Protein phosphatase 2C, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2C, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WTA2_LEIDO

TriTrypDb:

LdBPK_150170.1 , LdCL_150006600 , LDHU3_15.0240

Length:

404

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S7WTA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WTA2

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	24
GO:0006793	phosphorus metabolic process	3	24
GO:0006796	phosphate-containing compound metabolic process	4	24
GO:0006807	nitrogen compound metabolic process	2	24
GO:0008152	metabolic process	1	24
GO:0009987	cellular process	1	24
GO:0016311	dephosphorylation	5	24
GO:0019538	protein metabolic process	3	24
GO:0036211	protein modification process	4	24
GO:0043170	macromolecule metabolic process	3	24
GO:0043412	macromolecule modification	4	24
GO:0044237	cellular metabolic process	2	24
GO:0044238	primary metabolic process	2	24
GO:0071704	organic substance metabolic process	2	24
GO:1901564	organonitrogen compound metabolic process	3	24

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	24
GO:0004721	phosphoprotein phosphatase activity	3	24
GO:0004722	protein serine/threonine phosphatase activity	4	24
GO:0016787	hydrolase activity	2	24
GO:0016788	hydrolase activity, acting on ester bonds	3	24
GO:0016791	phosphatase activity	5	24
GO:0017018	myosin phosphatase activity	5	5
GO:0042578	phosphoric ester hydrolase activity	4	24
GO:0140096	catalytic activity, acting on a protein	2	24
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	391	395	PF00656	0.363
CLV_NRD_NRD_1	6	8	PF00675	0.726
CLV_NRD_NRD_1	71	73	PF00675	0.533
CLV_PCSK_KEX2_1	310	312	PF00082	0.386
CLV_PCSK_KEX2_1	328	330	PF00082	0.452
CLV_PCSK_KEX2_1	6	8	PF00082	0.724
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.386
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.452
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.724
CLV_PCSK_SKI1_1	117	121	PF00082	0.413
CLV_PCSK_SKI1_1	194	198	PF00082	0.308
CLV_PCSK_SKI1_1	210	214	PF00082	0.319
CLV_PCSK_SKI1_1	217	221	PF00082	0.329
CLV_PCSK_SKI1_1	251	255	PF00082	0.310
CLV_PCSK_SKI1_1	359	363	PF00082	0.248
CLV_PCSK_SKI1_1	60	64	PF00082	0.503
DEG_Nend_UBRbox_1	1	4	PF02207	0.542
DOC_CKS1_1	195	200	PF01111	0.311
DOC_MAPK_DCC_7	359	369	PF00069	0.169
DOC_MAPK_gen_1	359	369	PF00069	0.203
DOC_MAPK_MEF2A_6	360	369	PF00069	0.406
DOC_PP2B_LxvP_1	317	320	PF13499	0.402
DOC_PP2B_PxIxI_1	364	370	PF00149	0.169
DOC_USP7_MATH_1	113	117	PF00917	0.549
DOC_USP7_MATH_1	331	335	PF00917	0.425
DOC_USP7_UBL2_3	2	6	PF12436	0.642
DOC_USP7_UBL2_3	306	310	PF12436	0.304
DOC_WW_Pin1_4	194	199	PF00397	0.311
DOC_WW_Pin1_4	235	240	PF00397	0.303
DOC_WW_Pin1_4	379	384	PF00397	0.442
LIG_14-3-3_CanoR_1	94	99	PF00244	0.570
LIG_BRCT_BRCA1_1	184	188	PF00533	0.244
LIG_FHA_1	232	238	PF00498	0.249
LIG_FHA_1	395	401	PF00498	0.342
LIG_FHA_1	48	54	PF00498	0.505
LIG_FHA_1	82	88	PF00498	0.636
LIG_FHA_2	307	313	PF00498	0.299
LIG_LIR_Apic_2	193	198	PF02991	0.217
LIG_LIR_Apic_2	234	239	PF02991	0.217
LIG_LIR_Gen_1	209	219	PF02991	0.289
LIG_LIR_Gen_1	334	343	PF02991	0.305
LIG_LIR_Gen_1	36	46	PF02991	0.437
LIG_LIR_Nem_3	166	172	PF02991	0.309
LIG_LIR_Nem_3	209	215	PF02991	0.287
LIG_LIR_Nem_3	334	338	PF02991	0.305
LIG_LIR_Nem_3	341	347	PF02991	0.307
LIG_LIR_Nem_3	36	42	PF02991	0.454
LIG_NRBOX	99	105	PF00104	0.508
LIG_PCNA_yPIPBox_3	94	108	PF02747	0.477
LIG_Pex14_2	208	212	PF04695	0.335
LIG_PTB_Apo_2	127	134	PF02174	0.403
LIG_PTB_Apo_2	151	158	PF02174	0.244
LIG_RPA_C_Fungi	89	101	PF08784	0.404
LIG_SH2_CRK	195	199	PF00017	0.426
LIG_SH2_NCK_1	195	199	PF00017	0.337
LIG_SH2_PTP2	236	239	PF00017	0.408
LIG_SH2_PTP2	335	338	PF00017	0.408
LIG_SH2_STAT5	168	171	PF00017	0.444
LIG_SH2_STAT5	236	239	PF00017	0.446
LIG_SH2_STAT5	335	338	PF00017	0.408
LIG_SH3_3	316	322	PF00018	0.354
LIG_SH3_3	377	383	PF00018	0.244
LIG_SUMO_SIM_anti_2	397	402	PF11976	0.367
LIG_SUMO_SIM_par_1	396	402	PF11976	0.355
LIG_TRAF2_1	238	241	PF00917	0.385
LIG_TRAF2_1	348	351	PF00917	0.335
LIG_UBA3_1	352	360	PF00899	0.408
LIG_UBA3_1	399	404	PF00899	0.360
MOD_CK1_1	228	234	PF00069	0.339
MOD_CK1_1	44	50	PF00069	0.484
MOD_CK2_1	187	193	PF00069	0.456
MOD_CK2_1	235	241	PF00069	0.304
MOD_CK2_1	306	312	PF00069	0.302
MOD_CK2_1	345	351	PF00069	0.319
MOD_CK2_1	378	384	PF00069	0.397
MOD_CK2_1	80	86	PF00069	0.579
MOD_GlcNHglycan	158	161	PF01048	0.348
MOD_GlcNHglycan	175	178	PF01048	0.138
MOD_GlcNHglycan	179	182	PF01048	0.232
MOD_GlcNHglycan	227	230	PF01048	0.349
MOD_GlcNHglycan	329	332	PF01048	0.395
MOD_GSK3_1	113	120	PF00069	0.497
MOD_GSK3_1	121	128	PF00069	0.475
MOD_GSK3_1	173	180	PF00069	0.471
MOD_GSK3_1	182	189	PF00069	0.434
MOD_GSK3_1	231	238	PF00069	0.263
MOD_GSK3_1	323	330	PF00069	0.420
MOD_GSK3_1	390	397	PF00069	0.428
MOD_N-GLC_1	14	19	PF02516	0.620
MOD_N-GLC_1	394	399	PF02516	0.344
MOD_N-GLC_1	8	13	PF02516	0.571
MOD_N-GLC_2	182	184	PF02516	0.203
MOD_N-GLC_2	375	377	PF02516	0.439
MOD_NEK2_1	294	299	PF00069	0.313
MOD_NEK2_1	46	51	PF00069	0.558
MOD_PIKK_1	182	188	PF00454	0.395
MOD_PKA_1	7	13	PF00069	0.571
MOD_PKA_2	81	87	PF00069	0.609
MOD_Plk_1	394	400	PF00069	0.342
MOD_Plk_4	231	237	PF00069	0.331
MOD_Plk_4	331	337	PF00069	0.303
MOD_Plk_4	394	400	PF00069	0.340
MOD_ProDKin_1	194	200	PF00069	0.311
MOD_ProDKin_1	235	241	PF00069	0.303
MOD_ProDKin_1	379	385	PF00069	0.442
MOD_SUMO_rev_2	264	269	PF00179	0.309
MOD_SUMO_rev_2	354	361	PF00179	0.217
TRG_DiLeu_BaEn_1	148	153	PF01217	0.328
TRG_DiLeu_BaEn_3	350	356	PF01217	0.401
TRG_ENDOCYTIC_2	168	171	PF00928	0.447
TRG_ENDOCYTIC_2	335	338	PF00928	0.408
TRG_NLS_MonoExtC_3	71	77	PF00514	0.582
TRG_NLS_MonoExtN_4	4	10	PF00514	0.711
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C7	Leptomonas seymouri	71%	100%
A0A0N0P8F8	Leptomonas seymouri	38%	100%
A0A0N1I0H9	Leptomonas seymouri	39%	100%
A0A0N1I8W9	Leptomonas seymouri	30%	93%
A0A0N1IHU6	Leptomonas seymouri	31%	99%
A0A0N1PAL8	Leptomonas seymouri	31%	100%
A0A0N1PET0	Leptomonas seymouri	38%	69%
A0A0S4IY95	Bodo saltans	37%	100%
A0A0S4J0A6	Bodo saltans	29%	99%
A0A0S4JPC3	Bodo saltans	42%	100%
A0A0S4JPM8	Bodo saltans	47%	100%
A0A0S4KIS4	Bodo saltans	35%	89%
A0A0S4KJV9	Bodo saltans	40%	93%
A0A1X0NRG3	Trypanosomatidae	37%	100%
A0A1X0NVC4	Trypanosomatidae	53%	98%
A0A1X0P568	Trypanosomatidae	32%	99%
A0A1X0P991	Trypanosomatidae	40%	100%
A0A1X0PAN4	Trypanosomatidae	28%	100%
A0A3Q8IEK6	Leishmania donovani	41%	100%
A0A3Q8IFG7	Leishmania donovani	31%	100%
A0A3Q8IGS1	Leishmania donovani	36%	72%
A0A3Q8IK65	Leishmania donovani	41%	100%
A0A3S7WZ14	Leishmania donovani	30%	100%
A0A3S7X808	Leishmania donovani	29%	90%
A0A422N8D7	Trypanosoma rangeli	28%	100%
A0A422NAJ1	Trypanosoma rangeli	37%	100%
A0A422NL94	Trypanosoma rangeli	38%	92%
A0A422NML6	Trypanosoma rangeli	32%	100%
A0A422NS77	Trypanosoma rangeli	50%	98%
A0A422P293	Trypanosoma rangeli	40%	100%
A0BLX0	Paramecium tetraurelia	34%	100%
A0BQL0	Paramecium tetraurelia	36%	100%
A0CUB5	Paramecium tetraurelia	32%	100%
A0DSB3	Paramecium tetraurelia	33%	100%
A0DTY1	Paramecium tetraurelia	35%	100%
A3A8W2	Oryza sativa subsp. japonica	30%	100%
A3A8W6	Oryza sativa subsp. japonica	26%	70%
A4H7Y6	Leishmania braziliensis	80%	100%
A4HAW6	Leishmania braziliensis	28%	90%
A4HE10	Leishmania braziliensis	29%	100%
A4HG10	Leishmania braziliensis	41%	100%
A4HHY5	Leishmania braziliensis	31%	100%
A4HKF6	Leishmania braziliensis	35%	71%
A4HNR1	Leishmania braziliensis	40%	100%
A4HWB4	Leishmania infantum	100%	100%
A4I1B7	Leishmania infantum	30%	100%
A4I329	Leishmania infantum	41%	100%
A4I565	Leishmania infantum	31%	100%
A4I7Y4	Leishmania infantum	36%	72%
A4IA26	Leishmania infantum	29%	90%
A4ICT4	Leishmania infantum	41%	100%
A5PJZ2	Bos taurus	32%	100%
C9ZJK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZMJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZNW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	95%
D0A2L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ACV0	Leishmania major	41%	100%
E9AQ14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9ASH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AXF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AZD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B0G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B2U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	72%
E9B541	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
O62829	Bos taurus	35%	100%
O62830	Bos taurus	37%	83%
O75688	Homo sapiens	37%	84%
O81716	Arabidopsis thaliana	32%	100%
P20650	Rattus norvegicus	35%	100%
P34221	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	86%
P35182	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P35813	Homo sapiens	35%	100%
P35814	Oryctolagus cuniculus	35%	100%
P35815	Rattus norvegicus	37%	100%
P36982	Leishmania chagasi	30%	100%
P36993	Mus musculus	37%	100%
P38089	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P39966	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	87%
P49443	Mus musculus	35%	100%
P49444	Paramecium tetraurelia	34%	100%
P49593	Homo sapiens	30%	89%
P49594	Caenorhabditis elegans	25%	90%
P49596	Caenorhabditis elegans	39%	100%
P49599	Arabidopsis thaliana	28%	100%
Q09172	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
Q09173	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	98%
Q0IIF0	Bos taurus	31%	100%
Q0J2L7	Oryza sativa subsp. japonica	33%	100%
Q0JL75	Oryza sativa subsp. japonica	32%	100%
Q0JLP9	Oryza sativa subsp. japonica	33%	87%
Q10MN6	Oryza sativa subsp. japonica	29%	94%
Q10MX1	Oryza sativa subsp. japonica	30%	100%
Q19775	Caenorhabditis elegans	35%	86%
Q2QWE3	Oryza sativa subsp. japonica	27%	96%
Q2R637	Oryza sativa subsp. japonica	29%	94%
Q4Q225	Leishmania major	38%	100%
Q4Q2U5	Leishmania major	29%	90%
Q4Q5B1	Leishmania major	36%	72%
Q4Q7S1	Leishmania major	31%	100%
Q4QA19	Leishmania major	31%	100%
Q4QFG7	Leishmania major	95%	100%
Q53Q11	Oryza sativa subsp. japonica	30%	100%
Q5SGD2	Homo sapiens	32%	100%
Q5SMK6	Oryza sativa subsp. japonica	28%	100%
Q5SN75	Oryza sativa subsp. japonica	30%	100%
Q5Z6F5	Oryza sativa subsp. japonica	31%	100%
Q653S3	Oryza sativa subsp. japonica	32%	100%
Q65XG6	Oryza sativa subsp. japonica	33%	97%
Q67UP9	Oryza sativa subsp. japonica	33%	100%
Q67UX7	Oryza sativa subsp. japonica	32%	100%
Q69QZ0	Oryza sativa subsp. japonica	28%	100%
Q6AUQ4	Oryza sativa subsp. japonica	30%	100%
Q6ETK3	Oryza sativa subsp. japonica	33%	100%
Q6K1U4	Oryza sativa subsp. japonica	26%	78%
Q6K5I0	Oryza sativa subsp. japonica	26%	78%
Q6L4R7	Oryza sativa subsp. japonica	31%	91%
Q6L5H6	Oryza sativa subsp. japonica	33%	100%
Q6NKS1	Arabidopsis thaliana	29%	100%
Q7XJ53	Arabidopsis thaliana	27%	100%
Q7XU84	Oryza sativa subsp. japonica	31%	100%
Q8BHN0	Mus musculus	32%	100%
Q8CGA0	Mus musculus	30%	89%
Q8LAY8	Arabidopsis thaliana	31%	100%
Q8N819	Homo sapiens	34%	94%
Q8R0F6	Mus musculus	31%	100%
Q93YS2	Arabidopsis thaliana	24%	77%
Q9CAJ0	Arabidopsis thaliana	32%	79%
Q9FYN7	Oryza sativa subsp. japonica	31%	100%
Q9H0C8	Homo sapiens	31%	100%
Q9LNF4	Arabidopsis thaliana	29%	100%
Q9LNP9	Arabidopsis thaliana	31%	79%
Q9M1V8	Arabidopsis thaliana	24%	96%
Q9SZ53	Arabidopsis thaliana	33%	100%
Q9WVR7	Rattus norvegicus	31%	90%
Q9Z1Z6	Rattus norvegicus	31%	100%
V5BA03	Trypanosoma cruzi	41%	100%
V5BCX6	Trypanosoma cruzi	35%	100%
V5BH00	Trypanosoma cruzi	32%	100%
V5DCR6	Trypanosoma cruzi	51%	98%