Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTC2_LEIDO

TriTrypDb:

LdBPK_150300.1 , LdCL_150007900 , LDHU3_15.0390

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7WTC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.535
CLV_C14_Caspase3-7	436	440	PF00656	0.701
CLV_C14_Caspase3-7	84	88	PF00656	0.577
CLV_NRD_NRD_1	115	117	PF00675	0.514
CLV_NRD_NRD_1	153	155	PF00675	0.535
CLV_NRD_NRD_1	201	203	PF00675	0.714
CLV_NRD_NRD_1	268	270	PF00675	0.625
CLV_PCSK_FUR_1	113	117	PF00082	0.524
CLV_PCSK_KEX2_1	115	117	PF00082	0.492
CLV_PCSK_KEX2_1	151	153	PF00082	0.544
CLV_PCSK_KEX2_1	268	270	PF00082	0.625
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.586
CLV_PCSK_PC7_1	147	153	PF00082	0.626
CLV_PCSK_SKI1_1	205	209	PF00082	0.540
CLV_PCSK_SKI1_1	222	226	PF00082	0.572
CLV_PCSK_SKI1_1	268	272	PF00082	0.601
CLV_PCSK_SKI1_1	309	313	PF00082	0.711
CLV_PCSK_SKI1_1	31	35	PF00082	0.560
CLV_PCSK_SKI1_1	332	336	PF00082	0.519
CLV_PCSK_SKI1_1	340	344	PF00082	0.409
CLV_PCSK_SKI1_1	371	375	PF00082	0.514
DEG_Nend_UBRbox_2	1	3	PF02207	0.620
DEG_SPOP_SBC_1	405	409	PF00917	0.580
DOC_USP7_MATH_1	352	356	PF00917	0.577
DOC_USP7_MATH_1	405	409	PF00917	0.584
DOC_USP7_MATH_1	434	438	PF00917	0.755
DOC_WW_Pin1_4	280	285	PF00397	0.667
DOC_WW_Pin1_4	350	355	PF00397	0.572
DOC_WW_Pin1_4	406	411	PF00397	0.778
LIG_14-3-3_CanoR_1	103	111	PF00244	0.584
LIG_14-3-3_CanoR_1	116	122	PF00244	0.370
LIG_14-3-3_CanoR_1	123	129	PF00244	0.475
LIG_14-3-3_CanoR_1	268	278	PF00244	0.697
LIG_14-3-3_CanoR_1	362	366	PF00244	0.521
LIG_14-3-3_CanoR_1	59	69	PF00244	0.694
LIG_Actin_WH2_2	175	193	PF00022	0.638
LIG_BIR_III_2	429	433	PF00653	0.701
LIG_BRCT_BRCA1_1	63	67	PF00533	0.651
LIG_FHA_1	463	469	PF00498	0.545
LIG_FHA_2	1	7	PF00498	0.661
LIG_FHA_2	207	213	PF00498	0.499
LIG_FHA_2	269	275	PF00498	0.643
LIG_LIR_Gen_1	232	240	PF02991	0.485
LIG_LIR_LC3C_4	420	424	PF02991	0.711
LIG_LIR_Nem_3	2	7	PF02991	0.610
LIG_LIR_Nem_3	232	236	PF02991	0.488
LIG_LIR_Nem_3	28	33	PF02991	0.564
LIG_Pex14_1	117	121	PF04695	0.468
LIG_Pex14_2	236	240	PF04695	0.577
LIG_SH2_CRK	30	34	PF00017	0.600
LIG_SH2_CRK	472	476	PF00017	0.528
LIG_SH2_STAP1	233	237	PF00017	0.470
LIG_SH2_STAT5	470	473	PF00017	0.533
LIG_SH3_2	66	71	PF14604	0.561
LIG_SH3_3	193	199	PF00018	0.684
LIG_SH3_3	278	284	PF00018	0.736
LIG_SH3_3	410	416	PF00018	0.768
LIG_SH3_3	6	12	PF00018	0.701
LIG_SH3_3	63	69	PF00018	0.634
LIG_TRAF2_1	209	212	PF00917	0.623
LIG_TRAF2_1	90	93	PF00917	0.541
LIG_UBA3_1	454	462	PF00899	0.577
LIG_ULM_U2AF65_1	202	207	PF00076	0.590
LIG_WRC_WIRS_1	118	123	PF05994	0.469
MOD_CK1_1	19	25	PF00069	0.748
MOD_CK1_1	280	286	PF00069	0.669
MOD_CK1_1	325	331	PF00069	0.595
MOD_CK1_1	390	396	PF00069	0.740
MOD_CK1_1	70	76	PF00069	0.594
MOD_CK1_1	82	88	PF00069	0.594
MOD_CK2_1	124	130	PF00069	0.518
MOD_CK2_1	206	212	PF00069	0.512
MOD_CK2_1	235	241	PF00069	0.506
MOD_CK2_1	280	286	PF00069	0.653
MOD_GlcNHglycan	171	174	PF01048	0.721
MOD_GlcNHglycan	18	21	PF01048	0.757
MOD_GlcNHglycan	327	330	PF01048	0.609
MOD_GlcNHglycan	392	395	PF01048	0.745
MOD_GlcNHglycan	43	46	PF01048	0.683
MOD_GlcNHglycan	436	439	PF01048	0.695
MOD_GlcNHglycan	444	447	PF01048	0.666
MOD_GlcNHglycan	63	66	PF01048	0.582
MOD_GSK3_1	105	112	PF00069	0.663
MOD_GSK3_1	124	131	PF00069	0.365
MOD_GSK3_1	16	23	PF00069	0.724
MOD_GSK3_1	165	172	PF00069	0.648
MOD_GSK3_1	186	193	PF00069	0.738
MOD_GSK3_1	37	44	PF00069	0.673
MOD_GSK3_1	400	407	PF00069	0.633
MOD_GSK3_1	458	465	PF00069	0.569
MOD_N-GLC_1	169	174	PF02516	0.700
MOD_N-GLC_1	260	265	PF02516	0.543
MOD_N-GLC_1	60	65	PF02516	0.683
MOD_NEK2_1	190	195	PF00069	0.717
MOD_PIKK_1	105	111	PF00454	0.663
MOD_PIKK_1	14	20	PF00454	0.641
MOD_PIKK_1	462	468	PF00454	0.587
MOD_PKA_1	268	274	PF00069	0.636
MOD_PKA_2	102	108	PF00069	0.651
MOD_PKA_2	268	274	PF00069	0.598
MOD_PKA_2	361	367	PF00069	0.577
MOD_PKA_2	37	43	PF00069	0.688
MOD_Plk_1	260	266	PF00069	0.595
MOD_Plk_1	381	387	PF00069	0.648
MOD_Plk_4	277	283	PF00069	0.679
MOD_Plk_4	381	387	PF00069	0.688
MOD_ProDKin_1	280	286	PF00069	0.667
MOD_ProDKin_1	350	356	PF00069	0.572
MOD_ProDKin_1	406	412	PF00069	0.776
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.622
TRG_ENDOCYTIC_2	233	236	PF00928	0.472
TRG_ENDOCYTIC_2	30	33	PF00928	0.598
TRG_ENDOCYTIC_2	4	7	PF00928	0.609
TRG_ER_diArg_1	113	116	PF00400	0.530
TRG_ER_diArg_1	152	154	PF00400	0.574
TRG_ER_diArg_1	267	269	PF00400	0.629
TRG_ER_diArg_1	330	333	PF00400	0.576
TRG_NLS_MonoCore_2	201	206	PF00514	0.593
TRG_NLS_MonoExtN_4	199	206	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	133	138	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P362	Leptomonas seymouri	65%	100%
A0A0S4JPG7	Bodo saltans	36%	98%
A0A1X0NUB6	Trypanosomatidae	41%	100%
A0A3R7NLS4	Trypanosoma rangeli	41%	100%
A4H7Z9	Leishmania braziliensis	80%	100%
A4HWC7	Leishmania infantum	100%	100%
C9ZNW9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AQ27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QFF4	Leishmania major	94%	100%