Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTX7_LEIDO

TriTrypDb:

LdBPK_160670.1 , LdCL_160011900 , LDHU3_16.0810

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTX7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	425	429	PF00656	0.648
CLV_NRD_NRD_1	268	270	PF00675	0.513
CLV_NRD_NRD_1	278	280	PF00675	0.397
CLV_NRD_NRD_1	345	347	PF00675	0.742
CLV_NRD_NRD_1	5	7	PF00675	0.777
CLV_NRD_NRD_1	664	666	PF00675	0.503
CLV_PCSK_KEX2_1	268	270	PF00082	0.513
CLV_PCSK_KEX2_1	278	280	PF00082	0.397
CLV_PCSK_KEX2_1	345	347	PF00082	0.623
CLV_PCSK_KEX2_1	5	7	PF00082	0.777
CLV_PCSK_KEX2_1	537	539	PF00082	0.678
CLV_PCSK_KEX2_1	671	673	PF00082	0.671
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.678
CLV_PCSK_PC1ET2_1	671	673	PF00082	0.677
CLV_PCSK_SKI1_1	119	123	PF00082	0.686
CLV_PCSK_SKI1_1	203	207	PF00082	0.740
CLV_PCSK_SKI1_1	268	272	PF00082	0.474
CLV_PCSK_SKI1_1	278	282	PF00082	0.389
CLV_PCSK_SKI1_1	321	325	PF00082	0.564
DEG_Nend_Nbox_1	1	3	PF02207	0.733
DEG_SCF_FBW7_1	43	48	PF00400	0.560
DEG_SCF_FBW7_1	569	576	PF00400	0.721
DEG_SPOP_SBC_1	298	302	PF00917	0.436
DEG_SPOP_SBC_1	411	415	PF00917	0.486
DEG_SPOP_SBC_1	573	577	PF00917	0.795
DOC_CKS1_1	236	241	PF01111	0.569
DOC_CYCLIN_RxL_1	116	125	PF00134	0.651
DOC_PP4_FxxP_1	270	273	PF00568	0.411
DOC_PP4_MxPP_1	571	574	PF00568	0.679
DOC_USP7_MATH_1	117	121	PF00917	0.655
DOC_USP7_MATH_1	260	264	PF00917	0.513
DOC_USP7_MATH_1	411	415	PF00917	0.598
DOC_USP7_MATH_1	440	444	PF00917	0.737
DOC_USP7_MATH_1	45	49	PF00917	0.695
DOC_USP7_MATH_1	553	557	PF00917	0.814
DOC_USP7_MATH_1	565	569	PF00917	0.582
DOC_USP7_MATH_1	574	578	PF00917	0.630
DOC_USP7_MATH_1	599	603	PF00917	0.594
DOC_USP7_MATH_2	445	451	PF00917	0.670
DOC_WW_Pin1_4	235	240	PF00397	0.611
DOC_WW_Pin1_4	269	274	PF00397	0.411
DOC_WW_Pin1_4	370	375	PF00397	0.518
DOC_WW_Pin1_4	380	385	PF00397	0.413
DOC_WW_Pin1_4	41	46	PF00397	0.722
DOC_WW_Pin1_4	418	423	PF00397	0.534
DOC_WW_Pin1_4	512	517	PF00397	0.603
DOC_WW_Pin1_4	569	574	PF00397	0.759
DOC_WW_Pin1_4	577	582	PF00397	0.631
LIG_14-3-3_CanoR_1	126	132	PF00244	0.813
LIG_14-3-3_CanoR_1	203	208	PF00244	0.811
LIG_14-3-3_CanoR_1	262	270	PF00244	0.299
LIG_14-3-3_CanoR_1	321	326	PF00244	0.539
LIG_14-3-3_CanoR_1	36	41	PF00244	0.597
LIG_Actin_WH2_2	649	667	PF00022	0.442
LIG_APCC_ABBA_1	636	641	PF00400	0.546
LIG_BRCT_BRCA1_1	372	376	PF00533	0.623
LIG_Clathr_ClatBox_1	308	312	PF01394	0.513
LIG_FHA_1	113	119	PF00498	0.553
LIG_FHA_1	285	291	PF00498	0.387
LIG_FHA_1	299	305	PF00498	0.292
LIG_FHA_1	324	330	PF00498	0.622
LIG_FHA_1	495	501	PF00498	0.464
LIG_FHA_1	513	519	PF00498	0.627
LIG_FHA_1	633	639	PF00498	0.510
LIG_FHA_1	97	103	PF00498	0.738
LIG_FHA_2	225	231	PF00498	0.672
LIG_FHA_2	287	293	PF00498	0.350
LIG_FHA_2	322	328	PF00498	0.621
LIG_FHA_2	423	429	PF00498	0.634
LIG_FHA_2	621	627	PF00498	0.686
LIG_Integrin_RGD_1	548	550	PF01839	0.742
LIG_LIR_Apic_2	416	422	PF02991	0.523
LIG_LIR_Apic_2	536	542	PF02991	0.525
LIG_LIR_Gen_1	150	157	PF02991	0.588
LIG_LIR_Gen_1	470	478	PF02991	0.671
LIG_LIR_Gen_1	580	589	PF02991	0.596
LIG_LIR_Nem_3	150	154	PF02991	0.589
LIG_LIR_Nem_3	373	379	PF02991	0.619
LIG_LIR_Nem_3	470	475	PF02991	0.597
LIG_LIR_Nem_3	580	586	PF02991	0.604
LIG_MAD2	532	540	PF02301	0.654
LIG_NRBOX	117	123	PF00104	0.762
LIG_PCNA_yPIPBox_3	650	660	PF02747	0.574
LIG_PDZ_Wminus1_1	672	674	PF00595	0.548
LIG_Pex14_2	270	274	PF04695	0.411
LIG_Pex14_2	344	348	PF04695	0.571
LIG_Rb_LxCxE_1	182	202	PF01857	0.690
LIG_SH2_CRK	508	512	PF00017	0.504
LIG_SH2_GRB2like	460	463	PF00017	0.572
LIG_SH2_NCK_1	151	155	PF00017	0.619
LIG_SH2_NCK_1	461	465	PF00017	0.568
LIG_SH2_STAP1	433	437	PF00017	0.667
LIG_SH2_STAT5	504	507	PF00017	0.573
LIG_SH3_1	229	235	PF00018	0.630
LIG_SH3_3	229	235	PF00018	0.698
LIG_SH3_3	26	32	PF00018	0.735
LIG_SH3_3	371	377	PF00018	0.449
LIG_SH3_3	626	632	PF00018	0.659
LIG_SUMO_SIM_par_1	286	294	PF11976	0.513
LIG_TRAF2_1	289	292	PF00917	0.424
LIG_TRAF2_1	445	448	PF00917	0.684
LIG_TYR_ITIM	458	463	PF00017	0.471
MOD_CK1_1	112	118	PF00069	0.670
MOD_CK1_1	125	131	PF00069	0.633
MOD_CK1_1	256	262	PF00069	0.436
MOD_CK1_1	450	456	PF00069	0.737
MOD_CK1_1	48	54	PF00069	0.788
MOD_CK1_1	556	562	PF00069	0.694
MOD_CK1_1	577	583	PF00069	0.592
MOD_CK1_1	602	608	PF00069	0.600
MOD_CK2_1	140	146	PF00069	0.756
MOD_CK2_1	176	182	PF00069	0.675
MOD_CK2_1	224	230	PF00069	0.709
MOD_CK2_1	238	244	PF00069	0.669
MOD_CK2_1	260	266	PF00069	0.478
MOD_CK2_1	286	292	PF00069	0.332
MOD_CK2_1	321	327	PF00069	0.566
MOD_CK2_1	410	416	PF00069	0.511
MOD_CMANNOS	499	502	PF00535	0.461
MOD_CMANNOS	670	673	PF00535	0.578
MOD_DYRK1A_RPxSP_1	380	384	PF00069	0.461
MOD_GlcNHglycan	129	132	PF01048	0.796
MOD_GlcNHglycan	166	169	PF01048	0.727
MOD_GlcNHglycan	240	243	PF01048	0.655
MOD_GlcNHglycan	258	261	PF01048	0.300
MOD_GlcNHglycan	47	50	PF01048	0.689
MOD_GlcNHglycan	562	565	PF01048	0.715
MOD_GlcNHglycan	576	579	PF01048	0.657
MOD_GlcNHglycan	60	64	PF01048	0.669
MOD_GSK3_1	122	129	PF00069	0.668
MOD_GSK3_1	203	210	PF00069	0.762
MOD_GSK3_1	256	263	PF00069	0.476
MOD_GSK3_1	366	373	PF00069	0.511
MOD_GSK3_1	41	48	PF00069	0.699
MOD_GSK3_1	418	425	PF00069	0.708
MOD_GSK3_1	549	556	PF00069	0.713
MOD_GSK3_1	565	572	PF00069	0.669
MOD_GSK3_1	573	580	PF00069	0.628
MOD_GSK3_1	599	606	PF00069	0.815
MOD_GSK3_1	614	621	PF00069	0.701
MOD_GSK3_1	96	103	PF00069	0.780
MOD_LATS_1	124	130	PF00433	0.806
MOD_N-GLC_1	224	229	PF02516	0.640
MOD_NEK2_1	1	6	PF00069	0.721
MOD_NEK2_1	122	127	PF00069	0.647
MOD_NEK2_1	216	221	PF00069	0.717
MOD_NEK2_1	274	279	PF00069	0.513
MOD_NEK2_1	297	302	PF00069	0.410
MOD_NEK2_1	311	316	PF00069	0.329
MOD_NEK2_1	366	371	PF00069	0.470
MOD_NEK2_1	664	669	PF00069	0.440
MOD_NEK2_2	340	345	PF00069	0.571
MOD_PIKK_1	109	115	PF00454	0.534
MOD_PIKK_1	218	224	PF00454	0.635
MOD_PIKK_1	80	86	PF00454	0.790
MOD_PK_1	557	563	PF00069	0.587
MOD_PKA_2	125	131	PF00069	0.725
MOD_PKA_2	140	146	PF00069	0.684
MOD_PKA_2	261	267	PF00069	0.383
MOD_PKA_2	488	494	PF00069	0.609
MOD_PKA_2	556	562	PF00069	0.682
MOD_PKA_2	664	670	PF00069	0.493
MOD_PKB_1	336	344	PF00069	0.620
MOD_Plk_1	311	317	PF00069	0.375
MOD_Plk_1	429	435	PF00069	0.730
MOD_Plk_4	117	123	PF00069	0.690
MOD_Plk_4	300	306	PF00069	0.450
MOD_Plk_4	405	411	PF00069	0.585
MOD_Plk_4	495	501	PF00069	0.464
MOD_ProDKin_1	235	241	PF00069	0.608
MOD_ProDKin_1	269	275	PF00069	0.411
MOD_ProDKin_1	370	376	PF00069	0.514
MOD_ProDKin_1	380	386	PF00069	0.405
MOD_ProDKin_1	41	47	PF00069	0.726
MOD_ProDKin_1	418	424	PF00069	0.533
MOD_ProDKin_1	512	518	PF00069	0.594
MOD_ProDKin_1	569	575	PF00069	0.761
MOD_ProDKin_1	577	583	PF00069	0.633
TRG_DiLeu_BaEn_1	293	298	PF01217	0.513
TRG_DiLeu_BaEn_2	265	271	PF01217	0.513
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.562
TRG_ENDOCYTIC_2	151	154	PF00928	0.623
TRG_ENDOCYTIC_2	460	463	PF00928	0.474
TRG_ER_diArg_1	268	270	PF00400	0.513
TRG_ER_diArg_1	331	334	PF00400	0.618
TRG_ER_diArg_1	344	346	PF00400	0.534
TRG_ER_diArg_1	377	380	PF00400	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUK6	Leptomonas seymouri	32%	100%
A4H8I9	Leishmania braziliensis	61%	100%
E9AGN3	Leishmania infantum	99%	100%
E9AQM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
Q4QEV2	Leishmania major	86%	100%