LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WTH2_LEIDO
TriTrypDb:
LdBPK_150920.1 * , LdCL_150014700 , LDHU3_15.1190
Length:
323

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTH2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTH2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 158 162 PF00656 0.568
CLV_C14_Caspase3-7 292 296 PF00656 0.669
CLV_NRD_NRD_1 319 321 PF00675 0.647
CLV_NRD_NRD_1 66 68 PF00675 0.571
CLV_PCSK_KEX2_1 66 68 PF00082 0.571
CLV_PCSK_SKI1_1 54 58 PF00082 0.517
CLV_Separin_Metazoa 51 55 PF03568 0.406
DEG_SPOP_SBC_1 221 225 PF00917 0.650
DEG_SPOP_SBC_1 60 64 PF00917 0.592
DOC_ANK_TNKS_1 66 73 PF00023 0.635
DOC_MAPK_MEF2A_6 29 38 PF00069 0.514
DOC_USP7_MATH_1 104 108 PF00917 0.475
DOC_USP7_MATH_1 192 196 PF00917 0.573
DOC_USP7_MATH_1 221 225 PF00917 0.586
DOC_USP7_MATH_1 230 234 PF00917 0.584
DOC_USP7_MATH_1 257 261 PF00917 0.641
DOC_USP7_MATH_1 271 275 PF00917 0.637
DOC_USP7_MATH_1 60 64 PF00917 0.640
DOC_USP7_MATH_1 65 69 PF00917 0.663
DOC_USP7_MATH_2 208 214 PF00917 0.579
DOC_USP7_UBL2_3 198 202 PF12436 0.619
DOC_USP7_UBL2_3 232 236 PF12436 0.621
DOC_USP7_UBL2_3 250 254 PF12436 0.628
DOC_WW_Pin1_4 204 209 PF00397 0.789
DOC_WW_Pin1_4 272 277 PF00397 0.717
DOC_WW_Pin1_4 5 10 PF00397 0.643
DOC_WW_Pin1_4 87 92 PF00397 0.524
LIG_14-3-3_CanoR_1 112 119 PF00244 0.621
LIG_14-3-3_CanoR_1 29 38 PF00244 0.528
LIG_Actin_WH2_2 186 204 PF00022 0.483
LIG_BIR_II_1 1 5 PF00653 0.657
LIG_BIR_III_1 1 5 PF00653 0.632
LIG_BIR_III_3 1 5 PF00653 0.632
LIG_FHA_1 147 153 PF00498 0.559
LIG_FHA_1 165 171 PF00498 0.577
LIG_FHA_1 298 304 PF00498 0.458
LIG_FHA_1 30 36 PF00498 0.524
LIG_FHA_1 47 53 PF00498 0.333
LIG_FHA_2 257 263 PF00498 0.652
LIG_LIR_Gen_1 213 222 PF02991 0.732
LIG_LIR_Gen_1 24 35 PF02991 0.613
LIG_LIR_Gen_1 299 310 PF02991 0.617
LIG_LIR_Gen_1 93 102 PF02991 0.408
LIG_LIR_Nem_3 213 218 PF02991 0.734
LIG_LIR_Nem_3 24 30 PF02991 0.617
LIG_LIR_Nem_3 93 98 PF02991 0.395
LIG_NRP_CendR_1 320 323 PF00754 0.664
LIG_PTAP_UEV_1 3 8 PF05743 0.583
LIG_SH2_PTP2 27 30 PF00017 0.505
LIG_SH2_STAT5 27 30 PF00017 0.523
LIG_SH3_3 1 7 PF00018 0.763
LIG_SH3_3 239 245 PF00018 0.799
LIG_SH3_3 265 271 PF00018 0.765
LIG_SH3_3 273 279 PF00018 0.761
LIG_SH3_3 74 80 PF00018 0.746
LIG_SUMO_SIM_anti_2 144 159 PF11976 0.559
LIG_SUMO_SIM_anti_2 314 320 PF11976 0.568
LIG_TRAF2_1 18 21 PF00917 0.534
LIG_TRAF2_1 22 25 PF00917 0.548
LIG_TRAF2_1 260 263 PF00917 0.725
LIG_WW_2 278 281 PF00397 0.656
LIG_WW_3 245 249 PF00397 0.652
MOD_CK1_1 107 113 PF00069 0.645
MOD_CK1_1 127 133 PF00069 0.512
MOD_CK1_1 134 140 PF00069 0.630
MOD_CK1_1 197 203 PF00069 0.658
MOD_CK1_1 213 219 PF00069 0.673
MOD_CK1_1 224 230 PF00069 0.632
MOD_CK1_1 272 278 PF00069 0.671
MOD_CK2_1 134 140 PF00069 0.685
MOD_CK2_1 153 159 PF00069 0.657
MOD_CK2_1 19 25 PF00069 0.565
MOD_CK2_1 204 210 PF00069 0.532
MOD_CK2_1 256 262 PF00069 0.722
MOD_CK2_1 87 93 PF00069 0.631
MOD_GlcNHglycan 104 107 PF01048 0.613
MOD_GlcNHglycan 126 129 PF01048 0.589
MOD_GlcNHglycan 133 136 PF01048 0.577
MOD_GlcNHglycan 176 179 PF01048 0.616
MOD_GlcNHglycan 212 215 PF01048 0.691
MOD_GlcNHglycan 224 227 PF01048 0.622
MOD_GlcNHglycan 232 235 PF01048 0.639
MOD_GlcNHglycan 271 274 PF01048 0.737
MOD_GSK3_1 104 111 PF00069 0.650
MOD_GSK3_1 120 127 PF00069 0.548
MOD_GSK3_1 129 136 PF00069 0.621
MOD_GSK3_1 164 171 PF00069 0.650
MOD_GSK3_1 220 227 PF00069 0.713
MOD_GSK3_1 61 68 PF00069 0.714
MOD_N-GLC_1 257 262 PF02516 0.723
MOD_NEK2_1 102 107 PF00069 0.449
MOD_NEK2_1 61 66 PF00069 0.644
MOD_PIKK_1 29 35 PF00454 0.511
MOD_PKA_2 111 117 PF00069 0.632
MOD_PKA_2 65 71 PF00069 0.614
MOD_Plk_1 168 174 PF00069 0.669
MOD_Plk_1 257 263 PF00069 0.725
MOD_Plk_2-3 146 152 PF00069 0.659
MOD_Plk_2-3 153 159 PF00069 0.607
MOD_Plk_2-3 161 167 PF00069 0.544
MOD_Plk_4 168 174 PF00069 0.669
MOD_Plk_4 297 303 PF00069 0.462
MOD_ProDKin_1 204 210 PF00069 0.791
MOD_ProDKin_1 272 278 PF00069 0.715
MOD_ProDKin_1 5 11 PF00069 0.639
MOD_ProDKin_1 87 93 PF00069 0.524
TRG_DiLeu_BaLyEn_6 184 189 PF01217 0.578
TRG_ENDOCYTIC_2 27 30 PF00928 0.560
TRG_Pf-PMV_PEXEL_1 187 191 PF00026 0.575

Homologs

Protein Taxonomy Sequence identity Coverage
A4H858 Leishmania braziliensis 58% 100%
A4HWI4 Leishmania infantum 99% 100%
E9AQ85 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 96%
Q4QF98 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS