MOD_ProDKin_1	613	619	PF00069	0.503
MOD_ProDKin_1	626	632	PF00069	0.561
MOD_ProDKin_1	642	648	PF00069	0.439
MOD_ProDKin_1	697	703	PF00069	0.493
MOD_ProDKin_1	710	716	PF00069	0.530
MOD_SUMO_for_1	138	141	PF00179	0.541
MOD_SUMO_rev_2	616	626	PF00179	0.617
TRG_DiLeu_BaEn_1	724	729	PF01217	0.506
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.769
TRG_DiLeu_BaLyEn_6	723	728	PF01217	0.597
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.468
TRG_ENDOCYTIC_2	156	159	PF00928	0.397
TRG_ENDOCYTIC_2	164	167	PF00928	0.439
TRG_ENDOCYTIC_2	227	230	PF00928	0.459
TRG_ENDOCYTIC_2	291	294	PF00928	0.542
TRG_ENDOCYTIC_2	503	506	PF00928	0.454
TRG_ENDOCYTIC_2	625	628	PF00928	0.603
TRG_ENDOCYTIC_2	739	742	PF00928	0.585
TRG_ER_diArg_1	127	130	PF00400	0.534
TRG_ER_diArg_1	172	175	PF00400	0.753
TRG_ER_diArg_1	294	296	PF00400	0.610
TRG_ER_diArg_1	576	578	PF00400	0.618
TRG_ER_diArg_1	583	585	PF00400	0.678
TRG_ER_diArg_1	669	671	PF00400	0.574
TRG_NLS_MonoExtN_4	530	537	PF00514	0.655
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	778	783	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I059	Leptomonas seymouri	51%	99%
A0A1X0NQD9	Trypanosomatidae	25%	100%
A0A3R7NAY7	Trypanosoma rangeli	29%	100%
A4H8K8	Leishmania braziliensis	74%	98%
C9ZPM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AGN5	Leishmania infantum	100%	100%
E9AQP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QET5	Leishmania major	92%	100%
V5BLP9	Trypanosoma cruzi	27%	100%