MGT1 magnesium transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MGT1 magnesium transporter

Species:

Leishmania donovani

UniProt:

A0A3S7WTL5_LEIDO

TriTrypDb:

LdBPK_151330.1 , LdCL_150018600 , LDHU3_15.1640

Length:

834

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0005886	plasma membrane	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WTL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTL5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0006811	monoatomic ion transport	4	6
GO:0006812	monoatomic cation transport	5	6
GO:0015693	magnesium ion transport	7	6
GO:0030001	metal ion transport	6	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0008324	monoatomic cation transmembrane transporter activity	4	7
GO:0015075	monoatomic ion transmembrane transporter activity	3	7
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	7
GO:0022857	transmembrane transporter activity	2	7
GO:0022890	inorganic cation transmembrane transporter activity	4	7
GO:0046873	metal ion transmembrane transporter activity	5	7
GO:0000287	magnesium ion binding	5	1
GO:0005488	binding	1	1
GO:0015087	cobalt ion transmembrane transporter activity	7	1
GO:0015095	magnesium ion transmembrane transporter activity	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0046915	transition metal ion transmembrane transporter activity	6	1
GO:0050897	cobalt ion binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.656
CLV_C14_Caspase3-7	344	348	PF00656	0.685
CLV_C14_Caspase3-7	497	501	PF00656	0.541
CLV_NRD_NRD_1	139	141	PF00675	0.506
CLV_NRD_NRD_1	143	145	PF00675	0.514
CLV_NRD_NRD_1	146	148	PF00675	0.512
CLV_NRD_NRD_1	461	463	PF00675	0.405
CLV_NRD_NRD_1	478	480	PF00675	0.562
CLV_NRD_NRD_1	679	681	PF00675	0.293
CLV_NRD_NRD_1	704	706	PF00675	0.273
CLV_NRD_NRD_1	85	87	PF00675	0.453
CLV_PCSK_FUR_1	137	141	PF00082	0.525
CLV_PCSK_FUR_1	144	148	PF00082	0.579
CLV_PCSK_KEX2_1	134	136	PF00082	0.518
CLV_PCSK_KEX2_1	139	141	PF00082	0.506
CLV_PCSK_KEX2_1	142	144	PF00082	0.506
CLV_PCSK_KEX2_1	146	148	PF00082	0.512
CLV_PCSK_KEX2_1	461	463	PF00082	0.434
CLV_PCSK_KEX2_1	478	480	PF00082	0.446
CLV_PCSK_KEX2_1	601	603	PF00082	0.324
CLV_PCSK_KEX2_1	663	665	PF00082	0.356
CLV_PCSK_KEX2_1	679	681	PF00082	0.277
CLV_PCSK_KEX2_1	704	706	PF00082	0.273
CLV_PCSK_KEX2_1	85	87	PF00082	0.453
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.518
CLV_PCSK_PC1ET2_1	601	603	PF00082	0.324
CLV_PCSK_PC1ET2_1	663	665	PF00082	0.270
CLV_PCSK_PC7_1	135	141	PF00082	0.510
CLV_PCSK_PC7_1	142	148	PF00082	0.517
CLV_PCSK_PC7_1	597	603	PF00082	0.324
CLV_PCSK_SKI1_1	338	342	PF00082	0.502
CLV_PCSK_SKI1_1	478	482	PF00082	0.486
CLV_PCSK_SKI1_1	511	515	PF00082	0.319
CLV_PCSK_SKI1_1	551	555	PF00082	0.307
CLV_PCSK_SKI1_1	663	667	PF00082	0.363
CLV_PCSK_SKI1_1	679	683	PF00082	0.208
CLV_PCSK_SKI1_1	722	726	PF00082	0.279
CLV_PCSK_SKI1_1	757	761	PF00082	0.291
DEG_APCC_DBOX_1	84	92	PF00400	0.636
DEG_MDM2_SWIB_1	489	496	PF02201	0.559
DEG_SCF_FBW7_1	651	657	PF00400	0.524
DEG_SPOP_SBC_1	155	159	PF00917	0.712
DOC_CDC14_PxL_1	240	248	PF14671	0.703
DOC_CKS1_1	301	306	PF01111	0.715
DOC_CKS1_1	34	39	PF01111	0.728
DOC_CKS1_1	651	656	PF01111	0.524
DOC_CKS1_1	784	789	PF01111	0.309
DOC_CYCLIN_RxL_1	674	686	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	408	414	PF00134	0.612
DOC_CYCLIN_yCln2_LP_2	784	790	PF00134	0.309
DOC_MAPK_MEF2A_6	570	577	PF00069	0.473
DOC_MAPK_MEF2A_6	578	585	PF00069	0.473
DOC_MAPK_MEF2A_6	757	766	PF00069	0.473
DOC_MAPK_NFAT4_5	757	765	PF00069	0.473
DOC_PP2B_LxvP_1	35	38	PF13499	0.659
DOC_PP2B_LxvP_1	531	534	PF13499	0.539
DOC_PP4_FxxP_1	317	320	PF00568	0.692
DOC_PP4_FxxP_1	34	37	PF00568	0.708
DOC_SPAK_OSR1_1	204	208	PF12202	0.683
DOC_USP7_MATH_1	155	159	PF00917	0.693
DOC_USP7_MATH_1	184	188	PF00917	0.761
DOC_USP7_MATH_1	290	294	PF00917	0.714
DOC_USP7_MATH_1	318	322	PF00917	0.780
DOC_USP7_MATH_1	331	335	PF00917	0.645
DOC_USP7_MATH_1	426	430	PF00917	0.756
DOC_USP7_MATH_1	480	484	PF00917	0.693
DOC_USP7_MATH_1	654	658	PF00917	0.473
DOC_USP7_MATH_1	670	674	PF00917	0.486
DOC_USP7_MATH_1	69	73	PF00917	0.709
DOC_USP7_MATH_1	75	79	PF00917	0.678
DOC_USP7_UBL2_3	130	134	PF12436	0.762
DOC_USP7_UBL2_3	639	643	PF12436	0.473
DOC_USP7_UBL2_3	722	726	PF12436	0.534
DOC_WW_Pin1_4	19	24	PF00397	0.694
DOC_WW_Pin1_4	246	251	PF00397	0.726
DOC_WW_Pin1_4	300	305	PF00397	0.730
DOC_WW_Pin1_4	316	321	PF00397	0.643
DOC_WW_Pin1_4	33	38	PF00397	0.708
DOC_WW_Pin1_4	536	541	PF00397	0.536
DOC_WW_Pin1_4	6	11	PF00397	0.698
DOC_WW_Pin1_4	650	655	PF00397	0.524
DOC_WW_Pin1_4	672	677	PF00397	0.584
DOC_WW_Pin1_4	685	690	PF00397	0.426
DOC_WW_Pin1_4	783	788	PF00397	0.309
LIG_14-3-3_CanoR_1	153	163	PF00244	0.750
LIG_14-3-3_CanoR_1	168	177	PF00244	0.647
LIG_14-3-3_CanoR_1	338	346	PF00244	0.697
LIG_14-3-3_CanoR_1	427	431	PF00244	0.756
LIG_14-3-3_CanoR_1	479	485	PF00244	0.689
LIG_14-3-3_CanoR_1	551	559	PF00244	0.521
LIG_14-3-3_CanoR_1	704	709	PF00244	0.466
LIG_14-3-3_CanoR_1	770	778	PF00244	0.598
LIG_14-3-3_CanoR_1	780	784	PF00244	0.226
LIG_Actin_WH2_2	223	239	PF00022	0.657
LIG_BIR_II_1	1	5	PF00653	0.705
LIG_BRCT_BRCA1_1	201	205	PF00533	0.691
LIG_BRCT_BRCA1_1	447	451	PF00533	0.659
LIG_BRCT_BRCA1_1	481	485	PF00533	0.673
LIG_CORNRBOX	615	623	PF00104	0.482
LIG_deltaCOP1_diTrp_1	805	815	PF00928	0.273
LIG_eIF4E_1	542	548	PF01652	0.509
LIG_FHA_1	170	176	PF00498	0.732
LIG_FHA_1	290	296	PF00498	0.724
LIG_FHA_1	301	307	PF00498	0.673
LIG_FHA_1	403	409	PF00498	0.597
LIG_FHA_1	528	534	PF00498	0.615
LIG_FHA_1	552	558	PF00498	0.522
LIG_FHA_1	623	629	PF00498	0.568
LIG_FHA_1	632	638	PF00498	0.408
LIG_FHA_1	651	657	PF00498	0.473
LIG_FHA_1	714	720	PF00498	0.483
LIG_FHA_1	769	775	PF00498	0.487
LIG_FHA_1	815	821	PF00498	0.389
LIG_FHA_2	105	111	PF00498	0.612
LIG_FHA_2	171	177	PF00498	0.726
LIG_FHA_2	19	25	PF00498	0.741
LIG_FHA_2	214	220	PF00498	0.721
LIG_FHA_2	306	312	PF00498	0.655
LIG_FHA_2	342	348	PF00498	0.682
LIG_FHA_2	455	461	PF00498	0.665
LIG_FHA_2	495	501	PF00498	0.558
LIG_FHA_2	650	656	PF00498	0.491
LIG_IRF3_LxIS_1	759	765	PF10401	0.473
LIG_LIR_Apic_2	31	37	PF02991	0.712
LIG_LIR_Apic_2	314	320	PF02991	0.692
LIG_LIR_Gen_1	202	213	PF02991	0.673
LIG_LIR_Gen_1	568	577	PF02991	0.473
LIG_LIR_Gen_1	610	619	PF02991	0.493
LIG_LIR_Gen_1	809	820	PF02991	0.327
LIG_LIR_Nem_3	202	208	PF02991	0.686
LIG_LIR_Nem_3	211	217	PF02991	0.655
LIG_LIR_Nem_3	486	492	PF02991	0.542
LIG_LIR_Nem_3	568	574	PF02991	0.473
LIG_LIR_Nem_3	598	603	PF02991	0.465
LIG_LIR_Nem_3	610	614	PF02991	0.516
LIG_LIR_Nem_3	782	788	PF02991	0.317
LIG_LIR_Nem_3	809	815	PF02991	0.393
LIG_MLH1_MIPbox_1	481	485	PF16413	0.673
LIG_NRBOX	677	683	PF00104	0.473
LIG_Pex14_1	808	812	PF04695	0.273
LIG_Pex14_2	485	489	PF04695	0.601
LIG_Pex14_2	799	803	PF04695	0.277
LIG_SH2_GRB2like	387	390	PF00017	0.526
LIG_SH2_NCK_1	240	244	PF00017	0.701
LIG_SH2_SRC	282	285	PF00017	0.733
LIG_SH2_STAP1	339	343	PF00017	0.660
LIG_SH2_STAP1	624	628	PF00017	0.524
LIG_SH2_STAP1	812	816	PF00017	0.288
LIG_SH2_STAT3	484	487	PF00017	0.579
LIG_SH2_STAT3	542	545	PF00017	0.522
LIG_SH2_STAT5	387	390	PF00017	0.526
LIG_SH2_STAT5	484	487	PF00017	0.579
LIG_SH2_STAT5	512	515	PF00017	0.624
LIG_SH2_STAT5	546	549	PF00017	0.527
LIG_SH2_STAT5	624	627	PF00017	0.561
LIG_SH2_STAT5	660	663	PF00017	0.491
LIG_SH3_3	244	250	PF00018	0.696
LIG_SH3_3	298	304	PF00018	0.682
LIG_SH3_3	37	43	PF00018	0.687
LIG_SH3_3	420	426	PF00018	0.732
LIG_SH3_3	427	433	PF00018	0.709
LIG_SH3_3	52	58	PF00018	0.673
LIG_SH3_3	63	69	PF00018	0.780
LIG_SH3_3	643	649	PF00018	0.512
LIG_SUMO_SIM_par_1	571	576	PF11976	0.473
LIG_SUMO_SIM_par_1	86	93	PF11976	0.674
LIG_TRAF2_1	107	110	PF00917	0.623
LIG_TRAF2_1	220	223	PF00917	0.701
LIG_TRAF2_1	457	460	PF00917	0.629
LIG_TRAF2_1	463	466	PF00917	0.606
LIG_TRAF2_1	610	613	PF00917	0.473
LIG_WRC_WIRS_1	695	700	PF05994	0.299
LIG_WRC_WIRS_1	766	771	PF05994	0.309
LIG_WW_3	56	60	PF00397	0.632
MOD_CDC14_SPxK_1	22	25	PF00782	0.572
MOD_CDK_SPxK_1	19	25	PF00069	0.580
MOD_CDK_SPxxK_3	672	679	PF00069	0.444
MOD_CDK_SPxxK_3	685	692	PF00069	0.269
MOD_CK1_1	121	127	PF00069	0.569
MOD_CK1_1	133	139	PF00069	0.649
MOD_CK1_1	148	154	PF00069	0.543
MOD_CK1_1	156	162	PF00069	0.653
MOD_CK1_1	169	175	PF00069	0.577
MOD_CK1_1	185	191	PF00069	0.682
MOD_CK1_1	193	199	PF00069	0.705
MOD_CK1_1	3	9	PF00069	0.699
MOD_CK1_1	44	50	PF00069	0.714
MOD_CK1_1	472	478	PF00069	0.599
MOD_CK1_1	560	566	PF00069	0.403
MOD_CK1_1	607	613	PF00069	0.311
MOD_CK1_1	672	678	PF00069	0.314
MOD_CK1_1	765	771	PF00069	0.326
MOD_CK2_1	104	110	PF00069	0.516
MOD_CK2_1	454	460	PF00069	0.586
MOD_CK2_1	480	486	PF00069	0.531
MOD_CK2_1	560	566	PF00069	0.475
MOD_CK2_1	607	613	PF00069	0.309
MOD_CK2_1	649	655	PF00069	0.311
MOD_CK2_1	738	744	PF00069	0.381
MOD_Cter_Amidation	137	140	PF01082	0.719
MOD_Cter_Amidation	144	147	PF01082	0.589
MOD_GlcNHglycan	120	124	PF01048	0.616
MOD_GlcNHglycan	153	156	PF01048	0.621
MOD_GlcNHglycan	178	181	PF01048	0.697
MOD_GlcNHglycan	296	299	PF01048	0.693
MOD_GlcNHglycan	320	323	PF01048	0.608
MOD_GlcNHglycan	341	344	PF01048	0.626
MOD_GlcNHglycan	393	396	PF01048	0.442
MOD_GlcNHglycan	43	46	PF01048	0.640
MOD_GlcNHglycan	655	659	PF01048	0.281
MOD_GlcNHglycan	71	74	PF01048	0.638
MOD_GSK3_1	118	125	PF00069	0.542
MOD_GSK3_1	145	152	PF00069	0.639
MOD_GSK3_1	154	161	PF00069	0.644
MOD_GSK3_1	166	173	PF00069	0.597
MOD_GSK3_1	178	185	PF00069	0.641
MOD_GSK3_1	186	193	PF00069	0.618
MOD_GSK3_1	194	201	PF00069	0.606
MOD_GSK3_1	24	31	PF00069	0.672
MOD_GSK3_1	246	253	PF00069	0.644
MOD_GSK3_1	290	297	PF00069	0.687
MOD_GSK3_1	305	312	PF00069	0.543
MOD_GSK3_1	316	323	PF00069	0.564
MOD_GSK3_1	387	394	PF00069	0.408
MOD_GSK3_1	44	51	PF00069	0.716
MOD_GSK3_1	465	472	PF00069	0.565
MOD_GSK3_1	622	629	PF00069	0.341
MOD_GSK3_1	650	657	PF00069	0.333
MOD_GSK3_1	75	82	PF00069	0.609
MOD_GSK3_1	765	772	PF00069	0.490
MOD_GSK3_1	779	786	PF00069	0.342
MOD_N-GLC_1	149	154	PF02516	0.643
MOD_N-GLC_1	3	8	PF02516	0.697
MOD_N-GLC_1	506	511	PF02516	0.387
MOD_N-GLC_1	607	612	PF02516	0.381
MOD_N-GLC_1	713	718	PF02516	0.310
MOD_NEK2_1	119	124	PF00069	0.422
MOD_NEK2_1	29	34	PF00069	0.652
MOD_NEK2_1	403	408	PF00069	0.567
MOD_NEK2_1	467	472	PF00069	0.575
MOD_NEK2_1	485	490	PF00069	0.525
MOD_NEK2_1	49	54	PF00069	0.620
MOD_NEK2_1	519	524	PF00069	0.423
MOD_NEK2_1	565	570	PF00069	0.389
MOD_NEK2_1	669	674	PF00069	0.313
MOD_NEK2_1	738	743	PF00069	0.381
MOD_NEK2_1	762	767	PF00069	0.352
MOD_NEK2_1	814	819	PF00069	0.253
MOD_NEK2_2	506	511	PF00069	0.387
MOD_PIKK_1	403	409	PF00454	0.564
MOD_PIKK_1	416	422	PF00454	0.537
MOD_PIKK_1	445	451	PF00454	0.576
MOD_PIKK_1	595	601	PF00454	0.334
MOD_PIKK_1	713	719	PF00454	0.309
MOD_PK_1	704	710	PF00069	0.299
MOD_PKA_1	704	710	PF00069	0.299
MOD_PKA_2	145	151	PF00069	0.640
MOD_PKA_2	161	167	PF00069	0.627
MOD_PKA_2	169	175	PF00069	0.617
MOD_PKA_2	182	188	PF00069	0.816
MOD_PKA_2	24	30	PF00069	0.649
MOD_PKA_2	426	432	PF00069	0.708
MOD_PKA_2	445	451	PF00069	0.459
MOD_PKA_2	703	709	PF00069	0.309
MOD_PKA_2	75	81	PF00069	0.609
MOD_PKA_2	769	775	PF00069	0.484
MOD_PKA_2	779	785	PF00069	0.226
MOD_PKB_1	147	155	PF00069	0.660
MOD_PKB_1	168	176	PF00069	0.672
MOD_Plk_1	16	22	PF00069	0.652
MOD_Plk_1	454	460	PF00069	0.709
MOD_Plk_1	485	491	PF00069	0.402
MOD_Plk_1	506	512	PF00069	0.388
MOD_Plk_1	527	533	PF00069	0.509
MOD_Plk_1	560	566	PF00069	0.403
MOD_Plk_1	607	613	PF00069	0.309
MOD_Plk_1	804	810	PF00069	0.309
MOD_Plk_2-3	284	290	PF00069	0.665
MOD_Plk_4	30	36	PF00069	0.593
MOD_Plk_4	480	486	PF00069	0.519
MOD_Plk_4	519	525	PF00069	0.419
MOD_Plk_4	527	533	PF00069	0.479
MOD_Plk_4	560	566	PF00069	0.434
MOD_Plk_4	694	700	PF00069	0.299
MOD_Plk_4	755	761	PF00069	0.309
MOD_Plk_4	779	785	PF00069	0.317
MOD_Plk_4	786	792	PF00069	0.364
MOD_ProDKin_1	19	25	PF00069	0.620
MOD_ProDKin_1	246	252	PF00069	0.663
MOD_ProDKin_1	300	306	PF00069	0.672
MOD_ProDKin_1	316	322	PF00069	0.550
MOD_ProDKin_1	33	39	PF00069	0.639
MOD_ProDKin_1	536	542	PF00069	0.398
MOD_ProDKin_1	6	12	PF00069	0.625
MOD_ProDKin_1	650	656	PF00069	0.381
MOD_ProDKin_1	672	678	PF00069	0.465
MOD_ProDKin_1	685	691	PF00069	0.243
MOD_ProDKin_1	783	789	PF00069	0.309
MOD_SUMO_rev_2	638	645	PF00179	0.323
MOD_SUMO_rev_2	751	759	PF00179	0.309
TRG_DiLeu_BaEn_2	640	646	PF01217	0.309
TRG_DiLeu_BaEn_2	693	699	PF01217	0.309
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.567
TRG_DiLeu_BaLyEn_6	677	682	PF01217	0.309
TRG_ENDOCYTIC_2	282	285	PF00928	0.624
TRG_ENDOCYTIC_2	354	357	PF00928	0.491
TRG_ENDOCYTIC_2	812	815	PF00928	0.343
TRG_ER_diArg_1	137	140	PF00400	0.644
TRG_ER_diArg_1	142	144	PF00400	0.639
TRG_ER_diArg_1	146	149	PF00400	0.649
TRG_ER_diArg_1	678	680	PF00400	0.331
TRG_ER_diArg_1	85	87	PF00400	0.562
TRG_NLS_MonoExtN_4	132	138	PF00514	0.630
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	679	683	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7K4	Leptomonas seymouri	61%	100%
A4H894	Leishmania braziliensis	74%	98%
A4HWL6	Leishmania infantum	99%	100%
E9AQC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%
Q4QF51	Leishmania major	94%	100%