Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTR1_LEIDO

TriTrypDb:

LdBPK_160190.1 , LdCL_160006800 , LDHU3_16.0220

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	96	98	PF00675	0.671
CLV_PCSK_KEX2_1	122	124	PF00082	0.647
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.647
CLV_PCSK_SKI1_1	106	110	PF00082	0.499
DEG_Nend_UBRbox_2	1	3	PF02207	0.590
DOC_CKS1_1	12	17	PF01111	0.608
DOC_MAPK_gen_1	104	111	PF00069	0.522
DOC_WW_Pin1_4	11	16	PF00397	0.540
DOC_WW_Pin1_4	128	133	PF00397	0.615
LIG_14-3-3_CanoR_1	123	129	PF00244	0.658
LIG_14-3-3_CanoR_1	6	15	PF00244	0.718
LIG_14-3-3_CterR_2	148	152	PF00244	0.553
LIG_BRCT_BRCA1_1	41	45	PF00533	0.586
LIG_FHA_2	12	18	PF00498	0.606
LIG_FHA_2	125	131	PF00498	0.500
LIG_FHA_2	55	61	PF00498	0.517
LIG_LIR_Apic_2	10	15	PF02991	0.601
LIG_LIR_Gen_1	62	72	PF02991	0.563
LIG_LIR_Nem_3	62	67	PF02991	0.543
LIG_SH2_CRK	64	68	PF00017	0.554
LIG_SH2_PTP2	12	15	PF00017	0.657
LIG_SH2_STAT5	12	15	PF00017	0.657
MOD_CK1_1	11	17	PF00069	0.765
MOD_CK1_1	33	39	PF00069	0.576
MOD_CK1_1	88	94	PF00069	0.694
MOD_CK2_1	11	17	PF00069	0.518
MOD_CK2_1	128	134	PF00069	0.616
MOD_CK2_1	33	39	PF00069	0.601
MOD_CK2_1	54	60	PF00069	0.520
MOD_GlcNHglycan	32	35	PF01048	0.599
MOD_GlcNHglycan	87	90	PF01048	0.722
MOD_GSK3_1	124	131	PF00069	0.624
MOD_GSK3_1	26	33	PF00069	0.595
MOD_GSK3_1	35	42	PF00069	0.582
MOD_GSK3_1	4	11	PF00069	0.742
MOD_GSK3_1	56	63	PF00069	0.504
MOD_NEK2_1	109	114	PF00069	0.604
MOD_NEK2_1	44	49	PF00069	0.501
MOD_NEK2_1	67	72	PF00069	0.543
MOD_PIKK_1	109	115	PF00454	0.479
MOD_PKA_2	124	130	PF00069	0.577
MOD_PKA_2	60	66	PF00069	0.558
MOD_Plk_2-3	130	136	PF00069	0.671
MOD_Plk_4	26	32	PF00069	0.454
MOD_Plk_4	39	45	PF00069	0.529
MOD_Plk_4	8	14	PF00069	0.674
MOD_ProDKin_1	11	17	PF00069	0.543
MOD_ProDKin_1	128	134	PF00069	0.616
TRG_ENDOCYTIC_2	64	67	PF00928	0.550
TRG_ENDOCYTIC_2	99	102	PF00928	0.525
TRG_ER_diArg_1	123	126	PF00400	0.569
TRG_ER_diArg_1	147	150	PF00400	0.531
TRG_NLS_MonoCore_2	121	126	PF00514	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NG26	Trypanosomatidae	32%	82%
A0A422NDE0	Trypanosoma rangeli	37%	81%
A4HWR7	Leishmania infantum	99%	100%
C9ZW57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	77%
E9AI52	Leishmania braziliensis	93%	100%
E9AQH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QF02	Leishmania major	86%	100%
V5AP83	Trypanosoma cruzi	35%	81%