Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTU8_LEIDO

TriTrypDb:

LdBPK_160440.1 , LdCL_160009300 , LDHU3_16.0520

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTU8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.671
CLV_C14_Caspase3-7	170	174	PF00656	0.665
CLV_NRD_NRD_1	132	134	PF00675	0.559
CLV_NRD_NRD_1	139	141	PF00675	0.575
CLV_NRD_NRD_1	15	17	PF00675	0.677
CLV_NRD_NRD_1	9	11	PF00675	0.710
CLV_PCSK_KEX2_1	132	134	PF00082	0.559
CLV_PCSK_KEX2_1	15	17	PF00082	0.682
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.715
CLV_PCSK_SKI1_1	145	149	PF00082	0.704
DEG_SPOP_SBC_1	83	87	PF00917	0.657
DOC_MAPK_gen_1	137	146	PF00069	0.695
DOC_MAPK_gen_1	14	23	PF00069	0.657
DOC_MAPK_gen_1	157	166	PF00069	0.609
DOC_USP7_MATH_1	27	31	PF00917	0.711
DOC_USP7_MATH_1	39	43	PF00917	0.542
DOC_USP7_MATH_1	59	63	PF00917	0.719
DOC_USP7_MATH_1	67	71	PF00917	0.766
DOC_USP7_MATH_1	84	88	PF00917	0.716
DOC_USP7_UBL2_3	11	15	PF12436	0.646
DOC_USP7_UBL2_3	137	141	PF12436	0.616
DOC_WW_Pin1_4	79	84	PF00397	0.723
LIG_14-3-3_CanoR_1	159	164	PF00244	0.612
LIG_14-3-3_CanoR_1	31	37	PF00244	0.584
LIG_BIR_II_1	1	5	PF00653	0.669
LIG_BRCT_BRCA1_1	29	33	PF00533	0.665
LIG_BRCT_BRCA1_1	85	89	PF00533	0.652
LIG_FHA_1	33	39	PF00498	0.616
LIG_FHA_2	117	123	PF00498	0.735
LIG_LIR_Apic_2	104	110	PF02991	0.571
LIG_LIR_Gen_1	30	39	PF02991	0.643
LIG_LIR_Gen_1	53	59	PF02991	0.666
LIG_LIR_Gen_1	95	106	PF02991	0.582
LIG_LIR_Nem_3	125	130	PF02991	0.616
LIG_LIR_Nem_3	30	36	PF02991	0.643
LIG_LIR_Nem_3	53	58	PF02991	0.683
LIG_LIR_Nem_3	86	92	PF02991	0.610
LIG_LIR_Nem_3	95	101	PF02991	0.546
LIG_RPA_C_Fungi	26	38	PF08784	0.702
LIG_SH3_3	148	154	PF00018	0.721
LIG_SH3_3	33	39	PF00018	0.561
LIG_TRAF2_1	111	114	PF00917	0.580
LIG_TRAF2_2	45	50	PF00917	0.698
LIG_UBA3_1	97	105	PF00899	0.635
MOD_CK1_1	167	173	PF00069	0.690
MOD_CK1_1	63	69	PF00069	0.689
MOD_CK1_1	70	76	PF00069	0.697
MOD_CK1_1	82	88	PF00069	0.649
MOD_CK2_1	108	114	PF00069	0.607
MOD_Cter_Amidation	12	15	PF01082	0.695
MOD_GlcNHglycan	62	65	PF01048	0.656
MOD_GlcNHglycan	72	75	PF01048	0.630
MOD_GlcNHglycan	77	80	PF01048	0.691
MOD_GlcNHglycan	86	89	PF01048	0.666
MOD_GSK3_1	164	171	PF00069	0.719
MOD_GSK3_1	27	34	PF00069	0.653
MOD_GSK3_1	59	66	PF00069	0.676
MOD_GSK3_1	68	75	PF00069	0.649
MOD_GSK3_1	79	86	PF00069	0.621
MOD_NEK2_1	166	171	PF00069	0.713
MOD_PKA_2	21	27	PF00069	0.583
MOD_PKA_2	39	45	PF00069	0.427
MOD_Plk_4	159	165	PF00069	0.655
MOD_Plk_4	50	56	PF00069	0.662
MOD_ProDKin_1	79	85	PF00069	0.721
MOD_SUMO_for_1	147	150	PF00179	0.715
MOD_SUMO_rev_2	129	139	PF00179	0.620
TRG_ENDOCYTIC_2	55	58	PF00928	0.721
TRG_ER_diArg_1	20	23	PF00400	0.585
TRG_NLS_MonoCore_2	13	18	PF00514	0.718
TRG_NLS_MonoExtN_4	11	18	PF00514	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8B0	Leptomonas seymouri	64%	100%
A0A0S4JAB3	Bodo saltans	43%	100%
A0A1X0P0C9	Trypanosomatidae	54%	100%
A0A3R7M9R7	Trypanosoma rangeli	58%	100%
A4H8G8	Leishmania braziliensis	74%	100%
A4HWU1	Leishmania infantum	100%	100%
C9ZW40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AQK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	97%
Q4QEX7	Leishmania major	86%	100%