Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTT1_LEIDO

TriTrypDb:

LdBPK_160380.1 , LdCL_160008700 , LDHU3_16.0450

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTT1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.535
CLV_C14_Caspase3-7	468	472	PF00656	0.536
CLV_C14_Caspase3-7	70	74	PF00656	0.729
CLV_C14_Caspase3-7	81	85	PF00656	0.661
CLV_NRD_NRD_1	290	292	PF00675	0.732
CLV_NRD_NRD_1	33	35	PF00675	0.685
CLV_NRD_NRD_1	55	57	PF00675	0.577
CLV_PCSK_KEX2_1	33	35	PF00082	0.684
CLV_PCSK_KEX2_1	8	10	PF00082	0.732
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.696
CLV_PCSK_SKI1_1	117	121	PF00082	0.583
CLV_PCSK_SKI1_1	128	132	PF00082	0.475
CLV_PCSK_SKI1_1	241	245	PF00082	0.512
CLV_PCSK_SKI1_1	294	298	PF00082	0.533
CLV_PCSK_SKI1_1	56	60	PF00082	0.675
CLV_PCSK_SKI1_1	9	13	PF00082	0.692
DEG_APCC_DBOX_1	195	203	PF00400	0.433
DEG_COP1_1	157	166	PF00400	0.748
DEG_Nend_Nbox_1	1	3	PF02207	0.695
DOC_CYCLIN_RxL_1	125	134	PF00134	0.544
DOC_MAPK_gen_1	8	14	PF00069	0.702
DOC_MAPK_MEF2A_6	196	203	PF00069	0.419
DOC_MAPK_MEF2A_6	323	330	PF00069	0.384
DOC_MAPK_MEF2A_6	36	44	PF00069	0.659
DOC_PP4_FxxP_1	299	302	PF00568	0.526
DOC_USP7_MATH_1	149	153	PF00917	0.740
DOC_USP7_MATH_1	159	163	PF00917	0.590
DOC_USP7_MATH_1	302	306	PF00917	0.424
DOC_USP7_MATH_1	398	402	PF00917	0.742
DOC_USP7_MATH_1	83	87	PF00917	0.702
DOC_USP7_MATH_1	97	101	PF00917	0.626
DOC_WW_Pin1_4	135	140	PF00397	0.745
DOC_WW_Pin1_4	396	401	PF00397	0.665
LIG_14-3-3_CanoR_1	110	120	PF00244	0.526
LIG_14-3-3_CanoR_1	180	186	PF00244	0.555
LIG_14-3-3_CanoR_1	196	202	PF00244	0.528
LIG_14-3-3_CanoR_1	23	32	PF00244	0.730
LIG_14-3-3_CanoR_1	316	326	PF00244	0.535
LIG_14-3-3_CanoR_1	355	359	PF00244	0.439
LIG_Actin_WH2_2	246	263	PF00022	0.441
LIG_BRCT_BRCA1_1	247	251	PF00533	0.452
LIG_BRCT_BRCA1_1	411	415	PF00533	0.507
LIG_Clathr_ClatBox_1	207	211	PF01394	0.475
LIG_FHA_1	173	179	PF00498	0.593
LIG_FHA_1	198	204	PF00498	0.485
LIG_FHA_1	279	285	PF00498	0.705
LIG_FHA_1	295	301	PF00498	0.404
LIG_FHA_1	354	360	PF00498	0.554
LIG_FHA_1	392	398	PF00498	0.710
LIG_FHA_1	471	477	PF00498	0.481
LIG_FHA_1	53	59	PF00498	0.753
LIG_FHA_2	179	185	PF00498	0.471
LIG_FHA_2	68	74	PF00498	0.749
LIG_FHA_2	79	85	PF00498	0.613
LIG_FHA_2	86	92	PF00498	0.463
LIG_LIR_Apic_2	297	302	PF02991	0.561
LIG_LIR_Gen_1	249	260	PF02991	0.384
LIG_LIR_Gen_1	366	376	PF02991	0.549
LIG_LIR_Nem_3	211	216	PF02991	0.466
LIG_LIR_Nem_3	249	255	PF02991	0.398
LIG_LIR_Nem_3	366	372	PF02991	0.528
LIG_LYPXL_S_1	38	42	PF13949	0.683
LIG_LYPXL_yS_3	39	42	PF13949	0.680
LIG_NRBOX	126	132	PF00104	0.660
LIG_NRBOX	198	204	PF00104	0.399
LIG_PCNA_yPIPBox_3	117	131	PF02747	0.606
LIG_SH2_CRK	213	217	PF00017	0.511
LIG_SH2_CRK	369	373	PF00017	0.461
LIG_SH2_CRK	411	415	PF00017	0.574
LIG_SH2_NCK_1	411	415	PF00017	0.574
LIG_SH2_SRC	213	216	PF00017	0.513
LIG_SH2_STAP1	411	415	PF00017	0.574
LIG_SH2_STAP1	455	459	PF00017	0.378
LIG_SH2_STAT5	327	330	PF00017	0.493
LIG_SH3_3	209	215	PF00018	0.583
LIG_SH3_3	394	400	PF00018	0.755
LIG_SH3_3	421	427	PF00018	0.441
LIG_SUMO_SIM_anti_2	10	15	PF11976	0.567
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.406
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.558
LIG_SUMO_SIM_par_1	10	15	PF11976	0.567
LIG_SUMO_SIM_par_1	129	134	PF11976	0.682
LIG_TRAF2_1	181	184	PF00917	0.534
LIG_TRFH_1	208	212	PF08558	0.558
LIG_TYR_ITIM	37	42	PF00017	0.684
LIG_UBA3_1	130	137	PF00899	0.505
LIG_UBA3_1	232	239	PF00899	0.529
MOD_CK1_1	100	106	PF00069	0.470
MOD_CK1_1	162	168	PF00069	0.772
MOD_CK1_1	194	200	PF00069	0.468
MOD_CK1_1	3	9	PF00069	0.642
MOD_CK1_1	332	338	PF00069	0.466
MOD_CK1_1	357	363	PF00069	0.553
MOD_CK1_1	417	423	PF00069	0.498
MOD_CK1_1	43	49	PF00069	0.732
MOD_CK1_1	67	73	PF00069	0.685
MOD_CK1_1	85	91	PF00069	0.644
MOD_CK2_1	178	184	PF00069	0.463
MOD_CK2_1	83	89	PF00069	0.774
MOD_Cter_Amidation	289	292	PF01082	0.737
MOD_GlcNHglycan	133	136	PF01048	0.633
MOD_GlcNHglycan	14	17	PF01048	0.711
MOD_GlcNHglycan	151	154	PF01048	0.678
MOD_GlcNHglycan	186	189	PF01048	0.547
MOD_GlcNHglycan	245	248	PF01048	0.523
MOD_GlcNHglycan	304	307	PF01048	0.459
MOD_GlcNHglycan	320	323	PF01048	0.471
MOD_GlcNHglycan	359	362	PF01048	0.543
MOD_GlcNHglycan	389	392	PF01048	0.638
MOD_GlcNHglycan	400	403	PF01048	0.722
MOD_GlcNHglycan	416	419	PF01048	0.554
MOD_GlcNHglycan	466	470	PF01048	0.513
MOD_GlcNHglycan	66	69	PF01048	0.681
MOD_GlcNHglycan	84	88	PF01048	0.449
MOD_GlcNHglycan	99	102	PF01048	0.409
MOD_GSK3_1	131	138	PF00069	0.701
MOD_GSK3_1	154	161	PF00069	0.737
MOD_GSK3_1	191	198	PF00069	0.616
MOD_GSK3_1	3	10	PF00069	0.637
MOD_GSK3_1	353	360	PF00069	0.560
MOD_GSK3_1	387	394	PF00069	0.573
MOD_GSK3_1	40	47	PF00069	0.686
MOD_GSK3_1	409	416	PF00069	0.536
MOD_GSK3_1	449	456	PF00069	0.587
MOD_GSK3_1	470	477	PF00069	0.455
MOD_GSK3_1	64	71	PF00069	0.727
MOD_GSK3_1	78	85	PF00069	0.641
MOD_GSK3_1	97	104	PF00069	0.388
MOD_N-GLC_1	218	223	PF02516	0.489
MOD_NEK2_1	12	17	PF00069	0.763
MOD_NEK2_1	131	136	PF00069	0.626
MOD_NEK2_1	44	49	PF00069	0.733
MOD_NEK2_1	52	57	PF00069	0.661
MOD_PIKK_1	120	126	PF00454	0.570
MOD_PIKK_1	434	440	PF00454	0.582
MOD_PKA_2	179	185	PF00069	0.525
MOD_PKA_2	195	201	PF00069	0.556
MOD_PKA_2	221	227	PF00069	0.491
MOD_PKA_2	24	30	PF00069	0.708
MOD_PKA_2	315	321	PF00069	0.541
MOD_PKA_2	354	360	PF00069	0.487
MOD_Plk_1	194	200	PF00069	0.468
MOD_Plk_1	218	224	PF00069	0.484
MOD_Plk_1	90	96	PF00069	0.669
MOD_Plk_4	197	203	PF00069	0.456
MOD_Plk_4	221	227	PF00069	0.491
MOD_Plk_4	354	360	PF00069	0.487
MOD_Plk_4	409	415	PF00069	0.600
MOD_ProDKin_1	135	141	PF00069	0.747
MOD_ProDKin_1	396	402	PF00069	0.666
MOD_SUMO_for_1	463	466	PF00179	0.594
MOD_SUMO_rev_2	114	119	PF00179	0.651
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.538
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.745
TRG_ENDOCYTIC_2	213	216	PF00928	0.460
TRG_ENDOCYTIC_2	327	330	PF00928	0.391
TRG_ENDOCYTIC_2	349	352	PF00928	0.395
TRG_ENDOCYTIC_2	369	372	PF00928	0.202
TRG_ENDOCYTIC_2	39	42	PF00928	0.680
TRG_ENDOCYTIC_2	411	414	PF00928	0.582
TRG_ER_diArg_1	220	223	PF00400	0.601
TRG_ER_diArg_1	288	291	PF00400	0.548
TRG_ER_diArg_1	32	34	PF00400	0.690
TRG_ER_diArg_1	338	341	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA0	Leptomonas seymouri	52%	100%
A0A3R7NAP5	Trypanosoma rangeli	31%	100%
A4HWT6	Leishmania infantum	100%	100%
E9AQJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QEY3	Leishmania major	86%	100%