Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTC9_LEIDO

TriTrypDb:

LdBPK_150460.1 , LdCL_150009500 , LDHU3_15.0560

Length:

694

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WTC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.447
CLV_C14_Caspase3-7	537	541	PF00656	0.583
CLV_NRD_NRD_1	161	163	PF00675	0.318
CLV_NRD_NRD_1	212	214	PF00675	0.303
CLV_NRD_NRD_1	3	5	PF00675	0.417
CLV_NRD_NRD_1	300	302	PF00675	0.399
CLV_NRD_NRD_1	306	308	PF00675	0.270
CLV_NRD_NRD_1	38	40	PF00675	0.319
CLV_NRD_NRD_1	481	483	PF00675	0.361
CLV_PCSK_KEX2_1	160	162	PF00082	0.321
CLV_PCSK_KEX2_1	212	214	PF00082	0.373
CLV_PCSK_KEX2_1	260	262	PF00082	0.296
CLV_PCSK_KEX2_1	3	5	PF00082	0.417
CLV_PCSK_KEX2_1	300	302	PF00082	0.372
CLV_PCSK_KEX2_1	306	308	PF00082	0.239
CLV_PCSK_KEX2_1	38	40	PF00082	0.319
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.339
CLV_PCSK_PC7_1	157	163	PF00082	0.322
CLV_PCSK_SKI1_1	353	357	PF00082	0.565
CLV_PCSK_SKI1_1	4	8	PF00082	0.444
CLV_PCSK_SKI1_1	638	642	PF00082	0.272
CLV_PCSK_SKI1_1	88	92	PF00082	0.292
CLV_PCSK_SKI1_1	93	97	PF00082	0.285
DEG_APCC_DBOX_1	160	168	PF00400	0.477
DEG_APCC_DBOX_1	195	203	PF00400	0.492
DEG_APCC_DBOX_1	306	314	PF00400	0.448
DEG_Nend_Nbox_1	1	3	PF02207	0.610
DEG_SPOP_SBC_1	438	442	PF00917	0.350
DEG_SPOP_SBC_1	573	577	PF00917	0.752
DOC_CKS1_1	52	57	PF01111	0.500
DOC_CYCLIN_RxL_1	681	693	PF00134	0.492
DOC_CYCLIN_yCln2_LP_2	250	256	PF00134	0.539
DOC_MAPK_gen_1	108	117	PF00069	0.507
DOC_MAPK_gen_1	157	167	PF00069	0.489
DOC_MAPK_gen_1	212	220	PF00069	0.526
DOC_MAPK_gen_1	306	312	PF00069	0.438
DOC_MAPK_gen_1	44	50	PF00069	0.512
DOC_MAPK_gen_1	53	61	PF00069	0.509
DOC_MAPK_gen_1	679	688	PF00069	0.507
DOC_MAPK_gen_1	88	97	PF00069	0.490
DOC_MAPK_MEF2A_6	91	99	PF00069	0.492
DOC_PP1_RVXF_1	685	691	PF00149	0.489
DOC_PP2B_LxvP_1	250	253	PF13499	0.503
DOC_USP7_MATH_1	430	434	PF00917	0.421
DOC_USP7_MATH_1	438	442	PF00917	0.378
DOC_USP7_MATH_1	572	576	PF00917	0.680
DOC_WW_Pin1_4	204	209	PF00397	0.488
DOC_WW_Pin1_4	391	396	PF00397	0.314
DOC_WW_Pin1_4	424	429	PF00397	0.461
DOC_WW_Pin1_4	51	56	PF00397	0.501
LIG_14-3-3_CanoR_1	261	271	PF00244	0.609
LIG_14-3-3_CanoR_1	3	7	PF00244	0.702
LIG_14-3-3_CanoR_1	300	310	PF00244	0.523
LIG_14-3-3_CanoR_1	559	564	PF00244	0.624
LIG_14-3-3_CanoR_1	60	64	PF00244	0.542
LIG_14-3-3_CanoR_1	75	81	PF00244	0.437
LIG_Actin_WH2_2	478	494	PF00022	0.559
LIG_AP2alpha_2	391	393	PF02296	0.349
LIG_APCC_ABBA_1	121	126	PF00400	0.468
LIG_BRCT_BRCA1_1	402	406	PF00533	0.423
LIG_CSL_BTD_1	392	395	PF09270	0.310
LIG_deltaCOP1_diTrp_1	57	61	PF00928	0.527
LIG_EH1_1	181	189	PF00400	0.538
LIG_FHA_1	486	492	PF00498	0.506
LIG_FHA_2	142	148	PF00498	0.527
LIG_FHA_2	272	278	PF00498	0.534
LIG_FHA_2	52	58	PF00498	0.501
LIG_FHA_2	77	83	PF00498	0.544
LIG_Integrin_isoDGR_2	683	685	PF01839	0.403
LIG_LIR_Gen_1	118	129	PF02991	0.473
LIG_LIR_Gen_1	166	176	PF02991	0.478
LIG_LIR_Gen_1	57	66	PF02991	0.519
LIG_LIR_Gen_1	592	601	PF02991	0.469
LIG_LIR_Gen_1	628	637	PF02991	0.455
LIG_LIR_Gen_1	642	651	PF02991	0.496
LIG_LIR_LC3C_4	631	636	PF02991	0.524
LIG_LIR_Nem_3	118	124	PF02991	0.468
LIG_LIR_Nem_3	166	171	PF02991	0.480
LIG_LIR_Nem_3	209	214	PF02991	0.475
LIG_LIR_Nem_3	364	370	PF02991	0.324
LIG_LIR_Nem_3	391	396	PF02991	0.326
LIG_LIR_Nem_3	403	409	PF02991	0.309
LIG_LIR_Nem_3	5	9	PF02991	0.633
LIG_LIR_Nem_3	57	61	PF02991	0.514
LIG_LIR_Nem_3	592	597	PF02991	0.473
LIG_LIR_Nem_3	62	66	PF02991	0.497
LIG_LIR_Nem_3	642	646	PF02991	0.509
LIG_NRBOX	101	107	PF00104	0.519
LIG_Pex14_1	27	31	PF04695	0.519
LIG_PTB_Apo_2	62	69	PF02174	0.508
LIG_PTB_Phospho_1	62	68	PF10480	0.507
LIG_Rb_pABgroove_1	118	126	PF01858	0.471
LIG_SH2_CRK	168	172	PF00017	0.472
LIG_SH2_CRK	63	67	PF00017	0.522
LIG_SH2_NCK_1	112	116	PF00017	0.516
LIG_SH2_SRC	112	115	PF00017	0.607
LIG_SH2_STAP1	31	35	PF00017	0.534
LIG_SH2_STAP1	323	327	PF00017	0.289
LIG_SH2_STAP1	400	404	PF00017	0.400
LIG_SH2_STAT5	170	173	PF00017	0.488
LIG_SH2_STAT5	214	217	PF00017	0.466
LIG_SH2_STAT5	235	238	PF00017	0.597
LIG_SH2_STAT5	309	312	PF00017	0.360
LIG_SH2_STAT5	386	389	PF00017	0.271
LIG_SH3_3	14	20	PF00018	0.544
LIG_SH3_3	371	377	PF00018	0.383
LIG_SH3_3	389	395	PF00018	0.238
LIG_SH3_3	49	55	PF00018	0.502
LIG_SH3_3	5	11	PF00018	0.638
LIG_SUMO_SIM_par_1	216	223	PF11976	0.485
LIG_SUMO_SIM_par_1	483	488	PF11976	0.554
LIG_TRAF2_1	172	175	PF00917	0.473
LIG_TRAF2_1	507	510	PF00917	0.657
LIG_TRFH_1	7	11	PF08558	0.519
LIG_UBA3_1	327	336	PF00899	0.339
LIG_UBA3_1	484	492	PF00899	0.519
MOD_CDK_SPK_2	51	56	PF00069	0.512
MOD_CK1_1	138	144	PF00069	0.569
MOD_CK1_1	30	36	PF00069	0.535
MOD_CK1_1	418	424	PF00069	0.529
MOD_CK1_1	440	446	PF00069	0.446
MOD_CK1_1	575	581	PF00069	0.681
MOD_CK2_1	141	147	PF00069	0.547
MOD_CK2_1	271	277	PF00069	0.524
MOD_CK2_1	76	82	PF00069	0.496
MOD_GlcNHglycan	188	191	PF01048	0.418
MOD_GlcNHglycan	318	321	PF01048	0.274
MOD_GlcNHglycan	323	326	PF01048	0.274
MOD_GlcNHglycan	359	362	PF01048	0.498
MOD_GlcNHglycan	420	423	PF01048	0.705
MOD_GlcNHglycan	457	460	PF01048	0.558
MOD_GlcNHglycan	498	501	PF01048	0.459
MOD_GlcNHglycan	503	506	PF01048	0.431
MOD_GlcNHglycan	666	669	PF01048	0.392
MOD_GSK3_1	202	209	PF00069	0.493
MOD_GSK3_1	27	34	PF00069	0.540
MOD_GSK3_1	276	283	PF00069	0.519
MOD_GSK3_1	311	318	PF00069	0.332
MOD_GSK3_1	413	420	PF00069	0.486
MOD_GSK3_1	501	508	PF00069	0.710
MOD_GSK3_1	574	581	PF00069	0.723
MOD_GSK3_1	9	16	PF00069	0.605
MOD_N-GLC_1	202	207	PF02516	0.371
MOD_N-GLC_1	578	583	PF02516	0.535
MOD_NEK2_1	2	7	PF00069	0.596
MOD_NEK2_1	202	207	PF00069	0.503
MOD_NEK2_1	220	225	PF00069	0.512
MOD_NEK2_1	254	259	PF00069	0.495
MOD_NEK2_1	315	320	PF00069	0.285
MOD_NEK2_1	356	361	PF00069	0.318
MOD_NEK2_1	59	64	PF00069	0.510
MOD_NEK2_1	645	650	PF00069	0.586
MOD_NEK2_1	664	669	PF00069	0.543
MOD_PIKK_1	413	419	PF00454	0.520
MOD_PIKK_1	505	511	PF00454	0.683
MOD_PIKK_1	645	651	PF00454	0.540
MOD_PK_1	44	50	PF00069	0.534
MOD_PKA_1	44	50	PF00069	0.520
MOD_PKA_2	156	162	PF00069	0.573
MOD_PKA_2	2	8	PF00069	0.697
MOD_PKA_2	356	362	PF00069	0.324
MOD_PKA_2	558	564	PF00069	0.631
MOD_PKA_2	573	579	PF00069	0.625
MOD_PKA_2	59	65	PF00069	0.591
MOD_Plk_1	125	131	PF00069	0.516
MOD_Plk_1	202	208	PF00069	0.585
MOD_Plk_1	400	406	PF00069	0.410
MOD_Plk_2-3	135	141	PF00069	0.580
MOD_Plk_4	141	147	PF00069	0.509
MOD_Plk_4	206	212	PF00069	0.477
MOD_Plk_4	220	226	PF00069	0.483
MOD_Plk_4	254	260	PF00069	0.513
MOD_Plk_4	280	286	PF00069	0.487
MOD_Plk_4	311	317	PF00069	0.283
MOD_ProDKin_1	204	210	PF00069	0.485
MOD_ProDKin_1	391	397	PF00069	0.315
MOD_ProDKin_1	424	430	PF00069	0.462
MOD_ProDKin_1	51	57	PF00069	0.500
TRG_DiLeu_BaEn_2	226	232	PF01217	0.527
TRG_DiLeu_BaEn_4	174	180	PF01217	0.482
TRG_DiLeu_BaLyEn_6	347	352	PF01217	0.315
TRG_DiLeu_BaLyEn_6	593	598	PF01217	0.474
TRG_ENDOCYTIC_2	112	115	PF00928	0.515
TRG_ENDOCYTIC_2	168	171	PF00928	0.467
TRG_ENDOCYTIC_2	214	217	PF00928	0.550
TRG_ENDOCYTIC_2	309	312	PF00928	0.328
TRG_ENDOCYTIC_2	367	370	PF00928	0.331
TRG_ENDOCYTIC_2	535	538	PF00928	0.646
TRG_ENDOCYTIC_2	63	66	PF00928	0.530
TRG_ENDOCYTIC_2	87	90	PF00928	0.471
TRG_ER_diArg_1	160	162	PF00400	0.511
TRG_ER_diArg_1	2	4	PF00400	0.622
TRG_ER_diArg_1	211	213	PF00400	0.503
TRG_ER_diArg_1	300	302	PF00400	0.561
TRG_ER_diArg_1	306	308	PF00400	0.428
TRG_ER_diArg_1	679	682	PF00400	0.497
TRG_ER_diArg_1	685	688	PF00400	0.493
TRG_NES_CRM1_1	163	177	PF08389	0.479
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	638	642	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	687	692	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1B6	Leptomonas seymouri	76%	100%
A0A0S4JZM2	Bodo saltans	44%	100%
A0A1X0NV52	Trypanosomatidae	54%	97%
A0A422NLJ2	Trypanosoma rangeli	57%	100%
A4H813	Leishmania braziliensis	86%	100%
A4HWE3	Leishmania infantum	99%	100%
C9ZNY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AQ43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QFD9	Leishmania major	94%	100%
V5BGN8	Trypanosoma cruzi	55%	100%