FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WTW8_LEIDO

TriTrypDb:

LdBPK_160750.1 , LdCL_160012700 , LDHU3_16.0900

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.483
CLV_C14_Caspase3-7	290	294	PF00656	0.570
CLV_C14_Caspase3-7	321	325	PF00656	0.419
CLV_C14_Caspase3-7	338	342	PF00656	0.513
CLV_C14_Caspase3-7	368	372	PF00656	0.588
CLV_C14_Caspase3-7	451	455	PF00656	0.480
CLV_C14_Caspase3-7	490	494	PF00656	0.608
CLV_C14_Caspase3-7	557	561	PF00656	0.587
CLV_C14_Caspase3-7	95	99	PF00656	0.556
CLV_NRD_NRD_1	552	554	PF00675	0.530
CLV_NRD_NRD_1	585	587	PF00675	0.479
CLV_PCSK_FUR_1	550	554	PF00082	0.432
CLV_PCSK_FUR_1	582	586	PF00082	0.478
CLV_PCSK_KEX2_1	550	552	PF00082	0.527
CLV_PCSK_KEX2_1	584	586	PF00082	0.489
CLV_PCSK_KEX2_1	68	70	PF00082	0.386
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.376
CLV_PCSK_SKI1_1	213	217	PF00082	0.551
CLV_PCSK_SKI1_1	230	234	PF00082	0.254
CLV_PCSK_SKI1_1	25	29	PF00082	0.456
CLV_PCSK_SKI1_1	252	256	PF00082	0.451
CLV_PCSK_SKI1_1	425	429	PF00082	0.439
CLV_PCSK_SKI1_1	51	55	PF00082	0.337
DEG_Nend_Nbox_1	1	3	PF02207	0.368
DEG_SCF_FBW7_1	15	20	PF00400	0.405
DEG_SPOP_SBC_1	365	369	PF00917	0.560
DEG_SPOP_SBC_1	487	491	PF00917	0.628
DEG_SPOP_SBC_1	554	558	PF00917	0.564
DOC_CYCLIN_RxL_1	21	30	PF00134	0.395
DOC_CYCLIN_RxL_1	420	432	PF00134	0.431
DOC_MAPK_DCC_7	42	52	PF00069	0.385
DOC_MAPK_MEF2A_6	44	52	PF00069	0.384
DOC_PP4_MxPP_1	177	180	PF00568	0.442
DOC_USP7_MATH_1	109	113	PF00917	0.619
DOC_USP7_MATH_1	200	204	PF00917	0.640
DOC_USP7_MATH_1	206	210	PF00917	0.588
DOC_USP7_MATH_1	364	368	PF00917	0.499
DOC_USP7_MATH_1	554	558	PF00917	0.586
DOC_WW_Pin1_4	104	109	PF00397	0.665
DOC_WW_Pin1_4	13	18	PF00397	0.380
DOC_WW_Pin1_4	155	160	PF00397	0.533
DOC_WW_Pin1_4	305	310	PF00397	0.446
DOC_WW_Pin1_4	466	471	PF00397	0.420
LIG_14-3-3_CanoR_1	213	218	PF00244	0.425
LIG_14-3-3_CanoR_1	42	50	PF00244	0.451
LIG_14-3-3_CanoR_1	510	519	PF00244	0.498
LIG_14-3-3_CanoR_1	69	78	PF00244	0.426
LIG_14-3-3_CterR_2	597	602	PF00244	0.534
LIG_APCC_ABBA_1	50	55	PF00400	0.376
LIG_BIR_III_2	328	332	PF00653	0.405
LIG_BIR_III_4	114	118	PF00653	0.474
LIG_BIR_III_4	199	203	PF00653	0.592
LIG_EVH1_2	461	465	PF00568	0.397
LIG_FHA_1	116	122	PF00498	0.348
LIG_FHA_1	294	300	PF00498	0.520
LIG_FHA_1	563	569	PF00498	0.402
LIG_FHA_1	57	63	PF00498	0.344
LIG_FHA_2	336	342	PF00498	0.511
LIG_FHA_2	488	494	PF00498	0.640
LIG_FHA_2	93	99	PF00498	0.527
LIG_LIR_Gen_1	132	142	PF02991	0.451
LIG_LIR_Gen_1	260	271	PF02991	0.405
LIG_LIR_Nem_3	132	138	PF02991	0.446
LIG_LIR_Nem_3	186	191	PF02991	0.427
LIG_LIR_Nem_3	260	266	PF02991	0.416
LIG_LIR_Nem_3	359	365	PF02991	0.413
LIG_LIR_Nem_3	72	78	PF02991	0.424
LIG_LYPXL_S_1	74	78	PF13949	0.413
LIG_LYPXL_yS_3	75	78	PF13949	0.416
LIG_MYND_1	76	80	PF01753	0.417
LIG_NRBOX	270	276	PF00104	0.362
LIG_NRBOX	532	538	PF00104	0.374
LIG_Pex14_1	49	53	PF04695	0.331
LIG_Pex14_1	71	75	PF04695	0.364
LIG_Pex14_2	2	6	PF04695	0.345
LIG_Pex14_2	358	362	PF04695	0.355
LIG_PTAP_UEV_1	151	156	PF05743	0.635
LIG_SH2_CRK	263	267	PF00017	0.359
LIG_SH2_STAT3	191	194	PF00017	0.458
LIG_SH2_STAT3	31	34	PF00017	0.393
LIG_SH2_STAT5	120	123	PF00017	0.334
LIG_SH2_STAT5	26	29	PF00017	0.377
LIG_SH2_STAT5	31	34	PF00017	0.394
LIG_SH3_3	100	106	PF00018	0.676
LIG_SH3_3	149	155	PF00018	0.604
LIG_SH3_3	277	283	PF00018	0.511
LIG_SH3_3	303	309	PF00018	0.396
LIG_SH3_3	450	456	PF00018	0.410
LIG_TRAF2_1	184	187	PF00917	0.455
LIG_TRAF2_2	354	359	PF00917	0.322
LIG_TYR_ITSM	259	266	PF00017	0.373
MOD_CDK_SPK_2	466	471	PF00069	0.431
MOD_CDK_SPxK_1	15	21	PF00069	0.410
MOD_CK1_1	209	215	PF00069	0.499
MOD_CK1_1	367	373	PF00069	0.598
MOD_CK1_1	374	380	PF00069	0.522
MOD_CK1_1	491	497	PF00069	0.623
MOD_Cter_Amidation	66	69	PF01082	0.380
MOD_GlcNHglycan	152	155	PF01048	0.638
MOD_GlcNHglycan	208	211	PF01048	0.601
MOD_GlcNHglycan	287	292	PF01048	0.623
MOD_GlcNHglycan	373	376	PF01048	0.576
MOD_GlcNHglycan	490	493	PF01048	0.655
MOD_GlcNHglycan	514	517	PF01048	0.495
MOD_GSK3_1	11	18	PF00069	0.377
MOD_GSK3_1	209	216	PF00069	0.514
MOD_GSK3_1	258	265	PF00069	0.431
MOD_GSK3_1	289	296	PF00069	0.641
MOD_GSK3_1	301	308	PF00069	0.381
MOD_GSK3_1	367	374	PF00069	0.590
MOD_GSK3_1	403	410	PF00069	0.403
MOD_GSK3_1	487	494	PF00069	0.635
MOD_GSK3_1	595	602	PF00069	0.516
MOD_LATS_1	148	154	PF00433	0.587
MOD_LATS_1	23	29	PF00433	0.447
MOD_NEK2_1	11	16	PF00069	0.368
MOD_NEK2_1	129	134	PF00069	0.358
MOD_NEK2_1	27	32	PF00069	0.371
MOD_NEK2_1	301	306	PF00069	0.391
MOD_NEK2_1	438	443	PF00069	0.400
MOD_NEK2_1	512	517	PF00069	0.565
MOD_PIKK_1	200	206	PF00454	0.653
MOD_PIKK_1	403	409	PF00454	0.407
MOD_PIKK_1	438	444	PF00454	0.437
MOD_PIKK_1	69	75	PF00454	0.430
MOD_PK_1	262	268	PF00069	0.358
MOD_PKA_2	596	602	PF00069	0.563
MOD_PKB_1	551	559	PF00069	0.445
MOD_Plk_1	562	568	PF00069	0.467
MOD_Plk_4	115	121	PF00069	0.366
MOD_Plk_4	262	268	PF00069	0.358
MOD_ProDKin_1	104	110	PF00069	0.667
MOD_ProDKin_1	13	19	PF00069	0.387
MOD_ProDKin_1	155	161	PF00069	0.532
MOD_ProDKin_1	305	311	PF00069	0.447
MOD_ProDKin_1	466	472	PF00069	0.434
MOD_SUMO_rev_2	398	406	PF00179	0.413
TRG_DiLeu_BaEn_1	432	437	PF01217	0.492
TRG_ENDOCYTIC_2	26	29	PF00928	0.377
TRG_ENDOCYTIC_2	263	266	PF00928	0.366
TRG_ENDOCYTIC_2	75	78	PF00928	0.351
TRG_ER_diArg_1	130	133	PF00400	0.351
TRG_ER_diArg_1	394	397	PF00400	0.469
TRG_ER_diArg_1	549	552	PF00400	0.515
TRG_ER_diArg_1	582	585	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	425	430	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Z9	Leptomonas seymouri	52%	100%
A4H8J7	Leishmania braziliensis	80%	100%
A4HWX2	Leishmania infantum	99%	100%
E9AQN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4QEU4	Leishmania major	93%	100%