Nucleotide-sugar transporter, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleotide-sugar transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTI2_LEIDO

TriTrypDb:

LdBPK_150900.1 , LdCL_150014500 , LDHU3_15.1150

Length:

461

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	9
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	9
GO:0098588	bounding membrane of organelle	4	9
GO:0110165	cellular anatomical entity	1	9

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Expansion

Sequence features

A0A3S7WTI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTI2

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0008643	carbohydrate transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0071702	organic substance transport	4	7

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	9
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	9
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	9
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	9
GO:0022857	transmembrane transporter activity	2	9
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.699
CLV_NRD_NRD_1	194	196	PF00675	0.263
CLV_NRD_NRD_1	255	257	PF00675	0.278
CLV_NRD_NRD_1	32	34	PF00675	0.501
CLV_NRD_NRD_1	60	62	PF00675	0.490
CLV_PCSK_KEX2_1	16	18	PF00082	0.550
CLV_PCSK_KEX2_1	194	196	PF00082	0.262
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.550
CLV_PCSK_SKI1_1	100	104	PF00082	0.526
CLV_PCSK_SKI1_1	237	241	PF00082	0.294

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R3	Leptomonas seymouri	62%	100%
A0A0S4JKR6	Bodo saltans	40%	100%
A0A1X0NTU7	Trypanosomatidae	44%	100%
A0A422NRC3	Trypanosoma rangeli	43%	100%
A4HWI2	Leishmania infantum	100%	100%
B8B350	Oryza sativa subsp. indica	28%	100%
E9AQ83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
P78382	Homo sapiens	26%	100%
Q02334	Caenorhabditis elegans	23%	100%
Q61420	Mus musculus	26%	100%

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