LeishMANIAdb
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Protein kinase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase, putative
Gene product:
protein kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WTT7_LEIDO
TriTrypDb:
LdBPK_160310.1 * , LdCL_160008000 , LDHU3_16.0370
Length:
611

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTT7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTT7

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 16
GO:0006793 phosphorus metabolic process 3 16
GO:0006796 phosphate-containing compound metabolic process 4 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0016310 phosphorylation 5 16
GO:0019538 protein metabolic process 3 16
GO:0036211 protein modification process 4 16
GO:0043170 macromolecule metabolic process 3 16
GO:0043412 macromolecule modification 4 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0071704 organic substance metabolic process 2 16
GO:1901564 organonitrogen compound metabolic process 3 16
GO:0007165 signal transduction 2 1
GO:0009966 regulation of signal transduction 4 1
GO:0010646 regulation of cell communication 4 1
GO:0023051 regulation of signaling 3 1
GO:0035556 intracellular signal transduction 3 1
GO:0043408 regulation of MAPK cascade 6 1
GO:0048583 regulation of response to stimulus 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:1902531 regulation of intracellular signal transduction 5 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 16
GO:0003824 catalytic activity 1 16
GO:0004672 protein kinase activity 3 16
GO:0005488 binding 1 16
GO:0005524 ATP binding 5 16
GO:0016301 kinase activity 4 16
GO:0016740 transferase activity 2 16
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 16
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 16
GO:0017076 purine nucleotide binding 4 16
GO:0030554 adenyl nucleotide binding 5 16
GO:0032553 ribonucleotide binding 3 16
GO:0032555 purine ribonucleotide binding 4 16
GO:0032559 adenyl ribonucleotide binding 5 16
GO:0035639 purine ribonucleoside triphosphate binding 4 16
GO:0036094 small molecule binding 2 16
GO:0043167 ion binding 2 16
GO:0043168 anion binding 3 16
GO:0097159 organic cyclic compound binding 2 16
GO:0097367 carbohydrate derivative binding 2 16
GO:0140096 catalytic activity, acting on a protein 2 16
GO:1901265 nucleoside phosphate binding 3 16
GO:1901363 heterocyclic compound binding 2 16
GO:0004674 protein serine/threonine kinase activity 4 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 303 307 PF00656 0.659
CLV_NRD_NRD_1 113 115 PF00675 0.393
CLV_NRD_NRD_1 175 177 PF00675 0.308
CLV_NRD_NRD_1 254 256 PF00675 0.356
CLV_NRD_NRD_1 298 300 PF00675 0.502
CLV_NRD_NRD_1 304 306 PF00675 0.559
CLV_NRD_NRD_1 362 364 PF00675 0.741
CLV_PCSK_KEX2_1 113 115 PF00082 0.334
CLV_PCSK_KEX2_1 175 177 PF00082 0.293
CLV_PCSK_KEX2_1 254 256 PF00082 0.267
CLV_PCSK_KEX2_1 297 299 PF00082 0.459
CLV_PCSK_KEX2_1 304 306 PF00082 0.525
CLV_PCSK_KEX2_1 362 364 PF00082 0.739
CLV_PCSK_SKI1_1 143 147 PF00082 0.355
CLV_PCSK_SKI1_1 18 22 PF00082 0.381
CLV_PCSK_SKI1_1 226 230 PF00082 0.260
CLV_PCSK_SKI1_1 254 258 PF00082 0.334
CLV_PCSK_SKI1_1 396 400 PF00082 0.582
CLV_PCSK_SKI1_1 418 422 PF00082 0.676
CLV_PCSK_SKI1_1 563 567 PF00082 0.479
DEG_APCC_DBOX_1 125 133 PF00400 0.315
DEG_APCC_DBOX_1 395 403 PF00400 0.578
DEG_SCF_FBW7_1 502 507 PF00400 0.496
DOC_CDC14_PxL_1 397 405 PF14671 0.539
DOC_CYCLIN_RxL_1 251 260 PF00134 0.333
DOC_CYCLIN_yCln2_LP_2 116 122 PF00134 0.306
DOC_MAPK_DCC_7 396 405 PF00069 0.575
DOC_MAPK_gen_1 143 152 PF00069 0.315
DOC_MAPK_HePTP_8 393 405 PF00069 0.577
DOC_MAPK_MEF2A_6 396 405 PF00069 0.633
DOC_PP1_RVXF_1 224 231 PF00149 0.295
DOC_PP4_FxxP_1 229 232 PF00568 0.285
DOC_PP4_FxxP_1 275 278 PF00568 0.395
DOC_USP7_MATH_1 280 284 PF00917 0.589
DOC_USP7_MATH_1 426 430 PF00917 0.636
DOC_USP7_MATH_1 504 508 PF00917 0.677
DOC_WW_Pin1_4 243 248 PF00397 0.260
DOC_WW_Pin1_4 362 367 PF00397 0.645
DOC_WW_Pin1_4 500 505 PF00397 0.661
DOC_WW_Pin1_4 544 549 PF00397 0.463
LIG_14-3-3_CanoR_1 113 119 PF00244 0.360
LIG_14-3-3_CanoR_1 126 130 PF00244 0.430
LIG_14-3-3_CanoR_1 175 180 PF00244 0.318
LIG_14-3-3_CanoR_1 297 302 PF00244 0.594
LIG_14-3-3_CanoR_1 322 327 PF00244 0.568
LIG_14-3-3_CanoR_1 39 49 PF00244 0.244
LIG_Actin_WH2_2 249 266 PF00022 0.334
LIG_Actin_WH2_2 585 600 PF00022 0.598
LIG_AP2alpha_2 273 275 PF02296 0.260
LIG_APCC_ABBA_1 272 277 PF00400 0.265
LIG_APCC_ABBAyCdc20_2 138 144 PF00400 0.393
LIG_Clathr_ClatBox_1 402 406 PF01394 0.666
LIG_deltaCOP1_diTrp_1 243 252 PF00928 0.260
LIG_FHA_1 207 213 PF00498 0.409
LIG_FHA_1 321 327 PF00498 0.674
LIG_FHA_1 41 47 PF00498 0.294
LIG_FHA_1 423 429 PF00498 0.542
LIG_FHA_1 501 507 PF00498 0.494
LIG_FHA_1 554 560 PF00498 0.690
LIG_FHA_1 573 579 PF00498 0.412
LIG_FHA_2 105 111 PF00498 0.313
LIG_FHA_2 190 196 PF00498 0.250
LIG_FHA_2 206 212 PF00498 0.260
LIG_FHA_2 55 61 PF00498 0.393
LIG_FHA_2 559 565 PF00498 0.559
LIG_LIR_Apic_2 182 188 PF02991 0.315
LIG_LIR_Apic_2 273 278 PF02991 0.396
LIG_LIR_Gen_1 106 116 PF02991 0.369
LIG_LIR_Gen_1 19 29 PF02991 0.365
LIG_LIR_Gen_1 86 95 PF02991 0.301
LIG_LIR_Nem_3 106 112 PF02991 0.287
LIG_LIR_Nem_3 19 24 PF02991 0.411
LIG_LIR_Nem_3 407 413 PF02991 0.560
LIG_LIR_Nem_3 507 512 PF02991 0.580
LIG_PCNA_yPIPBox_3 284 298 PF02747 0.503
LIG_Rb_LxCxE_1 547 564 PF01857 0.457
LIG_SH2_CRK 109 113 PF00017 0.276
LIG_SH2_CRK 513 517 PF00017 0.536
LIG_SH2_STAP1 196 200 PF00017 0.260
LIG_SH2_STAP1 574 578 PF00017 0.616
LIG_SH2_STAT5 123 126 PF00017 0.297
LIG_SH2_STAT5 134 137 PF00017 0.337
LIG_SH2_STAT5 219 222 PF00017 0.301
LIG_SH2_STAT5 470 473 PF00017 0.541
LIG_SH2_STAT5 487 490 PF00017 0.463
LIG_SH2_STAT5 550 553 PF00017 0.613
LIG_SH2_STAT5 571 574 PF00017 0.565
LIG_SH2_STAT5 99 102 PF00017 0.298
LIG_SH3_3 453 459 PF00018 0.524
LIG_SH3_3 509 515 PF00018 0.563
LIG_SUMO_SIM_anti_2 68 74 PF11976 0.277
LIG_SUMO_SIM_par_1 208 214 PF11976 0.334
LIG_TRAF2_1 282 285 PF00917 0.496
LIG_TRAF2_1 333 336 PF00917 0.614
LIG_WW_1 510 513 PF00397 0.564
MOD_CK1_1 104 110 PF00069 0.385
MOD_CK1_1 266 272 PF00069 0.371
MOD_CK1_1 312 318 PF00069 0.567
MOD_CK2_1 205 211 PF00069 0.260
MOD_CK2_1 280 286 PF00069 0.477
MOD_CK2_1 297 303 PF00069 0.572
MOD_CK2_1 54 60 PF00069 0.393
MOD_CK2_1 558 564 PF00069 0.633
MOD_CK2_1 576 582 PF00069 0.414
MOD_GlcNHglycan 265 268 PF01048 0.399
MOD_GlcNHglycan 277 281 PF01048 0.595
MOD_GlcNHglycan 314 317 PF01048 0.593
MOD_GlcNHglycan 4 7 PF01048 0.544
MOD_GlcNHglycan 413 416 PF01048 0.682
MOD_GlcNHglycan 428 431 PF01048 0.529
MOD_GlcNHglycan 441 444 PF01048 0.781
MOD_GlcNHglycan 496 499 PF01048 0.536
MOD_GlcNHglycan 506 509 PF01048 0.519
MOD_GlcNHglycan 541 544 PF01048 0.593
MOD_GSK3_1 171 178 PF00069 0.291
MOD_GSK3_1 201 208 PF00069 0.260
MOD_GSK3_1 276 283 PF00069 0.388
MOD_GSK3_1 293 300 PF00069 0.499
MOD_GSK3_1 311 318 PF00069 0.605
MOD_GSK3_1 422 429 PF00069 0.626
MOD_GSK3_1 476 483 PF00069 0.556
MOD_GSK3_1 500 507 PF00069 0.647
MOD_GSK3_1 554 561 PF00069 0.574
MOD_GSK3_1 572 579 PF00069 0.602
MOD_GSK3_1 601 608 PF00069 0.498
MOD_N-GLC_1 312 317 PF02516 0.601
MOD_N-GLC_1 474 479 PF02516 0.567
MOD_NEK2_1 150 155 PF00069 0.487
MOD_NEK2_1 169 174 PF00069 0.260
MOD_NEK2_1 179 184 PF00069 0.260
MOD_NEK2_1 205 210 PF00069 0.274
MOD_NEK2_1 421 426 PF00069 0.685
MOD_NEK2_1 480 485 PF00069 0.516
MOD_NEK2_1 532 537 PF00069 0.447
MOD_NEK2_1 554 559 PF00069 0.576
MOD_NEK2_1 592 597 PF00069 0.476
MOD_NEK2_1 83 88 PF00069 0.424
MOD_NEK2_2 416 421 PF00069 0.548
MOD_PIKK_1 280 286 PF00454 0.479
MOD_PK_1 322 328 PF00069 0.568
MOD_PKA_1 175 181 PF00069 0.260
MOD_PKA_1 297 303 PF00069 0.500
MOD_PKA_2 125 131 PF00069 0.371
MOD_PKA_2 175 181 PF00069 0.285
MOD_PKA_2 263 269 PF00069 0.260
MOD_PKA_2 297 303 PF00069 0.587
MOD_PKA_2 321 327 PF00069 0.553
MOD_PKA_2 40 46 PF00069 0.262
MOD_Plk_1 312 318 PF00069 0.689
MOD_Plk_1 406 412 PF00069 0.608
MOD_Plk_1 554 560 PF00069 0.577
MOD_Plk_2-3 101 107 PF00069 0.276
MOD_Plk_2-3 189 195 PF00069 0.250
MOD_Plk_2-3 406 412 PF00069 0.667
MOD_Plk_4 125 131 PF00069 0.410
MOD_Plk_4 175 181 PF00069 0.273
MOD_Plk_4 266 272 PF00069 0.286
MOD_Plk_4 315 321 PF00069 0.554
MOD_Plk_4 322 328 PF00069 0.538
MOD_Plk_4 476 482 PF00069 0.542
MOD_Plk_4 592 598 PF00069 0.461
MOD_Plk_4 61 67 PF00069 0.371
MOD_ProDKin_1 243 249 PF00069 0.260
MOD_ProDKin_1 362 368 PF00069 0.645
MOD_ProDKin_1 500 506 PF00069 0.661
MOD_ProDKin_1 544 550 PF00069 0.464
MOD_SUMO_rev_2 14 20 PF00179 0.396
MOD_SUMO_rev_2 162 172 PF00179 0.413
MOD_SUMO_rev_2 579 586 PF00179 0.602
TRG_DiLeu_BaEn_1 534 539 PF01217 0.610
TRG_DiLeu_BaLyEn_6 116 121 PF01217 0.332
TRG_DiLeu_BaLyEn_6 252 257 PF01217 0.276
TRG_DiLeu_BaLyEn_6 398 403 PF01217 0.671
TRG_ENDOCYTIC_2 109 112 PF00928 0.287
TRG_ENDOCYTIC_2 219 222 PF00928 0.298
TRG_ENDOCYTIC_2 87 90 PF00928 0.382
TRG_ER_diArg_1 112 114 PF00400 0.393
TRG_ER_diArg_1 253 255 PF00400 0.308
TRG_ER_diArg_1 297 299 PF00400 0.578
TRG_NES_CRM1_1 44 58 PF08389 0.260
TRG_NES_CRM1_1 60 74 PF08389 0.433
TRG_Pf-PMV_PEXEL_1 114 118 PF00026 0.334
TRG_Pf-PMV_PEXEL_1 133 137 PF00026 0.334
TRG_Pf-PMV_PEXEL_1 18 22 PF00026 0.336
TRG_Pf-PMV_PEXEL_1 255 260 PF00026 0.238

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEW4 Leptomonas seymouri 58% 100%
A0A0S4IHW4 Bodo saltans 45% 100%
A0A3R7K109 Trypanosoma rangeli 49% 100%
A0A3S5H5G0 Leishmania donovani 27% 100%
A4H459 Leishmania braziliensis 27% 100%
A4H8F5 Leishmania braziliensis 80% 100%
A4HSE2 Leishmania infantum 27% 100%
A4HWS9 Leishmania infantum 100% 100%
C9ZW46 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AQI7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QEZ0 Leishmania major 91% 100%
Q4QJJ0 Leishmania major 27% 100%
V5B141 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS