AAA domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AAA domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTV2_LEIDO

TriTrypDb:

LdBPK_160570.1 , LdCL_160010600 , LDHU3_16.0680

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.697
CLV_C14_Caspase3-7	36	40	PF00656	0.455
CLV_C14_Caspase3-7	394	398	PF00656	0.553
CLV_NRD_NRD_1	145	147	PF00675	0.553
CLV_NRD_NRD_1	214	216	PF00675	0.576
CLV_NRD_NRD_1	223	225	PF00675	0.648
CLV_NRD_NRD_1	293	295	PF00675	0.466
CLV_NRD_NRD_1	300	302	PF00675	0.542
CLV_NRD_NRD_1	415	417	PF00675	0.678
CLV_NRD_NRD_1	466	468	PF00675	0.511
CLV_NRD_NRD_1	545	547	PF00675	0.564
CLV_NRD_NRD_1	700	702	PF00675	0.568
CLV_PCSK_FUR_1	212	216	PF00082	0.635
CLV_PCSK_FUR_1	413	417	PF00082	0.621
CLV_PCSK_KEX2_1	145	147	PF00082	0.553
CLV_PCSK_KEX2_1	212	214	PF00082	0.542
CLV_PCSK_KEX2_1	223	225	PF00082	0.615
CLV_PCSK_KEX2_1	293	295	PF00082	0.466
CLV_PCSK_KEX2_1	300	302	PF00082	0.542
CLV_PCSK_KEX2_1	415	417	PF00082	0.630
CLV_PCSK_KEX2_1	466	468	PF00082	0.511
CLV_PCSK_KEX2_1	545	547	PF00082	0.564
CLV_PCSK_KEX2_1	700	702	PF00082	0.568
CLV_PCSK_PC7_1	411	417	PF00082	0.613
CLV_PCSK_SKI1_1	293	297	PF00082	0.445
CLV_PCSK_SKI1_1	396	400	PF00082	0.573
CLV_PCSK_SKI1_1	573	577	PF00082	0.544
DEG_APCC_DBOX_1	395	403	PF00400	0.578
DEG_APCC_DBOX_1	570	578	PF00400	0.485
DEG_SCF_FBW7_2	550	557	PF00400	0.631
DEG_SPOP_SBC_1	173	177	PF00917	0.562
DEG_SPOP_SBC_1	495	499	PF00917	0.497
DEG_SPOP_SBC_1	618	622	PF00917	0.506
DOC_CDC14_PxL_1	135	143	PF14671	0.438
DOC_CKS1_1	296	301	PF01111	0.553
DOC_CYCLIN_RxL_1	300	311	PF00134	0.450
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.360
DOC_MAPK_MEF2A_6	9	16	PF00069	0.363
DOC_PP1_RVXF_1	660	666	PF00149	0.512
DOC_PP2B_LxvP_1	136	139	PF13499	0.608
DOC_PP4_FxxP_1	252	255	PF00568	0.402
DOC_PP4_FxxP_1	296	299	PF00568	0.471
DOC_PP4_FxxP_1	407	410	PF00568	0.625
DOC_USP7_MATH_1	173	177	PF00917	0.732
DOC_USP7_MATH_1	308	312	PF00917	0.556
DOC_USP7_MATH_1	418	422	PF00917	0.732
DOC_USP7_MATH_1	445	449	PF00917	0.662
DOC_USP7_MATH_1	453	457	PF00917	0.609
DOC_USP7_MATH_1	495	499	PF00917	0.504
DOC_USP7_MATH_1	513	517	PF00917	0.565
DOC_WW_Pin1_4	167	172	PF00397	0.639
DOC_WW_Pin1_4	180	185	PF00397	0.549
DOC_WW_Pin1_4	295	300	PF00397	0.470
DOC_WW_Pin1_4	37	42	PF00397	0.408
DOC_WW_Pin1_4	380	385	PF00397	0.660
DOC_WW_Pin1_4	400	405	PF00397	0.638
DOC_WW_Pin1_4	449	454	PF00397	0.627
DOC_WW_Pin1_4	497	502	PF00397	0.525
DOC_WW_Pin1_4	545	550	PF00397	0.770
DOC_WW_Pin1_4	588	593	PF00397	0.748
DOC_WW_Pin1_4	87	92	PF00397	0.379
DOC_WW_Pin1_4	98	103	PF00397	0.530
LIG_14-3-3_CanoR_1	212	218	PF00244	0.590
LIG_14-3-3_CanoR_1	271	277	PF00244	0.538
LIG_14-3-3_CanoR_1	496	501	PF00244	0.521
LIG_14-3-3_CanoR_1	545	549	PF00244	0.649
LIG_14-3-3_CanoR_1	664	669	PF00244	0.569
LIG_14-3-3_CanoR_1	75	80	PF00244	0.430
LIG_APCC_ABBA_1	482	487	PF00400	0.517
LIG_BIR_II_1	1	5	PF00653	0.430
LIG_BIR_III_1	1	5	PF00653	0.434
LIG_BIR_III_3	1	5	PF00653	0.434
LIG_BRCT_BRCA1_1	48	52	PF00533	0.314
LIG_CSL_BTD_1	252	255	PF09270	0.402
LIG_FHA_1	287	293	PF00498	0.413
LIG_FHA_1	361	367	PF00498	0.501
LIG_FHA_1	619	625	PF00498	0.529
LIG_FHA_1	84	90	PF00498	0.434
LIG_FHA_2	176	182	PF00498	0.721
LIG_FHA_2	392	398	PF00498	0.679
LIG_FHA_2	59	65	PF00498	0.386
LIG_FHA_2	675	681	PF00498	0.645
LIG_FHA_2	719	725	PF00498	0.479
LIG_GBD_Chelix_1	30	38	PF00786	0.408
LIG_Integrin_isoDGR_2	707	709	PF01839	0.451
LIG_LIR_Apic_2	405	410	PF02991	0.557
LIG_LIR_Gen_1	479	490	PF02991	0.489
LIG_LIR_Gen_1	49	59	PF02991	0.339
LIG_LIR_Nem_3	263	268	PF02991	0.385
LIG_LIR_Nem_3	275	279	PF02991	0.383
LIG_LIR_Nem_3	479	485	PF02991	0.477
LIG_LIR_Nem_3	49	55	PF02991	0.457
LIG_LIR_Nem_3	61	65	PF02991	0.401
LIG_LIR_Nem_3	639	645	PF02991	0.433
LIG_LIR_Nem_3	652	658	PF02991	0.477
LIG_LIR_Nem_3	69	73	PF02991	0.365
LIG_MLH1_MIPbox_1	48	52	PF16413	0.314
LIG_NRP_CendR_1	731	734	PF00754	0.473
LIG_PCNA_yPIPBox_3	270	284	PF02747	0.304
LIG_Pex14_1	486	490	PF04695	0.506
LIG_Pex14_2	482	486	PF04695	0.488
LIG_Pex14_2	636	640	PF04695	0.438
LIG_Rb_LxCxE_1	579	596	PF01857	0.551
LIG_REV1ctd_RIR_1	293	298	PF16727	0.453
LIG_SH2_CRK	651	655	PF00017	0.366
LIG_SH2_CRK	70	74	PF00017	0.344
LIG_SH2_GRB2like	563	566	PF00017	0.570
LIG_SH2_NCK_1	651	655	PF00017	0.420
LIG_SH2_STAP1	279	283	PF00017	0.321
LIG_SH2_STAP1	638	642	PF00017	0.436
LIG_SH2_STAP1	651	655	PF00017	0.393
LIG_SH2_STAT5	259	262	PF00017	0.296
LIG_SH2_STAT5	276	279	PF00017	0.436
LIG_SH2_STAT5	306	309	PF00017	0.592
LIG_SH2_STAT5	563	566	PF00017	0.494
LIG_SH2_STAT5	644	647	PF00017	0.451
LIG_SH3_3	338	344	PF00018	0.563
LIG_SH3_3	38	44	PF00018	0.376
LIG_SH3_3	406	412	PF00018	0.576
LIG_SH3_3	586	592	PF00018	0.669
LIG_SH3_CIN85_PxpxPR_1	695	700	PF14604	0.575
LIG_SUMO_SIM_anti_2	397	403	PF11976	0.563
LIG_SUMO_SIM_par_1	85	90	PF11976	0.439
LIG_TRAF2_1	207	210	PF00917	0.689
LIG_TRAF2_1	460	463	PF00917	0.498
LIG_TRAF2_1	555	558	PF00917	0.647
LIG_TRAF2_1	91	94	PF00917	0.436
LIG_TYR_ITIM	649	654	PF00017	0.400
LIG_TYR_ITIM	68	73	PF00017	0.348
LIG_UBA3_1	135	143	PF00899	0.438
LIG_WW_3	408	412	PF00397	0.563
LIG_WW_3	548	552	PF00397	0.625
MOD_CDC14_SPxK_1	548	551	PF00782	0.627
MOD_CDK_SPK_2	295	300	PF00069	0.470
MOD_CDK_SPxK_1	295	301	PF00069	0.473
MOD_CDK_SPxK_1	545	551	PF00069	0.626
MOD_CDK_SPxxK_3	98	105	PF00069	0.616
MOD_CK1_1	153	159	PF00069	0.658
MOD_CK1_1	175	181	PF00069	0.702
MOD_CK1_1	25	31	PF00069	0.364
MOD_CK1_1	388	394	PF00069	0.663
MOD_CK1_1	448	454	PF00069	0.670
MOD_CK1_1	497	503	PF00069	0.582
MOD_CK1_1	620	626	PF00069	0.521
MOD_CK1_1	85	91	PF00069	0.357
MOD_CK2_1	175	181	PF00069	0.822
MOD_CK2_1	230	236	PF00069	0.620
MOD_CK2_1	552	558	PF00069	0.580
MOD_CK2_1	578	584	PF00069	0.543
MOD_CK2_1	587	593	PF00069	0.520
MOD_CK2_1	674	680	PF00069	0.695
MOD_CK2_1	87	93	PF00069	0.430
MOD_Cter_Amidation	210	213	PF01082	0.520
MOD_Cter_Amidation	464	467	PF01082	0.514
MOD_GlcNHglycan	107	110	PF01048	0.727
MOD_GlcNHglycan	152	155	PF01048	0.735
MOD_GlcNHglycan	22	25	PF01048	0.382
MOD_GlcNHglycan	238	241	PF01048	0.674
MOD_GlcNHglycan	310	313	PF01048	0.579
MOD_GlcNHglycan	421	424	PF01048	0.620
MOD_GlcNHglycan	431	434	PF01048	0.673
MOD_GlcNHglycan	453	456	PF01048	0.706
MOD_GlcNHglycan	468	471	PF01048	0.562
MOD_GlcNHglycan	472	475	PF01048	0.466
MOD_GlcNHglycan	501	504	PF01048	0.661
MOD_GlcNHglycan	603	606	PF01048	0.634
MOD_GlcNHglycan	630	633	PF01048	0.468
MOD_GlcNHglycan	671	675	PF01048	0.608
MOD_GlcNHglycan	682	685	PF01048	0.563
MOD_GlcNHglycan	726	729	PF01048	0.360
MOD_GSK3_1	149	156	PF00069	0.710
MOD_GSK3_1	22	29	PF00069	0.375
MOD_GSK3_1	227	234	PF00069	0.588
MOD_GSK3_1	33	40	PF00069	0.496
MOD_GSK3_1	380	387	PF00069	0.709
MOD_GSK3_1	445	452	PF00069	0.654
MOD_GSK3_1	466	473	PF00069	0.594
MOD_GSK3_1	495	502	PF00069	0.580
MOD_GSK3_1	540	547	PF00069	0.715
MOD_GSK3_1	618	625	PF00069	0.588
MOD_GSK3_1	670	677	PF00069	0.691
MOD_GSK3_1	83	90	PF00069	0.438
MOD_N-GLC_1	540	545	PF02516	0.707
MOD_NEK2_1	272	277	PF00069	0.436
MOD_NEK2_1	494	499	PF00069	0.603
MOD_NEK2_1	544	549	PF00069	0.738
MOD_NEK2_1	576	581	PF00069	0.569
MOD_NEK2_2	46	51	PF00069	0.300
MOD_NEK2_2	513	518	PF00069	0.584
MOD_PIKK_1	218	224	PF00454	0.570
MOD_PIKK_1	319	325	PF00454	0.599
MOD_PIKK_1	718	724	PF00454	0.415
MOD_PK_1	213	219	PF00069	0.588
MOD_PK_1	664	670	PF00069	0.572
MOD_PK_1	75	81	PF00069	0.433
MOD_PKA_1	213	219	PF00069	0.703
MOD_PKA_1	466	472	PF00069	0.493
MOD_PKA_2	213	219	PF00069	0.711
MOD_PKA_2	466	472	PF00069	0.497
MOD_PKA_2	495	501	PF00069	0.579
MOD_PKA_2	544	550	PF00069	0.648
MOD_PKB_1	662	670	PF00069	0.549
MOD_Plk_1	198	204	PF00069	0.596
MOD_Plk_1	319	325	PF00069	0.554
MOD_Plk_2-3	191	197	PF00069	0.670
MOD_Plk_4	157	163	PF00069	0.637
MOD_Plk_4	272	278	PF00069	0.437
MOD_Plk_4	46	52	PF00069	0.305
MOD_Plk_4	75	81	PF00069	0.548
MOD_ProDKin_1	167	173	PF00069	0.640
MOD_ProDKin_1	180	186	PF00069	0.550
MOD_ProDKin_1	295	301	PF00069	0.473
MOD_ProDKin_1	37	43	PF00069	0.406
MOD_ProDKin_1	380	386	PF00069	0.663
MOD_ProDKin_1	400	406	PF00069	0.638
MOD_ProDKin_1	449	455	PF00069	0.627
MOD_ProDKin_1	497	503	PF00069	0.522
MOD_ProDKin_1	545	551	PF00069	0.772
MOD_ProDKin_1	588	594	PF00069	0.748
MOD_ProDKin_1	87	93	PF00069	0.392
MOD_ProDKin_1	98	104	PF00069	0.529
MOD_SUMO_rev_2	678	683	PF00179	0.508
TRG_DiLeu_LyEn_5	263	268	PF01217	0.312
TRG_ENDOCYTIC_2	306	309	PF00928	0.459
TRG_ENDOCYTIC_2	637	640	PF00928	0.436
TRG_ENDOCYTIC_2	642	645	PF00928	0.426
TRG_ENDOCYTIC_2	65	68	PF00928	0.388
TRG_ENDOCYTIC_2	651	654	PF00928	0.398
TRG_ENDOCYTIC_2	70	73	PF00928	0.380
TRG_ER_diArg_1	144	146	PF00400	0.496
TRG_ER_diArg_1	212	215	PF00400	0.630
TRG_ER_diArg_1	292	294	PF00400	0.452
TRG_ER_diArg_1	299	301	PF00400	0.540
TRG_ER_diArg_1	342	345	PF00400	0.572
TRG_ER_diArg_1	350	353	PF00400	0.509
TRG_ER_diArg_1	410	413	PF00400	0.590
TRG_ER_diArg_1	544	546	PF00400	0.563
TRG_ER_diArg_1	571	574	PF00400	0.458
TRG_ER_diArg_1	662	665	PF00400	0.449
TRG_ER_diArg_1	699	701	PF00400	0.592
TRG_NES_CRM1_1	361	373	PF08389	0.580
TRG_Pf-PMV_PEXEL_1	305	310	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVQ0	Leptomonas seymouri	34%	100%
A4H8I1	Leishmania braziliensis	64%	100%
A4HWV3	Leishmania infantum	99%	100%
E9AQL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	97%
Q4QEW4	Leishmania major	89%	100%