Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTU6_LEIDO

TriTrypDb:

LdBPK_160410.1 , LdCL_160009000 , LDHU3_16.0490

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WTU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.403
CLV_C14_Caspase3-7	228	232	PF00656	0.438
CLV_C14_Caspase3-7	247	251	PF00656	0.382
CLV_C14_Caspase3-7	254	258	PF00656	0.433
CLV_NRD_NRD_1	13	15	PF00675	0.367
CLV_NRD_NRD_1	189	191	PF00675	0.584
CLV_PCSK_KEX2_1	13	15	PF00082	0.367
CLV_PCSK_KEX2_1	189	191	PF00082	0.612
CLV_PCSK_PC7_1	9	15	PF00082	0.340
CLV_PCSK_SKI1_1	155	159	PF00082	0.528
CLV_PCSK_SKI1_1	195	199	PF00082	0.607
CLV_PCSK_SKI1_1	9	13	PF00082	0.360
DEG_APCC_DBOX_1	154	162	PF00400	0.344
DEG_APCC_DBOX_1	8	16	PF00400	0.556
DEG_SPOP_SBC_1	225	229	PF00917	0.454
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.452
DOC_MAPK_gen_1	13	23	PF00069	0.602
DOC_MAPK_gen_1	162	171	PF00069	0.358
DOC_MAPK_gen_1	195	203	PF00069	0.388
DOC_MAPK_gen_1	284	292	PF00069	0.374
DOC_MAPK_JIP1_4	284	290	PF00069	0.370
DOC_MAPK_MEF2A_6	165	173	PF00069	0.357
DOC_MAPK_MEF2A_6	17	25	PF00069	0.531
DOC_MAPK_MEF2A_6	284	292	PF00069	0.374
DOC_PP1_RVXF_1	168	174	PF00149	0.416
DOC_PP2B_LxvP_1	288	291	PF13499	0.403
DOC_SPAK_OSR1_1	301	305	PF12202	0.311
DOC_USP7_MATH_1	149	153	PF00917	0.352
DOC_USP7_MATH_1	253	257	PF00917	0.491
DOC_USP7_MATH_1	31	35	PF00917	0.480
DOC_USP7_MATH_1	77	81	PF00917	0.442
DOC_WW_Pin1_4	173	178	PF00397	0.373
DOC_WW_Pin1_4	205	210	PF00397	0.485
DOC_WW_Pin1_4	75	80	PF00397	0.564
LIG_14-3-3_CanoR_1	17	21	PF00244	0.460
LIG_14-3-3_CanoR_1	170	174	PF00244	0.372
LIG_14-3-3_CanoR_1	189	194	PF00244	0.351
LIG_14-3-3_CanoR_1	284	289	PF00244	0.343
LIG_14-3-3_CanoR_1	308	314	PF00244	0.366
LIG_14-3-3_CanoR_1	40	44	PF00244	0.464
LIG_14-3-3_CanoR_1	94	101	PF00244	0.416
LIG_AP2alpha_2	275	277	PF02296	0.421
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BIR_III_2	148	152	PF00653	0.387
LIG_BRCT_BRCA1_1	177	181	PF00533	0.355
LIG_BRCT_BRCA1_1	309	313	PF00533	0.374
LIG_CaMK_CASK_1	241	246	PF00069	0.456
LIG_DLG_GKlike_1	142	150	PF00625	0.408
LIG_eIF4E_1	324	330	PF01652	0.388
LIG_FHA_1	219	225	PF00498	0.474
LIG_FHA_1	285	291	PF00498	0.346
LIG_FHA_1	30	36	PF00498	0.443
LIG_FHA_1	321	327	PF00498	0.243
LIG_FHA_2	226	232	PF00498	0.487
LIG_LIR_Apic_2	293	298	PF02991	0.432
LIG_LIR_Gen_1	178	188	PF02991	0.357
LIG_LIR_Gen_1	19	30	PF02991	0.419
LIG_LIR_Gen_1	323	332	PF02991	0.248
LIG_LIR_Gen_1	48	57	PF02991	0.491
LIG_LIR_Gen_1	99	108	PF02991	0.438
LIG_LIR_Nem_3	102	108	PF02991	0.389
LIG_LIR_Nem_3	178	184	PF02991	0.358
LIG_LIR_Nem_3	19	25	PF02991	0.426
LIG_LIR_Nem_3	274	280	PF02991	0.371
LIG_LIR_Nem_3	323	328	PF02991	0.276
LIG_LIR_Nem_3	33	39	PF02991	0.462
LIG_LIR_Nem_3	48	53	PF02991	0.489
LIG_Pex14_1	327	331	PF04695	0.312
LIG_Pex14_2	321	325	PF04695	0.315
LIG_Pex14_2	60	64	PF04695	0.477
LIG_SH2_CRK	105	109	PF00017	0.353
LIG_SH2_CRK	295	299	PF00017	0.491
LIG_SH2_CRK	338	342	PF00017	0.312
LIG_SH2_NCK_1	338	342	PF00017	0.291
LIG_SH2_STAP1	101	105	PF00017	0.429
LIG_SH2_STAT5	101	104	PF00017	0.439
LIG_SH2_STAT5	156	159	PF00017	0.353
LIG_SH2_STAT5	324	327	PF00017	0.371
LIG_SH2_STAT5	334	337	PF00017	0.262
LIG_SH2_STAT5	338	341	PF00017	0.246
LIG_SH2_STAT5	37	40	PF00017	0.489
LIG_SH3_3	116	122	PF00018	0.357
LIG_SH3_3	273	279	PF00018	0.435
LIG_TYR_ITIM	332	337	PF00017	0.312
LIG_UBA3_1	49	58	PF00899	0.414
MOD_CDK_SPxxK_3	205	212	PF00069	0.493
MOD_CK2_1	39	45	PF00069	0.421
MOD_CK2_1	77	83	PF00069	0.512
MOD_CK2_1	93	99	PF00069	0.379
MOD_CMANNOS	64	67	PF00535	0.673
MOD_GlcNHglycan	138	141	PF01048	0.730
MOD_GlcNHglycan	162	165	PF01048	0.547
MOD_GlcNHglycan	253	256	PF01048	0.705
MOD_GlcNHglycan	270	273	PF01048	0.653
MOD_GlcNHglycan	342	345	PF01048	0.390
MOD_GlcNHglycan	4	7	PF01048	0.360
MOD_GlcNHglycan	79	82	PF01048	0.720
MOD_GSK3_1	169	176	PF00069	0.369
MOD_GSK3_1	266	273	PF00069	0.421
MOD_GSK3_1	336	343	PF00069	0.312
MOD_GSK3_1	85	92	PF00069	0.495
MOD_NEK2_1	21	26	PF00069	0.375
MOD_NEK2_1	224	229	PF00069	0.424
MOD_NEK2_1	29	34	PF00069	0.318
MOD_NEK2_1	309	314	PF00069	0.355
MOD_NEK2_1	340	345	PF00069	0.544
MOD_NEK2_1	89	94	PF00069	0.545
MOD_NEK2_2	259	264	PF00069	0.499
MOD_NEK2_2	31	36	PF00069	0.388
MOD_PIKK_1	99	105	PF00454	0.405
MOD_PK_1	189	195	PF00069	0.411
MOD_PK_1	286	292	PF00069	0.398
MOD_PKA_1	189	195	PF00069	0.411
MOD_PKA_2	136	142	PF00069	0.537
MOD_PKA_2	16	22	PF00069	0.478
MOD_PKA_2	169	175	PF00069	0.369
MOD_PKA_2	188	194	PF00069	0.351
MOD_PKA_2	307	313	PF00069	0.355
MOD_PKA_2	39	45	PF00069	0.467
MOD_PKA_2	93	99	PF00069	0.430
MOD_PKB_1	284	292	PF00069	0.374
MOD_Plk_1	234	240	PF00069	0.461
MOD_Plk_1	259	265	PF00069	0.452
MOD_Plk_4	16	22	PF00069	0.475
MOD_Plk_4	169	175	PF00069	0.372
MOD_Plk_4	309	315	PF00069	0.373
MOD_Plk_4	31	37	PF00069	0.395
MOD_Plk_4	320	326	PF00069	0.263
MOD_Plk_4	336	342	PF00069	0.361
MOD_Plk_4	85	91	PF00069	0.437
MOD_ProDKin_1	173	179	PF00069	0.367
MOD_ProDKin_1	205	211	PF00069	0.488
MOD_ProDKin_1	75	81	PF00069	0.562
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.335
TRG_ENDOCYTIC_2	101	104	PF00928	0.385
TRG_ENDOCYTIC_2	105	108	PF00928	0.337
TRG_ENDOCYTIC_2	334	337	PF00928	0.312
TRG_ENDOCYTIC_2	338	341	PF00928	0.312
TRG_ENDOCYTIC_2	36	39	PF00928	0.487
TRG_ER_diArg_1	116	119	PF00400	0.383
TRG_ER_diArg_1	12	14	PF00400	0.567
TRG_ER_diArg_1	153	156	PF00400	0.343
TRG_ER_diArg_1	188	190	PF00400	0.408
TRG_ER_diArg_1	283	286	PF00400	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0F8	Leptomonas seymouri	40%	92%
A4H8G5	Leishmania braziliensis	65%	100%
E9AGN1	Leishmania infantum	100%	100%
E9AQJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QEY0	Leishmania major	85%	100%