RNA pseudouridylate synthase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTI6_LEIDO

TriTrypDb:

LdBPK_150410.1 , LdCL_150009000 , LDHU3_15.0510

Length:

1030

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTI6

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	6
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009451	RNA modification	5	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0009982	pseudouridine synthase activity	4	6
GO:0016853	isomerase activity	2	6
GO:0016866	intramolecular transferase activity	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.580
CLV_C14_Caspase3-7	583	587	PF00656	0.688
CLV_NRD_NRD_1	143	145	PF00675	0.569
CLV_NRD_NRD_1	170	172	PF00675	0.619
CLV_NRD_NRD_1	200	202	PF00675	0.527
CLV_NRD_NRD_1	214	216	PF00675	0.582
CLV_NRD_NRD_1	351	353	PF00675	0.516
CLV_NRD_NRD_1	411	413	PF00675	0.538
CLV_NRD_NRD_1	433	435	PF00675	0.703
CLV_NRD_NRD_1	474	476	PF00675	0.683
CLV_NRD_NRD_1	623	625	PF00675	0.650
CLV_NRD_NRD_1	675	677	PF00675	0.470
CLV_NRD_NRD_1	852	854	PF00675	0.380
CLV_PCSK_FUR_1	212	216	PF00082	0.527
CLV_PCSK_KEX2_1	143	145	PF00082	0.569
CLV_PCSK_KEX2_1	170	172	PF00082	0.619
CLV_PCSK_KEX2_1	200	202	PF00082	0.527
CLV_PCSK_KEX2_1	214	216	PF00082	0.582
CLV_PCSK_KEX2_1	351	353	PF00082	0.516
CLV_PCSK_KEX2_1	433	435	PF00082	0.703
CLV_PCSK_KEX2_1	474	476	PF00082	0.718
CLV_PCSK_KEX2_1	553	555	PF00082	0.751
CLV_PCSK_KEX2_1	623	625	PF00082	0.594
CLV_PCSK_KEX2_1	807	809	PF00082	0.727
CLV_PCSK_KEX2_1	852	854	PF00082	0.380
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.753
CLV_PCSK_PC1ET2_1	807	809	PF00082	0.691
CLV_PCSK_PC7_1	196	202	PF00082	0.509
CLV_PCSK_PC7_1	470	476	PF00082	0.658
CLV_PCSK_SKI1_1	16	20	PF00082	0.546
CLV_PCSK_SKI1_1	170	174	PF00082	0.586
CLV_PCSK_SKI1_1	203	207	PF00082	0.485
CLV_PCSK_SKI1_1	280	284	PF00082	0.539
CLV_PCSK_SKI1_1	300	304	PF00082	0.603
CLV_PCSK_SKI1_1	511	515	PF00082	0.594
CLV_PCSK_SKI1_1	518	522	PF00082	0.726
CLV_PCSK_SKI1_1	550	554	PF00082	0.846
CLV_PCSK_SKI1_1	556	560	PF00082	0.754
CLV_PCSK_SKI1_1	810	814	PF00082	0.690
CLV_PCSK_SKI1_1	862	866	PF00082	0.309
CLV_PCSK_SKI1_1	90	94	PF00082	0.498
CLV_Separin_Metazoa	363	367	PF03568	0.426
DEG_APCC_DBOX_1	279	287	PF00400	0.501
DEG_APCC_DBOX_1	685	693	PF00400	0.476
DEG_APCC_DBOX_1	894	902	PF00400	0.542
DEG_SCF_FBW7_1	941	948	PF00400	0.702
DEG_SPOP_SBC_1	125	129	PF00917	0.664
DEG_SPOP_SBC_1	671	675	PF00917	0.576
DOC_CKS1_1	701	706	PF01111	0.513
DOC_CKS1_1	942	947	PF01111	0.706
DOC_CYCLIN_RxL_1	297	306	PF00134	0.594
DOC_CYCLIN_RxL_1	508	517	PF00134	0.587
DOC_CYCLIN_RxL_1	84	94	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	901	907	PF00134	0.495
DOC_MAPK_gen_1	862	870	PF00069	0.513
DOC_MAPK_HePTP_8	459	473	PF00069	0.533
DOC_MAPK_MEF2A_6	732	741	PF00069	0.419
DOC_MAPK_MEF2A_6	890	898	PF00069	0.542
DOC_MAPK_MEF2A_6	90	97	PF00069	0.500
DOC_MAPK_MEF2A_6	910	918	PF00069	0.301
DOC_MAPK_NFAT4_5	90	98	PF00069	0.507
DOC_PP1_RVXF_1	278	285	PF00149	0.523
DOC_PP1_RVXF_1	63	70	PF00149	0.572
DOC_PP2B_LxvP_1	35	38	PF13499	0.649
DOC_PP2B_LxvP_1	668	671	PF13499	0.783
DOC_PP2B_LxvP_1	715	718	PF13499	0.740
DOC_PP4_FxxP_1	172	175	PF00568	0.546
DOC_PP4_FxxP_1	79	82	PF00568	0.514
DOC_USP7_MATH_1	1024	1028	PF00917	0.555
DOC_USP7_MATH_1	156	160	PF00917	0.687
DOC_USP7_MATH_1	2	6	PF00917	0.729
DOC_USP7_MATH_1	213	217	PF00917	0.584
DOC_USP7_MATH_1	270	274	PF00917	0.584
DOC_USP7_MATH_1	455	459	PF00917	0.569
DOC_USP7_MATH_1	487	491	PF00917	0.770
DOC_USP7_MATH_1	525	529	PF00917	0.745
DOC_USP7_MATH_1	56	60	PF00917	0.667
DOC_USP7_MATH_1	607	611	PF00917	0.496
DOC_USP7_MATH_1	63	67	PF00917	0.579
DOC_USP7_MATH_1	630	634	PF00917	0.755
DOC_USP7_MATH_1	671	675	PF00917	0.599
DOC_USP7_MATH_1	721	725	PF00917	0.729
DOC_USP7_MATH_1	945	949	PF00917	0.699
DOC_USP7_MATH_1	962	966	PF00917	0.627
DOC_WW_Pin1_4	152	157	PF00397	0.600
DOC_WW_Pin1_4	374	379	PF00397	0.654
DOC_WW_Pin1_4	473	478	PF00397	0.613
DOC_WW_Pin1_4	488	493	PF00397	0.554
DOC_WW_Pin1_4	700	705	PF00397	0.579
DOC_WW_Pin1_4	754	759	PF00397	0.655
DOC_WW_Pin1_4	795	800	PF00397	0.670
DOC_WW_Pin1_4	941	946	PF00397	0.687
LIG_14-3-3_CanoR_1	170	175	PF00244	0.541
LIG_14-3-3_CanoR_1	412	417	PF00244	0.507
LIG_14-3-3_CanoR_1	454	460	PF00244	0.552
LIG_14-3-3_CanoR_1	623	629	PF00244	0.666
LIG_14-3-3_CanoR_1	710	718	PF00244	0.742
LIG_14-3-3_CanoR_1	73	78	PF00244	0.576
LIG_14-3-3_CanoR_1	732	740	PF00244	0.428
LIG_14-3-3_CanoR_1	784	789	PF00244	0.688
LIG_14-3-3_CanoR_1	862	871	PF00244	0.538
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_BIR_III_1	1	5	PF00653	0.610
LIG_BIR_III_3	1	5	PF00653	0.610
LIG_BIR_III_4	719	723	PF00653	0.696
LIG_BRCT_BRCA1_1	128	132	PF00533	0.637
LIG_BRCT_BRCA1_1	75	79	PF00533	0.500
LIG_BRCT_BRCA1_1	983	987	PF00533	0.633
LIG_Clathr_ClatBox_1	1018	1022	PF01394	0.637
LIG_deltaCOP1_diTrp_1	274	278	PF00928	0.548
LIG_deltaCOP1_diTrp_1	505	514	PF00928	0.670
LIG_eIF4E_1	1013	1019	PF01652	0.643
LIG_FHA_1	111	117	PF00498	0.561
LIG_FHA_1	415	421	PF00498	0.504
LIG_FHA_1	574	580	PF00498	0.697
LIG_FHA_1	6	12	PF00498	0.676
LIG_FHA_1	607	613	PF00498	0.607
LIG_FHA_1	816	822	PF00498	0.572
LIG_FHA_1	889	895	PF00498	0.542
LIG_FHA_2	317	323	PF00498	0.513
LIG_FHA_2	47	53	PF00498	0.786
LIG_FHA_2	501	507	PF00498	0.651
LIG_LIR_Apic_2	169	175	PF02991	0.579
LIG_LIR_Apic_2	439	445	PF02991	0.569
LIG_LIR_Apic_2	753	758	PF02991	0.553
LIG_LIR_Apic_2	76	82	PF02991	0.509
LIG_LIR_Gen_1	505	515	PF02991	0.675
LIG_LIR_Gen_1	66	77	PF02991	0.565
LIG_LIR_Gen_1	908	918	PF02991	0.527
LIG_LIR_Gen_1	99	105	PF02991	0.601
LIG_LIR_Nem_3	505	510	PF02991	0.572
LIG_LIR_Nem_3	66	72	PF02991	0.495
LIG_LIR_Nem_3	908	914	PF02991	0.622
LIG_LIR_Nem_3	99	105	PF02991	0.601
LIG_MYND_1	374	378	PF01753	0.490
LIG_PCNA_TLS_4	90	97	PF02747	0.500
LIG_Pex14_2	96	100	PF04695	0.540
LIG_SH2_CRK	442	446	PF00017	0.676
LIG_SH2_CRK	456	460	PF00017	0.511
LIG_SH2_CRK	75	79	PF00017	0.500
LIG_SH2_NCK_1	1009	1013	PF00017	0.475
LIG_SH2_NCK_1	873	877	PF00017	0.542
LIG_SH2_PTP2	911	914	PF00017	0.619
LIG_SH2_SRC	1013	1016	PF00017	0.549
LIG_SH2_STAP1	1009	1013	PF00017	0.487
LIG_SH2_STAP1	456	460	PF00017	0.624
LIG_SH2_STAP1	595	599	PF00017	0.695
LIG_SH2_STAP1	75	79	PF00017	0.500
LIG_SH2_STAT5	1009	1012	PF00017	0.429
LIG_SH2_STAT5	17	20	PF00017	0.557
LIG_SH2_STAT5	177	180	PF00017	0.485
LIG_SH2_STAT5	595	598	PF00017	0.708
LIG_SH2_STAT5	679	682	PF00017	0.482
LIG_SH2_STAT5	77	80	PF00017	0.506
LIG_SH2_STAT5	857	860	PF00017	0.613
LIG_SH2_STAT5	911	914	PF00017	0.521
LIG_SH3_3	1018	1024	PF00018	0.540
LIG_SH3_3	237	243	PF00018	0.653
LIG_SH3_3	326	332	PF00018	0.697
LIG_SH3_3	394	400	PF00018	0.616
LIG_SH3_3	401	407	PF00018	0.552
LIG_SH3_3	449	455	PF00018	0.632
LIG_SH3_3	549	555	PF00018	0.842
LIG_SH3_3	663	669	PF00018	0.712
LIG_SH3_3	738	744	PF00018	0.488
LIG_SH3_3	939	945	PF00018	0.689
LIG_SUMO_SIM_par_1	1017	1022	PF11976	0.638
LIG_TRAF2_1	529	532	PF00917	0.754
LIG_WW_1	592	595	PF00397	0.663
LIG_WW_2	666	669	PF00397	0.599
MOD_CDK_SPxxK_3	473	480	PF00069	0.627
MOD_CK1_1	124	130	PF00069	0.685
MOD_CK1_1	152	158	PF00069	0.666
MOD_CK1_1	216	222	PF00069	0.655
MOD_CK1_1	265	271	PF00069	0.728
MOD_CK1_1	310	316	PF00069	0.660
MOD_CK1_1	415	421	PF00069	0.504
MOD_CK1_1	491	497	PF00069	0.701
MOD_CK1_1	5	11	PF00069	0.667
MOD_CK1_1	647	653	PF00069	0.776
MOD_CK1_1	705	711	PF00069	0.686
MOD_CK1_1	728	734	PF00069	0.639
MOD_CK1_1	786	792	PF00069	0.590
MOD_CK1_1	848	854	PF00069	0.600
MOD_CK1_1	863	869	PF00069	0.459
MOD_CK1_1	948	954	PF00069	0.645
MOD_CK2_1	287	293	PF00069	0.587
MOD_CK2_1	415	421	PF00069	0.479
MOD_CK2_1	493	499	PF00069	0.813
MOD_CK2_1	526	532	PF00069	0.744
MOD_CMANNOS	275	278	PF00535	0.526
MOD_Cter_Amidation	198	201	PF01082	0.510
MOD_GlcNHglycan	123	126	PF01048	0.705
MOD_GlcNHglycan	128	131	PF01048	0.788
MOD_GlcNHglycan	133	136	PF01048	0.642
MOD_GlcNHglycan	162	165	PF01048	0.775
MOD_GlcNHglycan	218	221	PF01048	0.615
MOD_GlcNHglycan	232	235	PF01048	0.756
MOD_GlcNHglycan	267	271	PF01048	0.745
MOD_GlcNHglycan	309	312	PF01048	0.711
MOD_GlcNHglycan	31	34	PF01048	0.657
MOD_GlcNHglycan	324	327	PF01048	0.635
MOD_GlcNHglycan	386	389	PF01048	0.686
MOD_GlcNHglycan	407	410	PF01048	0.565
MOD_GlcNHglycan	481	485	PF01048	0.622
MOD_GlcNHglycan	493	496	PF01048	0.757
MOD_GlcNHglycan	5	8	PF01048	0.633
MOD_GlcNHglycan	58	61	PF01048	0.590
MOD_GlcNHglycan	583	586	PF01048	0.664
MOD_GlcNHglycan	609	612	PF01048	0.483
MOD_GlcNHglycan	649	652	PF01048	0.806
MOD_GlcNHglycan	723	726	PF01048	0.769
MOD_GlcNHglycan	728	731	PF01048	0.777
MOD_GlcNHglycan	733	736	PF01048	0.746
MOD_GlcNHglycan	788	791	PF01048	0.742
MOD_GlcNHglycan	831	834	PF01048	0.682
MOD_GlcNHglycan	862	865	PF01048	0.342
MOD_GlcNHglycan	931	934	PF01048	0.679
MOD_GlcNHglycan	969	972	PF01048	0.746
MOD_GSK3_1	121	128	PF00069	0.697
MOD_GSK3_1	144	151	PF00069	0.691
MOD_GSK3_1	152	159	PF00069	0.724
MOD_GSK3_1	160	167	PF00069	0.498
MOD_GSK3_1	2	9	PF00069	0.590
MOD_GSK3_1	216	223	PF00069	0.707
MOD_GSK3_1	262	269	PF00069	0.734
MOD_GSK3_1	303	310	PF00069	0.591
MOD_GSK3_1	316	323	PF00069	0.604
MOD_GSK3_1	384	391	PF00069	0.603
MOD_GSK3_1	487	494	PF00069	0.750
MOD_GSK3_1	618	625	PF00069	0.553
MOD_GSK3_1	705	712	PF00069	0.666
MOD_GSK3_1	721	728	PF00069	0.527
MOD_GSK3_1	750	757	PF00069	0.685
MOD_GSK3_1	782	789	PF00069	0.602
MOD_GSK3_1	841	848	PF00069	0.717
MOD_GSK3_1	929	936	PF00069	0.698
MOD_GSK3_1	941	948	PF00069	0.667
MOD_N-GLC_1	630	635	PF02516	0.639
MOD_N-GLC_1	654	659	PF02516	0.593
MOD_NEK2_1	105	110	PF00069	0.657
MOD_NEK2_1	303	308	PF00069	0.583
MOD_NEK2_1	395	400	PF00069	0.447
MOD_NEK2_1	580	585	PF00069	0.712
MOD_NEK2_1	783	788	PF00069	0.563
MOD_NEK2_1	847	852	PF00069	0.580
MOD_NEK2_1	955	960	PF00069	0.596
MOD_NEK2_1	987	992	PF00069	0.565
MOD_NEK2_2	335	340	PF00069	0.491
MOD_NEK2_2	593	598	PF00069	0.603
MOD_NEK2_2	857	862	PF00069	0.542
MOD_PIKK_1	705	711	PF00454	0.747
MOD_PK_1	412	418	PF00069	0.506
MOD_PKA_1	170	176	PF00069	0.566
MOD_PKA_1	412	418	PF00069	0.506
MOD_PKA_2	160	166	PF00069	0.717
MOD_PKA_2	170	176	PF00069	0.557
MOD_PKA_2	213	219	PF00069	0.559
MOD_PKA_2	29	35	PF00069	0.643
MOD_PKA_2	580	586	PF00069	0.712
MOD_PKA_2	622	628	PF00069	0.608
MOD_PKA_2	709	715	PF00069	0.779
MOD_PKA_2	731	737	PF00069	0.485
MOD_PKA_2	783	789	PF00069	0.568
MOD_PKA_2	840	846	PF00069	0.697
MOD_PKB_1	228	236	PF00069	0.734
MOD_PKB_1	516	524	PF00069	0.775
MOD_PKB_1	808	816	PF00069	0.677
MOD_Plk_1	144	150	PF00069	0.634
MOD_Plk_1	311	317	PF00069	0.602
MOD_Plk_1	563	569	PF00069	0.704
MOD_Plk_1	63	69	PF00069	0.420
MOD_Plk_1	630	636	PF00069	0.644
MOD_Plk_1	877	883	PF00069	0.542
MOD_Plk_1	948	954	PF00069	0.598
MOD_Plk_2-3	1017	1023	PF00069	0.635
MOD_Plk_2-3	287	293	PF00069	0.697
MOD_Plk_4	144	150	PF00069	0.692
MOD_Plk_4	368	374	PF00069	0.452
MOD_Plk_4	415	421	PF00069	0.504
MOD_Plk_4	455	461	PF00069	0.628
MOD_Plk_4	509	515	PF00069	0.530
MOD_Plk_4	73	79	PF00069	0.510
MOD_Plk_4	750	756	PF00069	0.592
MOD_Plk_4	877	883	PF00069	0.595
MOD_ProDKin_1	152	158	PF00069	0.600
MOD_ProDKin_1	374	380	PF00069	0.658
MOD_ProDKin_1	473	479	PF00069	0.620
MOD_ProDKin_1	488	494	PF00069	0.553
MOD_ProDKin_1	700	706	PF00069	0.593
MOD_ProDKin_1	754	760	PF00069	0.659
MOD_ProDKin_1	795	801	PF00069	0.666
MOD_ProDKin_1	941	947	PF00069	0.672
MOD_SUMO_rev_2	637	647	PF00179	0.587
TRG_DiLeu_BaEn_1	293	298	PF01217	0.684
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.755
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.691
TRG_ENDOCYTIC_2	456	459	PF00928	0.529
TRG_ENDOCYTIC_2	75	78	PF00928	0.497
TRG_ENDOCYTIC_2	911	914	PF00928	0.521
TRG_ER_diArg_1	170	172	PF00400	0.619
TRG_ER_diArg_1	200	202	PF00400	0.527
TRG_ER_diArg_1	212	215	PF00400	0.561
TRG_ER_diArg_1	339	342	PF00400	0.511
TRG_ER_diArg_1	350	352	PF00400	0.558
TRG_ER_diArg_1	433	435	PF00400	0.697
TRG_ER_diArg_1	473	475	PF00400	0.683
TRG_ER_diArg_1	852	854	PF00400	0.580
TRG_NLS_MonoExtN_4	805	811	PF00514	0.525
TRG_Pf-PMV_PEXEL_1	16	21	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	919	924	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P442	Leptomonas seymouri	43%	100%
A4H810	Leishmania braziliensis	66%	98%
E9AQ38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QFE4	Leishmania major	87%	100%