Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTC1_LEIDO

TriTrypDb:

LdBPK_150450.1 , LdCL_150009400 , LDHU3_15.0550

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WTC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.590
CLV_C14_Caspase3-7	163	167	PF00656	0.493
CLV_C14_Caspase3-7	33	37	PF00656	0.653
CLV_C14_Caspase3-7	338	342	PF00656	0.502
CLV_C14_Caspase3-7	79	83	PF00656	0.687
CLV_NRD_NRD_1	111	113	PF00675	0.442
CLV_NRD_NRD_1	150	152	PF00675	0.673
CLV_NRD_NRD_1	219	221	PF00675	0.756
CLV_NRD_NRD_1	348	350	PF00675	0.513
CLV_NRD_NRD_1	440	442	PF00675	0.704
CLV_PCSK_KEX2_1	111	113	PF00082	0.442
CLV_PCSK_KEX2_1	150	152	PF00082	0.670
CLV_PCSK_KEX2_1	219	221	PF00082	0.756
CLV_PCSK_KEX2_1	348	350	PF00082	0.429
CLV_PCSK_KEX2_1	440	442	PF00082	0.704
CLV_PCSK_PC7_1	146	152	PF00082	0.543
CLV_PCSK_SKI1_1	6	10	PF00082	0.393
CLV_PCSK_SKI1_1	657	661	PF00082	0.621
DEG_SCF_FBW7_2	123	129	PF00400	0.504
DEG_SPOP_SBC_1	29	33	PF00917	0.681
DEG_SPOP_SBC_1	290	294	PF00917	0.734
DEG_SPOP_SBC_1	410	414	PF00917	0.581
DOC_CKS1_1	123	128	PF01111	0.552
DOC_CYCLIN_RxL_1	86	100	PF00134	0.585
DOC_CYCLIN_yCln2_LP_2	274	277	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.591
DOC_MAPK_gen_1	111	117	PF00069	0.422
DOC_MAPK_gen_1	227	237	PF00069	0.615
DOC_MAPK_gen_1	325	335	PF00069	0.529
DOC_MAPK_gen_1	610	617	PF00069	0.441
DOC_MAPK_MEF2A_6	102	110	PF00069	0.476
DOC_MAPK_MEF2A_6	610	617	PF00069	0.441
DOC_PP1_RVXF_1	90	97	PF00149	0.571
DOC_PP2B_LxvP_1	274	277	PF13499	0.512
DOC_PP2B_LxvP_1	8	11	PF13499	0.383
DOC_USP7_MATH_1	165	169	PF00917	0.585
DOC_USP7_MATH_1	290	294	PF00917	0.746
DOC_USP7_MATH_1	308	312	PF00917	0.616
DOC_USP7_MATH_1	410	414	PF00917	0.576
DOC_USP7_MATH_1	46	50	PF00917	0.699
DOC_USP7_MATH_1	469	473	PF00917	0.500
DOC_USP7_MATH_1	499	503	PF00917	0.520
DOC_USP7_MATH_1	626	630	PF00917	0.564
DOC_USP7_MATH_1	63	67	PF00917	0.522
DOC_USP7_MATH_1	90	94	PF00917	0.631
DOC_USP7_MATH_1	97	101	PF00917	0.572
DOC_USP7_UBL2_3	429	433	PF12436	0.592
DOC_WW_Pin1_4	122	127	PF00397	0.561
DOC_WW_Pin1_4	209	214	PF00397	0.737
DOC_WW_Pin1_4	286	291	PF00397	0.744
DOC_WW_Pin1_4	313	318	PF00397	0.678
DOC_WW_Pin1_4	352	357	PF00397	0.541
DOC_WW_Pin1_4	424	429	PF00397	0.638
DOC_WW_Pin1_4	59	64	PF00397	0.694
LIG_14-3-3_CanoR_1	247	251	PF00244	0.477
LIG_14-3-3_CanoR_1	295	301	PF00244	0.620
LIG_14-3-3_CanoR_1	328	336	PF00244	0.519
LIG_14-3-3_CanoR_1	361	366	PF00244	0.598
LIG_14-3-3_CanoR_1	421	430	PF00244	0.461
LIG_14-3-3_CanoR_1	539	545	PF00244	0.481
LIG_AP2alpha_1	20	24	PF02296	0.418
LIG_APCC_ABBA_1	248	253	PF00400	0.380
LIG_APCC_ABBAyCdc20_2	247	253	PF00400	0.411
LIG_BIR_III_4	166	170	PF00653	0.473
LIG_BRCT_BRCA1_1	204	208	PF00533	0.649
LIG_BRCT_BRCA1_1	92	96	PF00533	0.499
LIG_Clathr_ClatBox_1	506	510	PF01394	0.420
LIG_FHA_1	137	143	PF00498	0.573
LIG_FHA_1	292	298	PF00498	0.741
LIG_FHA_1	328	334	PF00498	0.565
LIG_FHA_1	415	421	PF00498	0.497
LIG_FHA_1	502	508	PF00498	0.448
LIG_FHA_1	520	526	PF00498	0.490
LIG_FHA_1	530	536	PF00498	0.372
LIG_FHA_1	568	574	PF00498	0.352
LIG_FHA_2	560	566	PF00498	0.400
LIG_FHA_2	629	635	PF00498	0.547
LIG_FHA_2	77	83	PF00498	0.777
LIG_Integrin_RGD_1	112	114	PF01839	0.429
LIG_LIR_Apic_2	306	310	PF02991	0.539
LIG_LIR_Nem_3	2	8	PF02991	0.425
LIG_LIR_Nem_3	22	27	PF02991	0.260
LIG_NRBOX	378	384	PF00104	0.681
LIG_Pex14_2	20	24	PF04695	0.346
LIG_Pex14_2	5	9	PF04695	0.521
LIG_SH2_CRK	307	311	PF00017	0.543
LIG_SH2_GRB2like	152	155	PF00017	0.538
LIG_SH2_NCK_1	152	156	PF00017	0.547
LIG_SH2_NCK_1	307	311	PF00017	0.543
LIG_SH2_NCK_1	663	667	PF00017	0.637
LIG_SH2_STAP1	256	260	PF00017	0.501
LIG_SH2_STAP1	645	649	PF00017	0.567
LIG_SH2_STAT5	198	201	PF00017	0.504
LIG_SH2_STAT5	236	239	PF00017	0.403
LIG_SH2_STAT5	256	259	PF00017	0.225
LIG_SH3_2	317	322	PF14604	0.522
LIG_SH3_3	270	276	PF00018	0.492
LIG_SH3_3	314	320	PF00018	0.634
LIG_SH3_3	356	362	PF00018	0.559
LIG_SH3_3	370	376	PF00018	0.383
LIG_SH3_3	570	576	PF00018	0.412
LIG_SH3_4	429	436	PF00018	0.600
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.454
LIG_SUMO_SIM_anti_2	341	347	PF11976	0.471
LIG_SUMO_SIM_anti_2	355	361	PF11976	0.561
LIG_SUMO_SIM_anti_2	471	477	PF11976	0.437
LIG_SUMO_SIM_anti_2	481	487	PF11976	0.440
LIG_SUMO_SIM_anti_2	504	511	PF11976	0.421
LIG_SUMO_SIM_par_1	504	511	PF11976	0.421
LIG_TRAF2_1	13	16	PF00917	0.475
LIG_TRAF2_1	443	446	PF00917	0.694
LIG_UBA3_1	482	487	PF00899	0.419
LIG_Vh1_VBS_1	549	567	PF01044	0.298
MOD_CDC14_SPxK_1	319	322	PF00782	0.500
MOD_CDK_SPK_2	424	429	PF00069	0.527
MOD_CDK_SPxK_1	316	322	PF00069	0.529
MOD_CK1_1	160	166	PF00069	0.736
MOD_CK1_1	207	213	PF00069	0.626
MOD_CK1_1	249	255	PF00069	0.482
MOD_CK1_1	289	295	PF00069	0.685
MOD_CK1_1	30	36	PF00069	0.594
MOD_CK1_1	316	322	PF00069	0.691
MOD_CK1_1	363	369	PF00069	0.598
MOD_CK1_1	377	383	PF00069	0.525
MOD_CK1_1	424	430	PF00069	0.481
MOD_CK1_1	434	440	PF00069	0.703
MOD_CK1_1	451	457	PF00069	0.412
MOD_CK1_1	481	487	PF00069	0.469
MOD_CK1_1	62	68	PF00069	0.712
MOD_CK2_1	223	229	PF00069	0.665
MOD_CK2_1	387	393	PF00069	0.725
MOD_CK2_1	440	446	PF00069	0.724
MOD_CK2_1	62	68	PF00069	0.682
MOD_CK2_1	628	634	PF00069	0.730
MOD_CK2_1	640	646	PF00069	0.598
MOD_GlcNHglycan	166	170	PF01048	0.694
MOD_GlcNHglycan	204	207	PF01048	0.554
MOD_GlcNHglycan	209	212	PF01048	0.642
MOD_GlcNHglycan	310	313	PF01048	0.666
MOD_GlcNHglycan	337	340	PF01048	0.456
MOD_GlcNHglycan	376	379	PF01048	0.606
MOD_GlcNHglycan	460	463	PF01048	0.599
MOD_GlcNHglycan	48	51	PF01048	0.711
MOD_GlcNHglycan	519	522	PF01048	0.422
MOD_GlcNHglycan	56	59	PF01048	0.701
MOD_GlcNHglycan	593	596	PF01048	0.559
MOD_GlcNHglycan	620	624	PF01048	0.630
MOD_GlcNHglycan	626	629	PF01048	0.622
MOD_GlcNHglycan	65	68	PF01048	0.548
MOD_GlcNHglycan	99	102	PF01048	0.612
MOD_GSK3_1	202	209	PF00069	0.565
MOD_GSK3_1	23	30	PF00069	0.507
MOD_GSK3_1	252	259	PF00069	0.538
MOD_GSK3_1	282	289	PF00069	0.633
MOD_GSK3_1	360	367	PF00069	0.510
MOD_GSK3_1	377	384	PF00069	0.499
MOD_GSK3_1	398	405	PF00069	0.630
MOD_GSK3_1	40	47	PF00069	0.448
MOD_GSK3_1	410	417	PF00069	0.564
MOD_GSK3_1	424	431	PF00069	0.475
MOD_GSK3_1	447	454	PF00069	0.619
MOD_GSK3_1	456	463	PF00069	0.504
MOD_GSK3_1	524	531	PF00069	0.365
MOD_GSK3_1	54	61	PF00069	0.652
MOD_GSK3_1	555	562	PF00069	0.383
MOD_GSK3_1	624	631	PF00069	0.662
MOD_N-GLC_1	286	291	PF02516	0.663
MOD_NEK2_1	173	178	PF00069	0.542
MOD_NEK2_1	204	209	PF00069	0.604
MOD_NEK2_1	251	256	PF00069	0.511
MOD_NEK2_1	27	32	PF00069	0.619
MOD_NEK2_1	335	340	PF00069	0.470
MOD_NEK2_1	350	355	PF00069	0.406
MOD_NEK2_1	382	387	PF00069	0.634
MOD_NEK2_1	435	440	PF00069	0.690
MOD_NEK2_1	478	483	PF00069	0.488
MOD_NEK2_1	508	513	PF00069	0.435
MOD_NEK2_1	52	57	PF00069	0.542
MOD_NEK2_1	559	564	PF00069	0.443
MOD_NEK2_1	602	607	PF00069	0.598
MOD_NEK2_2	246	251	PF00069	0.536
MOD_NEK2_2	640	645	PF00069	0.553
MOD_PIKK_1	136	142	PF00454	0.594
MOD_PIKK_1	327	333	PF00454	0.541
MOD_PIKK_1	387	393	PF00454	0.621
MOD_PIKK_1	501	507	PF00454	0.460
MOD_PK_1	440	446	PF00069	0.698
MOD_PKA_1	150	156	PF00069	0.695
MOD_PKA_1	440	446	PF00069	0.698
MOD_PKA_2	150	156	PF00069	0.648
MOD_PKA_2	246	252	PF00069	0.475
MOD_PKA_2	327	333	PF00069	0.566
MOD_PKA_2	360	366	PF00069	0.580
MOD_PKA_2	440	446	PF00069	0.649
MOD_PKA_2	76	82	PF00069	0.643
MOD_PKB_1	419	427	PF00069	0.406
MOD_Plk_1	252	258	PF00069	0.520
MOD_Plk_1	40	46	PF00069	0.635
MOD_Plk_4	23	29	PF00069	0.484
MOD_Plk_4	246	252	PF00069	0.486
MOD_Plk_4	471	477	PF00069	0.481
MOD_Plk_4	478	484	PF00069	0.397
MOD_Plk_4	555	561	PF00069	0.440
MOD_Plk_4	640	646	PF00069	0.614
MOD_ProDKin_1	122	128	PF00069	0.555
MOD_ProDKin_1	209	215	PF00069	0.739
MOD_ProDKin_1	286	292	PF00069	0.745
MOD_ProDKin_1	313	319	PF00069	0.670
MOD_ProDKin_1	352	358	PF00069	0.546
MOD_ProDKin_1	424	430	PF00069	0.645
MOD_ProDKin_1	59	65	PF00069	0.694
TRG_DiLeu_BaEn_3	667	673	PF01217	0.646
TRG_DiLeu_BaLyEn_6	654	659	PF01217	0.610
TRG_ER_diArg_1	110	112	PF00400	0.437
TRG_ER_diArg_1	132	135	PF00400	0.461
TRG_ER_diArg_1	150	152	PF00400	0.372
TRG_ER_diArg_1	218	220	PF00400	0.689
TRG_ER_diArg_1	347	349	PF00400	0.497
TRG_ER_diArg_1	418	421	PF00400	0.433
TRG_ER_diArg_1	536	539	PF00400	0.463
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	586	591	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD21	Leptomonas seymouri	51%	100%
A0A0S4JR70	Bodo saltans	27%	100%
A0A1X0NU73	Trypanosomatidae	28%	100%
A0A3R7NGV0	Trypanosoma rangeli	26%	100%
A4H812	Leishmania braziliensis	72%	96%
A4HWE2	Leishmania infantum	99%	100%
E9AQ42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QFE0	Leishmania major	92%	100%
V5DCS7	Trypanosoma cruzi	27%	100%