GPI-anchored protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WTK4_LEIDO

TriTrypDb:

LdBPK_150590.1 , LdCL_150011000 , LDHU3_15.0740

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.466
CLV_C14_Caspase3-7	273	277	PF00656	0.433
CLV_NRD_NRD_1	73	75	PF00675	0.617
CLV_PCSK_SKI1_1	286	290	PF00082	0.675
CLV_PCSK_SKI1_1	295	299	PF00082	0.771
CLV_PCSK_SKI1_1	316	320	PF00082	0.324
CLV_PCSK_SKI1_1	40	44	PF00082	0.607
DEG_ODPH_VHL_1	15	26	PF01847	0.417
DEG_SPOP_SBC_1	108	112	PF00917	0.400
DEG_SPOP_SBC_1	137	141	PF00917	0.415
DOC_CDC14_PxL_1	13	21	PF14671	0.427
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.444
DOC_MAPK_gen_1	230	240	PF00069	0.388
DOC_PP1_RVXF_1	284	290	PF00149	0.362
DOC_PP2B_LxvP_1	241	244	PF13499	0.409
DOC_PP2B_LxvP_1	9	12	PF13499	0.448
DOC_PP4_MxPP_1	182	185	PF00568	0.380
DOC_USP7_MATH_1	108	112	PF00917	0.402
DOC_USP7_MATH_1	226	230	PF00917	0.411
DOC_USP7_MATH_1	271	275	PF00917	0.395
DOC_USP7_MATH_1	310	314	PF00917	0.267
DOC_USP7_MATH_1	47	51	PF00917	0.403
DOC_USP7_UBL2_3	75	79	PF12436	0.404
DOC_WW_Pin1_4	115	120	PF00397	0.425
DOC_WW_Pin1_4	306	311	PF00397	0.447
LIG_14-3-3_CanoR_1	31	39	PF00244	0.499
LIG_14-3-3_CanoR_1	316	321	PF00244	0.338
LIG_APCC_ABBA_1	196	201	PF00400	0.420
LIG_BRCT_BRCA1_1	117	121	PF00533	0.433
LIG_Clathr_ClatBox_1	297	301	PF01394	0.544
LIG_CSL_BTD_1	119	122	PF09270	0.431
LIG_FHA_1	170	176	PF00498	0.407
LIG_FHA_1	20	26	PF00498	0.433
LIG_FHA_1	229	235	PF00498	0.461
LIG_FHA_1	256	262	PF00498	0.411
LIG_FHA_1	97	103	PF00498	0.461
LIG_FHA_2	137	143	PF00498	0.417
LIG_FHA_2	166	172	PF00498	0.407
LIG_FHA_2	59	65	PF00498	0.410
LIG_Integrin_isoDGR_2	264	266	PF01839	0.590
LIG_MYND_1	181	185	PF01753	0.411
LIG_NRBOX	19	25	PF00104	0.415
LIG_PCNA_yPIPBox_3	188	199	PF02747	0.418
LIG_SH2_CRK	205	209	PF00017	0.381
LIG_SH2_GRB2like	205	208	PF00017	0.393
LIG_SH2_NCK_1	106	110	PF00017	0.374
LIG_SH2_NCK_1	199	203	PF00017	0.486
LIG_SH2_NCK_1	205	209	PF00017	0.400
LIG_SH2_SRC	205	208	PF00017	0.374
LIG_SH2_SRC	52	55	PF00017	0.376
LIG_SH2_STAP1	199	203	PF00017	0.397
LIG_SH2_STAP1	52	56	PF00017	0.414
LIG_SH2_STAT5	106	109	PF00017	0.444
LIG_SH2_STAT5	199	202	PF00017	0.395
LIG_SH2_STAT5	203	206	PF00017	0.391
LIG_SH2_STAT5	291	294	PF00017	0.398
LIG_SH3_3	116	122	PF00018	0.433
LIG_SH3_3	141	147	PF00018	0.472
LIG_SH3_3	178	184	PF00018	0.373
LIG_SH3_3	304	310	PF00018	0.426
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.436
LIG_SUMO_SIM_par_1	16	22	PF11976	0.421
LIG_TRAF2_1	153	156	PF00917	0.533
LIG_TRFH_1	298	302	PF08558	0.389
MOD_CK1_1	110	116	PF00069	0.383
MOD_CK1_1	225	231	PF00069	0.527
MOD_CK1_1	306	312	PF00069	0.445
MOD_CK1_1	96	102	PF00069	0.403
MOD_CK2_1	136	142	PF00069	0.483
MOD_CK2_1	150	156	PF00069	0.501
MOD_CK2_1	221	227	PF00069	0.459
MOD_GlcNHglycan	160	163	PF01048	0.659
MOD_GlcNHglycan	224	227	PF01048	0.750
MOD_GlcNHglycan	273	276	PF01048	0.644
MOD_GlcNHglycan	278	281	PF01048	0.625
MOD_GlcNHglycan	282	285	PF01048	0.603
MOD_GlcNHglycan	49	52	PF01048	0.610
MOD_GlcNHglycan	5	8	PF01048	0.588
MOD_GSK3_1	104	111	PF00069	0.473
MOD_GSK3_1	165	172	PF00069	0.410
MOD_GSK3_1	221	228	PF00069	0.441
MOD_GSK3_1	276	283	PF00069	0.430
MOD_GSK3_1	287	294	PF00069	0.405
MOD_GSK3_1	306	313	PF00069	0.384
MOD_N-GLC_1	104	109	PF02516	0.612
MOD_N-GLC_1	221	226	PF02516	0.641
MOD_N-GLC_2	260	262	PF02516	0.536
MOD_NEK2_1	19	24	PF00069	0.362
MOD_NEK2_1	221	226	PF00069	0.533
MOD_NEK2_1	255	260	PF00069	0.410
MOD_NEK2_1	287	292	PF00069	0.381
MOD_NEK2_1	3	8	PF00069	0.495
MOD_NEK2_1	70	75	PF00069	0.400
MOD_NEK2_1	90	95	PF00069	0.345
MOD_PIKK_1	121	127	PF00454	0.435
MOD_PKA_2	255	261	PF00069	0.379
MOD_Plk_1	170	176	PF00069	0.433
MOD_Plk_1	90	96	PF00069	0.400
MOD_Plk_2-3	151	157	PF00069	0.448
MOD_Plk_4	127	133	PF00069	0.548
MOD_Plk_4	19	25	PF00069	0.418
MOD_Plk_4	310	316	PF00069	0.314
MOD_Plk_4	321	327	PF00069	0.255
MOD_ProDKin_1	115	121	PF00069	0.424
MOD_ProDKin_1	306	312	PF00069	0.445
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.450
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.231
TRG_ENDOCYTIC_2	205	208	PF00928	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P748	Leptomonas seymouri	40%	100%
A4H829	Leishmania braziliensis	64%	100%
A4HWF5	Leishmania infantum	99%	100%
E9AQ54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QFC8	Leishmania major	89%	100%