Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTN4_LEIDO

TriTrypDb:

LdBPK_150880.1 , LdCL_150014300 , LDHU3_15.1130

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.737
CLV_C14_Caspase3-7	357	361	PF00656	0.640
CLV_MEL_PAP_1	295	301	PF00089	0.626
CLV_NRD_NRD_1	117	119	PF00675	0.768
CLV_NRD_NRD_1	159	161	PF00675	0.812
CLV_NRD_NRD_1	383	385	PF00675	0.470
CLV_PCSK_KEX2_1	117	119	PF00082	0.763
CLV_PCSK_KEX2_1	142	144	PF00082	0.736
CLV_PCSK_KEX2_1	159	161	PF00082	0.537
CLV_PCSK_KEX2_1	383	385	PF00082	0.461
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.736
CLV_PCSK_SKI1_1	139	143	PF00082	0.716
CLV_PCSK_SKI1_1	145	149	PF00082	0.657
CLV_PCSK_SKI1_1	178	182	PF00082	0.621
CLV_PCSK_SKI1_1	33	37	PF00082	0.732
CLV_PCSK_SKI1_1	386	390	PF00082	0.501
CLV_PCSK_SKI1_1	77	81	PF00082	0.610
CLV_Separin_Metazoa	156	160	PF03568	0.653
DOC_CDC14_PxL_1	423	431	PF14671	0.617
DOC_CYCLIN_RxL_1	71	84	PF00134	0.588
DOC_CYCLIN_yCln2_LP_2	327	333	PF00134	0.685
DOC_CYCLIN_yCln2_LP_2	54	60	PF00134	0.696
DOC_PP2B_LxvP_1	54	57	PF13499	0.677
DOC_PP4_FxxP_1	82	85	PF00568	0.783
DOC_USP7_MATH_1	189	193	PF00917	0.675
DOC_USP7_MATH_1	248	252	PF00917	0.659
DOC_USP7_MATH_1	277	281	PF00917	0.663
DOC_USP7_MATH_1	348	352	PF00917	0.782
DOC_USP7_MATH_1	93	97	PF00917	0.713
DOC_WW_Pin1_4	163	168	PF00397	0.675
DOC_WW_Pin1_4	179	184	PF00397	0.651
DOC_WW_Pin1_4	187	192	PF00397	0.654
DOC_WW_Pin1_4	220	225	PF00397	0.628
DOC_WW_Pin1_4	308	313	PF00397	0.687
DOC_WW_Pin1_4	81	86	PF00397	0.781
LIG_14-3-3_CanoR_1	104	113	PF00244	0.688
LIG_14-3-3_CanoR_1	117	124	PF00244	0.734
LIG_14-3-3_CanoR_1	131	135	PF00244	0.461
LIG_14-3-3_CanoR_1	267	273	PF00244	0.633
LIG_14-3-3_CanoR_1	298	302	PF00244	0.525
LIG_14-3-3_CanoR_1	383	389	PF00244	0.581
LIG_14-3-3_CanoR_1	397	406	PF00244	0.499
LIG_14-3-3_CanoR_1	69	75	PF00244	0.691
LIG_APCC_ABBAyCdc20_2	403	409	PF00400	0.714
LIG_BIR_III_2	342	346	PF00653	0.731
LIG_BRCT_BRCA1_1	61	65	PF00533	0.662
LIG_CSL_BTD_1	241	244	PF09270	0.635
LIG_FHA_1	244	250	PF00498	0.677
LIG_FHA_1	271	277	PF00498	0.679
LIG_FHA_2	292	298	PF00498	0.469
LIG_LIR_Apic_2	42	47	PF02991	0.722
LIG_LIR_Gen_1	129	138	PF02991	0.615
LIG_LIR_Gen_1	255	265	PF02991	0.590
LIG_LIR_Nem_3	133	137	PF02991	0.575
LIG_LIR_Nem_3	208	213	PF02991	0.691
LIG_LIR_Nem_3	255	260	PF02991	0.590
LIG_LIR_Nem_3	48	52	PF02991	0.455
LIG_MYND_1	332	336	PF01753	0.634
LIG_Pex14_1	61	65	PF04695	0.662
LIG_PTAP_UEV_1	25	30	PF05743	0.620
LIG_SH2_CRK	257	261	PF00017	0.588
LIG_SH2_CRK	72	76	PF00017	0.721
LIG_SH2_SRC	187	190	PF00017	0.625
LIG_SH2_SRC	44	47	PF00017	0.710
LIG_SH2_STAT5	187	190	PF00017	0.625
LIG_SH2_STAT5	34	37	PF00017	0.730
LIG_SH2_STAT5	398	401	PF00017	0.664
LIG_SH2_STAT5	72	75	PF00017	0.708
LIG_SH3_2	345	350	PF14604	0.675
LIG_SH3_3	23	29	PF00018	0.630
LIG_SH3_3	309	315	PF00018	0.707
LIG_SH3_3	342	348	PF00018	0.786
LIG_SUMO_SIM_anti_2	51	56	PF11976	0.548
LIG_SUMO_SIM_par_1	245	252	PF11976	0.621
LIG_TRAF2_1	112	115	PF00917	0.828
LIG_TRFH_1	72	76	PF08558	0.721
LIG_TRFH_1	97	101	PF08558	0.643
LIG_TYR_ITSM	253	260	PF00017	0.590
LIG_WW_3	311	315	PF00397	0.681
MOD_CDC14_SPxK_1	311	314	PF00782	0.673
MOD_CDK_SPxK_1	308	314	PF00069	0.643
MOD_CDK_SPxxK_3	179	186	PF00069	0.675
MOD_CK1_1	103	109	PF00069	0.545
MOD_CK1_1	16	22	PF00069	0.660
MOD_CK1_1	223	229	PF00069	0.646
MOD_CK1_1	24	30	PF00069	0.763
MOD_CK1_1	268	274	PF00069	0.628
MOD_CK1_1	39	45	PF00069	0.630
MOD_CK1_1	48	54	PF00069	0.502
MOD_CK1_1	83	89	PF00069	0.631
MOD_CK2_1	163	169	PF00069	0.573
MOD_CK2_1	197	203	PF00069	0.667
MOD_CK2_1	229	235	PF00069	0.794
MOD_GlcNHglycan	120	123	PF01048	0.759
MOD_GlcNHglycan	128	131	PF01048	0.567
MOD_GlcNHglycan	26	29	PF01048	0.622
MOD_GlcNHglycan	267	270	PF01048	0.637
MOD_GlcNHglycan	432	435	PF01048	0.563
MOD_GlcNHglycan	85	88	PF01048	0.788
MOD_GSK3_1	102	109	PF00069	0.676
MOD_GSK3_1	126	133	PF00069	0.592
MOD_GSK3_1	13	20	PF00069	0.746
MOD_GSK3_1	187	194	PF00069	0.732
MOD_GSK3_1	219	226	PF00069	0.660
MOD_GSK3_1	229	236	PF00069	0.609
MOD_GSK3_1	248	255	PF00069	0.461
MOD_GSK3_1	263	270	PF00069	0.601
MOD_GSK3_1	35	42	PF00069	0.769
MOD_NEK2_1	265	270	PF00069	0.637
MOD_NEK2_1	291	296	PF00069	0.460
MOD_NEK2_1	399	404	PF00069	0.586
MOD_NEK2_1	407	412	PF00069	0.718
MOD_PK_1	233	239	PF00069	0.693
MOD_PKA_1	117	123	PF00069	0.758
MOD_PKA_2	103	109	PF00069	0.747
MOD_PKA_2	117	123	PF00069	0.614
MOD_PKA_2	126	132	PF00069	0.533
MOD_PKA_2	297	303	PF00069	0.628
MOD_PKA_2	407	413	PF00069	0.604
MOD_PKA_2	70	76	PF00069	0.709
MOD_PKB_1	143	151	PF00069	0.597
MOD_PKB_1	395	403	PF00069	0.556
MOD_PKB_1	6	14	PF00069	0.745
MOD_Plk_1	348	354	PF00069	0.617
MOD_Plk_1	362	368	PF00069	0.469
MOD_Plk_1	39	45	PF00069	0.752
MOD_Plk_2-3	197	203	PF00069	0.695
MOD_Plk_4	191	197	PF00069	0.683
MOD_Plk_4	291	297	PF00069	0.462
MOD_Plk_4	402	408	PF00069	0.606
MOD_Plk_4	70	76	PF00069	0.586
MOD_ProDKin_1	163	169	PF00069	0.673
MOD_ProDKin_1	179	185	PF00069	0.652
MOD_ProDKin_1	187	193	PF00069	0.655
MOD_ProDKin_1	220	226	PF00069	0.630
MOD_ProDKin_1	308	314	PF00069	0.697
MOD_ProDKin_1	81	87	PF00069	0.782
MOD_SUMO_rev_2	400	405	PF00179	0.690
TRG_DiLeu_BaEn_1	169	174	PF01217	0.612
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.548
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.610
TRG_ENDOCYTIC_2	138	141	PF00928	0.604
TRG_ENDOCYTIC_2	210	213	PF00928	0.643
TRG_ENDOCYTIC_2	257	260	PF00928	0.585
TRG_ENDOCYTIC_2	72	75	PF00928	0.708
TRG_ER_diArg_1	116	118	PF00400	0.646
TRG_ER_diArg_1	158	160	PF00400	0.706
TRG_ER_diArg_1	378	381	PF00400	0.529
TRG_ER_diArg_1	382	384	PF00400	0.485
TRG_ER_diArg_1	395	398	PF00400	0.367
TRG_ER_diArg_1	69	72	PF00400	0.672
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H855	Leishmania braziliensis	64%	98%
A4HWI0	Leishmania infantum	100%	100%
E9AQ81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%