LeishMANIAdb
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Sugar (And other) transporter, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Sugar (And other) transporter, putative
Gene product:
Sugar (and other) transporter, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WTH9_LEIDO
TriTrypDb:
LdBPK_150930.1 , LdCL_150014800 , LDHU3_15.1200
Length:
625

Annotations

LeishMANIAdb annotations

A family with high similarity to plant sugar transporters.. Might be an extensive family that already diverged in free-living Kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13

Expansion

Sequence features

A0A3S7WTH9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTH9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 12
GO:0022857 transmembrane transporter activity 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 4 8 PF00656 0.688
CLV_NRD_NRD_1 216 218 PF00675 0.535
CLV_NRD_NRD_1 365 367 PF00675 0.472
CLV_PCSK_KEX2_1 216 218 PF00082 0.476
CLV_PCSK_SKI1_1 23 27 PF00082 0.501
CLV_PCSK_SKI1_1 356 360 PF00082 0.491
CLV_PCSK_SKI1_1 367 371 PF00082 0.467
CLV_PCSK_SKI1_1 415 419 PF00082 0.348
CLV_PCSK_SKI1_1 520 524 PF00082 0.401
DEG_Nend_UBRbox_2 1 3 PF02207 0.649
DEG_SCF_TRCP1_1 7 12 PF00400 0.668
DEG_SPOP_SBC_1 13 17 PF00917 0.643
DOC_ANK_TNKS_1 392 399 PF00023 0.652
DOC_CYCLIN_RxL_1 20 27 PF00134 0.665
DOC_CYCLIN_RxL_1 362 371 PF00134 0.669
DOC_CYCLIN_yCln2_LP_2 227 233 PF00134 0.377
DOC_CYCLIN_yCln2_LP_2 591 597 PF00134 0.416
DOC_MAPK_gen_1 216 226 PF00069 0.306
DOC_MAPK_gen_1 325 334 PF00069 0.682
DOC_MAPK_MEF2A_6 217 226 PF00069 0.307
DOC_MAPK_MEF2A_6 486 495 PF00069 0.503
DOC_MAPK_MEF2A_6 52 60 PF00069 0.529
DOC_MAPK_NFAT4_5 219 227 PF00069 0.360
DOC_PP1_RVXF_1 323 329 PF00149 0.680
DOC_PP2B_LxvP_1 370 373 PF13499 0.666
DOC_PP2B_LxvP_1 591 594 PF13499 0.360
DOC_USP7_MATH_1 14 18 PF00917 0.694
DOC_USP7_MATH_1 288 292 PF00917 0.775
DOC_USP7_MATH_1 308 312 PF00917 0.598
DOC_USP7_MATH_1 40 44 PF00917 0.659
DOC_USP7_MATH_1 432 436 PF00917 0.355
DOC_USP7_MATH_1 469 473 PF00917 0.424
DOC_USP7_MATH_1 549 553 PF00917 0.366
DOC_WW_Pin1_4 284 289 PF00397 0.719
DOC_WW_Pin1_4 50 55 PF00397 0.567
DOC_WW_Pin1_4 618 623 PF00397 0.790
DOC_WW_Pin1_4 9 14 PF00397 0.633
LIG_14-3-3_CanoR_1 219 225 PF00244 0.360
LIG_14-3-3_CanoR_1 23 31 PF00244 0.739
LIG_14-3-3_CanoR_1 254 259 PF00244 0.714
LIG_14-3-3_CanoR_1 325 334 PF00244 0.710
LIG_14-3-3_CanoR_1 356 365 PF00244 0.686
LIG_14-3-3_CanoR_1 415 421 PF00244 0.627
LIG_14-3-3_CanoR_1 544 553 PF00244 0.503
LIG_14-3-3_CanoR_1 575 579 PF00244 0.332
LIG_Actin_WH2_2 312 329 PF00022 0.681
LIG_Actin_WH2_2 395 412 PF00022 0.650
LIG_Actin_WH2_2 68 86 PF00022 0.346
LIG_BIR_III_2 330 334 PF00653 0.683
LIG_BRCT_BRCA1_1 376 380 PF00533 0.637
LIG_eIF4E_1 199 205 PF01652 0.429
LIG_eIF4E_1 461 467 PF01652 0.317
LIG_FHA_1 141 147 PF00498 0.382
LIG_FHA_1 20 26 PF00498 0.729
LIG_FHA_1 221 227 PF00498 0.413
LIG_FHA_1 280 286 PF00498 0.757
LIG_FHA_1 319 325 PF00498 0.711
LIG_FHA_1 327 333 PF00498 0.729
LIG_FHA_1 479 485 PF00498 0.658
LIG_FHA_1 496 502 PF00498 0.364
LIG_FHA_1 529 535 PF00498 0.483
LIG_FHA_1 579 585 PF00498 0.452
LIG_FHA_1 615 621 PF00498 0.689
LIG_FHA_2 163 169 PF00498 0.369
LIG_FHA_2 276 282 PF00498 0.776
LIG_LIR_Gen_1 144 155 PF02991 0.304
LIG_LIR_Gen_1 2 11 PF02991 0.623
LIG_LIR_Gen_1 59 70 PF02991 0.388
LIG_LIR_Nem_3 144 150 PF02991 0.319
LIG_LIR_Nem_3 2 6 PF02991 0.617
LIG_LIR_Nem_3 412 417 PF02991 0.675
LIG_LIR_Nem_3 438 444 PF02991 0.341
LIG_LIR_Nem_3 59 65 PF02991 0.400
LIG_PCNA_yPIPBox_3 520 528 PF02747 0.360
LIG_Pex14_2 137 141 PF04695 0.469
LIG_PTB_Apo_2 522 529 PF02174 0.317
LIG_REV1ctd_RIR_1 204 212 PF16727 0.240
LIG_SH2_CRK 159 163 PF00017 0.446
LIG_SH2_STAP1 70 74 PF00017 0.360
LIG_SH2_STAT5 159 162 PF00017 0.416
LIG_SH2_STAT5 195 198 PF00017 0.407
LIG_SH2_STAT5 441 444 PF00017 0.348
LIG_SH2_STAT5 461 464 PF00017 0.175
LIG_SH2_STAT5 567 570 PF00017 0.334
LIG_SH3_3 282 288 PF00018 0.774
LIG_SH3_3 437 443 PF00018 0.362
LIG_SH3_3 51 57 PF00018 0.486
LIG_SH3_3 619 625 PF00018 0.770
LIG_SUMO_SIM_anti_2 551 557 PF11976 0.338
LIG_SUMO_SIM_anti_2 85 93 PF11976 0.276
LIG_SUMO_SIM_par_1 260 265 PF11976 0.753
LIG_SUMO_SIM_par_1 428 435 PF11976 0.415
LIG_SUMO_SIM_par_1 500 506 PF11976 0.240
LIG_SUMO_SIM_par_1 614 621 PF11976 0.767
LIG_SUMO_SIM_par_1 85 93 PF11976 0.331
LIG_TYR_ITIM 439 444 PF00017 0.363
LIG_WRC_WIRS_1 91 96 PF05994 0.317
MOD_CK1_1 12 18 PF00069 0.692
MOD_CK1_1 24 30 PF00069 0.625
MOD_CK1_1 253 259 PF00069 0.704
MOD_CK1_1 337 343 PF00069 0.778
MOD_CK1_1 42 48 PF00069 0.570
MOD_CK1_1 435 441 PF00069 0.331
MOD_CK1_1 50 56 PF00069 0.534
MOD_CK1_1 554 560 PF00069 0.374
MOD_CK1_1 68 74 PF00069 0.410
MOD_CK1_1 97 103 PF00069 0.451
MOD_CK2_1 162 168 PF00069 0.369
MOD_CK2_1 265 271 PF00069 0.747
MOD_CK2_1 275 281 PF00069 0.710
MOD_CK2_1 445 451 PF00069 0.315
MOD_CK2_1 545 551 PF00069 0.503
MOD_CMANNOS 139 142 PF00535 0.295
MOD_GlcNHglycan 17 20 PF01048 0.451
MOD_GlcNHglycan 267 270 PF01048 0.606
MOD_GlcNHglycan 334 337 PF01048 0.577
MOD_GlcNHglycan 370 373 PF01048 0.591
MOD_GlcNHglycan 376 379 PF01048 0.465
MOD_GlcNHglycan 434 437 PF01048 0.399
MOD_GlcNHglycan 547 550 PF01048 0.297
MOD_GlcNHglycan 558 561 PF01048 0.340
MOD_GlcNHglycan 7 10 PF01048 0.481
MOD_GlcNHglycan 94 97 PF01048 0.376
MOD_GlcNHglycan 99 102 PF01048 0.401
MOD_GSK3_1 13 20 PF00069 0.684
MOD_GSK3_1 157 164 PF00069 0.435
MOD_GSK3_1 250 257 PF00069 0.534
MOD_GSK3_1 275 282 PF00069 0.794
MOD_GSK3_1 284 291 PF00069 0.742
MOD_GSK3_1 314 321 PF00069 0.764
MOD_GSK3_1 405 412 PF00069 0.754
MOD_GSK3_1 461 468 PF00069 0.449
MOD_GSK3_1 5 12 PF00069 0.718
MOD_GSK3_1 502 509 PF00069 0.437
MOD_GSK3_1 545 552 PF00069 0.497
MOD_GSK3_1 554 561 PF00069 0.341
MOD_GSK3_1 574 581 PF00069 0.190
MOD_GSK3_1 614 621 PF00069 0.783
MOD_GSK3_1 90 97 PF00069 0.441
MOD_N-GLC_1 374 379 PF02516 0.547
MOD_N-GLC_1 386 391 PF02516 0.472
MOD_NEK2_1 141 146 PF00069 0.381
MOD_NEK2_1 171 176 PF00069 0.539
MOD_NEK2_1 409 414 PF00069 0.746
MOD_NEK2_1 478 483 PF00069 0.634
MOD_NEK2_1 495 500 PF00069 0.324
MOD_NEK2_1 502 507 PF00069 0.407
MOD_NEK2_1 523 528 PF00069 0.373
MOD_NEK2_1 578 583 PF00069 0.403
MOD_NEK2_1 586 591 PF00069 0.403
MOD_NEK2_1 602 607 PF00069 0.578
MOD_NEK2_1 65 70 PF00069 0.440
MOD_NEK2_1 82 87 PF00069 0.321
MOD_NEK2_1 94 99 PF00069 0.341
MOD_PIKK_1 24 30 PF00454 0.657
MOD_PIKK_1 254 260 PF00454 0.676
MOD_PIKK_1 294 300 PF00454 0.798
MOD_PK_1 119 125 PF00069 0.476
MOD_PKA_2 253 259 PF00069 0.746
MOD_PKA_2 326 332 PF00069 0.767
MOD_PKA_2 409 415 PF00069 0.641
MOD_PKA_2 574 580 PF00069 0.329
MOD_PKB_1 354 362 PF00069 0.641
MOD_PKB_1 413 421 PF00069 0.514
MOD_Plk_1 386 392 PF00069 0.764
MOD_Plk_1 602 608 PF00069 0.711
MOD_Plk_1 614 620 PF00069 0.625
MOD_Plk_4 302 308 PF00069 0.808
MOD_Plk_4 386 392 PF00069 0.831
MOD_Plk_4 397 403 PF00069 0.709
MOD_Plk_4 462 468 PF00069 0.437
MOD_Plk_4 523 529 PF00069 0.463
MOD_Plk_4 551 557 PF00069 0.360
MOD_Plk_4 574 580 PF00069 0.304
MOD_Plk_4 586 592 PF00069 0.439
MOD_Plk_4 68 74 PF00069 0.443
MOD_Plk_4 85 91 PF00069 0.393
MOD_ProDKin_1 284 290 PF00069 0.720
MOD_ProDKin_1 50 56 PF00069 0.558
MOD_ProDKin_1 618 624 PF00069 0.790
MOD_ProDKin_1 9 15 PF00069 0.633
TRG_DiLeu_BaEn_1 551 556 PF01217 0.338
TRG_ENDOCYTIC_2 159 162 PF00928 0.388
TRG_ENDOCYTIC_2 441 444 PF00928 0.326
TRG_ER_diArg_1 118 121 PF00400 0.507
TRG_ER_diArg_1 215 217 PF00400 0.304
TRG_ER_diArg_1 324 327 PF00400 0.681
TRG_Pf-PMV_PEXEL_1 23 28 PF00026 0.478

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5K5 Leptomonas seymouri 25% 100%
A0A1X0NU64 Trypanosomatidae 36% 100%
A0A1X0NVK4 Trypanosomatidae 32% 100%
A0A3Q8IIA5 Leishmania donovani 27% 100%
A4H859 Leishmania braziliensis 70% 100%
A4HWI5 Leishmania infantum 100% 100%
A4IA48 Leishmania infantum 26% 100%
E9AQ86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9B562 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
Q4Q2S3 Leishmania major 26% 100%
Q4QF97 Leishmania major 87% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS