Methyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative methyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTG3_LEIDO

TriTrypDb:

LdBPK_150770.1 , LdCL_150012700 , LDHU3_15.0960

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTG3

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.769
CLV_C14_Caspase3-7	214	218	PF00656	0.583
CLV_NRD_NRD_1	258	260	PF00675	0.605
CLV_NRD_NRD_1	320	322	PF00675	0.376
CLV_PCSK_FUR_1	256	260	PF00082	0.547
CLV_PCSK_KEX2_1	219	221	PF00082	0.504
CLV_PCSK_KEX2_1	255	257	PF00082	0.681
CLV_PCSK_KEX2_1	258	260	PF00082	0.606
CLV_PCSK_KEX2_1	320	322	PF00082	0.376
CLV_PCSK_KEX2_1	459	461	PF00082	0.559
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.504
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.620
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.578
CLV_PCSK_SKI1_1	291	295	PF00082	0.444
CLV_PCSK_SKI1_1	321	325	PF00082	0.376
CLV_PCSK_SKI1_1	8	12	PF00082	0.473
DEG_Nend_UBRbox_1	1	4	PF02207	0.475
DEG_SCF_FBW7_1	246	253	PF00400	0.758
DEG_SPOP_SBC_1	131	135	PF00917	0.791
DEG_SPOP_SBC_1	382	386	PF00917	0.625
DOC_ANK_TNKS_1	258	265	PF00023	0.468
DOC_CKS1_1	76	81	PF01111	0.456
DOC_CYCLIN_RxL_1	286	295	PF00134	0.501
DOC_MAPK_DCC_7	56	66	PF00069	0.460
DOC_MAPK_FxFP_2	109	112	PF00069	0.578
DOC_MAPK_JIP1_4	191	197	PF00069	0.538
DOC_MAPK_MEF2A_6	466	474	PF00069	0.489
DOC_MAPK_MEF2A_6	56	65	PF00069	0.496
DOC_PP1_RVXF_1	318	325	PF00149	0.376
DOC_PP4_FxxP_1	109	112	PF00568	0.642
DOC_PP4_FxxP_1	113	116	PF00568	0.605
DOC_PP4_FxxP_1	17	20	PF00568	0.485
DOC_PP4_FxxP_1	29	32	PF00568	0.433
DOC_PP4_FxxP_1	73	76	PF00568	0.462
DOC_USP7_MATH_1	130	134	PF00917	0.703
DOC_USP7_MATH_1	159	163	PF00917	0.533
DOC_USP7_MATH_1	212	216	PF00917	0.721
DOC_USP7_MATH_1	218	222	PF00917	0.628
DOC_USP7_MATH_1	250	254	PF00917	0.768
DOC_USP7_MATH_1	346	350	PF00917	0.518
DOC_USP7_MATH_1	382	386	PF00917	0.616
DOC_USP7_MATH_2	209	215	PF00917	0.607
DOC_WW_Pin1_4	112	117	PF00397	0.581
DOC_WW_Pin1_4	141	146	PF00397	0.650
DOC_WW_Pin1_4	198	203	PF00397	0.571
DOC_WW_Pin1_4	228	233	PF00397	0.573
DOC_WW_Pin1_4	242	247	PF00397	0.671
DOC_WW_Pin1_4	28	33	PF00397	0.446
DOC_WW_Pin1_4	357	362	PF00397	0.587
DOC_WW_Pin1_4	57	62	PF00397	0.452
DOC_WW_Pin1_4	75	80	PF00397	0.424
DOC_WW_Pin1_4	82	87	PF00397	0.438
LIG_14-3-3_CanoR_1	47	55	PF00244	0.472
LIG_ActinCP_TwfCPI_2	73	83	PF01115	0.461
LIG_APCC_ABBAyCdc20_2	320	326	PF00400	0.353
LIG_BRCT_BRCA1_1	220	224	PF00533	0.575
LIG_BRCT_BRCA1_1	48	52	PF00533	0.458
LIG_BRCT_BRCA1_1	84	88	PF00533	0.488
LIG_CSL_BTD_1	147	150	PF09270	0.571
LIG_deltaCOP1_diTrp_1	371	377	PF00928	0.416
LIG_EVH1_1	29	33	PF00568	0.438
LIG_FHA_1	188	194	PF00498	0.615
LIG_FHA_1	357	363	PF00498	0.564
LIG_FHA_1	423	429	PF00498	0.528
LIG_FHA_1	93	99	PF00498	0.507
LIG_FHA_2	124	130	PF00498	0.793
LIG_FHA_2	165	171	PF00498	0.469
LIG_FHA_2	228	234	PF00498	0.572
LIG_GBD_Chelix_1	411	419	PF00786	0.400
LIG_HP1_1	159	163	PF01393	0.586
LIG_LIR_Apic_2	15	21	PF02991	0.428
LIG_LIR_Gen_1	157	168	PF02991	0.590
LIG_LIR_Gen_1	371	378	PF02991	0.430
LIG_LIR_Gen_1	390	397	PF02991	0.475
LIG_LIR_Gen_1	49	59	PF02991	0.457
LIG_LIR_Nem_3	155	161	PF02991	0.586
LIG_LIR_Nem_3	371	375	PF02991	0.413
LIG_LIR_Nem_3	390	395	PF02991	0.487
LIG_LIR_Nem_3	49	55	PF02991	0.457
LIG_LIR_Nem_3	85	91	PF02991	0.495
LIG_Pex14_1	418	422	PF04695	0.474
LIG_Pex14_2	109	113	PF04695	0.629
LIG_SH2_CRK	267	271	PF00017	0.376
LIG_SH2_CRK	290	294	PF00017	0.430
LIG_SH2_STAT5	282	285	PF00017	0.376
LIG_SH2_STAT5	422	425	PF00017	0.449
LIG_SH2_STAT5	434	437	PF00017	0.381
LIG_SH2_STAT5	441	444	PF00017	0.317
LIG_SH3_3	139	145	PF00018	0.648
LIG_SH3_3	17	23	PF00018	0.437
LIG_SH3_3	27	33	PF00018	0.422
LIG_SH3_3	73	79	PF00018	0.491
MOD_CK1_1	115	121	PF00069	0.756
MOD_CK1_1	133	139	PF00069	0.675
MOD_CK1_1	154	160	PF00069	0.519
MOD_CK1_1	162	168	PF00069	0.526
MOD_CK1_1	201	207	PF00069	0.493
MOD_CK1_1	376	382	PF00069	0.557
MOD_CK1_1	399	405	PF00069	0.462
MOD_CK1_1	50	56	PF00069	0.460
MOD_CK1_1	77	83	PF00069	0.460
MOD_CK2_1	164	170	PF00069	0.522
MOD_CK2_1	227	233	PF00069	0.516
MOD_CK2_1	289	295	PF00069	0.473
MOD_DYRK1A_RPxSP_1	198	202	PF00069	0.335
MOD_DYRK1A_RPxSP_1	75	79	PF00069	0.458
MOD_GlcNHglycan	103	107	PF01048	0.746
MOD_GlcNHglycan	203	206	PF01048	0.705
MOD_GlcNHglycan	214	217	PF01048	0.773
MOD_GlcNHglycan	252	255	PF01048	0.667
MOD_GlcNHglycan	385	388	PF01048	0.666
MOD_GlcNHglycan	446	449	PF01048	0.488
MOD_GSK3_1	112	119	PF00069	0.689
MOD_GSK3_1	130	137	PF00069	0.740
MOD_GSK3_1	218	225	PF00069	0.601
MOD_GSK3_1	236	243	PF00069	0.581
MOD_GSK3_1	246	253	PF00069	0.685
MOD_GSK3_1	346	353	PF00069	0.551
MOD_GSK3_1	46	53	PF00069	0.460
MOD_GSK3_1	71	78	PF00069	0.502
MOD_LATS_1	45	51	PF00433	0.459
MOD_N-GLC_1	186	191	PF02516	0.488
MOD_N-GLC_1	346	351	PF02516	0.525
MOD_N-GLC_2	333	335	PF02516	0.397
MOD_NEK2_1	102	107	PF00069	0.704
MOD_NEK2_1	350	355	PF00069	0.556
MOD_NEK2_1	46	51	PF00069	0.460
MOD_NEK2_1	472	477	PF00069	0.442
MOD_NEK2_1	91	96	PF00069	0.756
MOD_PIKK_1	240	246	PF00454	0.671
MOD_PIKK_1	350	356	PF00454	0.492
MOD_PIKK_1	376	382	PF00454	0.631
MOD_PIKK_1	92	98	PF00454	0.481
MOD_PKA_2	46	52	PF00069	0.473
MOD_PKA_2	472	478	PF00069	0.503
MOD_PKA_2	71	77	PF00069	0.480
MOD_Plk_1	346	352	PF00069	0.537
MOD_Plk_1	373	379	PF00069	0.564
MOD_Plk_1	399	405	PF00069	0.409
MOD_Plk_2-3	164	170	PF00069	0.522
MOD_ProDKin_1	112	118	PF00069	0.581
MOD_ProDKin_1	141	147	PF00069	0.650
MOD_ProDKin_1	198	204	PF00069	0.581
MOD_ProDKin_1	228	234	PF00069	0.569
MOD_ProDKin_1	242	248	PF00069	0.675
MOD_ProDKin_1	28	34	PF00069	0.443
MOD_ProDKin_1	357	363	PF00069	0.567
MOD_ProDKin_1	57	63	PF00069	0.455
MOD_ProDKin_1	75	81	PF00069	0.424
MOD_ProDKin_1	82	88	PF00069	0.440
MOD_SUMO_for_1	254	257	PF00179	0.632
MOD_SUMO_rev_2	211	221	PF00179	0.543
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.566
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.458
TRG_ENDOCYTIC_2	267	270	PF00928	0.407
TRG_ENDOCYTIC_2	290	293	PF00928	0.392
TRG_ENDOCYTIC_2	441	444	PF00928	0.487
TRG_ER_diArg_1	320	322	PF00400	0.376
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G2	Leptomonas seymouri	58%	100%
A0A1X0NU45	Trypanosomatidae	37%	100%
A4H852	Leishmania braziliensis	81%	100%
A4HWH0	Leishmania infantum	99%	100%
E9AQ71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QFB2	Leishmania major	92%	99%