Nucleotide-sugar transporter, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleotide-sugar transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTI2_LEIDO

TriTrypDb:

LdBPK_150900.1 , LdCL_150014500 , LDHU3_15.1150

Length:

461

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	9
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	9
GO:0098588	bounding membrane of organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7WTI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTI2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0008643	carbohydrate transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0071702	organic substance transport	4	7

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	9
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	9
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	9
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	9
GO:0022857	transmembrane transporter activity	2	9
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.699
CLV_NRD_NRD_1	194	196	PF00675	0.263
CLV_NRD_NRD_1	255	257	PF00675	0.278
CLV_NRD_NRD_1	32	34	PF00675	0.501
CLV_NRD_NRD_1	60	62	PF00675	0.490
CLV_PCSK_KEX2_1	16	18	PF00082	0.550
CLV_PCSK_KEX2_1	194	196	PF00082	0.262
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.550
CLV_PCSK_SKI1_1	100	104	PF00082	0.526
CLV_PCSK_SKI1_1	237	241	PF00082	0.294
CLV_PCSK_SKI1_1	34	38	PF00082	0.500
CLV_PCSK_SKI1_1	457	461	PF00082	0.506
DEG_SPOP_SBC_1	345	349	PF00917	0.333
DOC_CDC14_PxL_1	41	49	PF14671	0.683
DOC_CYCLIN_RxL_1	234	241	PF00134	0.294
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.698
DOC_CYCLIN_yCln2_LP_2	408	414	PF00134	0.347
DOC_MAPK_gen_1	256	264	PF00069	0.495
DOC_MAPK_gen_1	306	313	PF00069	0.456
DOC_MAPK_HePTP_8	253	265	PF00069	0.524
DOC_MAPK_MEF2A_6	168	175	PF00069	0.326
DOC_MAPK_MEF2A_6	256	265	PF00069	0.474
DOC_MAPK_MEF2A_6	370	379	PF00069	0.295
DOC_PP1_RVXF_1	235	241	PF00149	0.294
DOC_PP1_RVXF_1	98	105	PF00149	0.678
DOC_PP2B_LxvP_1	103	106	PF13499	0.717
DOC_PP2B_LxvP_1	408	411	PF13499	0.347
DOC_USP7_MATH_1	205	209	PF00917	0.347
DOC_USP7_MATH_1	32	36	PF00917	0.700
DOC_USP7_MATH_1	335	339	PF00917	0.394
DOC_USP7_MATH_1	368	372	PF00917	0.322
DOC_USP7_MATH_1	403	407	PF00917	0.313
DOC_USP7_MATH_2	106	112	PF00917	0.759
DOC_WW_Pin1_4	113	118	PF00397	0.699
DOC_WW_Pin1_4	271	276	PF00397	0.313
DOC_WW_Pin1_4	36	41	PF00397	0.733
DOC_WW_Pin1_4	9	14	PF00397	0.724
LIG_14-3-3_CanoR_1	199	205	PF00244	0.443
LIG_14-3-3_CanoR_1	33	37	PF00244	0.702
LIG_14-3-3_CanoR_1	86	93	PF00244	0.678
LIG_14-3-3_CterR_2	457	461	PF00244	0.706
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_BIR_III_1	1	5	PF00653	0.667
LIG_BIR_III_3	1	5	PF00653	0.667
LIG_BRCT_BRCA1_1	137	141	PF00533	0.408
LIG_BRCT_BRCA1_1	388	392	PF00533	0.436
LIG_EH1_1	203	211	PF00400	0.347
LIG_eIF4E_1	204	210	PF01652	0.368
LIG_FHA_1	131	137	PF00498	0.424
LIG_FHA_1	227	233	PF00498	0.244
LIG_FHA_1	234	240	PF00498	0.266
LIG_FHA_1	275	281	PF00498	0.279
LIG_FHA_1	352	358	PF00498	0.326
LIG_FHA_1	411	417	PF00498	0.368
LIG_FHA_2	424	430	PF00498	0.243
LIG_HP1_1	374	378	PF01393	0.424
LIG_LIR_Apic_2	270	275	PF02991	0.408
LIG_LIR_Gen_1	212	222	PF02991	0.363
LIG_LIR_Gen_1	229	238	PF02991	0.162
LIG_LIR_Nem_3	137	143	PF02991	0.321
LIG_LIR_Nem_3	180	186	PF02991	0.439
LIG_LIR_Nem_3	208	214	PF02991	0.321
LIG_LIR_Nem_3	229	233	PF02991	0.281
LIG_LIR_Nem_3	241	247	PF02991	0.182
LIG_LIR_Nem_3	438	444	PF02991	0.311
LIG_MLH1_MIPbox_1	137	141	PF16413	0.394
LIG_NRBOX	284	290	PF00104	0.289
LIG_Pex14_2	240	244	PF04695	0.322
LIG_Pex14_2	327	331	PF04695	0.383
LIG_Pex14_2	392	396	PF04695	0.313
LIG_PTB_Apo_2	213	220	PF02174	0.294
LIG_PTB_Apo_2	325	332	PF02174	0.349
LIG_SH2_CRK	214	218	PF00017	0.302
LIG_SH2_CRK	323	327	PF00017	0.313
LIG_SH2_NCK_1	204	208	PF00017	0.368
LIG_SH2_NCK_1	214	218	PF00017	0.368
LIG_SH2_NCK_1	323	327	PF00017	0.347
LIG_SH2_SRC	321	324	PF00017	0.313
LIG_SH2_STAP1	323	327	PF00017	0.350
LIG_SH2_STAT5	147	150	PF00017	0.294
LIG_SH2_STAT5	211	214	PF00017	0.345
LIG_SH2_STAT5	321	324	PF00017	0.348
LIG_SH2_STAT5	444	447	PF00017	0.515
LIG_SH3_3	111	117	PF00018	0.734
LIG_SH3_3	37	43	PF00018	0.732
LIG_SH3_3	99	105	PF00018	0.682
LIG_SUMO_SIM_par_1	45	50	PF11976	0.672
LIG_TRAF2_1	96	99	PF00917	0.714
LIG_TRFH_1	245	249	PF08558	0.424
LIG_TYR_ITSM	210	217	PF00017	0.347
LIG_UBA3_1	160	168	PF00899	0.347
LIG_UBA3_1	263	271	PF00899	0.406
LIG_Vh1_VBS_1	248	266	PF01044	0.480
MOD_CDK_SPxxK_3	9	16	PF00069	0.692
MOD_CK1_1	274	280	PF00069	0.324
MOD_CK1_1	338	344	PF00069	0.314
MOD_CK1_1	455	461	PF00069	0.635
MOD_CK1_1	60	66	PF00069	0.740
MOD_CK1_1	68	74	PF00069	0.700
MOD_CK1_1	78	84	PF00069	0.582
MOD_CK2_1	403	409	PF00069	0.307
MOD_GlcNHglycan	110	113	PF01048	0.503
MOD_GlcNHglycan	126	129	PF01048	0.172
MOD_GlcNHglycan	20	25	PF01048	0.505
MOD_GlcNHglycan	29	32	PF01048	0.419
MOD_GlcNHglycan	383	386	PF01048	0.338
MOD_GlcNHglycan	388	391	PF01048	0.308
MOD_GlcNHglycan	405	408	PF01048	0.299
MOD_GlcNHglycan	457	460	PF01048	0.444
MOD_GlcNHglycan	81	84	PF01048	0.506
MOD_GSK3_1	104	111	PF00069	0.711
MOD_GSK3_1	113	120	PF00069	0.659
MOD_GSK3_1	130	137	PF00069	0.154
MOD_GSK3_1	141	148	PF00069	0.308
MOD_GSK3_1	184	191	PF00069	0.489
MOD_GSK3_1	205	212	PF00069	0.424
MOD_GSK3_1	267	274	PF00069	0.408
MOD_GSK3_1	32	39	PF00069	0.700
MOD_GSK3_1	344	351	PF00069	0.302
MOD_GSK3_1	53	60	PF00069	0.724
MOD_GSK3_1	75	82	PF00069	0.728
MOD_N-GLC_1	79	84	PF02516	0.520
MOD_NEK2_1	124	129	PF00069	0.542
MOD_NEK2_1	130	135	PF00069	0.307
MOD_NEK2_1	141	146	PF00069	0.254
MOD_NEK2_1	169	174	PF00069	0.335
MOD_NEK2_1	188	193	PF00069	0.345
MOD_NEK2_1	209	214	PF00069	0.436
MOD_NEK2_1	233	238	PF00069	0.312
MOD_NEK2_1	27	32	PF00069	0.694
MOD_NEK2_1	292	297	PF00069	0.300
MOD_NEK2_1	344	349	PF00069	0.281
MOD_NEK2_1	381	386	PF00069	0.341
MOD_NEK2_1	442	447	PF00069	0.374
MOD_NEK2_1	47	52	PF00069	0.506
MOD_NEK2_1	85	90	PF00069	0.722
MOD_PK_1	309	315	PF00069	0.524
MOD_PKA_2	145	151	PF00069	0.256
MOD_PKA_2	32	38	PF00069	0.700
MOD_PKA_2	60	66	PF00069	0.685
MOD_PKA_2	68	74	PF00069	0.700
MOD_PKA_2	85	91	PF00069	0.677
MOD_Plk_1	118	124	PF00069	0.607
MOD_Plk_1	450	456	PF00069	0.618
MOD_Plk_1	79	85	PF00069	0.720
MOD_Plk_4	130	136	PF00069	0.331
MOD_Plk_4	184	190	PF00069	0.459
MOD_Plk_4	205	211	PF00069	0.341
MOD_Plk_4	32	38	PF00069	0.700
MOD_Plk_4	335	341	PF00069	0.402
MOD_Plk_4	436	442	PF00069	0.275
MOD_Plk_4	68	74	PF00069	0.700
MOD_ProDKin_1	113	119	PF00069	0.697
MOD_ProDKin_1	271	277	PF00069	0.313
MOD_ProDKin_1	36	42	PF00069	0.732
MOD_ProDKin_1	9	15	PF00069	0.725
MOD_SUMO_for_1	305	308	PF00179	0.474
MOD_SUMO_rev_2	9	18	PF00179	0.694
TRG_DiLeu_BaEn_2	178	184	PF01217	0.495
TRG_ENDOCYTIC_2	214	217	PF00928	0.304
TRG_ENDOCYTIC_2	230	233	PF00928	0.294
TRG_ENDOCYTIC_2	323	326	PF00928	0.328
TRG_NES_CRM1_1	165	179	PF08389	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R3	Leptomonas seymouri	62%	100%
A0A0S4JKR6	Bodo saltans	40%	100%
A0A1X0NTU7	Trypanosomatidae	44%	100%
A0A422NRC3	Trypanosoma rangeli	43%	100%
A4HWI2	Leishmania infantum	100%	100%
B8B350	Oryza sativa subsp. indica	28%	100%
E9AQ83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
P78382	Homo sapiens	26%	100%
Q02334	Caenorhabditis elegans	23%	100%
Q61420	Mus musculus	26%	100%
Q654D9	Oryza sativa subsp. japonica	28%	100%
Q8LGE9	Arabidopsis thaliana	25%	100%
Q9VMU8	Drosophila melanogaster	32%	100%
Q9Y2D2	Homo sapiens	28%	100%
V5B4K3	Trypanosoma cruzi	42%	100%