Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WTA7_LEIDO

TriTrypDb:

LdBPK_150340.1 , LdCL_150008300 , LDHU3_15.0440

Length:

800

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WTA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.738
CLV_C14_Caspase3-7	200	204	PF00656	0.581
CLV_C14_Caspase3-7	407	411	PF00656	0.361
CLV_MEL_PAP_1	292	298	PF00089	0.421
CLV_NRD_NRD_1	117	119	PF00675	0.554
CLV_NRD_NRD_1	132	134	PF00675	0.346
CLV_NRD_NRD_1	306	308	PF00675	0.433
CLV_NRD_NRD_1	323	325	PF00675	0.376
CLV_NRD_NRD_1	333	335	PF00675	0.495
CLV_NRD_NRD_1	455	457	PF00675	0.507
CLV_NRD_NRD_1	611	613	PF00675	0.609
CLV_NRD_NRD_1	614	616	PF00675	0.608
CLV_NRD_NRD_1	620	622	PF00675	0.533
CLV_NRD_NRD_1	694	696	PF00675	0.561
CLV_NRD_NRD_1	728	730	PF00675	0.666
CLV_NRD_NRD_1	731	733	PF00675	0.686
CLV_NRD_NRD_1	773	775	PF00675	0.693
CLV_NRD_NRD_1	79	81	PF00675	0.625
CLV_PCSK_FUR_1	331	335	PF00082	0.464
CLV_PCSK_FUR_1	611	615	PF00082	0.699
CLV_PCSK_FUR_1	618	622	PF00082	0.629
CLV_PCSK_FUR_1	729	733	PF00082	0.627
CLV_PCSK_FUR_1	771	775	PF00082	0.658
CLV_PCSK_KEX2_1	117	119	PF00082	0.542
CLV_PCSK_KEX2_1	132	134	PF00082	0.346
CLV_PCSK_KEX2_1	306	308	PF00082	0.439
CLV_PCSK_KEX2_1	333	335	PF00082	0.456
CLV_PCSK_KEX2_1	455	457	PF00082	0.510
CLV_PCSK_KEX2_1	610	612	PF00082	0.618
CLV_PCSK_KEX2_1	613	615	PF00082	0.627
CLV_PCSK_KEX2_1	620	622	PF00082	0.535
CLV_PCSK_KEX2_1	694	696	PF00082	0.561
CLV_PCSK_KEX2_1	727	729	PF00082	0.665
CLV_PCSK_KEX2_1	731	733	PF00082	0.683
CLV_PCSK_KEX2_1	771	773	PF00082	0.674
CLV_PCSK_KEX2_1	79	81	PF00082	0.711
CLV_PCSK_PC1ET2_1	613	615	PF00082	0.620
CLV_PCSK_PC7_1	610	616	PF00082	0.620
CLV_PCSK_PC7_1	727	733	PF00082	0.572
CLV_PCSK_PC7_1	768	774	PF00082	0.591
CLV_PCSK_SKI1_1	155	159	PF00082	0.473
CLV_PCSK_SKI1_1	26	30	PF00082	0.539
CLV_PCSK_SKI1_1	284	288	PF00082	0.440
CLV_PCSK_SKI1_1	325	329	PF00082	0.438
CLV_PCSK_SKI1_1	37	41	PF00082	0.598
CLV_PCSK_SKI1_1	4	8	PF00082	0.672
CLV_PCSK_SKI1_1	418	422	PF00082	0.389
CLV_PCSK_SKI1_1	427	431	PF00082	0.452
CLV_PCSK_SKI1_1	555	559	PF00082	0.536
CLV_PCSK_SKI1_1	732	736	PF00082	0.701
DEG_APCC_DBOX_1	712	720	PF00400	0.640
DEG_SPOP_SBC_1	197	201	PF00917	0.561
DEG_SPOP_SBC_1	652	656	PF00917	0.805
DEG_SPOP_SBC_1	745	749	PF00917	0.609
DOC_CYCLIN_RxL_1	152	161	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	489	495	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	593	599	PF00134	0.675
DOC_MAPK_DCC_7	155	164	PF00069	0.511
DOC_MAPK_DCC_7	284	294	PF00069	0.410
DOC_MAPK_DCC_7	471	479	PF00069	0.427
DOC_MAPK_gen_1	117	128	PF00069	0.455
DOC_MAPK_gen_1	306	312	PF00069	0.398
DOC_MAPK_gen_1	357	365	PF00069	0.371
DOC_MAPK_MEF2A_6	155	164	PF00069	0.528
DOC_MAPK_MEF2A_6	471	479	PF00069	0.427
DOC_PP1_RVXF_1	293	299	PF00149	0.493
DOC_PP1_RVXF_1	553	560	PF00149	0.629
DOC_PP2B_LxvP_1	113	116	PF13499	0.699
DOC_PP2B_LxvP_1	157	160	PF13499	0.364
DOC_PP2B_LxvP_1	365	368	PF13499	0.426
DOC_PP2B_LxvP_1	593	596	PF13499	0.580
DOC_PP2B_LxvP_1	719	722	PF13499	0.634
DOC_PP4_FxxP_1	401	404	PF00568	0.409
DOC_USP7_MATH_1	197	201	PF00917	0.587
DOC_USP7_MATH_1	244	248	PF00917	0.356
DOC_USP7_MATH_1	337	341	PF00917	0.467
DOC_USP7_MATH_1	478	482	PF00917	0.535
DOC_USP7_MATH_1	599	603	PF00917	0.645
DOC_USP7_MATH_1	605	609	PF00917	0.562
DOC_USP7_MATH_1	651	655	PF00917	0.733
DOC_USP7_MATH_1	738	742	PF00917	0.751
DOC_USP7_MATH_1	745	749	PF00917	0.610
DOC_USP7_MATH_1	98	102	PF00917	0.689
DOC_USP7_MATH_2	585	591	PF00917	0.449
DOC_WW_Pin1_4	12	17	PF00397	0.684
DOC_WW_Pin1_4	172	177	PF00397	0.616
DOC_WW_Pin1_4	43	48	PF00397	0.628
DOC_WW_Pin1_4	469	474	PF00397	0.431
DOC_WW_Pin1_4	521	526	PF00397	0.411
DOC_WW_Pin1_4	601	606	PF00397	0.650
DOC_WW_Pin1_4	653	658	PF00397	0.609
DOC_WW_Pin1_4	734	739	PF00397	0.578
DOC_WW_Pin1_4	777	782	PF00397	0.743
LIG_14-3-3_CanoR_1	139	144	PF00244	0.465
LIG_14-3-3_CanoR_1	192	202	PF00244	0.539
LIG_14-3-3_CanoR_1	295	299	PF00244	0.488
LIG_14-3-3_CanoR_1	37	42	PF00244	0.678
LIG_14-3-3_CanoR_1	620	625	PF00244	0.570
LIG_Actin_WH2_2	279	297	PF00022	0.402
LIG_BIR_III_4	106	110	PF00653	0.629
LIG_CNOT1_NIM_1	205	214	PF04054	0.476
LIG_CtBP_PxDLS_1	671	675	PF00389	0.743
LIG_Dynein_DLC8_1	498	504	PF01221	0.575
LIG_eIF4E_1	226	232	PF01652	0.502
LIG_FHA_1	144	150	PF00498	0.450
LIG_FHA_1	20	26	PF00498	0.404
LIG_FHA_1	214	220	PF00498	0.460
LIG_FHA_1	271	277	PF00498	0.353
LIG_FHA_1	291	297	PF00498	0.508
LIG_FHA_1	330	336	PF00498	0.560
LIG_FHA_1	38	44	PF00498	0.426
LIG_FHA_1	441	447	PF00498	0.567
LIG_FHA_1	5	11	PF00498	0.730
LIG_FHA_1	57	63	PF00498	0.643
LIG_FHA_2	213	219	PF00498	0.460
LIG_FHA_2	405	411	PF00498	0.375
LIG_FHA_2	685	691	PF00498	0.584
LIG_FHA_2	792	798	PF00498	0.689
LIG_LIR_Gen_1	203	211	PF02991	0.509
LIG_LIR_Nem_3	151	157	PF02991	0.397
LIG_LIR_Nem_3	203	208	PF02991	0.543
LIG_LIR_Nem_3	210	214	PF02991	0.494
LIG_LIR_Nem_3	461	466	PF02991	0.372
LIG_MYND_1	156	160	PF01753	0.372
LIG_PCNA_yPIPBox_3	222	232	PF02747	0.490
LIG_SH2_CRK	211	215	PF00017	0.451
LIG_SH2_NCK_1	733	737	PF00017	0.637
LIG_SH2_PTP2	476	479	PF00017	0.420
LIG_SH2_SRC	571	574	PF00017	0.512
LIG_SH2_STAP1	205	209	PF00017	0.445
LIG_SH2_STAP1	345	349	PF00017	0.461
LIG_SH2_STAP1	361	365	PF00017	0.316
LIG_SH2_STAT3	345	348	PF00017	0.560
LIG_SH2_STAT3	397	400	PF00017	0.516
LIG_SH2_STAT5	143	146	PF00017	0.362
LIG_SH2_STAT5	239	242	PF00017	0.410
LIG_SH2_STAT5	259	262	PF00017	0.433
LIG_SH2_STAT5	476	479	PF00017	0.420
LIG_SH2_STAT5	546	549	PF00017	0.495
LIG_SH2_STAT5	571	574	PF00017	0.413
LIG_SH3_3	472	478	PF00018	0.433
LIG_SH3_3	51	57	PF00018	0.547
LIG_SH3_3	519	525	PF00018	0.441
LIG_SH3_3	589	595	PF00018	0.526
LIG_SH3_3	778	784	PF00018	0.669
LIG_SUMO_SIM_anti_2	215	221	PF11976	0.460
LIG_SUMO_SIM_anti_2	362	367	PF11976	0.337
LIG_SUMO_SIM_anti_2	380	388	PF11976	0.228
LIG_SUMO_SIM_par_1	155	161	PF11976	0.423
LIG_SUMO_SIM_par_1	215	221	PF11976	0.336
LIG_SUMO_SIM_par_1	278	285	PF11976	0.447
LIG_SUMO_SIM_par_1	308	314	PF11976	0.351
LIG_SUMO_SIM_par_1	530	536	PF11976	0.363
LIG_TRAF2_1	100	103	PF00917	0.575
LIG_TRAF2_1	640	643	PF00917	0.628
LIG_TRAF2_1	675	678	PF00917	0.732
LIG_TRAF2_1	681	684	PF00917	0.707
LIG_TYR_ITIM	209	214	PF00017	0.460
LIG_WRC_WIRS_1	240	245	PF05994	0.424
LIG_WW_1	473	476	PF00397	0.446
LIG_WW_3	1	5	PF00397	0.620
MOD_CDK_SPK_2	12	17	PF00069	0.785
MOD_CDK_SPK_2	172	177	PF00069	0.616
MOD_CDK_SPxK_1	601	607	PF00069	0.640
MOD_CDK_SPxxK_3	521	528	PF00069	0.399
MOD_CK1_1	196	202	PF00069	0.569
MOD_CK1_1	258	264	PF00069	0.368
MOD_CK1_1	467	473	PF00069	0.365
MOD_CK1_1	501	507	PF00069	0.727
MOD_CK1_1	521	527	PF00069	0.293
MOD_CK1_1	625	631	PF00069	0.734
MOD_CK1_1	634	640	PF00069	0.642
MOD_CK1_1	655	661	PF00069	0.769
MOD_CK1_1	747	753	PF00069	0.730
MOD_CK2_1	212	218	PF00069	0.459
MOD_CK2_1	310	316	PF00069	0.320
MOD_CK2_1	530	536	PF00069	0.475
MOD_CK2_1	636	642	PF00069	0.640
MOD_CK2_1	684	690	PF00069	0.641
MOD_CK2_1	791	797	PF00069	0.594
MOD_CK2_1	97	103	PF00069	0.658
MOD_Cter_Amidation	608	611	PF01082	0.533
MOD_GlcNHglycan	195	198	PF01048	0.595
MOD_GlcNHglycan	351	354	PF01048	0.439
MOD_GlcNHglycan	432	437	PF01048	0.615
MOD_GlcNHglycan	54	57	PF01048	0.661
MOD_GlcNHglycan	552	555	PF01048	0.498
MOD_GlcNHglycan	568	571	PF01048	0.363
MOD_GlcNHglycan	576	579	PF01048	0.387
MOD_GlcNHglycan	601	604	PF01048	0.728
MOD_GlcNHglycan	607	610	PF01048	0.665
MOD_GlcNHglycan	624	627	PF01048	0.595
MOD_GlcNHglycan	638	641	PF01048	0.540
MOD_GlcNHglycan	741	744	PF01048	0.714
MOD_GlcNHglycan	749	752	PF01048	0.726
MOD_GlcNHglycan	94	97	PF01048	0.795
MOD_GSK3_1	105	112	PF00069	0.698
MOD_GSK3_1	127	134	PF00069	0.440
MOD_GSK3_1	139	146	PF00069	0.388
MOD_GSK3_1	187	194	PF00069	0.633
MOD_GSK3_1	290	297	PF00069	0.479
MOD_GSK3_1	337	344	PF00069	0.583
MOD_GSK3_1	428	435	PF00069	0.580
MOD_GSK3_1	494	501	PF00069	0.585
MOD_GSK3_1	52	59	PF00069	0.531
MOD_GSK3_1	601	608	PF00069	0.765
MOD_GSK3_1	622	629	PF00069	0.699
MOD_GSK3_1	651	658	PF00069	0.810
MOD_GSK3_1	734	741	PF00069	0.687
MOD_N-GLC_2	88	90	PF02516	0.594
MOD_NEK2_1	193	198	PF00069	0.580
MOD_NEK2_1	384	389	PF00069	0.505
MOD_NEK2_1	62	67	PF00069	0.753
MOD_NEK2_2	127	132	PF00069	0.446
MOD_NEK2_2	6	11	PF00069	0.738
MOD_PIKK_1	337	343	PF00454	0.468
MOD_PIKK_1	385	391	PF00454	0.404
MOD_PIKK_1	499	505	PF00454	0.682
MOD_PKA_1	620	626	PF00069	0.606
MOD_PKA_2	131	137	PF00069	0.383
MOD_PKA_2	191	197	PF00069	0.779
MOD_PKA_2	294	300	PF00069	0.535
MOD_PKA_2	499	505	PF00069	0.729
MOD_PKA_2	620	626	PF00069	0.635
MOD_PKB_1	618	626	PF00069	0.628
MOD_Plk_1	255	261	PF00069	0.333
MOD_Plk_1	361	367	PF00069	0.361
MOD_Plk_1	634	640	PF00069	0.569
MOD_Plk_1	706	712	PF00069	0.598
MOD_Plk_2-3	792	798	PF00069	0.579
MOD_Plk_4	139	145	PF00069	0.392
MOD_Plk_4	244	250	PF00069	0.328
MOD_Plk_4	255	261	PF00069	0.398
MOD_Plk_4	317	323	PF00069	0.400
MOD_Plk_4	361	367	PF00069	0.372
MOD_Plk_4	464	470	PF00069	0.429
MOD_Plk_4	530	536	PF00069	0.475
MOD_Plk_4	715	721	PF00069	0.595
MOD_ProDKin_1	12	18	PF00069	0.681
MOD_ProDKin_1	172	178	PF00069	0.620
MOD_ProDKin_1	43	49	PF00069	0.632
MOD_ProDKin_1	469	475	PF00069	0.442
MOD_ProDKin_1	521	527	PF00069	0.406
MOD_ProDKin_1	601	607	PF00069	0.649
MOD_ProDKin_1	653	659	PF00069	0.613
MOD_ProDKin_1	734	740	PF00069	0.579
MOD_ProDKin_1	777	783	PF00069	0.746
MOD_SUMO_rev_2	792	800	PF00179	0.644
TRG_DiLeu_BaEn_1	23	28	PF01217	0.570
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.384
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.516
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.557
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.434
TRG_ENDOCYTIC_2	205	208	PF00928	0.544
TRG_ENDOCYTIC_2	211	214	PF00928	0.459
TRG_ENDOCYTIC_2	476	479	PF00928	0.420
TRG_ER_diArg_1	10	13	PF00400	0.736
TRG_ER_diArg_1	116	118	PF00400	0.573
TRG_ER_diArg_1	131	133	PF00400	0.349
TRG_ER_diArg_1	305	307	PF00400	0.418
TRG_ER_diArg_1	331	334	PF00400	0.460
TRG_ER_diArg_1	357	360	PF00400	0.446
TRG_ER_diArg_1	454	456	PF00400	0.531
TRG_ER_diArg_1	610	612	PF00400	0.595
TRG_ER_diArg_1	618	621	PF00400	0.524
TRG_ER_diArg_1	727	729	PF00400	0.665
TRG_ER_diArg_1	730	732	PF00400	0.672
TRG_ER_diArg_1	765	768	PF00400	0.630
TRG_ER_diArg_1	770	773	PF00400	0.657
TRG_ER_diArg_1	79	81	PF00400	0.700
TRG_NLS_MonoCore_2	611	616	PF00514	0.617
TRG_NLS_MonoExtN_4	610	617	PF00514	0.659
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU74	Leptomonas seymouri	64%	100%
A0A1X0NU60	Trypanosomatidae	46%	100%
A0A422N3L6	Trypanosoma rangeli	50%	100%
A4H803	Leishmania braziliensis	80%	99%
A4HWD1	Leishmania infantum	100%	100%
C9ZNX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AQ31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QFF1	Leishmania major	95%	100%
V5BL46	Trypanosoma cruzi	50%	100%