DUF4149 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2871), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTG8_LEIDO

TriTrypDb:

LdBPK_150780.1 , LdCL_150012900 , LDHU3_15.0980

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 2
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7WTG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.555
CLV_PCSK_KEX2_1	32	34	PF00082	0.555
CLV_PCSK_SKI1_1	113	117	PF00082	0.532
CLV_PCSK_SKI1_1	234	238	PF00082	0.428
DOC_PP1_RVXF_1	194	201	PF00149	0.273
DOC_USP7_MATH_1	138	142	PF00917	0.302
DOC_USP7_MATH_1	56	60	PF00917	0.623
DOC_USP7_UBL2_3	160	164	PF12436	0.473
DOC_USP7_UBL2_3	230	234	PF12436	0.698
DOC_WW_Pin1_4	21	26	PF00397	0.282
DOC_WW_Pin1_4	50	55	PF00397	0.664
LIG_14-3-3_CanoR_1	130	139	PF00244	0.376
LIG_14-3-3_CanoR_1	196	201	PF00244	0.273
LIG_14-3-3_CanoR_1	38	47	PF00244	0.699
LIG_14-3-3_CanoR_1	66	72	PF00244	0.647
LIG_14-3-3_CanoR_1	74	82	PF00244	0.584
LIG_14-3-3_CanoR_1	96	100	PF00244	0.302
LIG_BRCT_BRCA1_1	140	144	PF00533	0.302
LIG_BRCT_BRCA1_1	209	213	PF00533	0.302
LIG_EH1_1	88	96	PF00400	0.473
LIG_eIF4E_1	215	221	PF01652	0.302
LIG_FHA_1	114	120	PF00498	0.273
LIG_FHA_1	124	130	PF00498	0.236
LIG_FHA_1	166	172	PF00498	0.302
LIG_FHA_1	174	180	PF00498	0.261
LIG_FHA_1	183	189	PF00498	0.215
LIG_FHA_1	199	205	PF00498	0.214
LIG_FHA_1	74	80	PF00498	0.602
LIG_LIR_Gen_1	141	150	PF02991	0.333
LIG_LIR_Gen_1	24	34	PF02991	0.307
LIG_LIR_Gen_1	98	107	PF02991	0.302
LIG_LIR_Nem_3	12	17	PF02991	0.446
LIG_LIR_Nem_3	141	147	PF02991	0.498
LIG_LIR_Nem_3	20	26	PF02991	0.300
LIG_LIR_Nem_3	210	216	PF02991	0.302
LIG_LIR_Nem_3	85	89	PF02991	0.702
LIG_LIR_Nem_3	98	104	PF02991	0.302
LIG_MLH1_MIPbox_1	140	144	PF16413	0.302
LIG_NRBOX	144	150	PF00104	0.302
LIG_PCNA_yPIPBox_3	84	95	PF02747	0.580
LIG_Pex14_2	142	146	PF04695	0.405
LIG_SH2_CRK	217	221	PF00017	0.508
LIG_SH2_PTP2	14	17	PF00017	0.282
LIG_SH2_STAT5	101	104	PF00017	0.364
LIG_SH2_STAT5	121	124	PF00017	0.302
LIG_SH2_STAT5	14	17	PF00017	0.282
LIG_SH2_STAT5	166	169	PF00017	0.302
LIG_SH2_STAT5	215	218	PF00017	0.302
LIG_SH3_3	10	16	PF00018	0.258
LIG_SH3_3	44	50	PF00018	0.640
LIG_SUMO_SIM_anti_2	176	181	PF11976	0.302
LIG_SUMO_SIM_anti_2	185	190	PF11976	0.240
LIG_SUMO_SIM_par_1	146	151	PF11976	0.302
LIG_UBA3_1	145	152	PF00899	0.302
LIG_WRC_WIRS_1	139	144	PF05994	0.302
MOD_CK1_1	123	129	PF00069	0.273
MOD_CK1_1	68	74	PF00069	0.575
MOD_Cter_Amidation	231	234	PF01082	0.412
MOD_GlcNHglycan	107	110	PF01048	0.302
MOD_GlcNHglycan	221	224	PF01048	0.351
MOD_GlcNHglycan	226	229	PF01048	0.353
MOD_GlcNHglycan	40	43	PF01048	0.461
MOD_GSK3_1	120	127	PF00069	0.273
MOD_GSK3_1	17	24	PF00069	0.310
MOD_GSK3_1	192	199	PF00069	0.273
MOD_GSK3_1	232	239	PF00069	0.772
MOD_GSK3_1	48	55	PF00069	0.667
MOD_GSK3_1	78	85	PF00069	0.593
MOD_GSK3_1	95	102	PF00069	0.232
MOD_LATS_1	118	124	PF00433	0.383
MOD_N-GLC_1	123	128	PF02516	0.473
MOD_N-GLC_1	99	104	PF02516	0.302
MOD_NEK2_1	154	159	PF00069	0.473
MOD_NEK2_1	165	170	PF00069	0.433
MOD_NEK2_1	173	178	PF00069	0.204
MOD_NEK2_1	82	87	PF00069	0.576
MOD_NEK2_1	99	104	PF00069	0.302
MOD_NEK2_2	138	143	PF00069	0.302
MOD_PIKK_1	124	130	PF00454	0.273
MOD_PKA_2	224	230	PF00069	0.574
MOD_PKA_2	65	71	PF00069	0.744
MOD_PKA_2	73	79	PF00069	0.670
MOD_PKA_2	95	101	PF00069	0.302
MOD_Plk_1	99	105	PF00069	0.302
MOD_Plk_4	138	144	PF00069	0.302
MOD_Plk_4	184	190	PF00069	0.302
MOD_Plk_4	99	105	PF00069	0.457
MOD_ProDKin_1	21	27	PF00069	0.282
MOD_ProDKin_1	50	56	PF00069	0.663
MOD_SUMO_for_1	89	92	PF00179	0.580
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.273
TRG_ENDOCYTIC_2	101	104	PF00928	0.302
TRG_ENDOCYTIC_2	14	17	PF00928	0.282
TRG_ENDOCYTIC_2	162	165	PF00928	0.495
TRG_ENDOCYTIC_2	217	220	PF00928	0.467
TRG_ER_diArg_1	31	33	PF00400	0.758

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HWH1	Leishmania infantum	99%	100%
Q4QFB1	Leishmania major	87%	100%