Protein_tyrosine_phosphatase-likie_protein/GeneDB:LmjF.16.0250

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein tyrosine phosphatase-likie protein

Species:

Leishmania donovani

UniProt:

A0A3S7WTS0_LEIDO

TriTrypDb:

LdBPK_160260.1 , LdCL_160007500 , LDHU3_16.0310

Length:

176

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 27

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	1
GO:0018995	host cellular component	2	1
GO:0020023	kinetoplast	2	1
GO:0030430	host cell cytoplasm	5	1
GO:0031982	vesicle	4	1
GO:0033643	host cell part	3	1
GO:0033646	host intracellular part	4	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043230	extracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0065010	extracellular membrane-bounded organelle	4	1
GO:0070062	extracellular exosome	6	1
GO:0110165	cellular anatomical entity	1	2
GO:1903561	extracellular vesicle	5	1

Expansion

Sequence features

A0A3S7WTS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTS0

PDB structure(s): 3s4o_A , 3s4o_B

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	24
GO:0006793	phosphorus metabolic process	3	24
GO:0006796	phosphate-containing compound metabolic process	4	24
GO:0006807	nitrogen compound metabolic process	2	24
GO:0008152	metabolic process	1	24
GO:0009987	cellular process	1	24
GO:0016311	dephosphorylation	5	24
GO:0019538	protein metabolic process	3	24
GO:0036211	protein modification process	4	24
GO:0043170	macromolecule metabolic process	3	24
GO:0043412	macromolecule modification	4	24
GO:0044237	cellular metabolic process	2	24
GO:0044238	primary metabolic process	2	24
GO:0071704	organic substance metabolic process	2	24
GO:1901564	organonitrogen compound metabolic process	3	24

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	24
GO:0004721	phosphoprotein phosphatase activity	3	24
GO:0004725	protein tyrosine phosphatase activity	4	17
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	24
GO:0016787	hydrolase activity	2	24
GO:0016788	hydrolase activity, acting on ester bonds	3	24
GO:0016791	phosphatase activity	5	24
GO:0042578	phosphoric ester hydrolase activity	4	24
GO:0140096	catalytic activity, acting on a protein	2	24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.385
CLV_PCSK_FUR_1	138	142	PF00082	0.391
CLV_PCSK_KEX2_1	11	13	PF00082	0.490
CLV_PCSK_KEX2_1	140	142	PF00082	0.384
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.517
DEG_Nend_UBRbox_2	1	3	PF02207	0.576
DEG_SCF_FBW7_1	95	102	PF00400	0.502
DOC_CDC14_PxL_1	111	119	PF14671	0.391
DOC_CYCLIN_RxL_1	18	29	PF00134	0.459
DOC_MAPK_MEF2A_6	113	122	PF00069	0.394
DOC_PP2B_LxvP_1	25	28	PF13499	0.457
DOC_SPAK_OSR1_1	21	25	PF12202	0.421
DOC_USP7_MATH_1	28	32	PF00917	0.480
DOC_WW_Pin1_4	26	31	PF00397	0.471
DOC_WW_Pin1_4	95	100	PF00397	0.389
LIG_BIR_III_4	132	136	PF00653	0.384
LIG_Clathr_ClatBox_1	90	94	PF01394	0.341
LIG_FHA_1	100	106	PF00498	0.423
LIG_FHA_1	13	19	PF00498	0.502
LIG_FHA_1	78	84	PF00498	0.446
LIG_FHA_2	4	10	PF00498	0.483
LIG_FHA_2	70	76	PF00498	0.439
LIG_FHA_2	96	102	PF00498	0.489
LIG_LIR_Gen_1	35	40	PF02991	0.514
LIG_LIR_Gen_1	85	95	PF02991	0.431
LIG_LIR_Nem_3	17	23	PF02991	0.437
LIG_LIR_Nem_3	35	39	PF02991	0.362
LIG_LIR_Nem_3	85	90	PF02991	0.413
LIG_Pex14_1	152	156	PF04695	0.472
LIG_SH2_PTP2	36	39	PF00017	0.488
LIG_SH2_STAT5	136	139	PF00017	0.398
LIG_SH2_STAT5	36	39	PF00017	0.477
LIG_SUMO_SIM_anti_2	85	92	PF11976	0.506
LIG_SUMO_SIM_par_1	89	94	PF11976	0.321
LIG_UBA3_1	90	97	PF00899	0.463
MOD_CAAXbox	173	176	PF01239	0.614
MOD_CK1_1	164	170	PF00069	0.691
MOD_CK1_1	29	35	PF00069	0.455
MOD_CK2_1	95	101	PF00069	0.404
MOD_GSK3_1	164	171	PF00069	0.725
MOD_GSK3_1	28	35	PF00069	0.540
MOD_GSK3_1	95	102	PF00069	0.363
MOD_N-GLC_1	12	17	PF02516	0.502
MOD_N-GLC_1	3	8	PF02516	0.476
MOD_NEK2_1	168	173	PF00069	0.735
MOD_Plk_1	164	170	PF00069	0.605
MOD_Plk_2-3	89	95	PF00069	0.321
MOD_Plk_4	3	9	PF00069	0.484
MOD_Plk_4	32	38	PF00069	0.566
MOD_Plk_4	83	89	PF00069	0.406
MOD_ProDKin_1	26	32	PF00069	0.470
MOD_ProDKin_1	95	101	PF00069	0.389
TRG_ENDOCYTIC_2	125	128	PF00928	0.405
TRG_ENDOCYTIC_2	36	39	PF00928	0.472
TRG_ER_diArg_1	156	159	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	21	26	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y8	Leptomonas seymouri	61%	100%
A0A0N1IM31	Leptomonas seymouri	88%	100%
A0A0S4IS65	Bodo saltans	68%	97%
A0A1X0NFW2	Trypanosomatidae	57%	100%
A0A1X0NHQ7	Trypanosomatidae	77%	100%
A0A1X0NZ52	Trypanosomatidae	61%	100%
A0A3Q8I9A9	Leishmania donovani	61%	100%
A0A3S5IQZ9	Trypanosoma rangeli	73%	100%
A0A422N2F6	Trypanosoma rangeli	71%	100%
A0A422ND97	Trypanosoma rangeli	61%	100%
A2VDT1	Bos taurus	45%	100%
A4H8E9	Leishmania braziliensis	61%	100%
A4H8F1	Leishmania braziliensis	95%	100%
A4HWS2	Leishmania infantum	61%	100%
A4HWS4	Leishmania infantum	99%	100%
C9ZW52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AQI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
E9AQI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O61722	Drosophila melanogaster	44%	100%
O70274	Mus musculus	50%	100%
O75365	Homo sapiens	44%	100%
Q12974	Homo sapiens	50%	100%
Q4CUJ8	Trypanosoma cruzi (strain CL Brener)	72%	100%
Q4QEZ5	Leishmania major	97%	100%
Q4QEZ7	Leishmania major	62%	100%
Q54DU9	Dictyostelium discoideum	54%	100%
Q5R7J8	Pongo abelii	46%	100%
Q63739	Mus musculus	46%	100%
Q6NT99	Mus musculus	29%	100%
Q6P9X4	Rattus norvegicus	50%	100%
Q78EG7	Rattus norvegicus	46%	100%
Q86IL4	Dictyostelium discoideum	39%	100%
Q93096	Homo sapiens	46%	100%
Q9D658	Mus musculus	46%	100%
Q9TSM6	Macaca fascicularis	46%	100%
V5B959	Trypanosoma cruzi	58%	98%
V5BA64	Trypanosoma cruzi	73%	100%
V5BDR5	Trypanosoma cruzi	73%	100%