Calmodulin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calmodulin-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WTH8_LEIDO

TriTrypDb:

LdBPK_150990.1 , LdCL_150015400 , LDHU3_15.1270

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTH8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.430
CLV_NRD_NRD_1	57	59	PF00675	0.405
CLV_PCSK_KEX2_1	57	59	PF00082	0.420
CLV_PCSK_PC7_1	53	59	PF00082	0.406
CLV_PCSK_SKI1_1	133	137	PF00082	0.428
CLV_PCSK_SKI1_1	49	53	PF00082	0.484
DEG_APCC_DBOX_1	109	117	PF00400	0.451
DEG_APCC_DBOX_1	132	140	PF00400	0.510
DEG_SCF_FBW7_1	156	162	PF00400	0.454
DEG_SPOP_SBC_1	160	164	PF00917	0.626
DOC_CKS1_1	156	161	PF01111	0.447
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.518
DOC_MAPK_gen_1	110	119	PF00069	0.455
DOC_PP4_FxxP_1	22	25	PF00568	0.462
DOC_USP7_MATH_2	25	31	PF00917	0.525
DOC_WW_Pin1_4	13	18	PF00397	0.639
DOC_WW_Pin1_4	155	160	PF00397	0.435
DOC_WW_Pin1_4	161	166	PF00397	0.513
LIG_14-3-3_CanoR_1	110	120	PF00244	0.519
LIG_14-3-3_CanoR_1	57	64	PF00244	0.399
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_BIR_III_1	1	5	PF00653	0.658
LIG_BIR_III_3	1	5	PF00653	0.658
LIG_deltaCOP1_diTrp_1	27	35	PF00928	0.376
LIG_FHA_1	162	168	PF00498	0.496
LIG_FHA_1	29	35	PF00498	0.403
LIG_FHA_1	38	44	PF00498	0.414
LIG_FHA_2	120	126	PF00498	0.558
LIG_FHA_2	161	167	PF00498	0.576
LIG_FHA_2	58	64	PF00498	0.404
LIG_FHA_2	90	96	PF00498	0.483
LIG_LIR_Gen_1	29	37	PF02991	0.407
LIG_LIR_Gen_1	76	84	PF02991	0.397
LIG_LIR_Nem_3	29	35	PF02991	0.401
LIG_LIR_Nem_3	76	80	PF02991	0.394
LIG_NRBOX	115	121	PF00104	0.366
LIG_NRBOX	63	69	PF00104	0.427
LIG_SH2_CRK	88	92	PF00017	0.432
LIG_SH2_NCK_1	59	63	PF00017	0.409
LIG_SH2_STAP1	77	81	PF00017	0.502
LIG_SH2_STAT5	155	158	PF00017	0.548
LIG_SH2_STAT5	59	62	PF00017	0.407
LIG_SH2_STAT5	88	91	PF00017	0.491
LIG_SUMO_SIM_anti_2	114	122	PF11976	0.394
LIG_SUMO_SIM_par_1	114	122	PF11976	0.394
LIG_TRAF2_1	91	94	PF00917	0.564
LIG_UBA3_1	119	126	PF00899	0.417
MOD_CK2_1	119	125	PF00069	0.439
MOD_CK2_1	57	63	PF00069	0.404
MOD_Cter_Amidation	55	58	PF01082	0.391
MOD_GlcNHglycan	107	110	PF01048	0.395
MOD_GSK3_1	111	118	PF00069	0.406
MOD_GSK3_1	155	162	PF00069	0.384
MOD_GSK3_1	37	44	PF00069	0.402
MOD_NEK2_1	119	124	PF00069	0.418
MOD_NEK2_1	26	31	PF00069	0.596
MOD_PKA_1	57	63	PF00069	0.404
MOD_PKA_2	37	43	PF00069	0.440
MOD_PKA_2	57	63	PF00069	0.451
MOD_Plk_2-3	138	144	PF00069	0.474
MOD_ProDKin_1	13	19	PF00069	0.639
MOD_ProDKin_1	155	161	PF00069	0.446
MOD_SUMO_rev_2	42	51	PF00179	0.383
TRG_DiLeu_BaEn_1	115	120	PF01217	0.363
TRG_DiLeu_BaEn_1	63	68	PF01217	0.407
TRG_ENDOCYTIC_2	77	80	PF00928	0.422
TRG_ER_diArg_1	146	149	PF00400	0.499
TRG_ER_diArg_1	57	59	PF00400	0.398
TRG_NES_CRM1_1	94	107	PF08389	0.546
TRG_Pf-PMV_PEXEL_1	133	138	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P206	Leptomonas seymouri	28%	100%
A0A0N1HZV4	Leptomonas seymouri	88%	99%
A0A0S4IS38	Bodo saltans	28%	100%
A0A0S4IUE7	Bodo saltans	67%	100%
A0A0S4J7U6	Bodo saltans	24%	100%
A0A0S4JFC8	Bodo saltans	28%	100%
A0A0S4JFY6	Bodo saltans	30%	100%
A0A0S4JGZ3	Bodo saltans	29%	100%
A0A0S4KHL8	Bodo saltans	30%	77%
A0A1X0NMM5	Trypanosomatidae	28%	100%
A0A1X0NU74	Trypanosomatidae	66%	100%
A0A1X0NXW5	Trypanosomatidae	29%	100%
A0A1X0P9X3	Trypanosomatidae	25%	100%
A0A3Q8IHK5	Leishmania donovani	23%	100%
A0A3R7RDM4	Trypanosoma rangeli	71%	100%
A0A422MQ47	Trypanosoma rangeli	29%	100%
A0A422N5Z1	Trypanosoma rangeli	24%	99%
A0A422NIM0	Trypanosoma rangeli	31%	100%
A0A422P0I1	Trypanosoma rangeli	25%	100%
A2WN93	Oryza sativa subsp. indica	29%	100%
A2WNH1	Oryza sativa subsp. indica	30%	100%
A2Y609	Oryza sativa subsp. indica	29%	100%
A3E3H0	Pfiesteria piscicida	29%	100%
A3E4D8	Prorocentrum minimum	29%	100%
A3E4F9	Karlodinium veneficum	29%	100%
A4H5R9	Leishmania braziliensis	28%	100%
A4H866	Leishmania braziliensis	90%	100%
A4HPN5	Leishmania braziliensis	25%	100%
A4HU13	Leishmania infantum	28%	100%
A4HWJ1	Leishmania infantum	100%	100%
A4IA04	Leishmania infantum	23%	100%
A4IF97	Bos taurus	29%	100%
A4UHC0	Alexandrium fundyense	29%	100%
A8CEP3	Saccharina japonica	26%	100%
A8I1Q0	Heterocapsa triquetra	29%	100%
B1PSN3	Leishmania donovani	28%	100%
C9ZML6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZXV2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D0A9H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A9H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D2DGW3	Tyrophagus putrescentiae	26%	100%
E9AMU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AQ92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B525	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
F1SSF9	Sus scrofa	27%	100%
O00897	Dictyostelium discoideum	26%	100%
O02367	Ciona intestinalis	28%	100%
O14950	Homo sapiens	29%	100%
O16305	Caenorhabditis elegans	28%	100%
O23184	Arabidopsis thaliana	23%	100%
O23320	Arabidopsis thaliana	29%	100%
O60041	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	33%	100%
O82018	Mougeotia scalaris	28%	100%
O82659	Arabidopsis thaliana	24%	100%
O94739	Pleurotus ostreatus	26%	100%
O96081	Halocynthia roretzi	28%	100%
O96102	Physarum polycephalum	28%	100%
O97341	Suberites domuncula	28%	100%
P02585	Homo sapiens	24%	100%
P02586	Oryctolagus cuniculus	24%	100%
P02587	Sus scrofa	23%	100%
P02588	Gallus gallus	26%	100%
P02589	Pelophylax lessonae	24%	100%
P02591	Oryctolagus cuniculus	27%	100%
P02594	Electrophorus electricus	28%	100%
P02595	Patinopecten sp.	28%	100%
P02597	Gallus gallus	29%	100%
P02598	Tetrahymena pyriformis	29%	100%
P02599	Dictyostelium discoideum	29%	100%
P02607	Gallus gallus	31%	100%
P02609	Gallus gallus	24%	100%
P02611	Gallus gallus	24%	100%
P02612	Gallus gallus	27%	100%
P04352	Chlamydomonas reinhardtii	29%	100%
P04353	Spinacia oleracea	29%	100%
P04464	Triticum aestivum	29%	100%
P04466	Rattus norvegicus	24%	100%
P05419	Gallus gallus	29%	100%
P05434	Chlamydomonas reinhardtii	23%	100%
P05932	Arbacia punctulata	28%	100%
P05933	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P05936	Coturnix japonica	28%	100%
P06787	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P07461	Halocynthia roretzi	23%	100%
P07462	Halocynthia roretzi	31%	100%
P07463	Paramecium tetraurelia	28%	100%
P08053	Physarum polycephalum	32%	100%
P08733	Rattus norvegicus	23%	100%
P09542	Mus musculus	32%	93%
P09860	Gallus gallus	28%	100%
P0DH95	Arabidopsis thaliana	29%	100%
P0DH96	Arabidopsis thaliana	29%	100%
P0DH97	Arabidopsis thaliana	29%	100%
P0DH98	Arabidopsis thaliana	29%	100%
P0DP23	Homo sapiens	28%	100%
P0DP24	Homo sapiens	28%	100%
P0DP25	Homo sapiens	28%	100%
P0DP26	Mus musculus	28%	100%
P0DP27	Mus musculus	28%	100%
P0DP28	Mus musculus	28%	100%
P0DP29	Rattus norvegicus	28%	100%
P0DP30	Rattus norvegicus	28%	100%
P0DP31	Rattus norvegicus	28%	100%
P0DP33	Xenopus laevis	28%	100%
P0DP34	Xenopus laevis	28%	100%
P0DP35	Xenopus laevis	28%	100%
P10246	Meleagris gallopavo	25%	100%
P10916	Homo sapiens	25%	100%
P11118	Euglena gracilis	29%	100%
P11120	Pleurotus cornucopiae	26%	100%
P11121	Pyuridae sp.	28%	100%
P13832	Rattus norvegicus	27%	100%
P13868	Solanum tuberosum	29%	100%
P14533	Doryteuthis pealeii	26%	100%
P15094	Achlya klebsiana	25%	100%
P15159	Tachypleus tridentatus	25%	100%
P16409	Rattus norvegicus	32%	94%
P17928	Medicago sativa	29%	100%
P18061	Trypanosoma cruzi	28%	100%
P18666	Rattus norvegicus	28%	100%
P19105	Homo sapiens	28%	100%
P19123	Mus musculus	27%	100%
P19625	Caenorhabditis elegans	25%	100%
P19626	Caenorhabditis elegans	25%	100%
P20801	Mus musculus	25%	100%
P21251	Stichopus japonicus	28%	100%
P23286	Candida albicans	30%	100%
P24032	Gallus gallus	28%	100%
P24044	Plasmodium falciparum	29%	100%
P24844	Homo sapiens	28%	100%
P27161	Solanum lycopersicum	29%	100%
P27163	Petunia hybrida	27%	100%
P27164	Petunia hybrida	29%	100%
P27165	Phytophthora infestans	26%	100%
P27166	Stylonychia lemnae	29%	100%
P27482	Homo sapiens	28%	100%
P29269	Sus scrofa	28%	100%
P35622	Mizuhopecten yessoensis	28%	100%
P41040	Zea mays	28%	100%
P41041	Pneumocystis carinii	27%	100%
P41209	Mus musculus	24%	100%
P41210	Atriplex nummularia	24%	100%
P43646	Tetraselmis striata	23%	100%
P48976	Malus domestica	28%	100%
P49258	Drosophila melanogaster	28%	100%
P53141	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P53440	Naegleria gruberi	25%	100%
P54357	Drosophila melanogaster	34%	100%
P59220	Arabidopsis thaliana	29%	100%
P60204	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	100%
P60205	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	26%	100%
P60206	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	26%	100%
P61859	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	100%
P61860	Colletotrichum trifolii	26%	100%
P61861	Colletotrichum gloeosporioides	26%	100%
P62144	Anas platyrhynchos	28%	100%
P62145	Aplysia californica	28%	100%
P62146	Arbacia punctulata	29%	100%
P62147	Branchiostoma floridae	28%	100%
P62148	Branchiostoma lanceolatum	28%	100%
P62149	Gallus gallus	28%	100%
P62150	Oryzias latipes	29%	100%
P62151	Tetronarce californica	28%	100%
P62152	Drosophila melanogaster	28%	100%
P62153	Halocynthia roretzi	28%	100%
P62154	Locusta migratoria	28%	100%
P62156	Oncorhynchus sp.	28%	100%
P62157	Bos taurus	28%	100%
P62160	Oryctolagus cuniculus	28%	100%
P62162	Hordeum vulgare	29%	100%
P62163	Glycine max	29%	100%
P62184	Renilla reniformis	28%	100%
P62199	Petunia hybrida	29%	100%
P62200	Daucus carota	29%	100%
P62201	Lilium longiflorum	29%	100%
P62202	Bryonia dioica	29%	100%
P62203	Plasmodium falciparum (isolate 3D7)	29%	100%
P63315	Bos taurus	27%	100%
P63316	Homo sapiens	27%	100%
P63317	Sus scrofa	27%	100%
P69097	Trypanosoma brucei brucei	28%	100%
P69098	Trypanosoma brucei gambiense	28%	100%
P81660	Anguilla anguilla	25%	100%
P82159	Chelon ramada	30%	100%
P82160	Chelon ramada	27%	100%
P84339	Agaricus bisporus	25%	100%
P85100	Bos taurus	33%	95%
P93087	Capsicum annuum	30%	100%
P93171	Helianthus annuus	29%	100%
P97457	Mus musculus	24%	100%
Q01449	Homo sapiens	28%	100%
Q03509	Arabidopsis thaliana	29%	100%
Q06827	Scherffelia dubia	23%	100%
Q09510	Caenorhabditis elegans	29%	100%
Q09665	Caenorhabditis elegans	24%	100%
Q0IQB6	Oryza sativa subsp. japonica	27%	100%
Q0IUU4	Oryza sativa subsp. japonica	27%	100%
Q0JNL7	Oryza sativa subsp. japonica	30%	100%
Q0JNS6	Oryza sativa subsp. japonica	29%	100%
Q0P571	Bos taurus	24%	100%
Q12798	Homo sapiens	24%	100%
Q17133	Branchiostoma floridae	31%	100%
Q1HPS0	Bombyx mori	26%	94%
Q2R1Z5	Oryza sativa subsp. japonica	24%	100%
Q2TBN3	Bos taurus	23%	100%
Q32LE3	Bos taurus	24%	100%
Q39752	Fagus sylvatica	29%	100%
Q3SZE5	Bos taurus	25%	100%
Q3T0E8	Bos taurus	29%	100%
Q3THE2	Mus musculus	29%	100%
Q40302	Macrocystis pyrifera	26%	100%
Q40642	Oryza sativa subsp. indica	26%	100%
Q4Q2W1	Leishmania major	23%	100%
Q4QF91	Leishmania major	98%	100%
Q4QHT2	Leishmania major	28%	100%
Q5E9E2	Bos taurus	28%	100%
Q5RAD2	Pongo abelii	28%	100%
Q5RBA4	Pongo abelii	28%	100%
Q5RC34	Pongo abelii	28%	100%
Q5U206	Rattus norvegicus	28%	100%
Q5XGC7	Xenopus tropicalis	28%	100%
Q62082	Mus musculus	25%	94%
Q64119	Rattus norvegicus	31%	100%
Q64122	Rattus norvegicus	26%	100%
Q682T9	Arabidopsis thaliana	29%	100%
Q6F332	Oryza sativa subsp. japonica	29%	100%
Q6IT78	Ctenopharyngodon idella	28%	100%
Q6P0G6	Danio rerio	28%	99%
Q6PI52	Danio rerio	28%	100%
Q6R520	Oreochromis mossambicus	28%	100%
Q6YNX6	Ovis aries	28%	100%
Q71UH5	Globisporangium splendens	26%	100%
Q71UH6	Perca flavescens	28%	100%
Q7DMN9	Solanum tuberosum	30%	100%
Q7M2V4	Oryctolagus cuniculus	24%	100%
Q7T3T2	Epinephelus akaara	28%	100%
Q7Y052	Euphorbia characias	29%	100%
Q84MN0	Oryza sativa subsp. japonica	31%	100%
Q84VG0	Oryza sativa subsp. japonica	29%	100%
Q8RZB5	Oryza sativa subsp. japonica	27%	100%
Q8S1Y9	Oryza sativa subsp. japonica	26%	100%
Q8STF0	Strongylocentrotus intermedius	28%	100%
Q8VZ50	Arabidopsis thaliana	26%	100%
Q8X187	Paxillus involutus	26%	100%
Q948R0	Oryza sativa subsp. japonica	25%	100%
Q94AZ4	Arabidopsis thaliana	26%	100%
Q95NI4	Halichondria okadai	28%	100%
Q95NR9	Metridium senile	28%	100%
Q9BUA6	Homo sapiens	25%	84%
Q9C9U8	Arabidopsis thaliana	26%	100%
Q9CQ19	Mus musculus	28%	100%
Q9D6P8	Mus musculus	28%	100%
Q9GRJ1	Lumbricus rubellus	28%	100%
Q9HFY6	Blastocladiella emersonii	27%	100%
Q9JM83	Mus musculus	22%	100%
Q9LE22	Arabidopsis thaliana	27%	100%
Q9LIK5	Arabidopsis thaliana	29%	100%
Q9M7R0	Olea europaea	25%	100%
Q9NZT1	Homo sapiens	25%	100%
Q9QVP4	Mus musculus	30%	100%
Q9R1K9	Mus musculus	23%	100%
Q9U6D3	Myxine glutinosa	28%	100%
Q9UB37	Branchiostoma lanceolatum	28%	100%
Q9UWF0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	26%	100%
Q9XVI9	Caenorhabditis elegans	31%	100%
Q9XZP2	Branchiostoma floridae	25%	100%
V5BPQ4	Trypanosoma cruzi	70%	100%