Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WTM2_LEIDO

TriTrypDb:

LdBPK_150790.1 , LdCL_150013300 , LDHU3_15.1020

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	508	512	PF00656	0.545
CLV_C14_Caspase3-7	599	603	PF00656	0.708
CLV_C14_Caspase3-7	609	613	PF00656	0.612
CLV_C14_Caspase3-7	657	661	PF00656	0.659
CLV_NRD_NRD_1	173	175	PF00675	0.739
CLV_NRD_NRD_1	361	363	PF00675	0.554
CLV_NRD_NRD_1	420	422	PF00675	0.710
CLV_NRD_NRD_1	469	471	PF00675	0.599
CLV_NRD_NRD_1	576	578	PF00675	0.589
CLV_NRD_NRD_1	580	582	PF00675	0.665
CLV_NRD_NRD_1	588	590	PF00675	0.614
CLV_NRD_NRD_1	610	612	PF00675	0.583
CLV_PCSK_KEX2_1	173	175	PF00082	0.739
CLV_PCSK_KEX2_1	361	363	PF00082	0.554
CLV_PCSK_KEX2_1	420	422	PF00082	0.710
CLV_PCSK_KEX2_1	469	471	PF00082	0.584
CLV_PCSK_KEX2_1	576	578	PF00082	0.595
CLV_PCSK_KEX2_1	580	582	PF00082	0.659
CLV_PCSK_KEX2_1	588	590	PF00082	0.608
CLV_PCSK_KEX2_1	610	612	PF00082	0.583
CLV_PCSK_PC7_1	416	422	PF00082	0.711
CLV_PCSK_PC7_1	576	582	PF00082	0.578
CLV_PCSK_SKI1_1	477	481	PF00082	0.468
DEG_APCC_DBOX_1	496	504	PF00400	0.500
DEG_SCF_FBW7_1	228	233	PF00400	0.679
DEG_SPOP_SBC_1	164	168	PF00917	0.698
DEG_SPOP_SBC_1	186	190	PF00917	0.621
DEG_SPOP_SBC_1	203	207	PF00917	0.605
DOC_CKS1_1	308	313	PF01111	0.705
DOC_CKS1_1	464	469	PF01111	0.527
DOC_CKS1_1	91	96	PF01111	0.589
DOC_MAPK_gen_1	497	505	PF00069	0.466
DOC_PP2B_LxvP_1	162	165	PF13499	0.595
DOC_PP2B_LxvP_1	341	344	PF13499	0.619
DOC_PP2B_LxvP_1	542	545	PF13499	0.647
DOC_PP2B_LxvP_1	636	639	PF13499	0.671
DOC_PP4_FxxP_1	649	652	PF00568	0.524
DOC_SPAK_OSR1_1	337	341	PF12202	0.594
DOC_USP7_MATH_1	111	115	PF00917	0.668
DOC_USP7_MATH_1	149	153	PF00917	0.651
DOC_USP7_MATH_1	165	169	PF00917	0.571
DOC_USP7_MATH_1	186	190	PF00917	0.610
DOC_USP7_MATH_1	411	415	PF00917	0.706
DOC_USP7_MATH_1	419	423	PF00917	0.644
DOC_USP7_MATH_1	521	525	PF00917	0.671
DOC_USP7_MATH_1	545	549	PF00917	0.620
DOC_USP7_MATH_1	57	61	PF00917	0.603
DOC_USP7_MATH_1	579	583	PF00917	0.653
DOC_USP7_MATH_1	613	617	PF00917	0.676
DOC_USP7_MATH_1	652	656	PF00917	0.634
DOC_WW_Pin1_4	166	171	PF00397	0.700
DOC_WW_Pin1_4	187	192	PF00397	0.723
DOC_WW_Pin1_4	213	218	PF00397	0.715
DOC_WW_Pin1_4	226	231	PF00397	0.555
DOC_WW_Pin1_4	248	253	PF00397	0.705
DOC_WW_Pin1_4	262	267	PF00397	0.597
DOC_WW_Pin1_4	301	306	PF00397	0.680
DOC_WW_Pin1_4	307	312	PF00397	0.689
DOC_WW_Pin1_4	463	468	PF00397	0.659
DOC_WW_Pin1_4	51	56	PF00397	0.709
DOC_WW_Pin1_4	517	522	PF00397	0.632
DOC_WW_Pin1_4	90	95	PF00397	0.640
LIG_14-3-3_CanoR_1	361	369	PF00244	0.675
LIG_14-3-3_CanoR_1	410	419	PF00244	0.674
LIG_14-3-3_CanoR_1	420	429	PF00244	0.589
LIG_14-3-3_CanoR_1	631	637	PF00244	0.673
LIG_AP2alpha_2	550	552	PF02296	0.510
LIG_APCC_ABBA_1	643	648	PF00400	0.578
LIG_Clathr_ClatBox_1	644	648	PF01394	0.621
LIG_deltaCOP1_diTrp_1	481	490	PF00928	0.510
LIG_EVH1_1	341	345	PF00568	0.557
LIG_EVH1_2	343	347	PF00568	0.540
LIG_FHA_1	223	229	PF00498	0.675
LIG_FHA_1	537	543	PF00498	0.614
LIG_FHA_1	562	568	PF00498	0.465
LIG_FHA_1	631	637	PF00498	0.702
LIG_FHA_2	366	372	PF00498	0.703
LIG_FHA_2	592	598	PF00498	0.707
LIG_Integrin_RGD_1	402	404	PF01839	0.599
LIG_LIR_Apic_2	621	625	PF02991	0.613
LIG_LIR_Apic_2	648	652	PF02991	0.532
LIG_LIR_Gen_1	348	358	PF02991	0.578
LIG_LIR_Gen_1	481	491	PF02991	0.483
LIG_LIR_Nem_3	346	350	PF02991	0.547
LIG_LIR_Nem_3	424	429	PF02991	0.638
LIG_LIR_Nem_3	481	486	PF02991	0.509
LIG_PDZ_Class_2	659	664	PF00595	0.700
LIG_Pex14_2	350	354	PF04695	0.554
LIG_PTAP_UEV_1	40	45	PF05743	0.609
LIG_SH2_CRK	476	480	PF00017	0.484
LIG_SH2_NCK_1	622	626	PF00017	0.615
LIG_SH2_STAT5	92	95	PF00017	0.630
LIG_SH3_1	339	345	PF00018	0.559
LIG_SH3_3	16	22	PF00018	0.702
LIG_SH3_3	246	252	PF00018	0.699
LIG_SH3_3	297	303	PF00018	0.697
LIG_SH3_3	305	311	PF00018	0.636
LIG_SH3_3	337	343	PF00018	0.674
LIG_SH3_3	38	44	PF00018	0.636
LIG_SH3_3	99	105	PF00018	0.685
LIG_SUMO_SIM_anti_2	317	323	PF11976	0.576
LIG_TRAF2_1	44	47	PF00917	0.717
LIG_TRAF2_1	626	629	PF00917	0.742
LIG_WRC_WIRS_1	487	492	PF05994	0.322
MOD_CDK_SPxK_1	463	469	PF00069	0.509
MOD_CDK_SPxxK_3	166	173	PF00069	0.678
MOD_CDK_SPxxK_3	463	470	PF00069	0.573
MOD_CK1_1	11	17	PF00069	0.639
MOD_CK1_1	110	116	PF00069	0.729
MOD_CK1_1	128	134	PF00069	0.572
MOD_CK1_1	184	190	PF00069	0.677
MOD_CK1_1	207	213	PF00069	0.739
MOD_CK1_1	251	257	PF00069	0.775
MOD_CK1_1	301	307	PF00069	0.757
MOD_CK1_1	364	370	PF00069	0.734
MOD_CK1_1	374	380	PF00069	0.644
MOD_CK1_1	459	465	PF00069	0.699
MOD_CK1_1	603	609	PF00069	0.732
MOD_CK1_1	615	621	PF00069	0.624
MOD_CK1_1	653	659	PF00069	0.709
MOD_CK2_1	129	135	PF00069	0.738
MOD_CK2_1	365	371	PF00069	0.698
MOD_CK2_1	409	415	PF00069	0.721
MOD_CK2_1	427	433	PF00069	0.745
MOD_CK2_1	462	468	PF00069	0.669
MOD_CK2_1	489	495	PF00069	0.505
MOD_CK2_1	603	609	PF00069	0.758
MOD_CK2_1	623	629	PF00069	0.503
MOD_GlcNHglycan	109	112	PF01048	0.576
MOD_GlcNHglycan	150	154	PF01048	0.647
MOD_GlcNHglycan	182	186	PF01048	0.746
MOD_GlcNHglycan	207	210	PF01048	0.704
MOD_GlcNHglycan	259	262	PF01048	0.823
MOD_GlcNHglycan	363	366	PF01048	0.670
MOD_GlcNHglycan	421	424	PF01048	0.759
MOD_GlcNHglycan	429	432	PF01048	0.686
MOD_GlcNHglycan	458	461	PF01048	0.701
MOD_GlcNHglycan	523	526	PF01048	0.646
MOD_GlcNHglycan	547	550	PF01048	0.560
MOD_GlcNHglycan	605	608	PF01048	0.731
MOD_GlcNHglycan	625	628	PF01048	0.528
MOD_GlcNHglycan	652	655	PF01048	0.689
MOD_GlcNHglycan	95	98	PF01048	0.684
MOD_GSK3_1	107	114	PF00069	0.756
MOD_GSK3_1	125	132	PF00069	0.522
MOD_GSK3_1	149	156	PF00069	0.661
MOD_GSK3_1	160	167	PF00069	0.625
MOD_GSK3_1	173	180	PF00069	0.647
MOD_GSK3_1	181	188	PF00069	0.662
MOD_GSK3_1	203	210	PF00069	0.733
MOD_GSK3_1	222	229	PF00069	0.519
MOD_GSK3_1	294	301	PF00069	0.695
MOD_GSK3_1	310	317	PF00069	0.533
MOD_GSK3_1	356	363	PF00069	0.595
MOD_GSK3_1	370	377	PF00069	0.629
MOD_GSK3_1	459	466	PF00069	0.646
MOD_GSK3_1	517	524	PF00069	0.602
MOD_GSK3_1	536	543	PF00069	0.499
MOD_GSK3_1	58	65	PF00069	0.657
MOD_GSK3_1	650	657	PF00069	0.690
MOD_GSK3_1	8	15	PF00069	0.642
MOD_N-GLC_1	356	361	PF02516	0.577
MOD_N-GLC_1	58	63	PF02516	0.584
MOD_NEK2_1	160	165	PF00069	0.713
MOD_NEK2_1	202	207	PF00069	0.741
MOD_NEK2_1	212	217	PF00069	0.705
MOD_NEK2_1	222	227	PF00069	0.554
MOD_NEK2_1	293	298	PF00069	0.693
MOD_NEK2_1	353	358	PF00069	0.590
MOD_NEK2_1	409	414	PF00069	0.754
MOD_NEK2_1	632	637	PF00069	0.743
MOD_NEK2_1	647	652	PF00069	0.497
MOD_PIKK_1	376	382	PF00454	0.729
MOD_PIKK_1	42	48	PF00454	0.727
MOD_PIKK_1	654	660	PF00454	0.571
MOD_PK_1	173	179	PF00069	0.743
MOD_PKA_1	173	179	PF00069	0.743
MOD_PKA_1	361	367	PF00069	0.586
MOD_PKA_2	173	179	PF00069	0.743
MOD_PKA_2	360	366	PF00069	0.681
MOD_PKA_2	409	415	PF00069	0.726
MOD_PKA_2	419	425	PF00069	0.669
MOD_PKA_2	456	462	PF00069	0.711
MOD_PKA_2	579	585	PF00069	0.660
MOD_PKA_2	630	636	PF00069	0.677
MOD_Plk_1	453	459	PF00069	0.693
MOD_Plk_1	647	653	PF00069	0.673
MOD_Plk_4	173	179	PF00069	0.772
MOD_Plk_4	207	213	PF00069	0.704
MOD_Plk_4	317	323	PF00069	0.615
MOD_Plk_4	561	567	PF00069	0.448
MOD_Plk_4	62	68	PF00069	0.657
MOD_Plk_4	95	101	PF00069	0.684
MOD_ProDKin_1	166	172	PF00069	0.703
MOD_ProDKin_1	187	193	PF00069	0.719
MOD_ProDKin_1	213	219	PF00069	0.706
MOD_ProDKin_1	226	232	PF00069	0.557
MOD_ProDKin_1	248	254	PF00069	0.706
MOD_ProDKin_1	262	268	PF00069	0.595
MOD_ProDKin_1	301	307	PF00069	0.682
MOD_ProDKin_1	463	469	PF00069	0.652
MOD_ProDKin_1	51	57	PF00069	0.707
MOD_ProDKin_1	517	523	PF00069	0.638
MOD_ProDKin_1	90	96	PF00069	0.639
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.646
TRG_ENDOCYTIC_2	476	479	PF00928	0.516
TRG_ER_diArg_1	173	175	PF00400	0.739
TRG_ER_diArg_1	419	421	PF00400	0.706
TRG_ER_diArg_1	496	499	PF00400	0.497
TRG_ER_diArg_1	576	578	PF00400	0.624
TRG_ER_diArg_1	579	581	PF00400	0.686
TRG_ER_diArg_1	587	589	PF00400	0.620
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H850	Leishmania braziliensis	57%	94%
A4HWH2	Leishmania infantum	99%	100%
E9AQ73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	93%
Q4QFB0	Leishmania major	87%	99%