Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTR0_LEIDO

TriTrypDb:

LdBPK_160160.1 , LdCL_160006500 , LDHU3_16.0180

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.736
CLV_NRD_NRD_1	162	164	PF00675	0.630
CLV_PCSK_KEX2_1	126	128	PF00082	0.744
CLV_PCSK_KEX2_1	162	164	PF00082	0.627
CLV_PCSK_KEX2_1	219	221	PF00082	0.465
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.504
CLV_PCSK_PC7_1	158	164	PF00082	0.632
CLV_PCSK_SKI1_1	162	166	PF00082	0.568
CLV_PCSK_SKI1_1	24	28	PF00082	0.583
DEG_SCF_FBW7_1	109	116	PF00400	0.645
DOC_CDC14_PxL_1	17	25	PF14671	0.502
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.681
DOC_PP2B_LxvP_1	165	168	PF13499	0.674
DOC_USP7_MATH_1	115	119	PF00917	0.593
DOC_USP7_MATH_1	16	20	PF00917	0.584
DOC_USP7_MATH_1	179	183	PF00917	0.628
DOC_USP7_MATH_1	198	202	PF00917	0.612
DOC_USP7_MATH_1	229	233	PF00917	0.524
DOC_USP7_MATH_1	95	99	PF00917	0.491
DOC_WW_Pin1_4	107	112	PF00397	0.669
DOC_WW_Pin1_4	113	118	PF00397	0.726
DOC_WW_Pin1_4	127	132	PF00397	0.496
DOC_WW_Pin1_4	171	176	PF00397	0.643
DOC_WW_Pin1_4	196	201	PF00397	0.683
LIG_FHA_1	222	228	PF00498	0.535
LIG_Integrin_isoDGR_2	186	188	PF01839	0.708
LIG_Integrin_RGD_1	188	190	PF01839	0.593
LIG_LIR_Gen_1	207	216	PF02991	0.471
LIG_LIR_Gen_1	74	83	PF02991	0.623
LIG_LIR_Nem_3	19	23	PF02991	0.496
LIG_LIR_Nem_3	207	212	PF02991	0.502
LIG_LIR_Nem_3	52	58	PF02991	0.538
LIG_LIR_Nem_3	74	78	PF02991	0.586
LIG_LYPXL_yS_3	20	23	PF13949	0.498
LIG_NRBOX	22	28	PF00104	0.580
LIG_Pex14_2	209	213	PF04695	0.639
LIG_SH2_CRK	75	79	PF00017	0.670
LIG_SH2_STAP1	75	79	PF00017	0.670
LIG_SH3_3	114	120	PF00018	0.619
LIG_SH3_3	197	203	PF00018	0.646
LIG_SH3_3	62	68	PF00018	0.622
LIG_TRAF2_1	120	123	PF00917	0.622
MOD_CDC14_SPxK_1	116	119	PF00782	0.625
MOD_CDK_SPxK_1	113	119	PF00069	0.621
MOD_DYRK1A_RPxSP_1	127	131	PF00069	0.669
MOD_GlcNHglycan	182	185	PF01048	0.685
MOD_GlcNHglycan	200	203	PF01048	0.474
MOD_GlcNHglycan	74	78	PF01048	0.564
MOD_GSK3_1	109	116	PF00069	0.642
MOD_NEK2_1	1	6	PF00069	0.635
MOD_Plk_1	73	79	PF00069	0.635
MOD_ProDKin_1	107	113	PF00069	0.667
MOD_ProDKin_1	127	133	PF00069	0.496
MOD_ProDKin_1	171	177	PF00069	0.643
MOD_ProDKin_1	196	202	PF00069	0.679
MOD_SUMO_rev_2	214	221	PF00179	0.531
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.525
TRG_ENDOCYTIC_2	20	23	PF00928	0.498
TRG_ENDOCYTIC_2	75	78	PF00928	0.667
TRG_ER_diArg_1	125	127	PF00400	0.749
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFT2	Leptomonas seymouri	45%	100%
A4H8E2	Leishmania braziliensis	61%	100%
A4HWR4	Leishmania infantum	97%	100%
E9AQH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QF05	Leishmania major	88%	100%