Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTB9_LEIDO

TriTrypDb:

LdBPK_150360.1 , LdCL_150008500 , LDHU3_15.0460

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTB9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.649
CLV_NRD_NRD_1	192	194	PF00675	0.821
CLV_NRD_NRD_1	286	288	PF00675	0.747
CLV_NRD_NRD_1	4	6	PF00675	0.806
CLV_NRD_NRD_1	43	45	PF00675	0.614
CLV_NRD_NRD_1	535	537	PF00675	0.634
CLV_PCSK_FUR_1	189	193	PF00082	0.806
CLV_PCSK_KEX2_1	191	193	PF00082	0.814
CLV_PCSK_KEX2_1	286	288	PF00082	0.747
CLV_PCSK_KEX2_1	4	6	PF00082	0.806
CLV_PCSK_KEX2_1	43	45	PF00082	0.614
CLV_PCSK_KEX2_1	462	464	PF00082	0.742
CLV_PCSK_KEX2_1	534	536	PF00082	0.626
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.723
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.626
CLV_PCSK_PC7_1	531	537	PF00082	0.618
CLV_PCSK_SKI1_1	266	270	PF00082	0.600
CLV_PCSK_SKI1_1	286	290	PF00082	0.628
CLV_PCSK_SKI1_1	43	47	PF00082	0.655
CLV_PCSK_SKI1_1	631	635	PF00082	0.550
DEG_APCC_DBOX_1	630	638	PF00400	0.652
DEG_MDM2_SWIB_1	639	647	PF02201	0.502
DEG_ODPH_VHL_1	575	586	PF01847	0.723
DEG_SPOP_SBC_1	276	280	PF00917	0.708
DEG_SPOP_SBC_1	281	285	PF00917	0.656
DEG_SPOP_SBC_1	346	350	PF00917	0.699
DOC_CYCLIN_yClb1_LxF_4	634	639	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	617	623	PF00134	0.590
DOC_MAPK_gen_1	191	200	PF00069	0.762
DOC_MAPK_gen_1	373	382	PF00069	0.620
DOC_MAPK_MEF2A_6	375	384	PF00069	0.609
DOC_PP1_RVXF_1	634	640	PF00149	0.589
DOC_PP2B_LxvP_1	51	54	PF13499	0.661
DOC_PP2B_LxvP_1	617	620	PF13499	0.665
DOC_USP7_MATH_1	132	136	PF00917	0.828
DOC_USP7_MATH_1	143	147	PF00917	0.738
DOC_USP7_MATH_1	199	203	PF00917	0.722
DOC_USP7_MATH_1	276	280	PF00917	0.765
DOC_USP7_MATH_1	290	294	PF00917	0.564
DOC_USP7_MATH_1	304	308	PF00917	0.647
DOC_USP7_MATH_1	316	320	PF00917	0.531
DOC_USP7_MATH_1	346	350	PF00917	0.716
DOC_USP7_MATH_1	402	406	PF00917	0.821
DOC_USP7_MATH_1	413	417	PF00917	0.518
DOC_USP7_MATH_1	560	564	PF00917	0.741
DOC_USP7_MATH_1	77	81	PF00917	0.661
DOC_WW_Pin1_4	348	353	PF00397	0.728
DOC_WW_Pin1_4	436	441	PF00397	0.835
DOC_WW_Pin1_4	465	470	PF00397	0.729
DOC_WW_Pin1_4	483	488	PF00397	0.754
LIG_14-3-3_CanoR_1	218	225	PF00244	0.653
LIG_14-3-3_CanoR_1	232	240	PF00244	0.740
LIG_14-3-3_CanoR_1	317	325	PF00244	0.586
LIG_14-3-3_CanoR_1	347	352	PF00244	0.822
LIG_14-3-3_CanoR_1	373	382	PF00244	0.596
LIG_14-3-3_CanoR_1	4	14	PF00244	0.648
LIG_14-3-3_CanoR_1	409	418	PF00244	0.682
LIG_Actin_WH2_2	159	175	PF00022	0.645
LIG_Actin_WH2_2	616	633	PF00022	0.656
LIG_BIR_II_1	1	5	PF00653	0.752
LIG_BIR_III_4	213	217	PF00653	0.685
LIG_BIR_III_4	540	544	PF00653	0.566
LIG_BRCT_BRCA1_1	507	511	PF00533	0.691
LIG_CtBP_PxDLS_1	611	615	PF00389	0.587
LIG_EH_1	623	627	PF12763	0.509
LIG_FHA_1	349	355	PF00498	0.751
LIG_FHA_1	375	381	PF00498	0.607
LIG_FHA_1	504	510	PF00498	0.821
LIG_FHA_2	410	416	PF00498	0.684
LIG_LIR_Apic_2	238	243	PF02991	0.732
LIG_LIR_Gen_1	151	159	PF02991	0.614
LIG_LIR_Gen_1	520	530	PF02991	0.664
LIG_LIR_Nem_3	151	155	PF02991	0.628
LIG_LIR_Nem_3	520	526	PF02991	0.670
LIG_Pex14_2	639	643	PF04695	0.705
LIG_PTAP_UEV_1	193	198	PF05743	0.728
LIG_SH2_CRK	152	156	PF00017	0.618
LIG_SH2_CRK	240	244	PF00017	0.729
LIG_SH2_NCK_1	240	244	PF00017	0.729
LIG_SH2_SRC	168	171	PF00017	0.644
LIG_SH2_STAP1	164	168	PF00017	0.754
LIG_SH2_STAP1	323	327	PF00017	0.730
LIG_SH2_STAP1	337	341	PF00017	0.560
LIG_SH2_STAP1	640	644	PF00017	0.635
LIG_SH2_STAT5	240	243	PF00017	0.830
LIG_SH2_STAT5	638	641	PF00017	0.582
LIG_SH3_1	191	197	PF00018	0.731
LIG_SH3_3	11	17	PF00018	0.726
LIG_SH3_3	137	143	PF00018	0.804
LIG_SH3_3	191	197	PF00018	0.690
LIG_SH3_3	241	247	PF00018	0.810
LIG_SH3_3	396	402	PF00018	0.702
LIG_SH3_3	445	451	PF00018	0.732
LIG_SH3_3	478	484	PF00018	0.803
LIG_SH3_3	565	571	PF00018	0.720
LIG_SH3_3	601	607	PF00018	0.719
LIG_SH3_3	63	69	PF00018	0.800
LIG_TRAF2_1	127	130	PF00917	0.507
LIG_TRAF2_1	167	170	PF00917	0.646
LIG_TRAF2_1	404	407	PF00917	0.643
LIG_WW_3	344	348	PF00397	0.808
LIG_WW_3	52	56	PF00397	0.641
MOD_CDK_SPxK_1	465	471	PF00069	0.732
MOD_CK1_1	208	214	PF00069	0.762
MOD_CK1_1	233	239	PF00069	0.715
MOD_CK1_1	245	251	PF00069	0.697
MOD_CK1_1	272	278	PF00069	0.698
MOD_CK1_1	280	286	PF00069	0.695
MOD_CK1_1	306	312	PF00069	0.745
MOD_CK1_1	319	325	PF00069	0.536
MOD_CK1_1	348	354	PF00069	0.748
MOD_CK1_1	452	458	PF00069	0.805
MOD_CK1_1	486	492	PF00069	0.804
MOD_CK1_1	522	528	PF00069	0.497
MOD_CK1_1	562	568	PF00069	0.828
MOD_CK1_1	596	602	PF00069	0.679
MOD_CK1_1	615	621	PF00069	0.675
MOD_CK1_1	70	76	PF00069	0.762
MOD_CK2_1	164	170	PF00069	0.707
MOD_CK2_1	409	415	PF00069	0.737
MOD_CK2_1	547	553	PF00069	0.763
MOD_CK2_1	610	616	PF00069	0.583
MOD_GlcNHglycan	106	109	PF01048	0.568
MOD_GlcNHglycan	194	197	PF01048	0.742
MOD_GlcNHglycan	207	210	PF01048	0.527
MOD_GlcNHglycan	232	235	PF01048	0.626
MOD_GlcNHglycan	247	250	PF01048	0.742
MOD_GlcNHglycan	262	265	PF01048	0.641
MOD_GlcNHglycan	274	277	PF01048	0.733
MOD_GlcNHglycan	279	282	PF01048	0.753
MOD_GlcNHglycan	318	321	PF01048	0.642
MOD_GlcNHglycan	362	366	PF01048	0.749
MOD_GlcNHglycan	451	454	PF01048	0.816
MOD_GlcNHglycan	474	477	PF01048	0.787
MOD_GlcNHglycan	488	491	PF01048	0.735
MOD_GlcNHglycan	513	516	PF01048	0.718
MOD_GlcNHglycan	562	565	PF01048	0.770
MOD_GlcNHglycan	595	598	PF01048	0.693
MOD_GlcNHglycan	608	611	PF01048	0.720
MOD_GlcNHglycan	644	647	PF01048	0.612
MOD_GlcNHglycan	74	77	PF01048	0.727
MOD_GlcNHglycan	83	86	PF01048	0.481
MOD_GlcNHglycan	95	98	PF01048	0.560
MOD_GSK3_1	128	135	PF00069	0.746
MOD_GSK3_1	179	186	PF00069	0.675
MOD_GSK3_1	199	206	PF00069	0.773
MOD_GSK3_1	238	245	PF00069	0.816
MOD_GSK3_1	272	279	PF00069	0.715
MOD_GSK3_1	303	310	PF00069	0.712
MOD_GSK3_1	315	322	PF00069	0.648
MOD_GSK3_1	32	39	PF00069	0.629
MOD_GSK3_1	374	381	PF00069	0.616
MOD_GSK3_1	409	416	PF00069	0.711
MOD_GSK3_1	482	489	PF00069	0.812
MOD_GSK3_1	606	613	PF00069	0.661
MOD_GSK3_1	75	82	PF00069	0.674
MOD_N-GLC_1	544	549	PF02516	0.578
MOD_NEK2_1	184	189	PF00069	0.689
MOD_NEK2_1	203	208	PF00069	0.668
MOD_NEK2_1	262	267	PF00069	0.741
MOD_NEK2_1	269	274	PF00069	0.684
MOD_NEK2_1	511	516	PF00069	0.708
MOD_NEK2_1	642	647	PF00069	0.555
MOD_PIKK_1	177	183	PF00454	0.554
MOD_PKA_1	192	198	PF00069	0.674
MOD_PKA_1	4	10	PF00069	0.615
MOD_PKA_2	177	183	PF00069	0.692
MOD_PKA_2	192	198	PF00069	0.628
MOD_PKA_2	217	223	PF00069	0.729
MOD_PKA_2	245	251	PF00069	0.787
MOD_PKA_2	316	322	PF00069	0.595
MOD_PKA_2	346	352	PF00069	0.739
MOD_PKA_2	374	380	PF00069	0.615
MOD_PKA_2	4	10	PF00069	0.751
MOD_PKA_2	493	499	PF00069	0.661
MOD_PKA_2	530	536	PF00069	0.672
MOD_Plk_1	164	170	PF00069	0.629
MOD_Plk_1	519	525	PF00069	0.652
MOD_Plk_1	615	621	PF00069	0.715
MOD_Plk_4	269	275	PF00069	0.728
MOD_Plk_4	522	528	PF00069	0.451
MOD_ProDKin_1	348	354	PF00069	0.728
MOD_ProDKin_1	436	442	PF00069	0.833
MOD_ProDKin_1	465	471	PF00069	0.732
MOD_ProDKin_1	483	489	PF00069	0.758
MOD_SUMO_for_1	47	50	PF00179	0.726
TRG_ENDOCYTIC_2	152	155	PF00928	0.625
TRG_ER_diArg_1	188	191	PF00400	0.788
TRG_ER_diArg_1	192	194	PF00400	0.745
TRG_ER_diArg_1	286	288	PF00400	0.747
TRG_ER_diArg_1	327	330	PF00400	0.633
TRG_ER_diArg_1	355	358	PF00400	0.639
TRG_ER_diArg_1	372	375	PF00400	0.543
TRG_ER_diArg_1	42	44	PF00400	0.605
TRG_ER_diArg_1	492	495	PF00400	0.676
TRG_ER_diArg_1	629	632	PF00400	0.483
TRG_NLS_MonoExtC_3	533	539	PF00514	0.568
TRG_NLS_MonoExtN_4	531	538	PF00514	0.564
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.765
TRG_Pf-PMV_PEXEL_1	401	406	PF00026	0.707
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.711

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC10	Leptomonas seymouri	33%	100%
A4H805	Leishmania braziliensis	59%	96%
A4HWD3	Leishmania infantum	98%	100%
E9AQ33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QFE9	Leishmania major	84%	100%