Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTX4_LEIDO

TriTrypDb:

LdBPK_160660.1 , LdCL_160011800 , LDHU3_16.0800

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WTX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.493
CLV_NRD_NRD_1	162	164	PF00675	0.532
CLV_NRD_NRD_1	165	167	PF00675	0.541
CLV_NRD_NRD_1	371	373	PF00675	0.487
CLV_NRD_NRD_1	396	398	PF00675	0.454
CLV_NRD_NRD_1	411	413	PF00675	0.389
CLV_NRD_NRD_1	461	463	PF00675	0.510
CLV_NRD_NRD_1	485	487	PF00675	0.463
CLV_NRD_NRD_1	517	519	PF00675	0.596
CLV_NRD_NRD_1	53	55	PF00675	0.555
CLV_NRD_NRD_1	66	68	PF00675	0.555
CLV_PCSK_FUR_1	163	167	PF00082	0.425
CLV_PCSK_FUR_1	51	55	PF00082	0.472
CLV_PCSK_KEX2_1	164	166	PF00082	0.563
CLV_PCSK_KEX2_1	301	303	PF00082	0.408
CLV_PCSK_KEX2_1	411	413	PF00082	0.482
CLV_PCSK_KEX2_1	461	463	PF00082	0.548
CLV_PCSK_KEX2_1	509	511	PF00082	0.602
CLV_PCSK_KEX2_1	517	519	PF00082	0.569
CLV_PCSK_KEX2_1	53	55	PF00082	0.472
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.436
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.408
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.602
CLV_PCSK_SKI1_1	148	152	PF00082	0.612
CLV_PCSK_SKI1_1	491	495	PF00082	0.623
CLV_Separin_Metazoa	108	112	PF03568	0.529
DEG_APCC_DBOX_1	553	561	PF00400	0.624
DEG_Nend_UBRbox_1	1	4	PF02207	0.478
DEG_SPOP_SBC_1	274	278	PF00917	0.573
DOC_ANK_TNKS_1	229	236	PF00023	0.421
DOC_MAPK_gen_1	461	468	PF00069	0.441
DOC_MAPK_gen_1	51	59	PF00069	0.496
DOC_MAPK_gen_1	67	73	PF00069	0.490
DOC_MAPK_MEF2A_6	24	32	PF00069	0.443
DOC_PP2B_LxvP_1	11	14	PF13499	0.595
DOC_USP7_MATH_1	275	279	PF00917	0.728
DOC_USP7_MATH_1	346	350	PF00917	0.613
DOC_USP7_MATH_1	392	396	PF00917	0.603
LIG_14-3-3_CanoR_1	136	141	PF00244	0.556
LIG_14-3-3_CanoR_1	280	288	PF00244	0.506
LIG_14-3-3_CanoR_1	341	350	PF00244	0.514
LIG_14-3-3_CanoR_1	397	406	PF00244	0.585
LIG_14-3-3_CanoR_1	430	438	PF00244	0.470
LIG_Actin_WH2_2	196	214	PF00022	0.461
LIG_BRCT_BRCA1_1	277	281	PF00533	0.515
LIG_DLG_GKlike_1	136	144	PF00625	0.479
LIG_FHA_1	175	181	PF00498	0.509
LIG_FHA_1	206	212	PF00498	0.621
LIG_FHA_1	240	246	PF00498	0.425
LIG_FHA_1	274	280	PF00498	0.585
LIG_FHA_1	282	288	PF00498	0.437
LIG_FHA_1	323	329	PF00498	0.466
LIG_FHA_1	44	50	PF00498	0.563
LIG_FHA_1	54	60	PF00498	0.484
LIG_FHA_2	140	146	PF00498	0.549
LIG_FHA_2	413	419	PF00498	0.461
LIG_FHA_2	59	65	PF00498	0.482
LIG_LIR_Gen_1	535	545	PF02991	0.516
LIG_LIR_Nem_3	535	540	PF02991	0.514
LIG_NRBOX	6	12	PF00104	0.512
LIG_PCNA_yPIPBox_3	2	11	PF02747	0.480
LIG_RPA_C_Fungi	153	165	PF08784	0.628
LIG_SH2_CRK	38	42	PF00017	0.532
LIG_SH2_NCK_1	453	457	PF00017	0.535
LIG_SH2_SRC	453	456	PF00017	0.554
LIG_SH2_SRC	98	101	PF00017	0.452
LIG_SH2_STAP1	38	42	PF00017	0.402
LIG_SH2_STAT5	98	101	PF00017	0.532
LIG_SUMO_SIM_anti_2	244	249	PF11976	0.441
LIG_SUMO_SIM_par_1	55	61	PF11976	0.339
LIG_TRAF2_1	365	368	PF00917	0.506
LIG_TRAF2_1	415	418	PF00917	0.431
LIG_TRAF2_1	441	444	PF00917	0.426
MOD_CK1_1	139	145	PF00069	0.565
MOD_CK1_1	273	279	PF00069	0.713
MOD_CK1_1	391	397	PF00069	0.537
MOD_CK1_1	536	542	PF00069	0.574
MOD_CK2_1	139	145	PF00069	0.544
MOD_CK2_1	149	155	PF00069	0.447
MOD_CK2_1	280	286	PF00069	0.509
MOD_CK2_1	346	352	PF00069	0.602
MOD_CK2_1	412	418	PF00069	0.442
MOD_CK2_1	429	435	PF00069	0.457
MOD_CK2_1	444	450	PF00069	0.497
MOD_GlcNHglycan	262	265	PF01048	0.685
MOD_GlcNHglycan	272	275	PF01048	0.612
MOD_GlcNHglycan	306	310	PF01048	0.428
MOD_GlcNHglycan	344	347	PF01048	0.570
MOD_GlcNHglycan	390	393	PF01048	0.580
MOD_GlcNHglycan	394	397	PF01048	0.535
MOD_GlcNHglycan	400	403	PF01048	0.493
MOD_GlcNHglycan	421	424	PF01048	0.525
MOD_GlcNHglycan	446	449	PF01048	0.464
MOD_GSK3_1	235	242	PF00069	0.559
MOD_GSK3_1	256	263	PF00069	0.577
MOD_GSK3_1	266	273	PF00069	0.614
MOD_GSK3_1	342	349	PF00069	0.605
MOD_GSK3_1	388	395	PF00069	0.557
MOD_N-GLC_1	239	244	PF02516	0.557
MOD_NEK2_1	360	365	PF00069	0.577
MOD_NEK2_1	434	439	PF00069	0.467
MOD_NEK2_1	468	473	PF00069	0.467
MOD_NEK2_1	71	76	PF00069	0.488
MOD_NEK2_1	83	88	PF00069	0.452
MOD_NEK2_2	275	280	PF00069	0.645
MOD_PIKK_1	187	193	PF00454	0.527
MOD_PIKK_1	239	245	PF00454	0.415
MOD_PIKK_1	58	64	PF00454	0.531
MOD_PK_1	489	495	PF00069	0.531
MOD_PKA_1	53	59	PF00069	0.410
MOD_PKA_2	266	272	PF00069	0.676
MOD_PKA_2	388	394	PF00069	0.573
MOD_PKA_2	429	435	PF00069	0.436
MOD_PKA_2	53	59	PF00069	0.565
MOD_PKA_2	533	539	PF00069	0.542
MOD_PKB_1	51	59	PF00069	0.412
MOD_Plk_1	305	311	PF00069	0.417
MOD_Plk_1	367	373	PF00069	0.519
MOD_Plk_1	434	440	PF00069	0.441
MOD_Plk_1	489	495	PF00069	0.425
MOD_Plk_2-3	429	435	PF00069	0.468
MOD_Plk_4	533	539	PF00069	0.522
MOD_SUMO_rev_2	297	303	PF00179	0.430
MOD_SUMO_rev_2	358	366	PF00179	0.480
TRG_DiLeu_BaEn_3	226	232	PF01217	0.550
TRG_DiLeu_BaEn_4	107	113	PF01217	0.546
TRG_DiLeu_BaEn_4	47	53	PF01217	0.459
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.415
TRG_ENDOCYTIC_2	38	41	PF00928	0.532
TRG_ENDOCYTIC_2	463	466	PF00928	0.564
TRG_ER_diArg_1	110	113	PF00400	0.525
TRG_ER_diArg_1	163	166	PF00400	0.545
TRG_ER_diArg_1	21	24	PF00400	0.555
TRG_ER_diArg_1	228	231	PF00400	0.494
TRG_ER_diArg_1	411	413	PF00400	0.423
TRG_ER_diArg_1	461	463	PF00400	0.547
TRG_ER_diArg_1	51	54	PF00400	0.580
TRG_NES_CRM1_1	104	115	PF08389	0.531
TRG_NLS_MonoExtC_3	163	169	PF00514	0.428
TRG_NLS_MonoExtN_4	163	168	PF00514	0.428
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBD3	Leptomonas seymouri	68%	91%
A0A0S4JEJ6	Bodo saltans	35%	95%
A0A1X0NNU4	Trypanosomatidae	40%	98%
A0A422MW68	Trypanosoma rangeli	39%	98%
A4H8I8	Leishmania braziliensis	83%	100%
A4HWW5	Leishmania infantum	99%	100%
C9ZPQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AQM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QEV3	Leishmania major	93%	100%
V5AX96	Trypanosoma cruzi	40%	98%