Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTG4_LEIDO

TriTrypDb:

LdBPK_150820.1 , LdCL_150013700 , LDHU3_15.1070

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTG4

PDB structure(s): 7ane_ae

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	372	376	PF00656	0.545
CLV_NRD_NRD_1	169	171	PF00675	0.389
CLV_NRD_NRD_1	181	183	PF00675	0.434
CLV_NRD_NRD_1	210	212	PF00675	0.441
CLV_NRD_NRD_1	222	224	PF00675	0.392
CLV_NRD_NRD_1	454	456	PF00675	0.519
CLV_NRD_NRD_1	494	496	PF00675	0.431
CLV_PCSK_FUR_1	452	456	PF00082	0.522
CLV_PCSK_KEX2_1	169	171	PF00082	0.389
CLV_PCSK_KEX2_1	181	183	PF00082	0.434
CLV_PCSK_KEX2_1	210	212	PF00082	0.500
CLV_PCSK_KEX2_1	222	224	PF00082	0.435
CLV_PCSK_KEX2_1	454	456	PF00082	0.553
CLV_PCSK_SKI1_1	222	226	PF00082	0.395
CLV_PCSK_SKI1_1	234	238	PF00082	0.348
CLV_PCSK_SKI1_1	436	440	PF00082	0.580
DOC_CKS1_1	102	107	PF01111	0.400
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.410
DOC_MAPK_DCC_7	100	108	PF00069	0.416
DOC_MAPK_DCC_7	188	196	PF00069	0.591
DOC_MAPK_DCC_7	222	232	PF00069	0.376
DOC_MAPK_gen_1	185	194	PF00069	0.591
DOC_MAPK_gen_1	279	286	PF00069	0.382
DOC_MAPK_gen_1	312	320	PF00069	0.497
DOC_MAPK_MEF2A_6	188	196	PF00069	0.588
DOC_MAPK_MEF2A_6	223	232	PF00069	0.360
DOC_MAPK_MEF2A_6	90	97	PF00069	0.434
DOC_PP1_RVXF_1	283	289	PF00149	0.354
DOC_PP1_RVXF_1	505	511	PF00149	0.410
DOC_USP7_MATH_1	574	578	PF00917	0.581
DOC_USP7_MATH_1	589	593	PF00917	0.664
DOC_USP7_MATH_1	621	625	PF00917	0.669
DOC_USP7_MATH_1	644	648	PF00917	0.801
DOC_WW_Pin1_4	101	106	PF00397	0.404
DOC_WW_Pin1_4	629	634	PF00397	0.804
LIG_14-3-3_CanoR_1	116	122	PF00244	0.391
LIG_14-3-3_CanoR_1	222	228	PF00244	0.380
LIG_14-3-3_CanoR_1	234	242	PF00244	0.349
LIG_14-3-3_CanoR_1	314	319	PF00244	0.453
LIG_Actin_WH2_2	199	217	PF00022	0.378
LIG_Actin_WH2_2	346	364	PF00022	0.518
LIG_APCC_ABBA_1	250	255	PF00400	0.353
LIG_BIR_II_1	1	5	PF00653	0.476
LIG_BIR_III_4	410	414	PF00653	0.657
LIG_BRCT_BRCA1_1	257	261	PF00533	0.459
LIG_CaM_NSCaTE_8	475	482	PF13499	0.509
LIG_CSL_BTD_1	509	512	PF09270	0.496
LIG_FHA_1	116	122	PF00498	0.468
LIG_FHA_1	364	370	PF00498	0.503
LIG_FHA_1	534	540	PF00498	0.523
LIG_FHA_1	614	620	PF00498	0.716
LIG_FHA_1	632	638	PF00498	0.748
LIG_FHA_1	70	76	PF00498	0.496
LIG_FHA_1	77	83	PF00498	0.491
LIG_FHA_2	142	148	PF00498	0.463
LIG_FHA_2	332	338	PF00498	0.418
LIG_FHA_2	399	405	PF00498	0.548
LIG_FHA_2	420	426	PF00498	0.510
LIG_FHA_2	483	489	PF00498	0.498
LIG_FHA_2	72	78	PF00498	0.615
LIG_LIR_Gen_1	334	344	PF02991	0.461
LIG_LIR_Nem_3	124	128	PF02991	0.494
LIG_LIR_Nem_3	162	168	PF02991	0.433
LIG_LIR_Nem_3	219	224	PF02991	0.399
LIG_LIR_Nem_3	231	236	PF02991	0.358
LIG_LIR_Nem_3	334	339	PF02991	0.447
LIG_NRBOX	319	325	PF00104	0.337
LIG_PDZ_Class_1	650	655	PF00595	0.664
LIG_SH2_CRK	221	225	PF00017	0.404
LIG_SH2_CRK	233	237	PF00017	0.339
LIG_SH2_CRK	336	340	PF00017	0.389
LIG_SH2_CRK	531	535	PF00017	0.575
LIG_SH2_GRB2like	298	301	PF00017	0.388
LIG_SH2_SRC	298	301	PF00017	0.388
LIG_SH2_STAP1	298	302	PF00017	0.395
LIG_SH2_STAP1	336	340	PF00017	0.405
LIG_SH2_STAP1	395	399	PF00017	0.504
LIG_SH2_STAT3	554	557	PF00017	0.609
LIG_SH2_STAT5	128	131	PF00017	0.507
LIG_SH2_STAT5	179	182	PF00017	0.409
LIG_SH2_STAT5	24	27	PF00017	0.442
LIG_SH2_STAT5	262	265	PF00017	0.342
LIG_SH2_STAT5	322	325	PF00017	0.375
LIG_SH2_STAT5	338	341	PF00017	0.398
LIG_SH2_STAT5	398	401	PF00017	0.526
LIG_SH2_STAT5	468	471	PF00017	0.378
LIG_SH2_STAT5	493	496	PF00017	0.564
LIG_SH2_STAT5	554	557	PF00017	0.563
LIG_SH3_2	31	36	PF14604	0.464
LIG_SH3_3	142	148	PF00018	0.438
LIG_SH3_3	28	34	PF00018	0.444
LIG_SH3_3	382	388	PF00018	0.304
LIG_SH3_3	583	589	PF00018	0.660
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.421
LIG_SUMO_SIM_anti_2	306	311	PF11976	0.496
LIG_SUMO_SIM_anti_2	76	84	PF11976	0.533
LIG_SUMO_SIM_par_1	104	110	PF11976	0.407
LIG_SUMO_SIM_par_1	192	198	PF11976	0.560
LIG_TRAF2_1	217	220	PF00917	0.375
LIG_TRAF2_1	328	331	PF00917	0.494
LIG_TRAF2_1	401	404	PF00917	0.586
LIG_TRAF2_1	485	488	PF00917	0.535
MOD_CK1_1	107	113	PF00069	0.398
MOD_CK1_1	17	23	PF00069	0.544
MOD_CK1_1	497	503	PF00069	0.468
MOD_CK1_1	577	583	PF00069	0.686
MOD_CK1_1	611	617	PF00069	0.692
MOD_CK1_1	642	648	PF00069	0.683
MOD_CK1_1	65	71	PF00069	0.506
MOD_CK1_1	78	84	PF00069	0.479
MOD_CK1_1	96	102	PF00069	0.416
MOD_CK2_1	192	198	PF00069	0.560
MOD_CK2_1	398	404	PF00069	0.459
MOD_CK2_1	482	488	PF00069	0.485
MOD_GlcNHglycan	109	112	PF01048	0.413
MOD_GlcNHglycan	480	483	PF01048	0.561
MOD_GlcNHglycan	576	579	PF01048	0.574
MOD_GlcNHglycan	582	585	PF01048	0.711
MOD_GlcNHglycan	591	594	PF01048	0.559
MOD_GlcNHglycan	611	614	PF01048	0.526
MOD_GlcNHglycan	616	619	PF01048	0.651
MOD_GlcNHglycan	625	628	PF01048	0.711
MOD_GlcNHglycan	637	640	PF01048	0.561
MOD_GlcNHglycan	64	67	PF01048	0.467
MOD_GlcNHglycan	642	645	PF01048	0.573
MOD_GlcNHglycan	646	649	PF01048	0.638
MOD_GSK3_1	10	17	PF00069	0.508
MOD_GSK3_1	419	426	PF00069	0.509
MOD_GSK3_1	478	485	PF00069	0.586
MOD_GSK3_1	604	611	PF00069	0.690
MOD_GSK3_1	62	69	PF00069	0.456
MOD_GSK3_1	631	638	PF00069	0.675
MOD_GSK3_1	640	647	PF00069	0.629
MOD_GSK3_1	71	78	PF00069	0.465
MOD_N-GLC_1	141	146	PF02516	0.474
MOD_N-GLC_1	608	613	PF02516	0.672
MOD_NEK2_1	180	185	PF00069	0.445
MOD_NEK2_1	323	328	PF00069	0.474
MOD_NEK2_1	377	382	PF00069	0.444
MOD_NEK2_1	478	483	PF00069	0.502
MOD_NEK2_1	494	499	PF00069	0.435
MOD_NEK2_1	50	55	PF00069	0.496
MOD_NEK2_1	598	603	PF00069	0.627
MOD_NEK2_1	604	609	PF00069	0.639
MOD_NEK2_1	650	655	PF00069	0.664
MOD_NEK2_1	75	80	PF00069	0.515
MOD_PIKK_1	377	383	PF00454	0.559
MOD_PK_1	223	229	PF00069	0.440
MOD_PKA_1	181	187	PF00069	0.553
MOD_PKA_1	222	228	PF00069	0.369
MOD_PKA_1	454	460	PF00069	0.567
MOD_PKA_2	10	16	PF00069	0.554
MOD_PKA_2	115	121	PF00069	0.385
MOD_PKA_2	180	186	PF00069	0.448
MOD_PKA_2	222	228	PF00069	0.413
MOD_PKA_2	454	460	PF00069	0.559
MOD_PKA_2	494	500	PF00069	0.430
MOD_PKA_2	639	645	PF00069	0.738
MOD_PKB_1	312	320	PF00069	0.456
MOD_PKB_1	452	460	PF00069	0.557
MOD_Plk_1	141	147	PF00069	0.467
MOD_Plk_1	539	545	PF00069	0.488
MOD_Plk_1	546	552	PF00069	0.533
MOD_Plk_1	75	81	PF00069	0.472
MOD_Plk_1	93	99	PF00069	0.407
MOD_Plk_2-3	141	147	PF00069	0.467
MOD_Plk_2-3	331	337	PF00069	0.420
MOD_Plk_4	104	110	PF00069	0.426
MOD_Plk_4	14	20	PF00069	0.465
MOD_Plk_4	489	495	PF00069	0.474
MOD_Plk_4	598	604	PF00069	0.647
MOD_Plk_4	78	84	PF00069	0.412
MOD_ProDKin_1	101	107	PF00069	0.409
MOD_ProDKin_1	629	635	PF00069	0.804
MOD_SUMO_for_1	84	87	PF00179	0.439
MOD_SUMO_rev_2	337	345	PF00179	0.486
TRG_DiLeu_BaEn_2	86	92	PF01217	0.543
TRG_ENDOCYTIC_2	165	168	PF00928	0.377
TRG_ENDOCYTIC_2	221	224	PF00928	0.402
TRG_ENDOCYTIC_2	233	236	PF00928	0.342
TRG_ENDOCYTIC_2	290	293	PF00928	0.370
TRG_ENDOCYTIC_2	298	301	PF00928	0.404
TRG_ENDOCYTIC_2	336	339	PF00928	0.362
TRG_ER_diArg_1	161	164	PF00400	0.379
TRG_ER_diArg_1	168	170	PF00400	0.395
TRG_ER_diArg_1	180	182	PF00400	0.418
TRG_ER_diArg_1	221	223	PF00400	0.437
TRG_ER_diArg_1	26	29	PF00400	0.445
TRG_ER_diArg_1	283	286	PF00400	0.367
TRG_ER_diArg_1	453	455	PF00400	0.525
TRG_NLS_MonoExtC_3	494	499	PF00514	0.426
TRG_Pf-PMV_PEXEL_1	553	557	PF00026	0.504
TRG_PTS1	652	655	PF00515	0.727

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I655	Leptomonas seymouri	76%	99%
A0A0S4JKP6	Bodo saltans	55%	100%
A0A1X0NU53	Trypanosomatidae	66%	95%
A0A3R7NKZ5	Trypanosoma rangeli	61%	96%
A4H846	Leishmania braziliensis	90%	100%
A4HWH4	Leishmania infantum	100%	100%
C9ZXX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	98%
E9AQ76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QFA7	Leishmania major	96%	100%