Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTG9_LEIDO

TriTrypDb:

LdBPK_150810.1 , LdCL_150013500 , LDHU3_15.1050

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WTG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTG9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004713	protein tyrosine kinase activity	4	4
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	389	393	PF00656	0.641
CLV_NRD_NRD_1	15	17	PF00675	0.700
CLV_NRD_NRD_1	151	153	PF00675	0.316
CLV_NRD_NRD_1	463	465	PF00675	0.666
CLV_PCSK_KEX2_1	15	17	PF00082	0.692
CLV_PCSK_KEX2_1	151	153	PF00082	0.316
CLV_PCSK_KEX2_1	261	263	PF00082	0.302
CLV_PCSK_KEX2_1	463	465	PF00082	0.595
CLV_PCSK_KEX2_1	650	652	PF00082	0.638
CLV_PCSK_KEX2_1	94	96	PF00082	0.302
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.302
CLV_PCSK_PC1ET2_1	650	652	PF00082	0.638
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.302
CLV_PCSK_PC7_1	646	652	PF00082	0.649
CLV_PCSK_SKI1_1	463	467	PF00082	0.568
CLV_PCSK_SKI1_1	497	501	PF00082	0.736
CLV_PCSK_SKI1_1	535	539	PF00082	0.729
CLV_PCSK_SKI1_1	95	99	PF00082	0.302
DEG_Nend_UBRbox_3	1	3	PF02207	0.703
DOC_CYCLIN_RxL_1	83	96	PF00134	0.356
DOC_CYCLIN_yCln2_LP_2	282	288	PF00134	0.396
DOC_MAPK_gen_1	194	203	PF00069	0.427
DOC_MAPK_MEF2A_6	131	140	PF00069	0.321
DOC_PP2B_LxvP_1	282	285	PF13499	0.291
DOC_PP4_FxxP_1	249	252	PF00568	0.346
DOC_PP4_FxxP_1	624	627	PF00568	0.735
DOC_USP7_MATH_1	176	180	PF00917	0.321
DOC_USP7_MATH_1	305	309	PF00917	0.308
DOC_USP7_MATH_1	479	483	PF00917	0.757
DOC_USP7_MATH_1	556	560	PF00917	0.694
DOC_USP7_MATH_1	637	641	PF00917	0.609
DOC_WW_Pin1_4	471	476	PF00397	0.716
DOC_WW_Pin1_4	505	510	PF00397	0.669
DOC_WW_Pin1_4	519	524	PF00397	0.615
LIG_14-3-3_CanoR_1	151	161	PF00244	0.385
LIG_14-3-3_CanoR_1	164	170	PF00244	0.358
LIG_14-3-3_CanoR_1	646	654	PF00244	0.666
LIG_AP2alpha_1	500	504	PF02296	0.628
LIG_AP2alpha_1	654	658	PF02296	0.643
LIG_AP2alpha_2	256	258	PF02296	0.427
LIG_AP2alpha_2	652	654	PF02296	0.596
LIG_BRCT_BRCA1_1	540	544	PF00533	0.795
LIG_deltaCOP1_diTrp_1	295	301	PF00928	0.410
LIG_deltaCOP1_diTrp_1	357	362	PF00928	0.537
LIG_FHA_1	176	182	PF00498	0.318
LIG_FHA_1	308	314	PF00498	0.328
LIG_FHA_1	620	626	PF00498	0.759
LIG_FHA_1	79	85	PF00498	0.418
LIG_FHA_2	164	170	PF00498	0.427
LIG_FHA_2	190	196	PF00498	0.411
LIG_FHA_2	228	234	PF00498	0.427
LIG_FHA_2	352	358	PF00498	0.579
LIG_Integrin_isoDGR_2	417	419	PF01839	0.668
LIG_LIR_Apic_2	382	386	PF02991	0.744
LIG_LIR_Apic_2	622	627	PF02991	0.740
LIG_LIR_Gen_1	327	337	PF02991	0.370
LIG_LIR_Gen_1	498	507	PF02991	0.683
LIG_LIR_Gen_1	652	658	PF02991	0.598
LIG_LIR_Gen_1	72	78	PF02991	0.314
LIG_LIR_Nem_3	327	332	PF02991	0.371
LIG_LIR_Nem_3	335	340	PF02991	0.390
LIG_LIR_Nem_3	400	406	PF02991	0.630
LIG_LIR_Nem_3	498	503	PF02991	0.683
LIG_LIR_Nem_3	652	657	PF02991	0.598
LIG_LIR_Nem_3	72	77	PF02991	0.331
LIG_LIR_Nem_3	96	100	PF02991	0.335
LIG_LYPXL_yS_3	555	558	PF13949	0.683
LIG_MAD2	368	376	PF02301	0.633
LIG_MYND_1	549	553	PF01753	0.628
LIG_Pex14_1	297	301	PF04695	0.427
LIG_Pex14_2	500	504	PF04695	0.628
LIG_Pex14_2	654	658	PF04695	0.599
LIG_PTAP_UEV_1	522	527	PF05743	0.715
LIG_PTB_Apo_2	243	250	PF02174	0.411
LIG_SH2_CRK	150	154	PF00017	0.358
LIG_SH2_CRK	608	612	PF00017	0.736
LIG_SH2_NCK_1	383	387	PF00017	0.719
LIG_SH2_NCK_1	608	612	PF00017	0.740
LIG_SH2_PTP2	74	77	PF00017	0.321
LIG_SH2_SRC	183	186	PF00017	0.308
LIG_SH2_SRC	608	611	PF00017	0.740
LIG_SH2_STAP1	309	313	PF00017	0.375
LIG_SH2_STAT3	585	588	PF00017	0.755
LIG_SH2_STAT5	144	147	PF00017	0.316
LIG_SH2_STAT5	183	186	PF00017	0.302
LIG_SH2_STAT5	281	284	PF00017	0.316
LIG_SH2_STAT5	309	312	PF00017	0.302
LIG_SH2_STAT5	74	77	PF00017	0.330
LIG_SH3_1	608	614	PF00018	0.670
LIG_SH3_3	282	288	PF00018	0.427
LIG_SH3_3	296	302	PF00018	0.427
LIG_SH3_3	37	43	PF00018	0.388
LIG_SH3_3	373	379	PF00018	0.622
LIG_SH3_3	473	479	PF00018	0.748
LIG_SH3_3	50	56	PF00018	0.566
LIG_SH3_3	517	523	PF00018	0.701
LIG_SH3_3	550	556	PF00018	0.691
LIG_SH3_3	607	613	PF00018	0.704
LIG_SH3_3	82	88	PF00018	0.380
LIG_SUMO_SIM_anti_2	109	114	PF11976	0.354
LIG_SUMO_SIM_anti_2	34	41	PF11976	0.390
LIG_TRAF2_1	230	233	PF00917	0.427
LIG_TRAF2_1	397	400	PF00917	0.671
LIG_TRAF2_1	428	431	PF00917	0.730
LIG_WRC_WIRS_1	348	353	PF05994	0.508
LIG_WW_1	54	57	PF00397	0.665
MOD_CK1_1	127	133	PF00069	0.332
MOD_CK1_1	156	162	PF00069	0.388
MOD_CK1_1	308	314	PF00069	0.415
MOD_CK1_1	7	13	PF00069	0.616
MOD_CK2_1	111	117	PF00069	0.479
MOD_CK2_1	127	133	PF00069	0.360
MOD_CK2_1	163	169	PF00069	0.427
MOD_CK2_1	227	233	PF00069	0.456
MOD_CK2_1	351	357	PF00069	0.552
MOD_CK2_1	379	385	PF00069	0.676
MOD_CK2_1	394	400	PF00069	0.512
MOD_GlcNHglycan	155	158	PF01048	0.424
MOD_GlcNHglycan	178	181	PF01048	0.346
MOD_GlcNHglycan	20	23	PF01048	0.700
MOD_GlcNHglycan	396	399	PF01048	0.576
MOD_GlcNHglycan	481	485	PF01048	0.769
MOD_GlcNHglycan	505	508	PF01048	0.700
MOD_GlcNHglycan	523	526	PF01048	0.803
MOD_GlcNHglycan	538	541	PF01048	0.671
MOD_GlcNHglycan	546	549	PF01048	0.642
MOD_GlcNHglycan	574	577	PF01048	0.667
MOD_GlcNHglycan	9	12	PF01048	0.651
MOD_GSK3_1	152	159	PF00069	0.414
MOD_GSK3_1	300	307	PF00069	0.430
MOD_GSK3_1	347	354	PF00069	0.526
MOD_GSK3_1	390	397	PF00069	0.598
MOD_GSK3_1	503	510	PF00069	0.696
MOD_GSK3_1	538	545	PF00069	0.725
MOD_GSK3_1	637	644	PF00069	0.712
MOD_N-GLC_1	219	224	PF02516	0.420
MOD_NEK2_1	136	141	PF00069	0.302
MOD_NEK2_1	175	180	PF00069	0.323
MOD_NEK2_1	332	337	PF00069	0.356
MOD_NEK2_1	351	356	PF00069	0.566
MOD_NEK2_1	4	9	PF00069	0.677
MOD_NEK2_1	503	508	PF00069	0.712
MOD_NEK2_1	543	548	PF00069	0.719
MOD_NEK2_1	557	562	PF00069	0.472
MOD_NEK2_1	93	98	PF00069	0.350
MOD_NEK2_2	309	314	PF00069	0.273
MOD_PIKK_1	300	306	PF00454	0.277
MOD_PIKK_1	512	518	PF00454	0.685
MOD_PIKK_1	631	637	PF00454	0.806
MOD_PKA_2	153	159	PF00069	0.464
MOD_PKA_2	163	169	PF00069	0.392
MOD_PKA_2	62	68	PF00069	0.433
MOD_PKA_2	645	651	PF00069	0.777
MOD_Plk_4	33	39	PF00069	0.412
MOD_Plk_4	507	513	PF00069	0.632
MOD_Plk_4	70	76	PF00069	0.356
MOD_ProDKin_1	471	477	PF00069	0.721
MOD_ProDKin_1	505	511	PF00069	0.670
MOD_ProDKin_1	519	525	PF00069	0.617
MOD_SUMO_rev_2	111	121	PF00179	0.432
MOD_SUMO_rev_2	360	370	PF00179	0.534
TRG_DiLeu_BaEn_1	35	40	PF01217	0.364
TRG_ENDOCYTIC_2	150	153	PF00928	0.358
TRG_ENDOCYTIC_2	277	280	PF00928	0.302
TRG_ENDOCYTIC_2	281	284	PF00928	0.302
TRG_ENDOCYTIC_2	337	340	PF00928	0.504
TRG_ENDOCYTIC_2	403	406	PF00928	0.578
TRG_ENDOCYTIC_2	555	558	PF00928	0.719
TRG_ENDOCYTIC_2	74	77	PF00928	0.354
TRG_ER_diArg_1	150	152	PF00400	0.316
TRG_ER_diArg_1	462	464	PF00400	0.720
TRG_NLS_MonoExtC_3	259	265	PF00514	0.427
TRG_NLS_MonoExtN_4	257	264	PF00514	0.427
TRG_Pf-PMV_PEXEL_1	394	399	PF00026	0.793

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7R8	Leptomonas seymouri	63%	94%
A0A1X0NUC1	Trypanosomatidae	44%	87%
A0A422NRC0	Trypanosoma rangeli	41%	96%
A4H848	Leishmania braziliensis	67%	99%
A4HWH3	Leishmania infantum	100%	100%
C9ZXX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AQ75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QFA8	Leishmania major	90%	100%
V5BK24	Trypanosoma cruzi	41%	96%