tRNA (guanine(37)-N1)-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Met-10+ like-protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTS8_LEIDO

TriTrypDb:

LdBPK_160320.1 , LdCL_160008100 , LDHU3_16.0390

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0005737	cytoplasm	2	1
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7

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Expansion

Sequence features

A0A3S7WTS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTS8

Function

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Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	1
GO:0002939	tRNA N1-guanine methylation	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008168	methyltransferase activity	4	7
GO:0008173	RNA methyltransferase activity	4	7
GO:0008175	tRNA methyltransferase activity	5	7
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	7
GO:0009019	tRNA (guanine-N1-)-methyltransferase activity	7	7
GO:0016423	tRNA (guanine) methyltransferase activity	6	7
GO:0016740	transferase activity	2	7
GO:0016741	transferase activity, transferring one-carbon groups	3	7
GO:0052906	tRNA (guanine(37)-N(1))-methyltransferase activity	8	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.784
CLV_C14_Caspase3-7	350	354	PF00656	0.654
CLV_NRD_NRD_1	190	192	PF00675	0.576
CLV_NRD_NRD_1	240	242	PF00675	0.749
CLV_NRD_NRD_1	524	526	PF00675	0.321
CLV_NRD_NRD_1	54	56	PF00675	0.527
CLV_PCSK_KEX2_1	239	241	PF00082	0.671
CLV_PCSK_KEX2_1	524	526	PF00082	0.333
CLV_PCSK_KEX2_1	53	55	PF00082	0.487
CLV_PCSK_KEX2_1	632	634	PF00082	0.452

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I219	Leptomonas seymouri	51%	100%
A4H8F7	Leishmania braziliensis	73%	100%
A4HWT0	Leishmania infantum	99%	100%
B7G5J1	Phaeodactylum tricornutum (strain CCAP 1055/1)	25%	100%
E9AQI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
F4NUJ6	Batrachochytrium dendrobatidis (strain JAM81 / FGSC 10211)	31%	100%
F6VSS6	Xenopus tropicalis	31%	100%
Q4QEY9	Leishmania major	93%	100%

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