Ecotin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ecotin, putative

Gene product:

ecotin, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTD9_LEIDO

TriTrypDb:

LdBPK_150540.1 , LdCL_150010500 , LDHU3_15.0690

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTD9

Function

Biological processes
Term	Name	Level	Count
GO:0009605	response to external stimulus	2	1
GO:0009607	response to biotic stimulus	2	1
GO:0042783	evasion of host immune response	6	1
GO:0042784	evasion of host immune response via modulation of host complement system	7	1
GO:0043207	response to external biotic stimulus	3	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044419	biological process involved in interspecies interaction between organisms	1	1
GO:0050896	response to stimulus	1	1
GO:0051701	biological process involved in interaction with host	3	1
GO:0051707	response to other organism	2	1
GO:0052173	response to defenses of other organism	3	1
GO:0052200	response to host defenses	4	1
GO:0052572	response to host immune response	5	1
GO:0075136	response to host	3	1

Molecular functions
Term	Name	Level	Count
GO:0004857	enzyme inhibitor activity	3	6
GO:0004866	endopeptidase inhibitor activity	5	6
GO:0004867	serine-type endopeptidase inhibitor activity	6	6
GO:0030234	enzyme regulator activity	2	6
GO:0030414	peptidase inhibitor activity	4	6
GO:0061134	peptidase regulator activity	3	6
GO:0061135	endopeptidase regulator activity	4	6
GO:0098772	molecular function regulator activity	1	6
GO:0140678	molecular function inhibitor activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.452
CLV_NRD_NRD_1	258	260	PF00675	0.683
CLV_NRD_NRD_1	307	309	PF00675	0.840
CLV_NRD_NRD_1	360	362	PF00675	0.780
CLV_PCSK_KEX2_1	257	259	PF00082	0.688
CLV_PCSK_KEX2_1	297	299	PF00082	0.831
CLV_PCSK_KEX2_1	307	309	PF00082	0.730
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.688
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.749
CLV_PCSK_SKI1_1	346	350	PF00082	0.599
CLV_Separin_Metazoa	165	169	PF03568	0.704
DOC_ANK_TNKS_1	167	174	PF00023	0.600
DOC_MAPK_MEF2A_6	111	118	PF00069	0.530
DOC_USP7_MATH_1	107	111	PF00917	0.530
DOC_USP7_MATH_1	217	221	PF00917	0.760
DOC_USP7_MATH_1	276	280	PF00917	0.770
DOC_USP7_MATH_1	306	310	PF00917	0.814
DOC_USP7_MATH_1	363	367	PF00917	0.841
DOC_USP7_MATH_1	84	88	PF00917	0.452
DOC_USP7_MATH_2	249	255	PF00917	0.777
DOC_WW_Pin1_4	194	199	PF00397	0.692
DOC_WW_Pin1_4	274	279	PF00397	0.842
DOC_WW_Pin1_4	296	301	PF00397	0.766
DOC_WW_Pin1_4	356	361	PF00397	0.806
LIG_14-3-3_CanoR_1	127	136	PF00244	0.668
LIG_14-3-3_CanoR_1	192	198	PF00244	0.622
LIG_14-3-3_CanoR_1	258	268	PF00244	0.728
LIG_14-3-3_CanoR_1	269	278	PF00244	0.634
LIG_14-3-3_CanoR_1	280	290	PF00244	0.644
LIG_14-3-3_CanoR_1	307	315	PF00244	0.778
LIG_14-3-3_CanoR_1	86	91	PF00244	0.452
LIG_14-3-3_CanoR_1	93	98	PF00244	0.364
LIG_FHA_1	131	137	PF00498	0.483
LIG_FHA_1	180	186	PF00498	0.621
LIG_FHA_1	195	201	PF00498	0.611
LIG_FHA_1	56	62	PF00498	0.530
LIG_FHA_1	93	99	PF00498	0.452
LIG_FHA_2	312	318	PF00498	0.564
LIG_LIR_Apic_2	6	10	PF02991	0.653
LIG_LIR_Gen_1	95	105	PF02991	0.452
LIG_LIR_Nem_3	72	76	PF02991	0.417
LIG_LIR_Nem_3	95	100	PF02991	0.464
LIG_MYND_1	151	155	PF01753	0.696
LIG_MYND_1	198	202	PF01753	0.728
LIG_Pex14_1	69	73	PF04695	0.530
LIG_SH2_CRK	7	11	PF00017	0.530
LIG_SH2_STAP1	344	348	PF00017	0.732
LIG_SH2_STAP1	71	75	PF00017	0.452
LIG_SH2_STAT3	175	178	PF00017	0.725
LIG_SH2_STAT3	24	27	PF00017	0.433
LIG_SH2_STAT3	288	291	PF00017	0.683
LIG_SH2_STAT5	117	120	PF00017	0.530
LIG_SH2_STAT5	175	178	PF00017	0.725
LIG_SH2_STAT5	24	27	PF00017	0.369
LIG_SH2_STAT5	74	77	PF00017	0.530
LIG_SH3_3	113	119	PF00018	0.483
LIG_SH3_3	140	146	PF00018	0.680
LIG_SH3_3	196	202	PF00018	0.718
LIG_SH3_3	275	281	PF00018	0.759
LIG_SH3_3	317	323	PF00018	0.734
LIG_SH3_3	6	12	PF00018	0.452
LIG_SUMO_SIM_par_1	182	189	PF11976	0.692
LIG_TRAF2_1	186	189	PF00917	0.743
LIG_TRAF2_1	249	252	PF00917	0.741
LIG_TRAF2_1	314	317	PF00917	0.780
LIG_WRC_WIRS_1	94	99	PF05994	0.316
MOD_CDC14_SPxK_1	277	280	PF00782	0.722
MOD_CDC14_SPxK_1	359	362	PF00782	0.827
MOD_CDK_SPK_2	356	361	PF00069	0.806
MOD_CDK_SPxK_1	274	280	PF00069	0.727
MOD_CDK_SPxK_1	356	362	PF00069	0.811
MOD_CK1_1	183	189	PF00069	0.697
MOD_CK1_1	194	200	PF00069	0.579
MOD_CK1_1	260	266	PF00069	0.844
MOD_CK1_1	309	315	PF00069	0.748
MOD_CK1_1	328	334	PF00069	0.609
MOD_CK1_1	364	370	PF00069	0.777
MOD_CK2_1	183	189	PF00069	0.736
MOD_CK2_1	205	211	PF00069	0.769
MOD_CK2_1	269	275	PF00069	0.784
MOD_CK2_1	281	287	PF00069	0.615
MOD_CK2_1	311	317	PF00069	0.566
MOD_CK2_1	57	63	PF00069	0.530
MOD_DYRK1A_RPxSP_1	356	360	PF00069	0.776
MOD_GlcNHglycan	202	205	PF01048	0.756
MOD_GlcNHglycan	207	210	PF01048	0.703
MOD_GlcNHglycan	219	222	PF01048	0.543
MOD_GlcNHglycan	271	274	PF01048	0.822
MOD_GlcNHglycan	300	303	PF01048	0.854
MOD_GlcNHglycan	311	314	PF01048	0.676
MOD_GlcNHglycan	331	334	PF01048	0.513
MOD_GlcNHglycan	363	366	PF01048	0.847
MOD_GlcNHglycan	369	372	PF01048	0.757
MOD_GSK3_1	127	134	PF00069	0.575
MOD_GSK3_1	179	186	PF00069	0.618
MOD_GSK3_1	257	264	PF00069	0.848
MOD_GSK3_1	296	303	PF00069	0.787
MOD_GSK3_1	307	314	PF00069	0.714
MOD_GSK3_1	325	332	PF00069	0.699
MOD_GSK3_1	363	370	PF00069	0.819
MOD_GSK3_1	55	62	PF00069	0.491
MOD_N-GLC_1	325	330	PF02516	0.780
MOD_N-GLC_1	371	376	PF02516	0.797
MOD_NEK2_1	135	140	PF00069	0.672
MOD_NEK2_1	193	198	PF00069	0.600
MOD_NEK2_1	57	62	PF00069	0.530
MOD_NEK2_2	344	349	PF00069	0.658
MOD_PIKK_1	174	180	PF00454	0.633
MOD_PKA_1	257	263	PF00069	0.732
MOD_PKA_1	307	313	PF00069	0.852
MOD_PKA_1	361	367	PF00069	0.769
MOD_PKA_2	191	197	PF00069	0.727
MOD_PKA_2	205	211	PF00069	0.592
MOD_PKA_2	257	263	PF00069	0.770
MOD_PKA_2	281	287	PF00069	0.810
MOD_PKA_2	306	312	PF00069	0.792
MOD_PKA_2	326	332	PF00069	0.526
MOD_PKA_2	85	91	PF00069	0.452
MOD_PKA_2	92	98	PF00069	0.364
MOD_PKB_1	125	133	PF00069	0.452
MOD_PKB_1	280	288	PF00069	0.730
MOD_Plk_1	130	136	PF00069	0.599
MOD_Plk_1	251	257	PF00069	0.741
MOD_Plk_1	344	350	PF00069	0.658
MOD_Plk_1	62	68	PF00069	0.530
MOD_Plk_2-3	311	317	PF00069	0.566
MOD_Plk_4	131	137	PF00069	0.483
MOD_Plk_4	180	186	PF00069	0.694
MOD_Plk_4	69	75	PF00069	0.429
MOD_Plk_4	93	99	PF00069	0.452
MOD_ProDKin_1	194	200	PF00069	0.696
MOD_ProDKin_1	274	280	PF00069	0.843
MOD_ProDKin_1	296	302	PF00069	0.766
MOD_ProDKin_1	356	362	PF00069	0.811
MOD_SUMO_rev_2	174	183	PF00179	0.686
TRG_DiLeu_BaEn_4	188	194	PF01217	0.707
TRG_DiLeu_BaEn_4	251	257	PF01217	0.741
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.736
TRG_ENDOCYTIC_2	73	76	PF00928	0.530
TRG_ER_diArg_1	280	283	PF00400	0.727
TRG_ER_diArg_1	306	308	PF00400	0.860
TRG_NLS_Bipartite_1	307	328	PF00514	0.851
TRG_NLS_MonoExtN_4	323	328	PF00514	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H824	Leishmania braziliensis	46%	82%
A4HWF0	Leishmania infantum	99%	100%
E9AQ49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
Q4QFD3	Leishmania major	90%	100%