EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTM7_LEIDO

TriTrypDb:

LdBPK_151360.1 , LdCL_150018900 , LDHU3_15.1680

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WTM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTM7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005509	calcium ion binding	5	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	54	58	PF00656	0.649
CLV_NRD_NRD_1	118	120	PF00675	0.440
CLV_NRD_NRD_1	17	19	PF00675	0.523
CLV_NRD_NRD_1	214	216	PF00675	0.503
CLV_NRD_NRD_1	366	368	PF00675	0.698
CLV_PCSK_KEX2_1	118	120	PF00082	0.440
CLV_PCSK_KEX2_1	132	134	PF00082	0.647
CLV_PCSK_KEX2_1	16	18	PF00082	0.550
CLV_PCSK_KEX2_1	214	216	PF00082	0.697
CLV_PCSK_KEX2_1	366	368	PF00082	0.698
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.542
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.500
CLV_PCSK_SKI1_1	110	114	PF00082	0.435
CLV_PCSK_SKI1_1	121	125	PF00082	0.431
CLV_PCSK_SKI1_1	142	146	PF00082	0.470
CLV_PCSK_SKI1_1	17	21	PF00082	0.559
CLV_PCSK_SKI1_1	277	281	PF00082	0.654
CLV_PCSK_SKI1_1	300	304	PF00082	0.613
DEG_Kelch_Keap1_1	230	235	PF01344	0.633
DEG_SCF_TRCP1_1	57	63	PF00400	0.609
DOC_CYCLIN_RxL_1	139	148	PF00134	0.537
DOC_MAPK_gen_1	16	24	PF00069	0.552
DOC_MAPK_gen_1	300	310	PF00069	0.673
DOC_MAPK_MEF2A_6	303	312	PF00069	0.699
DOC_MAPK_NFAT4_5	303	311	PF00069	0.697
DOC_PP4_FxxP_1	181	184	PF00568	0.726
DOC_USP7_MATH_1	126	130	PF00917	0.538
DOC_USP7_MATH_1	177	181	PF00917	0.732
DOC_USP7_MATH_1	188	192	PF00917	0.611
DOC_USP7_UBL2_3	16	20	PF12436	0.558
DOC_WW_Pin1_4	163	168	PF00397	0.523
DOC_WW_Pin1_4	179	184	PF00397	0.734
DOC_WW_Pin1_4	250	255	PF00397	0.481
DOC_WW_Pin1_4	81	86	PF00397	0.525
LIG_14-3-3_CanoR_1	239	243	PF00244	0.588
LIG_14-3-3_CterR_2	366	371	PF00244	0.670
LIG_Actin_WH2_2	105	123	PF00022	0.589
LIG_Actin_WH2_2	12	27	PF00022	0.481
LIG_BRCT_BRCA1_1	252	256	PF00533	0.464
LIG_FHA_1	107	113	PF00498	0.473
LIG_FHA_1	262	268	PF00498	0.498
LIG_FHA_1	27	33	PF00498	0.558
LIG_FHA_2	281	287	PF00498	0.608
LIG_FHA_2	52	58	PF00498	0.644
LIG_FHA_2	6	12	PF00498	0.643
LIG_FHA_2	82	88	PF00498	0.528
LIG_HCF-1_HBM_1	325	328	PF13415	0.686
LIG_LIR_Apic_2	179	184	PF02991	0.724
LIG_LIR_Apic_2	325	331	PF02991	0.668
LIG_LIR_Gen_1	147	157	PF02991	0.587
LIG_LIR_Gen_1	244	252	PF02991	0.427
LIG_LIR_Gen_1	316	327	PF02991	0.610
LIG_LIR_Nem_3	147	152	PF02991	0.574
LIG_LIR_Nem_3	241	245	PF02991	0.439
LIG_LIR_Nem_3	316	322	PF02991	0.491
LIG_LIR_Nem_3	348	352	PF02991	0.567
LIG_LRP6_Inhibitor_1	4	10	PF00058	0.676
LIG_RPA_C_Fungi	114	126	PF08784	0.489
LIG_SH2_CRK	249	253	PF00017	0.461
LIG_SH2_NCK_1	158	162	PF00017	0.497
LIG_SH2_PTP2	328	331	PF00017	0.584
LIG_SH2_SRC	328	331	PF00017	0.593
LIG_SH2_STAP1	242	246	PF00017	0.538
LIG_SH2_STAT5	245	248	PF00017	0.526
LIG_SH2_STAT5	301	304	PF00017	0.672
LIG_SH2_STAT5	328	331	PF00017	0.573
LIG_SH2_STAT5	349	352	PF00017	0.564
LIG_SH2_STAT5	90	93	PF00017	0.430
LIG_SH3_1	328	334	PF00018	0.580
LIG_SH3_3	328	334	PF00018	0.556
LIG_SUMO_SIM_par_1	292	297	PF11976	0.575
LIG_WRC_WIRS_1	146	151	PF05994	0.502
LIG_WRC_WIRS_1	178	183	PF05994	0.541
MOD_CK1_1	104	110	PF00069	0.551
MOD_CK1_1	313	319	PF00069	0.587
MOD_CK1_1	55	61	PF00069	0.687
MOD_CK2_1	238	244	PF00069	0.484
MOD_CK2_1	280	286	PF00069	0.638
MOD_CK2_1	5	11	PF00069	0.658
MOD_CK2_1	81	87	PF00069	0.488
MOD_GlcNHglycan	103	106	PF01048	0.534
MOD_GlcNHglycan	232	235	PF01048	0.562
MOD_GlcNHglycan	57	60	PF01048	0.701
MOD_GlcNHglycan	99	102	PF01048	0.553
MOD_GSK3_1	106	113	PF00069	0.447
MOD_GSK3_1	313	320	PF00069	0.577
MOD_GSK3_1	341	348	PF00069	0.633
MOD_GSK3_1	51	58	PF00069	0.657
MOD_GSK3_1	97	104	PF00069	0.526
MOD_N-GLC_1	138	143	PF02516	0.392
MOD_N-GLC_1	317	322	PF02516	0.581
MOD_N-GLC_1	5	10	PF02516	0.589
MOD_NEK2_1	144	149	PF00069	0.438
MOD_NEK2_1	189	194	PF00069	0.631
MOD_NEK2_1	219	224	PF00069	0.713
MOD_NEK2_1	280	285	PF00069	0.635
MOD_NEK2_1	310	315	PF00069	0.636
MOD_NEK2_1	341	346	PF00069	0.609
MOD_PKA_2	238	244	PF00069	0.592
MOD_PKA_2	50	56	PF00069	0.618
MOD_Plk_1	317	323	PF00069	0.582
MOD_Plk_1	5	11	PF00069	0.652
MOD_Plk_2-3	238	244	PF00069	0.559
MOD_Plk_4	207	213	PF00069	0.589
MOD_Plk_4	345	351	PF00069	0.642
MOD_ProDKin_1	163	169	PF00069	0.526
MOD_ProDKin_1	179	185	PF00069	0.734
MOD_ProDKin_1	250	256	PF00069	0.479
MOD_ProDKin_1	81	87	PF00069	0.521
TRG_ENDOCYTIC_2	245	248	PF00928	0.478
TRG_ENDOCYTIC_2	249	252	PF00928	0.452
TRG_ENDOCYTIC_2	319	322	PF00928	0.670
TRG_ENDOCYTIC_2	349	352	PF00928	0.617
TRG_ER_diArg_1	118	121	PF00400	0.495
TRG_ER_diArg_1	17	19	PF00400	0.517
TRG_NLS_MonoExtC_3	15	20	PF00514	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG2	Leptomonas seymouri	56%	100%
A0A0S4JMV6	Bodo saltans	30%	100%
A0A1X0NUM9	Trypanosomatidae	37%	100%
A0A3R7MLD6	Trypanosoma rangeli	36%	100%
A4H897	Leishmania braziliensis	75%	100%
A4HWL9	Leishmania infantum	100%	100%
E9AQC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QF48	Leishmania major	93%	100%
V5BUD9	Trypanosoma cruzi	37%	100%