Serine/threonine-protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTA3_LEIDO

TriTrypDb:

LdBPK_150180.1 , LdCL_150006700 , LDHU3_15.0250

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WTA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTA3

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0018210	peptidyl-threonine modification	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003712	transcription coregulator activity	2	1
GO:0003713	transcription coactivator activity	3	1
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.708
CLV_C14_Caspase3-7	344	348	PF00656	0.581
CLV_C14_Caspase3-7	43	47	PF00656	0.785
CLV_C14_Caspase3-7	664	668	PF00656	0.319
CLV_NRD_NRD_1	330	332	PF00675	0.624
CLV_NRD_NRD_1	394	396	PF00675	0.495
CLV_NRD_NRD_1	464	466	PF00675	0.495
CLV_NRD_NRD_1	615	617	PF00675	0.495
CLV_NRD_NRD_1	632	634	PF00675	0.213
CLV_PCSK_FUR_1	630	634	PF00082	0.495
CLV_PCSK_KEX2_1	330	332	PF00082	0.624
CLV_PCSK_KEX2_1	383	385	PF00082	0.495
CLV_PCSK_KEX2_1	394	396	PF00082	0.313
CLV_PCSK_KEX2_1	519	521	PF00082	0.495
CLV_PCSK_KEX2_1	615	617	PF00082	0.495
CLV_PCSK_KEX2_1	632	634	PF00082	0.213
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.495
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.495
CLV_PCSK_SKI1_1	425	429	PF00082	0.495
CLV_PCSK_SKI1_1	666	670	PF00082	0.401
CLV_PCSK_SKI1_1	728	732	PF00082	0.637
DEG_APCC_DBOX_1	546	554	PF00400	0.495
DEG_APCC_DBOX_1	614	622	PF00400	0.495
DEG_SPOP_SBC_1	211	215	PF00917	0.717
DEG_SPOP_SBC_1	266	270	PF00917	0.716
DEG_SPOP_SBC_1	99	103	PF00917	0.651
DOC_ANK_TNKS_1	127	134	PF00023	0.708
DOC_CKS1_1	541	546	PF01111	0.495
DOC_CKS1_1	634	639	PF01111	0.495
DOC_MAPK_gen_1	452	461	PF00069	0.495
DOC_MAPK_gen_1	528	538	PF00069	0.495
DOC_MAPK_HePTP_8	525	537	PF00069	0.495
DOC_MAPK_MEF2A_6	254	263	PF00069	0.706
DOC_MAPK_MEF2A_6	306	315	PF00069	0.650
DOC_MAPK_MEF2A_6	400	409	PF00069	0.495
DOC_MAPK_MEF2A_6	455	463	PF00069	0.495
DOC_MAPK_MEF2A_6	528	537	PF00069	0.495
DOC_PP1_RVXF_1	505	512	PF00149	0.495
DOC_PP2B_LxvP_1	351	354	PF13499	0.566
DOC_PP4_FxxP_1	673	676	PF00568	0.599
DOC_USP7_MATH_1	100	104	PF00917	0.699
DOC_USP7_MATH_1	156	160	PF00917	0.699
DOC_USP7_MATH_1	168	172	PF00917	0.562
DOC_USP7_MATH_1	2	6	PF00917	0.763
DOC_USP7_MATH_1	221	225	PF00917	0.632
DOC_USP7_MATH_1	244	248	PF00917	0.724
DOC_USP7_MATH_1	266	270	PF00917	0.671
DOC_USP7_MATH_1	293	297	PF00917	0.629
DOC_USP7_MATH_2	659	665	PF00917	0.319
DOC_WW_Pin1_4	10	15	PF00397	0.666
DOC_WW_Pin1_4	105	110	PF00397	0.706
DOC_WW_Pin1_4	123	128	PF00397	0.588
DOC_WW_Pin1_4	331	336	PF00397	0.653
DOC_WW_Pin1_4	529	534	PF00397	0.495
DOC_WW_Pin1_4	540	545	PF00397	0.313
DOC_WW_Pin1_4	588	593	PF00397	0.495
DOC_WW_Pin1_4	633	638	PF00397	0.495
DOC_WW_Pin1_4	715	720	PF00397	0.623
LIG_14-3-3_CanoR_1	117	127	PF00244	0.692
LIG_14-3-3_CanoR_1	394	400	PF00244	0.495
LIG_14-3-3_CanoR_1	547	551	PF00244	0.495
LIG_14-3-3_CanoR_1	615	619	PF00244	0.495
LIG_14-3-3_CanoR_1	662	669	PF00244	0.319
LIG_14-3-3_CanoR_1	735	743	PF00244	0.717
LIG_APCC_ABBA_1	535	540	PF00400	0.495
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_Clathr_ClatBox_1	475	479	PF01394	0.495
LIG_EH1_1	420	428	PF00400	0.495
LIG_FHA_1	470	476	PF00498	0.359
LIG_FHA_1	677	683	PF00498	0.634
LIG_FHA_1	725	731	PF00498	0.648
LIG_FHA_1	89	95	PF00498	0.708
LIG_FHA_2	127	133	PF00498	0.784
LIG_FHA_2	41	47	PF00498	0.721
LIG_FHA_2	541	547	PF00498	0.495
LIG_FHA_2	729	735	PF00498	0.733
LIG_Integrin_isoDGR_2	235	237	PF01839	0.761
LIG_LIR_Apic_2	302	307	PF02991	0.696
LIG_LIR_Apic_2	527	533	PF02991	0.495
LIG_LIR_Apic_2	540	544	PF02991	0.280
LIG_LIR_Gen_1	347	358	PF02991	0.548
LIG_LIR_Gen_1	646	655	PF02991	0.496
LIG_LIR_Nem_3	347	353	PF02991	0.555
LIG_LIR_Nem_3	356	362	PF02991	0.393
LIG_LIR_Nem_3	372	376	PF02991	0.230
LIG_LIR_Nem_3	444	448	PF02991	0.495
LIG_LIR_Nem_3	454	459	PF02991	0.329
LIG_LIR_Nem_3	641	647	PF02991	0.429
LIG_LIR_Nem_3	652	657	PF02991	0.402
LIG_MYND_1	672	676	PF01753	0.495
LIG_NRBOX	406	412	PF00104	0.495
LIG_PCNA_yPIPBox_3	412	423	PF02747	0.495
LIG_Pex14_2	650	654	PF04695	0.495
LIG_PTB_Apo_2	320	327	PF02174	0.602
LIG_PTB_Phospho_1	320	326	PF10480	0.607
LIG_RPA_C_Fungi	320	332	PF08784	0.573
LIG_SH2_CRK	304	308	PF00017	0.691
LIG_SH2_CRK	319	323	PF00017	0.347
LIG_SH2_CRK	448	452	PF00017	0.495
LIG_SH2_CRK	541	545	PF00017	0.495
LIG_SH2_NCK_1	304	308	PF00017	0.613
LIG_SH2_NCK_1	75	79	PF00017	0.707
LIG_SH2_STAP1	36	40	PF00017	0.762
LIG_SH2_STAP1	678	682	PF00017	0.635
LIG_SH2_STAT3	326	329	PF00017	0.611
LIG_SH2_STAT3	362	365	PF00017	0.528
LIG_SH2_STAT5	326	329	PF00017	0.611
LIG_SH2_STAT5	350	353	PF00017	0.548
LIG_SH2_STAT5	362	365	PF00017	0.330
LIG_SH2_STAT5	516	519	PF00017	0.463
LIG_SH2_STAT5	52	55	PF00017	0.698
LIG_SH2_STAT5	524	527	PF00017	0.393
LIG_SH2_STAT5	678	681	PF00017	0.633
LIG_SH3_1	713	719	PF00018	0.623
LIG_SH3_2	697	702	PF14604	0.737
LIG_SH3_3	150	156	PF00018	0.755
LIG_SH3_3	197	203	PF00018	0.656
LIG_SH3_3	236	242	PF00018	0.668
LIG_SH3_3	253	259	PF00018	0.622
LIG_SH3_3	687	693	PF00018	0.676
LIG_SH3_3	694	700	PF00018	0.736
LIG_SH3_3	713	719	PF00018	0.519
LIG_SH3_4	713	720	PF00018	0.759
LIG_SUMO_SIM_anti_2	406	411	PF11976	0.495
LIG_SUMO_SIM_anti_2	460	465	PF11976	0.495
LIG_SUMO_SIM_par_1	435	441	PF11976	0.495
LIG_UBA3_1	315	320	PF00899	0.608
LIG_UBA3_1	475	482	PF00899	0.353
LIG_WRC_WIRS_1	442	447	PF05994	0.495
MOD_CDC14_SPxK_1	13	16	PF00782	0.659
MOD_CDK_SPK_2	123	128	PF00069	0.703
MOD_CDK_SPK_2	588	593	PF00069	0.495
MOD_CDK_SPK_2	715	720	PF00069	0.621
MOD_CDK_SPxK_1	10	16	PF00069	0.667
MOD_CDK_SPxxK_3	331	338	PF00069	0.658
MOD_CDK_SPxxK_3	540	547	PF00069	0.495
MOD_CK1_1	103	109	PF00069	0.688
MOD_CK1_1	111	117	PF00069	0.658
MOD_CK1_1	123	129	PF00069	0.489
MOD_CK1_1	191	197	PF00069	0.780
MOD_CK1_1	212	218	PF00069	0.707
MOD_CK1_1	224	230	PF00069	0.569
MOD_CK1_1	264	270	PF00069	0.726
MOD_CK1_1	372	378	PF00069	0.495
MOD_CK1_1	398	404	PF00069	0.495
MOD_CK1_1	5	11	PF00069	0.765
MOD_CK1_1	709	715	PF00069	0.830
MOD_CK1_1	736	742	PF00069	0.727
MOD_CK1_1	76	82	PF00069	0.738
MOD_CK1_1	88	94	PF00069	0.610
MOD_CK2_1	126	132	PF00069	0.705
MOD_CK2_1	237	243	PF00069	0.699
MOD_CK2_1	728	734	PF00069	0.809
MOD_Cter_Amidation	630	633	PF01082	0.495
MOD_GlcNHglycan	110	113	PF01048	0.774
MOD_GlcNHglycan	170	173	PF01048	0.760
MOD_GlcNHglycan	191	194	PF01048	0.748
MOD_GlcNHglycan	223	226	PF01048	0.600
MOD_GlcNHglycan	269	272	PF01048	0.779
MOD_GlcNHglycan	280	283	PF01048	0.608
MOD_GlcNHglycan	340	343	PF01048	0.614
MOD_GlcNHglycan	503	506	PF01048	0.378
MOD_GlcNHglycan	512	515	PF01048	0.288
MOD_GlcNHglycan	603	606	PF01048	0.495
MOD_GlcNHglycan	694	697	PF01048	0.613
MOD_GlcNHglycan	738	741	PF01048	0.740
MOD_GlcNHglycan	77	81	PF01048	0.786
MOD_GSK3_1	1	8	PF00069	0.765
MOD_GSK3_1	111	118	PF00069	0.604
MOD_GSK3_1	119	126	PF00069	0.727
MOD_GSK3_1	188	195	PF00069	0.771
MOD_GSK3_1	224	231	PF00069	0.709
MOD_GSK3_1	245	252	PF00069	0.757
MOD_GSK3_1	261	268	PF00069	0.591
MOD_GSK3_1	390	397	PF00069	0.495
MOD_GSK3_1	40	47	PF00069	0.788
MOD_GSK3_1	510	517	PF00069	0.444
MOD_GSK3_1	724	731	PF00069	0.698
MOD_GSK3_1	98	105	PF00069	0.690
MOD_N-GLC_1	501	506	PF02516	0.495
MOD_N-GLC_1	600	605	PF02516	0.495
MOD_N-GLC_1	722	727	PF02516	0.583
MOD_N-GLC_2	163	165	PF02516	0.668
MOD_NEK2_1	1	6	PF00069	0.764
MOD_NEK2_1	120	125	PF00069	0.728
MOD_NEK2_1	157	162	PF00069	0.663
MOD_NEK2_1	390	395	PF00069	0.495
MOD_NEK2_1	471	476	PF00069	0.495
MOD_PIKK_1	398	404	PF00454	0.495
MOD_PIKK_1	40	46	PF00454	0.790
MOD_PIKK_1	703	709	PF00454	0.810
MOD_PKA_1	394	400	PF00069	0.495
MOD_PKA_2	118	124	PF00069	0.746
MOD_PKA_2	394	400	PF00069	0.495
MOD_PKA_2	546	552	PF00069	0.495
MOD_PKA_2	614	620	PF00069	0.495
MOD_PKA_2	661	667	PF00069	0.319
MOD_PKA_2	736	742	PF00069	0.733
MOD_PKA_2	88	94	PF00069	0.708
MOD_PKB_1	117	125	PF00069	0.743
MOD_Plk_1	576	582	PF00069	0.495
MOD_Plk_2-3	614	620	PF00069	0.495
MOD_Plk_4	372	378	PF00069	0.495
MOD_Plk_4	471	477	PF00069	0.495
MOD_Plk_4	617	623	PF00069	0.495
MOD_ProDKin_1	10	16	PF00069	0.667
MOD_ProDKin_1	105	111	PF00069	0.705
MOD_ProDKin_1	123	129	PF00069	0.588
MOD_ProDKin_1	331	337	PF00069	0.657
MOD_ProDKin_1	529	535	PF00069	0.495
MOD_ProDKin_1	540	546	PF00069	0.313
MOD_ProDKin_1	588	594	PF00069	0.495
MOD_ProDKin_1	633	639	PF00069	0.495
MOD_ProDKin_1	715	721	PF00069	0.622
MOD_SUMO_for_1	403	406	PF00179	0.495
MOD_SUMO_for_1	491	494	PF00179	0.495
MOD_SUMO_for_1	574	577	PF00179	0.495
TRG_DiLeu_BaEn_1	406	411	PF01217	0.495
TRG_DiLeu_BaEn_2	533	539	PF01217	0.495
TRG_DiLeu_BaEn_2	645	651	PF01217	0.311
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.495
TRG_DiLeu_BaLyEn_6	504	509	PF01217	0.495
TRG_ENDOCYTIC_2	319	322	PF00928	0.605
TRG_ENDOCYTIC_2	350	353	PF00928	0.548
TRG_ENDOCYTIC_2	448	451	PF00928	0.495
TRG_ENDOCYTIC_2	644	647	PF00928	0.495
TRG_ER_diArg_1	117	120	PF00400	0.780
TRG_ER_diArg_1	330	332	PF00400	0.624
TRG_ER_diArg_1	629	632	PF00400	0.495
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	653	658	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H7Y7	Leishmania braziliensis	76%	100%
A4HWB5	Leishmania infantum	99%	100%
E9AQ15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AVG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4QC19	Leishmania major	31%	100%
Q4QFG6	Leishmania major	94%	100%
Q5U4C9	Mus musculus	37%	100%
Q92630	Homo sapiens	35%	100%