Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTE7_LEIDO

TriTrypDb:

LdBPK_150720.1 , LdCL_150012300 , LDHU3_15.0920

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WTE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTE7

Function

Biological processes
Term	Name	Level	Count
GO:0006450	regulation of translational fidelity	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0006082	organic acid metabolic process	3	4
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006399	tRNA metabolic process	7	4
GO:0006520	amino acid metabolic process	3	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0016070	RNA metabolic process	5	4
GO:0019752	carboxylic acid metabolic process	5	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0034660	ncRNA metabolic process	6	4
GO:0043038	amino acid activation	4	4
GO:0043039	tRNA aminoacylation	5	4
GO:0043170	macromolecule metabolic process	3	4
GO:0043436	oxoacid metabolic process	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044281	small molecule metabolic process	2	4
GO:0046483	heterocycle metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:1901564	organonitrogen compound metabolic process	3	4
GO:0006418	tRNA aminoacylation for protein translation	6	3
GO:0006419	alanyl-tRNA aminoacylation	7	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0036094	small molecule binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0002161	aminoacyl-tRNA editing activity	5	1
GO:0002196	Ser-tRNA(Ala) hydrolase activity	6	1
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0052689	carboxylic ester hydrolase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	5
GO:0140101	catalytic activity, acting on a tRNA	4	5
GO:0140640	catalytic activity, acting on a nucleic acid	2	5
GO:0004812	aminoacyl-tRNA ligase activity	4	4
GO:0005524	ATP binding	5	4
GO:0016874	ligase activity	2	4
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	4
GO:0017076	purine nucleotide binding	4	4
GO:0030554	adenyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032559	adenyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0097367	carbohydrate derivative binding	2	4
GO:0004813	alanine-tRNA ligase activity	5	3
GO:0003676	nucleic acid binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.424
CLV_MEL_PAP_1	4	10	PF00089	0.456
CLV_NRD_NRD_1	103	105	PF00675	0.416
CLV_NRD_NRD_1	131	133	PF00675	0.387
CLV_NRD_NRD_1	235	237	PF00675	0.593
CLV_NRD_NRD_1	345	347	PF00675	0.427
CLV_NRD_NRD_1	389	391	PF00675	0.397
CLV_NRD_NRD_1	411	413	PF00675	0.472
CLV_PCSK_KEX2_1	103	105	PF00082	0.416
CLV_PCSK_KEX2_1	131	133	PF00082	0.399
CLV_PCSK_KEX2_1	235	237	PF00082	0.595
CLV_PCSK_KEX2_1	311	313	PF00082	0.359
CLV_PCSK_KEX2_1	345	347	PF00082	0.467
CLV_PCSK_KEX2_1	358	360	PF00082	0.368
CLV_PCSK_KEX2_1	389	391	PF00082	0.378
CLV_PCSK_KEX2_1	411	413	PF00082	0.472
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.287
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.479
CLV_PCSK_PC7_1	231	237	PF00082	0.535
CLV_PCSK_SKI1_1	20	24	PF00082	0.431
CLV_PCSK_SKI1_1	348	352	PF00082	0.438
CLV_PCSK_SKI1_1	355	359	PF00082	0.405
CLV_PCSK_SKI1_1	40	44	PF00082	0.648
CLV_PCSK_SKI1_1	412	416	PF00082	0.405
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	164	170	PF00134	0.433
DOC_MAPK_gen_1	355	364	PF00069	0.437
DOC_MAPK_gen_1	389	397	PF00069	0.453
DOC_MAPK_MEF2A_6	299	307	PF00069	0.371
DOC_MAPK_MEF2A_6	389	397	PF00069	0.486
DOC_PP1_RVXF_1	302	308	PF00149	0.341
DOC_PP1_RVXF_1	468	474	PF00149	0.554
DOC_PP2B_LxvP_1	155	158	PF13499	0.510
DOC_USP7_MATH_1	158	162	PF00917	0.419
DOC_USP7_MATH_1	240	244	PF00917	0.663
DOC_USP7_MATH_1	250	254	PF00917	0.447
DOC_USP7_MATH_1	271	275	PF00917	0.544
DOC_USP7_MATH_1	85	89	PF00917	0.630
DOC_USP7_UBL2_3	476	480	PF12436	0.462
DOC_WW_Pin1_4	110	115	PF00397	0.447
DOC_WW_Pin1_4	181	186	PF00397	0.493
DOC_WW_Pin1_4	443	448	PF00397	0.520
LIG_14-3-3_CanoR_1	265	270	PF00244	0.426
LIG_14-3-3_CanoR_1	359	363	PF00244	0.459
LIG_14-3-3_CanoR_1	423	429	PF00244	0.662
LIG_Actin_WH2_2	398	413	PF00022	0.521
LIG_BIR_II_1	1	5	PF00653	0.464
LIG_BIR_III_4	406	410	PF00653	0.493
LIG_BRCT_BRCA1_1	58	62	PF00533	0.373
LIG_FHA_1	106	112	PF00498	0.411
LIG_FHA_1	144	150	PF00498	0.429
LIG_FHA_1	152	158	PF00498	0.413
LIG_FHA_1	21	27	PF00498	0.423
LIG_FHA_1	259	265	PF00498	0.456
LIG_FHA_1	359	365	PF00498	0.403
LIG_FHA_1	381	387	PF00498	0.545
LIG_FHA_1	466	472	PF00498	0.522
LIG_FHA_1	49	55	PF00498	0.327
LIG_FHA_1	72	78	PF00498	0.513
LIG_FHA_2	282	288	PF00498	0.468
LIG_FHA_2	349	355	PF00498	0.510
LIG_FHA_2	440	446	PF00498	0.514
LIG_LIR_Gen_1	165	175	PF02991	0.398
LIG_LIR_Gen_1	338	343	PF02991	0.473
LIG_LIR_Gen_1	396	405	PF02991	0.387
LIG_LIR_Gen_1	481	489	PF02991	0.503
LIG_LIR_Gen_1	49	60	PF02991	0.362
LIG_LIR_Nem_3	165	171	PF02991	0.432
LIG_LIR_Nem_3	184	189	PF02991	0.523
LIG_LIR_Nem_3	338	342	PF02991	0.502
LIG_LIR_Nem_3	396	401	PF02991	0.368
LIG_LIR_Nem_3	481	485	PF02991	0.507
LIG_LIR_Nem_3	49	55	PF02991	0.378
LIG_PCNA_yPIPBox_3	142	156	PF02747	0.431
LIG_SH2_CRK	168	172	PF00017	0.467
LIG_SH2_CRK	52	56	PF00017	0.436
LIG_SH2_STAP1	52	56	PF00017	0.436
LIG_SH2_STAT5	168	171	PF00017	0.430
LIG_SH2_STAT5	189	192	PF00017	0.523
LIG_SH2_STAT5	292	295	PF00017	0.478
LIG_SH2_STAT5	306	309	PF00017	0.412
LIG_SH3_3	124	130	PF00018	0.446
LIG_SH3_3	179	185	PF00018	0.528
LIG_SH3_3	257	263	PF00018	0.499
LIG_SH3_3	381	387	PF00018	0.543
LIG_SH3_3	57	63	PF00018	0.333
LIG_SUMO_SIM_anti_2	338	344	PF11976	0.529
LIG_SUMO_SIM_par_1	265	270	PF11976	0.365
LIG_SUMO_SIM_par_1	360	366	PF11976	0.523
LIG_SUMO_SIM_par_1	412	417	PF11976	0.450
LIG_SUMO_SIM_par_1	95	100	PF11976	0.564
LIG_TYR_ITIM	50	55	PF00017	0.449
MOD_CK1_1	46	52	PF00069	0.502
MOD_CK2_1	281	287	PF00069	0.437
MOD_CK2_1	348	354	PF00069	0.510
MOD_CK2_1	439	445	PF00069	0.506
MOD_CK2_1	475	481	PF00069	0.500
MOD_Cter_Amidation	309	312	PF01082	0.277
MOD_GlcNHglycan	242	245	PF01048	0.719
MOD_GlcNHglycan	416	419	PF01048	0.412
MOD_GlcNHglycan	430	433	PF01048	0.472
MOD_GlcNHglycan	78	81	PF01048	0.602
MOD_GSK3_1	105	112	PF00069	0.203
MOD_GSK3_1	156	163	PF00069	0.418
MOD_GSK3_1	177	184	PF00069	0.465
MOD_GSK3_1	236	243	PF00069	0.552
MOD_GSK3_1	273	280	PF00069	0.362
MOD_GSK3_1	344	351	PF00069	0.484
MOD_GSK3_1	376	383	PF00069	0.595
MOD_GSK3_1	439	446	PF00069	0.539
MOD_GSK3_1	44	51	PF00069	0.550
MOD_GSK3_1	85	92	PF00069	0.700
MOD_NEK2_1	22	27	PF00069	0.435
MOD_NEK2_1	331	336	PF00069	0.484
MOD_NEK2_1	56	61	PF00069	0.353
MOD_NEK2_1	97	102	PF00069	0.538
MOD_NEK2_2	475	480	PF00069	0.498
MOD_PKA_1	194	200	PF00069	0.533
MOD_PKA_1	358	364	PF00069	0.512
MOD_PKA_2	344	350	PF00069	0.501
MOD_PKA_2	358	364	PF00069	0.384
MOD_PKA_2	422	428	PF00069	0.620
MOD_Plk_1	151	157	PF00069	0.331
MOD_Plk_2-3	363	369	PF00069	0.434
MOD_Plk_2-3	48	54	PF00069	0.352
MOD_Plk_4	14	20	PF00069	0.398
MOD_Plk_4	22	28	PF00069	0.448
MOD_Plk_4	298	304	PF00069	0.514
MOD_Plk_4	338	344	PF00069	0.560
MOD_Plk_4	481	487	PF00069	0.530
MOD_Plk_4	56	62	PF00069	0.340
MOD_ProDKin_1	110	116	PF00069	0.453
MOD_ProDKin_1	181	187	PF00069	0.492
MOD_ProDKin_1	443	449	PF00069	0.516
MOD_SUMO_for_1	202	205	PF00179	0.480
TRG_DiLeu_BaEn_1	481	486	PF01217	0.503
TRG_ENDOCYTIC_2	168	171	PF00928	0.430
TRG_ENDOCYTIC_2	52	55	PF00928	0.410
TRG_ER_diArg_1	102	104	PF00400	0.460
TRG_ER_diArg_1	130	132	PF00400	0.419
TRG_ER_diArg_1	251	254	PF00400	0.606
TRG_ER_diArg_1	388	390	PF00400	0.399
TRG_ER_diArg_1	401	404	PF00400	0.386
TRG_ER_diArg_1	410	412	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	325	330	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1V1	Leptomonas seymouri	73%	99%
A0A0S4J566	Bodo saltans	42%	100%
A0A1X0NTW0	Trypanosomatidae	43%	100%
A0A422NRG2	Trypanosoma rangeli	44%	100%
A4H839	Leishmania braziliensis	82%	100%
A4HWG6	Leishmania infantum	100%	100%
C9ZXY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AQ67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P53960	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q08B09	Xenopus laevis	28%	100%
Q3THG9	Mus musculus	30%	100%
Q4QFB6	Leishmania major	96%	100%
Q5XI97	Rattus norvegicus	30%	100%
Q6DEJ5	Danio rerio	30%	100%
Q7ZYJ9	Xenopus laevis	29%	100%
Q9BTE6	Homo sapiens	31%	100%