RING-H2_zinc_finger/Anaphase-promoting_complex_su bunit_11_RING-H2_finger/Ring_finger_domain_containing_prote in_putative/Pfam:PF12678/Pfam:PF12861/Pfam:PF13639

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-H2 zinc finger/Anaphase-promoting complex subunit 11 RING-H2 finger/Ring finger domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTV9_LEIDO

TriTrypDb:

LdCL_160011700 , LDHU3_16.0790

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTV9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.646
DEG_SCF_FBW7_1	1	7	PF00400	0.484
DEG_SPOP_SBC_1	5	9	PF00917	0.558
DEG_SPOP_SBC_1	90	94	PF00917	0.572
DOC_CKS1_1	1	6	PF01111	0.484
DOC_PP1_RVXF_1	140	146	PF00149	0.395
DOC_USP7_MATH_1	15	19	PF00917	0.550
DOC_USP7_MATH_1	4	8	PF00917	0.665
DOC_USP7_MATH_1	90	94	PF00917	0.537
DOC_WW_Pin1_4	116	121	PF00397	0.655
DOC_WW_Pin1_4	91	96	PF00397	0.571
LIG_14-3-3_CanoR_1	112	121	PF00244	0.742
LIG_14-3-3_CanoR_1	33	39	PF00244	0.487
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_FHA_1	25	31	PF00498	0.531
LIG_FHA_1	39	45	PF00498	0.457
LIG_FHA_1	7	13	PF00498	0.524
LIG_LIR_Gen_1	158	168	PF02991	0.484
LIG_SH2_CRK	154	158	PF00017	0.445
LIG_SH3_3	9	15	PF00018	0.686
LIG_SUMO_SIM_par_1	40	46	PF11976	0.416
LIG_SxIP_EBH_1	23	33	PF03271	0.502
MOD_CK1_1	24	30	PF00069	0.486
MOD_CK1_1	75	81	PF00069	0.567
MOD_CK1_1	99	105	PF00069	0.605
MOD_CK2_1	177	183	PF00069	0.578
MOD_GlcNHglycan	101	104	PF01048	0.668
MOD_GlcNHglycan	17	20	PF01048	0.620
MOD_GlcNHglycan	77	80	PF01048	0.493
MOD_GlcNHglycan	82	85	PF01048	0.516
MOD_GSK3_1	107	114	PF00069	0.629
MOD_GSK3_1	21	28	PF00069	0.603
MOD_GSK3_1	71	78	PF00069	0.492
MOD_GSK3_1	85	92	PF00069	0.474
MOD_OFUCOSY	141	148	PF10250	0.224
MOD_PIKK_1	85	91	PF00454	0.616
MOD_PKA_2	107	113	PF00069	0.744
MOD_PKA_2	32	38	PF00069	0.500
MOD_Plk_4	21	27	PF00069	0.532
MOD_Plk_4	96	102	PF00069	0.585
MOD_ProDKin_1	116	122	PF00069	0.653
MOD_ProDKin_1	91	97	PF00069	0.567
TRG_ENDOCYTIC_2	154	157	PF00928	0.295
TRG_ER_diArg_1	140	143	PF00400	0.224

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NP59	Trypanosomatidae	34%	100%
A0A422MVY9	Trypanosoma rangeli	37%	100%
C9ZPQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
V5BLR2	Trypanosoma cruzi	36%	100%