TPR repeat/DnaJ domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTD0_LEIDO

TriTrypDb:

LdBPK_141410.1 , LdCL_140020000 , LDHU3_14.1760

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 2
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WTD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTD0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	201	203	PF00675	0.494
CLV_NRD_NRD_1	228	230	PF00675	0.401
CLV_NRD_NRD_1	268	270	PF00675	0.467
CLV_NRD_NRD_1	281	283	PF00675	0.369
CLV_NRD_NRD_1	430	432	PF00675	0.507
CLV_NRD_NRD_1	450	452	PF00675	0.122
CLV_NRD_NRD_1	453	455	PF00675	0.306
CLV_PCSK_FUR_1	226	230	PF00082	0.437
CLV_PCSK_KEX2_1	228	230	PF00082	0.411
CLV_PCSK_KEX2_1	268	270	PF00082	0.461
CLV_PCSK_KEX2_1	281	283	PF00082	0.348
CLV_PCSK_KEX2_1	312	314	PF00082	0.516
CLV_PCSK_KEX2_1	426	428	PF00082	0.511
CLV_PCSK_KEX2_1	450	452	PF00082	0.306
CLV_PCSK_KEX2_1	497	499	PF00082	0.337
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.516
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.476
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.337
CLV_PCSK_SKI1_1	23	27	PF00082	0.508
CLV_PCSK_SKI1_1	247	251	PF00082	0.516
CLV_PCSK_SKI1_1	305	309	PF00082	0.429
CLV_PCSK_SKI1_1	455	459	PF00082	0.393
CLV_PCSK_SKI1_1	468	472	PF00082	0.395
CLV_PCSK_SKI1_1	489	493	PF00082	0.306
CLV_PCSK_SKI1_1	52	56	PF00082	0.384
DEG_APCC_DBOX_1	22	30	PF00400	0.471
DEG_APCC_DBOX_1	92	100	PF00400	0.366
DEG_SPOP_SBC_1	3	7	PF00917	0.555
DOC_CYCLIN_RxL_1	19	28	PF00134	0.471
DOC_CYCLIN_RxL_1	279	289	PF00134	0.411
DOC_CYCLIN_RxL_1	431	443	PF00134	0.453
DOC_CYCLIN_RxL_1	49	59	PF00134	0.452
DOC_MAPK_gen_1	142	150	PF00069	0.534
DOC_MAPK_gen_1	202	210	PF00069	0.506
DOC_MAPK_gen_1	317	325	PF00069	0.498
DOC_USP7_MATH_1	157	161	PF00917	0.505
DOC_USP7_MATH_1	3	7	PF00917	0.457
DOC_USP7_MATH_1	349	353	PF00917	0.506
DOC_USP7_MATH_1	457	461	PF00917	0.439
DOC_USP7_UBL2_3	152	156	PF12436	0.489
DOC_USP7_UBL2_3	308	312	PF12436	0.503
DOC_USP7_UBL2_3	432	436	PF12436	0.306
DOC_WW_Pin1_4	250	255	PF00397	0.563
DOC_WW_Pin1_4	372	377	PF00397	0.446
LIG_14-3-3_CanoR_1	127	131	PF00244	0.421
LIG_14-3-3_CanoR_1	176	184	PF00244	0.488
LIG_14-3-3_CanoR_1	354	362	PF00244	0.510
LIG_14-3-3_CanoR_1	4	10	PF00244	0.632
LIG_Actin_WH2_2	411	428	PF00022	0.526
LIG_BRCT_BRCA1_1	38	42	PF00533	0.453
LIG_FHA_1	241	247	PF00498	0.521
LIG_FHA_1	48	54	PF00498	0.374
LIG_FHA_1	75	81	PF00498	0.372
LIG_FHA_2	375	381	PF00498	0.527
LIG_FHA_2	469	475	PF00498	0.430
LIG_LIR_Apic_2	181	187	PF02991	0.570
LIG_LIR_Gen_1	174	183	PF02991	0.485
LIG_LIR_Gen_1	316	327	PF02991	0.468
LIG_LIR_Gen_1	74	84	PF02991	0.454
LIG_LIR_Gen_1	95	105	PF02991	0.468
LIG_LIR_LC3C_4	28	32	PF02991	0.659
LIG_LIR_Nem_3	174	180	PF02991	0.397
LIG_LIR_Nem_3	316	322	PF02991	0.438
LIG_LIR_Nem_3	433	438	PF02991	0.319
LIG_LIR_Nem_3	479	485	PF02991	0.306
LIG_LIR_Nem_3	74	79	PF02991	0.518
LIG_NRBOX	109	115	PF00104	0.347
LIG_NRBOX	25	31	PF00104	0.585
LIG_Pex14_2	519	523	PF04695	0.695
LIG_Pex14_2	527	531	PF04695	0.668
LIG_Pex14_2	535	539	PF04695	0.666
LIG_Pex14_2	543	547	PF04695	0.437
LIG_REV1ctd_RIR_1	562	570	PF16727	0.634
LIG_SH2_CRK	151	155	PF00017	0.553
LIG_SH2_CRK	435	439	PF00017	0.306
LIG_SH2_CRK	453	457	PF00017	0.306
LIG_SH2_CRK	76	80	PF00017	0.507
LIG_SH2_GRB2like	501	504	PF00017	0.476
LIG_SH2_NCK_1	17	21	PF00017	0.470
LIG_SH2_NCK_1	191	195	PF00017	0.549
LIG_SH2_NCK_1	91	95	PF00017	0.360
LIG_SH2_SRC	501	504	PF00017	0.476
LIG_SH2_STAP1	17	21	PF00017	0.582
LIG_SH2_STAP1	173	177	PF00017	0.442
LIG_SH2_STAP1	191	195	PF00017	0.490
LIG_SH2_STAP1	338	342	PF00017	0.510
LIG_SH2_STAP1	76	80	PF00017	0.337
LIG_SH2_STAT3	248	251	PF00017	0.426
LIG_SH2_STAT3	338	341	PF00017	0.434
LIG_SH2_STAT5	173	176	PF00017	0.420
LIG_SH2_STAT5	191	194	PF00017	0.528
LIG_SH2_STAT5	248	251	PF00017	0.419
LIG_SH2_STAT5	76	79	PF00017	0.362
LIG_SH3_3	331	337	PF00018	0.587
LIG_SH3_3	504	510	PF00018	0.537
LIG_SUMO_SIM_anti_2	206	212	PF11976	0.384
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.622
LIG_TRAF2_1	242	245	PF00917	0.397
LIG_TRAF2_1	337	340	PF00917	0.520
LIG_UBA3_1	113	118	PF00899	0.368
LIG_UBA3_1	306	312	PF00899	0.438
LIG_UBA3_1	437	442	PF00899	0.426
MOD_CK1_1	129	135	PF00069	0.457
MOD_CK1_1	160	166	PF00069	0.570
MOD_CK1_1	219	225	PF00069	0.532
MOD_CK1_1	5	11	PF00069	0.568
MOD_CK1_1	74	80	PF00069	0.515
MOD_CK2_1	273	279	PF00069	0.517
MOD_CK2_1	468	474	PF00069	0.307
MOD_CK2_1	89	95	PF00069	0.344
MOD_GlcNHglycan	133	136	PF01048	0.272
MOD_GlcNHglycan	38	41	PF01048	0.567
MOD_GlcNHglycan	444	447	PF01048	0.376
MOD_GSK3_1	157	164	PF00069	0.577
MOD_GSK3_1	171	178	PF00069	0.370
MOD_GSK3_1	2	9	PF00069	0.649
MOD_GSK3_1	349	356	PF00069	0.398
MOD_GSK3_1	464	471	PF00069	0.306
MOD_GSK3_1	74	81	PF00069	0.364
MOD_NEK2_1	126	131	PF00069	0.398
MOD_NEK2_1	2	7	PF00069	0.664
MOD_NEK2_1	25	30	PF00069	0.589
MOD_NEK2_1	273	278	PF00069	0.504
MOD_NEK2_1	425	430	PF00069	0.568
MOD_NEK2_1	440	445	PF00069	0.303
MOD_NEK2_1	456	461	PF00069	0.227
MOD_NEK2_1	518	523	PF00069	0.748
MOD_NEK2_2	349	354	PF00069	0.399
MOD_PIKK_1	129	135	PF00454	0.455
MOD_PIKK_1	157	163	PF00454	0.527
MOD_PIKK_1	182	188	PF00454	0.566
MOD_PIKK_1	240	246	PF00454	0.498
MOD_PIKK_1	247	253	PF00454	0.526
MOD_PK_1	216	222	PF00069	0.313
MOD_PKA_2	126	132	PF00069	0.400
MOD_PKA_2	175	181	PF00069	0.515
MOD_PKA_2	3	9	PF00069	0.640
MOD_PKA_2	353	359	PF00069	0.420
MOD_Plk_1	216	222	PF00069	0.450
MOD_Plk_1	273	279	PF00069	0.517
MOD_Plk_1	47	53	PF00069	0.467
MOD_Plk_4	25	31	PF00069	0.592
MOD_Plk_4	374	380	PF00069	0.500
MOD_Plk_4	95	101	PF00069	0.394
MOD_ProDKin_1	250	256	PF00069	0.559
MOD_ProDKin_1	372	378	PF00069	0.437
MOD_SUMO_for_1	420	423	PF00179	0.573
MOD_SUMO_for_1	84	87	PF00179	0.536
MOD_SUMO_rev_2	139	147	PF00179	0.522
MOD_SUMO_rev_2	311	319	PF00179	0.503
MOD_SUMO_rev_2	407	415	PF00179	0.583
MOD_SUMO_rev_2	484	491	PF00179	0.327
MOD_SUMO_rev_2	494	499	PF00179	0.312
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.297
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.452
TRG_ENDOCYTIC_2	151	154	PF00928	0.484
TRG_ENDOCYTIC_2	434	437	PF00928	0.306
TRG_ENDOCYTIC_2	453	456	PF00928	0.306
TRG_ENDOCYTIC_2	76	79	PF00928	0.509
TRG_ENDOCYTIC_2	97	100	PF00928	0.459
TRG_ER_diArg_1	12	15	PF00400	0.492
TRG_ER_diArg_1	225	228	PF00400	0.417
TRG_ER_diArg_1	267	269	PF00400	0.462
TRG_ER_diArg_1	280	282	PF00400	0.363
TRG_ER_diArg_1	449	451	PF00400	0.306
TRG_ER_diArg_1	498	501	PF00400	0.341
TRG_NES_CRM1_1	209	224	PF08389	0.436
TRG_NES_CRM1_1	275	289	PF08389	0.451
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0D1E2P6	Ustilago maydis (strain 521 / FGSC 9021)	24%	98%
A0A0D2XVZ5	Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)	28%	100%
A0A0N1PCC0	Leptomonas seymouri	66%	100%
A0A0N1PF59	Leptomonas seymouri	26%	100%
A0A0P0VG31	Oryza sativa subsp. japonica	29%	100%
A0A0S4JQ76	Bodo saltans	45%	100%
A0A1X0NP19	Trypanosomatidae	44%	100%
A0A422NFP3	Trypanosoma rangeli	48%	100%
A4H7V3	Leishmania braziliensis	85%	100%
A4HW79	Leishmania infantum	99%	100%
C9ZST7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9APY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
J9VKM5	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	27%	100%
Q13217	Homo sapiens	29%	100%
Q27968	Bos taurus	28%	100%
Q4QFK1	Leishmania major	93%	99%
Q54M21	Dictyostelium discoideum	26%	100%
Q5JNB5	Oryza sativa subsp. japonica	29%	100%
Q5R8D8	Pongo abelii	23%	100%
Q5ZI13	Gallus gallus	28%	100%
Q91YW3	Mus musculus	28%	100%
Q99615	Homo sapiens	23%	100%
Q9QYI3	Mus musculus	23%	100%
Q9R0T3	Rattus norvegicus	28%	100%
V5BKH0	Trypanosoma cruzi	48%	100%