Phosphomevalonate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphomevalonate kinase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WTM8_LEIDO

TriTrypDb:

LdBPK_151510.1 , LdCL_150020400 , LDHU3_15.1830

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WTM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTM8

Function

Biological processes
Term	Name	Level	Count
GO:0006084	acetyl-CoA metabolic process	5	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006163	purine nucleotide metabolic process	5	10
GO:0006629	lipid metabolic process	3	10
GO:0006637	acyl-CoA metabolic process	4	10
GO:0006644	phospholipid metabolic process	4	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006753	nucleoside phosphate metabolic process	4	10
GO:0006790	sulfur compound metabolic process	3	10
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	10
GO:0008654	phospholipid biosynthetic process	5	10
GO:0009058	biosynthetic process	2	10
GO:0009117	nucleotide metabolic process	5	10
GO:0009150	purine ribonucleotide metabolic process	6	10
GO:0009240	isopentenyl diphosphate biosynthetic process	6	10
GO:0009259	ribonucleotide metabolic process	5	10
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	6	10
GO:0019637	organophosphate metabolic process	3	10
GO:0019693	ribose phosphate metabolic process	4	10
GO:0033865	nucleoside bisphosphate metabolic process	5	10
GO:0033875	ribonucleoside bisphosphate metabolic process	6	10
GO:0034032	purine nucleoside bisphosphate metabolic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0035383	thioester metabolic process	3	10
GO:0043603	amide metabolic process	3	10
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0046490	isopentenyl diphosphate metabolic process	5	10
GO:0055086	nucleobase-containing small molecule metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0072521	purine-containing compound metabolic process	4	10
GO:0090407	organophosphate biosynthetic process	4	10
GO:1901135	carbohydrate derivative metabolic process	3	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0006720	isoprenoid metabolic process	4	1
GO:0006721	terpenoid metabolic process	5	1
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0010142	farnesyl diphosphate biosynthetic process, mevalonate pathway	6	1
GO:0016114	terpenoid biosynthetic process	5	1
GO:0044249	cellular biosynthetic process	3	1
GO:0045337	farnesyl diphosphate biosynthetic process	6	1
GO:0045338	farnesyl diphosphate metabolic process	5	1
GO:1902767	isoprenoid biosynthetic process via mevalonate	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004631	phosphomevalonate kinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.572
CLV_C14_Caspase3-7	298	302	PF00656	0.498
CLV_NRD_NRD_1	221	223	PF00675	0.384
CLV_NRD_NRD_1	247	249	PF00675	0.465
CLV_NRD_NRD_1	293	295	PF00675	0.453
CLV_NRD_NRD_1	308	310	PF00675	0.459
CLV_NRD_NRD_1	319	321	PF00675	0.561
CLV_PCSK_KEX2_1	221	223	PF00082	0.384
CLV_PCSK_KEX2_1	247	249	PF00082	0.624
CLV_PCSK_KEX2_1	293	295	PF00082	0.507
CLV_PCSK_KEX2_1	308	310	PF00082	0.494
CLV_PCSK_KEX2_1	319	321	PF00082	0.548
CLV_PCSK_SKI1_1	269	273	PF00082	0.446
CLV_PCSK_SKI1_1	369	373	PF00082	0.363
CLV_PCSK_SKI1_1	39	43	PF00082	0.492
DEG_APCC_DBOX_1	368	376	PF00400	0.507
DEG_Nend_UBRbox_2	1	3	PF02207	0.524
DEG_SPOP_SBC_1	166	170	PF00917	0.520
DEG_SPOP_SBC_1	43	47	PF00917	0.449
DOC_CDC14_PxL_1	339	347	PF14671	0.474
DOC_CYCLIN_RxL_1	363	374	PF00134	0.572
DOC_CYCLIN_RxL_1	5	14	PF00134	0.385
DOC_MAPK_DCC_7	144	152	PF00069	0.568
DOC_MAPK_DCC_7	437	445	PF00069	0.409
DOC_MAPK_MEF2A_6	144	152	PF00069	0.595
DOC_MAPK_MEF2A_6	263	272	PF00069	0.456
DOC_PP1_RVXF_1	286	293	PF00149	0.386
DOC_PP4_FxxP_1	262	265	PF00568	0.423
DOC_USP7_MATH_1	102	106	PF00917	0.524
DOC_USP7_MATH_1	365	369	PF00917	0.560
DOC_USP7_MATH_1	48	52	PF00917	0.518
DOC_USP7_MATH_1	71	75	PF00917	0.525
DOC_WW_Pin1_4	19	24	PF00397	0.576
DOC_WW_Pin1_4	279	284	PF00397	0.509
DOC_WW_Pin1_4	296	301	PF00397	0.462
DOC_WW_Pin1_4	57	62	PF00397	0.468
DOC_WW_Pin1_4	86	91	PF00397	0.485
LIG_14-3-3_CanoR_1	227	231	PF00244	0.508
LIG_14-3-3_CanoR_1	293	297	PF00244	0.464
LIG_14-3-3_CanoR_1	35	41	PF00244	0.480
LIG_14-3-3_CanoR_1	64	68	PF00244	0.610
LIG_APCC_ABBA_1	428	433	PF00400	0.432
LIG_BRCT_BRCA1_1	59	63	PF00533	0.411
LIG_BRCT_BRCA1_1	65	69	PF00533	0.408
LIG_CSL_BTD_1	255	258	PF09270	0.567
LIG_CtBP_PxDLS_1	385	389	PF00389	0.588
LIG_deltaCOP1_diTrp_1	254	262	PF00928	0.470
LIG_EVH1_2	258	262	PF00568	0.481
LIG_FHA_1	166	172	PF00498	0.520
LIG_FHA_1	35	41	PF00498	0.420
LIG_FHA_1	387	393	PF00498	0.517
LIG_FHA_2	108	114	PF00498	0.468
LIG_LIR_Apic_2	254	259	PF02991	0.580
LIG_LIR_Apic_2	260	265	PF02991	0.542
LIG_LIR_Gen_1	113	120	PF02991	0.519
LIG_LIR_Gen_1	14	23	PF02991	0.574
LIG_LIR_Gen_1	209	219	PF02991	0.567
LIG_LIR_Gen_1	413	420	PF02991	0.507
LIG_LIR_Gen_1	433	443	PF02991	0.462
LIG_LIR_Gen_1	66	75	PF02991	0.469
LIG_LIR_Nem_3	113	118	PF02991	0.446
LIG_LIR_Nem_3	14	18	PF02991	0.541
LIG_LIR_Nem_3	206	211	PF02991	0.507
LIG_LIR_Nem_3	217	223	PF02991	0.373
LIG_LIR_Nem_3	301	307	PF02991	0.470
LIG_LIR_Nem_3	413	419	PF02991	0.507
LIG_LIR_Nem_3	429	435	PF02991	0.393
LIG_LIR_Nem_3	66	70	PF02991	0.484
LIG_NRBOX	387	393	PF00104	0.520
LIG_Pex14_2	63	67	PF04695	0.456
LIG_RPA_C_Fungi	358	370	PF08784	0.406
LIG_SH2_CRK	211	215	PF00017	0.509
LIG_SH2_CRK	412	416	PF00017	0.360
LIG_SH2_NCK_1	211	215	PF00017	0.474
LIG_SH2_NCK_1	412	416	PF00017	0.360
LIG_SH2_NCK_1	98	102	PF00017	0.400
LIG_SH2_SRC	130	133	PF00017	0.475
LIG_SH2_SRC	15	18	PF00017	0.422
LIG_SH2_STAP1	211	215	PF00017	0.360
LIG_SH2_STAP1	332	336	PF00017	0.463
LIG_SH2_STAP1	412	416	PF00017	0.360
LIG_SH2_STAP1	98	102	PF00017	0.414
LIG_SH2_STAT5	130	133	PF00017	0.432
LIG_SH2_STAT5	15	18	PF00017	0.398
LIG_SH2_STAT5	188	191	PF00017	0.406
LIG_SH2_STAT5	211	214	PF00017	0.409
LIG_SH2_STAT5	314	317	PF00017	0.436
LIG_SH2_STAT5	435	438	PF00017	0.439
LIG_SH3_2	258	263	PF14604	0.532
LIG_SH3_3	145	151	PF00018	0.521
LIG_SH3_3	252	258	PF00018	0.563
LIG_SH3_3	340	346	PF00018	0.473
LIG_SH3_3	401	407	PF00018	0.341
LIG_SH3_3	451	457	PF00018	0.626
LIG_SUMO_SIM_par_1	384	390	PF11976	0.455
LIG_SUMO_SIM_par_1	441	448	PF11976	0.414
LIG_SUMO_SIM_par_1	8	14	PF11976	0.388
LIG_TRFH_1	262	266	PF08558	0.541
MOD_CDK_SPxxK_3	57	64	PF00069	0.516
MOD_CK1_1	105	111	PF00069	0.580
MOD_CK1_1	226	232	PF00069	0.564
MOD_CK1_1	51	57	PF00069	0.623
MOD_CK2_1	107	113	PF00069	0.481
MOD_CK2_1	236	242	PF00069	0.594
MOD_GlcNHglycan	163	166	PF01048	0.341
MOD_GlcNHglycan	2	6	PF01048	0.395
MOD_GlcNHglycan	205	208	PF01048	0.366
MOD_GlcNHglycan	233	236	PF01048	0.701
MOD_GlcNHglycan	447	452	PF01048	0.551
MOD_GlcNHglycan	50	53	PF01048	0.715
MOD_GlcNHglycan	72	76	PF01048	0.572
MOD_GlcNHglycan	85	89	PF01048	0.469
MOD_GSK3_1	102	109	PF00069	0.490
MOD_GSK3_1	156	163	PF00069	0.341
MOD_GSK3_1	292	299	PF00069	0.520
MOD_GSK3_1	44	51	PF00069	0.714
MOD_N-GLC_2	439	441	PF02516	0.430
MOD_NEK2_1	1	6	PF00069	0.529
MOD_NEK2_1	161	166	PF00069	0.380
MOD_NEK2_1	167	172	PF00069	0.389
MOD_NEK2_1	231	236	PF00069	0.560
MOD_NEK2_1	392	397	PF00069	0.379
MOD_NEK2_1	63	68	PF00069	0.481
MOD_NEK2_2	52	57	PF00069	0.565
MOD_PIKK_1	123	129	PF00454	0.398
MOD_PIKK_1	130	136	PF00454	0.445
MOD_PIKK_1	197	203	PF00454	0.474
MOD_PKA_2	226	232	PF00069	0.540
MOD_PKA_2	292	298	PF00069	0.464
MOD_PKA_2	34	40	PF00069	0.465
MOD_PKA_2	63	69	PF00069	0.425
MOD_Plk_4	11	17	PF00069	0.389
MOD_Plk_4	167	173	PF00069	0.360
MOD_Plk_4	226	232	PF00069	0.570
MOD_ProDKin_1	19	25	PF00069	0.567
MOD_ProDKin_1	279	285	PF00069	0.497
MOD_ProDKin_1	296	302	PF00069	0.456
MOD_ProDKin_1	57	63	PF00069	0.472
MOD_ProDKin_1	86	92	PF00069	0.476
MOD_SUMO_for_1	381	384	PF00179	0.474
MOD_SUMO_for_1	41	44	PF00179	0.572
MOD_SUMO_rev_2	374	383	PF00179	0.474
TRG_DiLeu_BaEn_1	387	392	PF01217	0.420
TRG_DiLeu_BaLyEn_6	439	444	PF01217	0.418
TRG_ENDOCYTIC_2	15	18	PF00928	0.447
TRG_ENDOCYTIC_2	211	214	PF00928	0.428
TRG_ENDOCYTIC_2	220	223	PF00928	0.384
TRG_ENDOCYTIC_2	412	415	PF00928	0.360
TRG_ENDOCYTIC_2	435	438	PF00928	0.412
TRG_ER_diArg_1	220	222	PF00400	0.379
TRG_ER_diArg_1	246	248	PF00400	0.462
TRG_ER_diArg_1	292	294	PF00400	0.488
TRG_ER_diArg_1	307	309	PF00400	0.494
TRG_ER_diArg_1	318	320	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	369	374	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P784	Leptomonas seymouri	76%	100%
A0A0S4JMH3	Bodo saltans	55%	100%
A0A1D8PLH0	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	100%
A0A1X0NVR4	Trypanosomatidae	56%	100%
A0A3S5IQX7	Trypanosoma rangeli	55%	98%
A4H8B3	Leishmania braziliensis	84%	100%
A4HWN3	Leishmania infantum	100%	100%
C9ZXQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
E9AQE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
I1RZD0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	31%	100%
P24521	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q4QF34	Leishmania major	95%	100%
Q4WV38	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	29%	95%
Q9C6T1	Arabidopsis thaliana	35%	91%
Q9UT88	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%