Meiotic recombination protein SPO11, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

meiotic recombination protein SPO11, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTW1_LEIDO

TriTrypDb:

LdBPK_160630.1 , LdCL_160011400 , LDHU3_16.0760

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005694	chromosome	5	6
GO:0043226	organelle	2	6
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6
GO:0000228	nuclear chromosome	6	1

Expansion

Sequence features

A0A3S7WTW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTW1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0000706	meiotic DNA double-strand break processing	3	1
GO:0000729	DNA double-strand break processing	5	1
GO:0006310	DNA recombination	5	1
GO:0007131	reciprocal meiotic recombination	3	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0035825	homologous recombination	6	1
GO:0042138	meiotic DNA double-strand break formation	4	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003676	nucleic acid binding	3	6
GO:0003677	DNA binding	4	6
GO:0003824	catalytic activity	1	6
GO:0003916	DNA topoisomerase activity	3	6
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0008094	ATP-dependent activity, acting on DNA	2	6
GO:0016853	isomerase activity	2	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140097	catalytic activity, acting on DNA	3	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6
GO:0140657	ATP-dependent activity	1	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	417	421	PF00656	0.714
CLV_NRD_NRD_1	27	29	PF00675	0.420
CLV_NRD_NRD_1	344	346	PF00675	0.484
CLV_NRD_NRD_1	502	504	PF00675	0.598
CLV_NRD_NRD_1	630	632	PF00675	0.784
CLV_NRD_NRD_1	650	652	PF00675	0.269
CLV_NRD_NRD_1	68	70	PF00675	0.814
CLV_PCSK_FUR_1	627	631	PF00082	0.531
CLV_PCSK_KEX2_1	27	29	PF00082	0.420
CLV_PCSK_KEX2_1	344	346	PF00082	0.484
CLV_PCSK_KEX2_1	46	48	PF00082	0.593
CLV_PCSK_KEX2_1	502	504	PF00082	0.619
CLV_PCSK_KEX2_1	629	631	PF00082	0.787
CLV_PCSK_KEX2_1	650	652	PF00082	0.502
CLV_PCSK_KEX2_1	67	69	PF00082	0.816
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.610
CLV_PCSK_SKI1_1	122	126	PF00082	0.706
CLV_PCSK_SKI1_1	344	348	PF00082	0.579
CLV_PCSK_SKI1_1	86	90	PF00082	0.577
CLV_Separin_Metazoa	24	28	PF03568	0.495
DEG_APCC_DBOX_1	133	141	PF00400	0.407
DEG_APCC_DBOX_1	320	328	PF00400	0.461
DEG_APCC_DBOX_1	343	351	PF00400	0.569
DEG_SCF_TRCP1_1	420	425	PF00400	0.616
DEG_SPOP_SBC_1	521	525	PF00917	0.517
DOC_CDC14_PxL_1	396	404	PF14671	0.570
DOC_CKS1_1	90	95	PF01111	0.569
DOC_MAPK_gen_1	184	192	PF00069	0.407
DOC_MAPK_gen_1	27	33	PF00069	0.482
DOC_MAPK_MEF2A_6	326	333	PF00069	0.457
DOC_MAPK_RevD_3	31	47	PF00069	0.540
DOC_PP2B_LxvP_1	183	186	PF13499	0.407
DOC_PP2B_LxvP_1	41	44	PF13499	0.658
DOC_PP4_FxxP_1	298	301	PF00568	0.449
DOC_PP4_FxxP_1	617	620	PF00568	0.360
DOC_USP7_MATH_1	104	108	PF00917	0.591
DOC_USP7_MATH_1	123	127	PF00917	0.591
DOC_USP7_MATH_1	258	262	PF00917	0.780
DOC_USP7_MATH_1	272	276	PF00917	0.683
DOC_USP7_MATH_1	286	290	PF00917	0.470
DOC_USP7_MATH_1	379	383	PF00917	0.643
DOC_USP7_MATH_1	461	465	PF00917	0.729
DOC_USP7_MATH_1	467	471	PF00917	0.770
DOC_USP7_MATH_1	490	494	PF00917	0.747
DOC_USP7_MATH_1	521	525	PF00917	0.732
DOC_USP7_MATH_1	62	66	PF00917	0.627
DOC_WW_Pin1_4	438	443	PF00397	0.823
DOC_WW_Pin1_4	486	491	PF00397	0.682
DOC_WW_Pin1_4	522	527	PF00397	0.729
DOC_WW_Pin1_4	6	11	PF00397	0.588
DOC_WW_Pin1_4	632	637	PF00397	0.545
DOC_WW_Pin1_4	86	91	PF00397	0.622
LIG_14-3-3_CanoR_1	122	128	PF00244	0.530
LIG_14-3-3_CanoR_1	164	172	PF00244	0.474
LIG_14-3-3_CanoR_1	207	212	PF00244	0.447
LIG_14-3-3_CanoR_1	460	469	PF00244	0.554
LIG_14-3-3_CanoR_1	571	575	PF00244	0.639
LIG_14-3-3_CanoR_1	583	587	PF00244	0.408
LIG_14-3-3_CanoR_1	69	75	PF00244	0.663
LIG_BIR_III_2	383	387	PF00653	0.531
LIG_EVH1_2	636	640	PF00568	0.547
LIG_FHA_1	166	172	PF00498	0.506
LIG_FHA_1	407	413	PF00498	0.525
LIG_FHA_1	83	89	PF00498	0.582
LIG_FHA_2	152	158	PF00498	0.407
LIG_FHA_2	499	505	PF00498	0.485
LIG_LIR_Apic_2	394	400	PF02991	0.503
LIG_LIR_Apic_2	606	612	PF02991	0.605
LIG_LIR_Gen_1	157	166	PF02991	0.407
LIG_LIR_Gen_1	2	13	PF02991	0.590
LIG_LIR_LC3C_4	230	235	PF02991	0.533
LIG_LIR_Nem_3	141	147	PF02991	0.474
LIG_LIR_Nem_3	157	163	PF02991	0.274
LIG_LIR_Nem_3	2	8	PF02991	0.582
LIG_LIR_Nem_3	205	209	PF02991	0.480
LIG_LIR_Nem_3	393	399	PF02991	0.541
LIG_LIR_Nem_3	401	407	PF02991	0.525
LIG_MYND_1	325	329	PF01753	0.458
LIG_NRBOX	36	42	PF00104	0.617
LIG_NRBOX	514	520	PF00104	0.638
LIG_SH2_CRK	160	164	PF00017	0.407
LIG_SH2_CRK	206	210	PF00017	0.493
LIG_SH2_CRK	397	401	PF00017	0.374
LIG_SH2_CRK	609	613	PF00017	0.623
LIG_SH2_CRK	72	76	PF00017	0.725
LIG_SH2_GRB2like	613	616	PF00017	0.480
LIG_SH2_NCK_1	397	401	PF00017	0.374
LIG_SH2_NCK_1	609	613	PF00017	0.623
LIG_SH2_STAP1	613	617	PF00017	0.528
LIG_SH2_STAT5	199	202	PF00017	0.535
LIG_SH2_STAT5	32	35	PF00017	0.482
LIG_SH2_STAT5	551	554	PF00017	0.533
LIG_SH2_STAT5	609	612	PF00017	0.528
LIG_SH3_3	429	435	PF00018	0.710
LIG_SH3_3	87	93	PF00018	0.778
LIG_SUMO_SIM_par_1	136	142	PF11976	0.506
LIG_SUMO_SIM_par_1	306	311	PF11976	0.424
LIG_TRAF2_1	219	222	PF00917	0.646
LIG_TYR_ITIM	158	163	PF00017	0.407
LIG_TYR_ITIM	204	209	PF00017	0.470
LIG_UBA3_1	40	46	PF00899	0.623
LIG_WW_3	48	52	PF00397	0.509
MOD_CDK_SPxxK_3	522	529	PF00069	0.531
MOD_CK1_1	257	263	PF00069	0.695
MOD_CK1_1	275	281	PF00069	0.657
MOD_CK1_1	287	293	PF00069	0.512
MOD_CK1_1	391	397	PF00069	0.526
MOD_CK1_1	463	469	PF00069	0.707
MOD_CK1_1	470	476	PF00069	0.667
MOD_CK1_1	489	495	PF00069	0.763
MOD_CK1_1	570	576	PF00069	0.654
MOD_CK1_1	635	641	PF00069	0.532
MOD_CK2_1	1	7	PF00069	0.589
MOD_CK2_1	547	553	PF00069	0.679
MOD_GlcNHglycan	229	232	PF01048	0.474
MOD_GlcNHglycan	254	257	PF01048	0.836
MOD_GlcNHglycan	291	294	PF01048	0.645
MOD_GlcNHglycan	420	423	PF01048	0.658
MOD_GlcNHglycan	424	427	PF01048	0.638
MOD_GlcNHglycan	429	432	PF01048	0.603
MOD_GlcNHglycan	447	450	PF01048	0.629
MOD_GlcNHglycan	465	468	PF01048	0.642
MOD_GlcNHglycan	469	472	PF01048	0.642
MOD_GlcNHglycan	476	479	PF01048	0.696
MOD_GlcNHglycan	558	561	PF01048	0.664
MOD_GlcNHglycan	562	565	PF01048	0.683
MOD_GlcNHglycan	62	65	PF01048	0.662
MOD_GSK3_1	252	259	PF00069	0.812
MOD_GSK3_1	261	268	PF00069	0.569
MOD_GSK3_1	271	278	PF00069	0.706
MOD_GSK3_1	418	425	PF00069	0.646
MOD_GSK3_1	441	448	PF00069	0.681
MOD_GSK3_1	452	459	PF00069	0.792
MOD_GSK3_1	463	470	PF00069	0.653
MOD_GSK3_1	474	481	PF00069	0.731
MOD_GSK3_1	486	493	PF00069	0.565
MOD_GSK3_1	498	505	PF00069	0.304
MOD_GSK3_1	556	563	PF00069	0.682
MOD_GSK3_1	78	85	PF00069	0.571
MOD_GSK3_1	88	95	PF00069	0.701
MOD_N-GLC_1	172	177	PF02516	0.407
MOD_N-GLC_1	261	266	PF02516	0.649
MOD_N-GLC_2	303	305	PF02516	0.473
MOD_NEK2_1	1	6	PF00069	0.705
MOD_NEK2_1	233	238	PF00069	0.566
MOD_NEK2_1	36	41	PF00069	0.544
MOD_NEK2_1	445	450	PF00069	0.828
MOD_NEK2_2	104	109	PF00069	0.541
MOD_NEK2_2	123	128	PF00069	0.500
MOD_NEK2_2	62	67	PF00069	0.512
MOD_PIKK_1	151	157	PF00454	0.481
MOD_PIKK_1	165	171	PF00454	0.305
MOD_PIKK_1	277	283	PF00454	0.570
MOD_PIKK_1	635	641	PF00454	0.643
MOD_PKA_1	502	508	PF00069	0.368
MOD_PKA_2	502	508	PF00069	0.398
MOD_PKA_2	556	562	PF00069	0.741
MOD_PKA_2	570	576	PF00069	0.490
MOD_PKA_2	582	588	PF00069	0.409
MOD_PKA_2	77	83	PF00069	0.614
MOD_PKB_1	76	84	PF00069	0.567
MOD_Plk_1	172	178	PF00069	0.407
MOD_Plk_4	233	239	PF00069	0.495
MOD_Plk_4	36	42	PF00069	0.531
MOD_Plk_4	502	508	PF00069	0.398
MOD_Plk_4	547	553	PF00069	0.707
MOD_Plk_4	582	588	PF00069	0.544
MOD_Plk_4	619	625	PF00069	0.629
MOD_ProDKin_1	438	444	PF00069	0.824
MOD_ProDKin_1	486	492	PF00069	0.681
MOD_ProDKin_1	522	528	PF00069	0.729
MOD_ProDKin_1	6	12	PF00069	0.589
MOD_ProDKin_1	632	638	PF00069	0.530
MOD_ProDKin_1	86	92	PF00069	0.621
MOD_SUMO_for_1	601	604	PF00179	0.477
TRG_DiLeu_BaEn_4	221	227	PF01217	0.594
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.492
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.572
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.272
TRG_ENDOCYTIC_2	159	162	PF00928	0.407
TRG_ENDOCYTIC_2	206	209	PF00928	0.491
TRG_ENDOCYTIC_2	396	399	PF00928	0.581
TRG_ER_diArg_1	26	28	PF00400	0.431
TRG_ER_diArg_1	344	346	PF00400	0.484
TRG_ER_diArg_1	626	629	PF00400	0.662
TRG_ER_diArg_1	649	651	PF00400	0.601
TRG_ER_diArg_1	66	69	PF00400	0.764
TRG_NES_CRM1_1	19	35	PF08389	0.474
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.717

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C1	Leptomonas seymouri	38%	98%
A4H8I5	Leishmania braziliensis	68%	100%
E9AQM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QEV6	Leishmania major	87%	100%