Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTS3_LEIDO

TriTrypDb:

LdBPK_160130.1 , LdCL_160006200 , LDHU3_16.0140

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	463	467	PF00656	0.590
CLV_C14_Caspase3-7	525	529	PF00656	0.524
CLV_NRD_NRD_1	195	197	PF00675	0.515
CLV_NRD_NRD_1	287	289	PF00675	0.526
CLV_NRD_NRD_1	316	318	PF00675	0.560
CLV_NRD_NRD_1	490	492	PF00675	0.609
CLV_NRD_NRD_1	496	498	PF00675	0.505
CLV_NRD_NRD_1	602	604	PF00675	0.526
CLV_NRD_NRD_1	775	777	PF00675	0.566
CLV_NRD_NRD_1	9	11	PF00675	0.601
CLV_PCSK_KEX2_1	195	197	PF00082	0.560
CLV_PCSK_KEX2_1	212	214	PF00082	0.492
CLV_PCSK_KEX2_1	287	289	PF00082	0.519
CLV_PCSK_KEX2_1	316	318	PF00082	0.560
CLV_PCSK_KEX2_1	376	378	PF00082	0.531
CLV_PCSK_KEX2_1	496	498	PF00082	0.516
CLV_PCSK_KEX2_1	602	604	PF00082	0.426
CLV_PCSK_KEX2_1	775	777	PF00082	0.566
CLV_PCSK_KEX2_1	9	11	PF00082	0.600
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.335
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.484
CLV_PCSK_PC7_1	5	11	PF00082	0.662
CLV_PCSK_SKI1_1	287	291	PF00082	0.519
CLV_PCSK_SKI1_1	504	508	PF00082	0.458
CLV_PCSK_SKI1_1	558	562	PF00082	0.389
CLV_PCSK_SKI1_1	574	578	PF00082	0.293
CLV_PCSK_SKI1_1	579	583	PF00082	0.355
CLV_PCSK_SKI1_1	610	614	PF00082	0.457
CLV_PCSK_SKI1_1	720	724	PF00082	0.493
CLV_Separin_Metazoa	772	776	PF03568	0.595
DEG_APCC_DBOX_1	203	211	PF00400	0.357
DEG_APCC_DBOX_1	573	581	PF00400	0.441
DEG_APCC_DBOX_1	609	617	PF00400	0.498
DEG_COP1_1	126	136	PF00400	0.667
DEG_Nend_UBRbox_1	1	4	PF02207	0.633
DEG_SPOP_SBC_1	154	158	PF00917	0.702
DOC_ANK_TNKS_1	9	16	PF00023	0.744
DOC_CYCLIN_RxL_1	553	564	PF00134	0.432
DOC_CYCLIN_RxL_1	80	91	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	736	742	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	759	765	PF00134	0.365
DOC_MAPK_DCC_7	438	448	PF00069	0.641
DOC_MAPK_gen_1	215	225	PF00069	0.595
DOC_MAPK_gen_1	80	89	PF00069	0.517
DOC_PP2B_LxvP_1	363	366	PF13499	0.481
DOC_PP2B_LxvP_1	616	619	PF13499	0.548
DOC_USP7_MATH_1	153	157	PF00917	0.754
DOC_USP7_MATH_1	18	22	PF00917	0.717
DOC_USP7_MATH_1	292	296	PF00917	0.575
DOC_USP7_MATH_1	37	41	PF00917	0.407
DOC_USP7_MATH_1	461	465	PF00917	0.611
DOC_USP7_MATH_1	521	525	PF00917	0.451
DOC_USP7_MATH_1	549	553	PF00917	0.595
DOC_USP7_MATH_1	591	595	PF00917	0.536
DOC_USP7_MATH_2	692	698	PF00917	0.325
DOC_WW_Pin1_4	142	147	PF00397	0.651
DOC_WW_Pin1_4	155	160	PF00397	0.677
DOC_WW_Pin1_4	181	186	PF00397	0.507
DOC_WW_Pin1_4	33	38	PF00397	0.517
DOC_WW_Pin1_4	411	416	PF00397	0.612
DOC_WW_Pin1_4	674	679	PF00397	0.762
LIG_14-3-3_CanoR_1	177	182	PF00244	0.584
LIG_14-3-3_CanoR_1	2	8	PF00244	0.661
LIG_14-3-3_CanoR_1	204	208	PF00244	0.510
LIG_14-3-3_CanoR_1	316	324	PF00244	0.462
LIG_14-3-3_CanoR_1	504	512	PF00244	0.507
LIG_14-3-3_CanoR_1	53	60	PF00244	0.498
LIG_14-3-3_CanoR_1	565	569	PF00244	0.452
LIG_14-3-3_CanoR_1	628	636	PF00244	0.522
LIG_14-3-3_CanoR_1	720	728	PF00244	0.516
LIG_14-3-3_CanoR_1	85	90	PF00244	0.517
LIG_14-3-3_CanoR_1	92	100	PF00244	0.508
LIG_Actin_WH2_2	200	217	PF00022	0.465
LIG_BIR_III_2	440	444	PF00653	0.591
LIG_BIR_III_2	777	781	PF00653	0.595
LIG_BIR_III_4	352	356	PF00653	0.501
LIG_Clathr_ClatBox_1	532	536	PF01394	0.601
LIG_FHA_1	220	226	PF00498	0.537
LIG_FHA_1	234	240	PF00498	0.505
LIG_FHA_1	275	281	PF00498	0.468
LIG_FHA_1	402	408	PF00498	0.432
LIG_FHA_1	473	479	PF00498	0.494
LIG_FHA_1	632	638	PF00498	0.466
LIG_FHA_1	84	90	PF00498	0.635
LIG_FHA_2	156	162	PF00498	0.537
LIG_FHA_2	292	298	PF00498	0.533
LIG_FHA_2	488	494	PF00498	0.416
LIG_FHA_2	633	639	PF00498	0.428
LIG_FHA_2	74	80	PF00498	0.445
LIG_FHA_2	93	99	PF00498	0.403
LIG_GBD_Chelix_1	728	736	PF00786	0.445
LIG_LIR_Apic_2	361	365	PF02991	0.534
LIG_LIR_Gen_1	160	171	PF02991	0.653
LIG_LIR_Gen_1	270	280	PF02991	0.540
LIG_LIR_Nem_3	160	166	PF02991	0.657
LIG_LIR_Nem_3	206	211	PF02991	0.392
LIG_LIR_Nem_3	270	275	PF02991	0.509
LIG_LIR_Nem_3	567	571	PF02991	0.478
LIG_LIR_Nem_3	598	604	PF02991	0.413
LIG_LIR_Nem_3	660	665	PF02991	0.465
LIG_LIR_Nem_3	750	755	PF02991	0.545
LIG_MYND_3	618	622	PF01753	0.508
LIG_NRBOX	177	183	PF00104	0.436
LIG_NRBOX	556	562	PF00104	0.397
LIG_PDZ_Class_2	781	786	PF00595	0.722
LIG_REV1ctd_RIR_1	135	145	PF16727	0.648
LIG_RPA_C_Fungi	721	733	PF08784	0.528
LIG_SH2_CRK	211	215	PF00017	0.334
LIG_SH2_CRK	568	572	PF00017	0.548
LIG_SH2_STAP1	332	336	PF00017	0.470
LIG_SH2_STAP1	41	45	PF00017	0.640
LIG_SH2_STAT3	402	405	PF00017	0.562
LIG_SH2_STAT5	136	139	PF00017	0.551
LIG_SH2_STAT5	402	405	PF00017	0.562
LIG_SH2_STAT5	539	542	PF00017	0.625
LIG_SH2_STAT5	705	708	PF00017	0.530
LIG_SH3_3	121	127	PF00018	0.576
LIG_SH3_3	276	282	PF00018	0.473
LIG_SH3_3	454	460	PF00018	0.522
LIG_SH3_3	56	62	PF00018	0.592
LIG_SH3_3	675	681	PF00018	0.705
LIG_SH3_3	736	742	PF00018	0.561
LIG_SUMO_SIM_anti_2	730	737	PF11976	0.435
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.631
LIG_SUMO_SIM_par_1	109	115	PF11976	0.466
LIG_SUMO_SIM_par_1	221	226	PF11976	0.517
LIG_SUMO_SIM_par_1	301	308	PF11976	0.466
LIG_SUMO_SIM_par_1	559	564	PF11976	0.368
LIG_SUMO_SIM_par_1	84	91	PF11976	0.634
LIG_TRAF2_1	167	170	PF00917	0.522
LIG_TRAF2_1	358	361	PF00917	0.664
LIG_TRAF2_1	629	632	PF00917	0.589
LIG_TRAF2_1	707	710	PF00917	0.518
LIG_TRAF2_1	76	79	PF00917	0.511
LIG_TRFH_1	512	516	PF08558	0.537
LIG_TYR_ITIM	566	571	PF00017	0.540
LIG_WW_3	679	683	PF00397	0.684
MOD_CDC14_SPxK_1	36	39	PF00782	0.501
MOD_CDC14_SPxK_1	679	682	PF00782	0.745
MOD_CDK_SPK_2	181	186	PF00069	0.538
MOD_CDK_SPxK_1	33	39	PF00069	0.511
MOD_CDK_SPxK_1	676	682	PF00069	0.752
MOD_CK1_1	157	163	PF00069	0.658
MOD_CK1_1	16	22	PF00069	0.685
MOD_CK1_1	259	265	PF00069	0.640
MOD_CK1_1	308	314	PF00069	0.524
MOD_CK1_1	481	487	PF00069	0.646
MOD_CK1_1	564	570	PF00069	0.478
MOD_CK1_1	630	636	PF00069	0.531
MOD_CK1_1	676	682	PF00069	0.697
MOD_CK1_1	685	691	PF00069	0.538
MOD_CK1_1	721	727	PF00069	0.478
MOD_CK2_1	164	170	PF00069	0.633
MOD_CK2_1	291	297	PF00069	0.552
MOD_CK2_1	387	393	PF00069	0.585
MOD_CK2_1	487	493	PF00069	0.432
MOD_CK2_1	591	597	PF00069	0.535
MOD_CK2_1	632	638	PF00069	0.441
MOD_CK2_1	73	79	PF00069	0.543
MOD_CK2_1	755	761	PF00069	0.591
MOD_CK2_1	85	91	PF00069	0.483
MOD_CK2_1	92	98	PF00069	0.443
MOD_Cter_Amidation	285	288	PF01082	0.476
MOD_GlcNHglycan	20	23	PF01048	0.697
MOD_GlcNHglycan	294	297	PF01048	0.599
MOD_GlcNHglycan	336	339	PF01048	0.465
MOD_GlcNHglycan	389	392	PF01048	0.499
MOD_GlcNHglycan	463	466	PF01048	0.525
MOD_GlcNHglycan	54	57	PF01048	0.513
MOD_GlcNHglycan	553	556	PF01048	0.557
MOD_GlcNHglycan	713	716	PF01048	0.546
MOD_GlcNHglycan	747	750	PF01048	0.509
MOD_GSK3_1	13	20	PF00069	0.749
MOD_GSK3_1	153	160	PF00069	0.753
MOD_GSK3_1	177	184	PF00069	0.548
MOD_GSK3_1	255	262	PF00069	0.732
MOD_GSK3_1	292	299	PF00069	0.527
MOD_GSK3_1	33	40	PF00069	0.530
MOD_GSK3_1	481	488	PF00069	0.559
MOD_GSK3_1	545	552	PF00069	0.684
MOD_GSK3_1	591	598	PF00069	0.516
MOD_GSK3_1	627	634	PF00069	0.573
MOD_GSK3_1	64	71	PF00069	0.470
MOD_GSK3_1	669	676	PF00069	0.639
MOD_GSK3_1	81	88	PF00069	0.479
MOD_N-GLC_1	154	159	PF02516	0.697
MOD_N-GLC_1	189	194	PF02516	0.602
MOD_NEK2_1	203	208	PF00069	0.551
MOD_NEK2_1	233	238	PF00069	0.383
MOD_NEK2_1	242	247	PF00069	0.424
MOD_NEK2_1	406	411	PF00069	0.546
MOD_NEK2_1	448	453	PF00069	0.581
MOD_NEK2_1	478	483	PF00069	0.469
MOD_NEK2_1	52	57	PF00069	0.582
MOD_NEK2_1	538	543	PF00069	0.641
MOD_NEK2_1	561	566	PF00069	0.379
MOD_NEK2_1	755	760	PF00069	0.541
MOD_NEK2_2	371	376	PF00069	0.546
MOD_NEK2_2	591	596	PF00069	0.543
MOD_NEK2_2	657	662	PF00069	0.543
MOD_PIKK_1	126	132	PF00454	0.761
MOD_PIKK_1	323	329	PF00454	0.462
MOD_PIKK_1	39	45	PF00454	0.600
MOD_PIKK_1	401	407	PF00454	0.551
MOD_PIKK_1	427	433	PF00454	0.691
MOD_PKA_1	316	322	PF00069	0.415
MOD_PKA_2	203	209	PF00069	0.380
MOD_PKA_2	316	322	PF00069	0.508
MOD_PKA_2	52	58	PF00069	0.590
MOD_PKA_2	564	570	PF00069	0.460
MOD_PKA_2	627	633	PF00069	0.633
MOD_Plk_1	189	195	PF00069	0.597
MOD_Plk_1	296	302	PF00069	0.509
MOD_Plk_1	37	43	PF00069	0.614
MOD_Plk_1	631	637	PF00069	0.558
MOD_Plk_2-3	221	227	PF00069	0.438
MOD_Plk_2-3	632	638	PF00069	0.582
MOD_Plk_4	177	183	PF00069	0.521
MOD_Plk_4	203	209	PF00069	0.545
MOD_Plk_4	325	331	PF00069	0.562
MOD_Plk_4	567	573	PF00069	0.517
MOD_Plk_4	632	638	PF00069	0.497
MOD_Plk_4	649	655	PF00069	0.450
MOD_Plk_4	657	663	PF00069	0.510
MOD_Plk_4	85	91	PF00069	0.491
MOD_ProDKin_1	142	148	PF00069	0.655
MOD_ProDKin_1	155	161	PF00069	0.673
MOD_ProDKin_1	181	187	PF00069	0.508
MOD_ProDKin_1	33	39	PF00069	0.513
MOD_ProDKin_1	411	417	PF00069	0.613
MOD_ProDKin_1	674	680	PF00069	0.761
MOD_SUMO_rev_2	72	81	PF00179	0.505
TRG_DiLeu_BaEn_1	325	330	PF01217	0.532
TRG_DiLeu_BaEn_4	173	179	PF01217	0.510
TRG_DiLeu_BaEn_4	693	699	PF01217	0.467
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.486
TRG_ENDOCYTIC_2	211	214	PF00928	0.490
TRG_ENDOCYTIC_2	568	571	PF00928	0.538
TRG_ER_diArg_1	287	289	PF00400	0.523
TRG_ER_diArg_1	315	317	PF00400	0.587
TRG_ER_diArg_1	496	498	PF00400	0.516
TRG_ER_diArg_1	601	603	PF00400	0.533
TRG_ER_diArg_1	689	692	PF00400	0.486
TRG_ER_diArg_1	774	776	PF00400	0.539
TRG_ER_diArg_1	8	10	PF00400	0.597
TRG_NLS_MonoExtN_4	80	86	PF00514	0.559
TRG_Pf-PMV_PEXEL_1	726	730	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y7	Leptomonas seymouri	45%	99%
A0A1X0NZ28	Trypanosomatidae	28%	100%
A0A3R7M3M3	Trypanosoma rangeli	29%	100%
A4H8D9	Leishmania braziliensis	72%	100%
A4HWR1	Leishmania infantum	100%	100%
C9ZPS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AQG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QF08	Leishmania major	91%	100%